Category: Books

Fingarette Provoked Thought on Alcohol and Death

When I was a graduate student in the late 1970s I attended a small seminar in Santa Barbara presented by Henry Fingarette on his thoughts on alcoholism. I do not know if I agree with those thoughts, or his thoughts on death, mentioned in the obituary quoted below. But I enjoyed his non-politically-correct seminar and still find his thoughts on both topics to be worth pondering. [I participated in the seminar as part of a month or two residency in Santa Barbara organized by the philosopher Tibor Machan and funded by the Reason Foundation. Other participants included David Levy, Doug Rasmussen, and Doug Den Uyl. Gary Becker told me that it was a mistake for me to attend; he said those weeks would be better spent staying in Chicago and improving my math skills. Becker’s advice was sincere and well-intentioned, but even now I am conflicted on whether I should have followed his advice.]

(p. 26) Herbert Fingarette, a contrarian philosopher who, while plumbing the perplexities of personal responsibility, defined heavy drinking as willful behavior rather than as a potential disease, died on Nov. 2 at his home in Berkeley, Calif. He was 97.

. . .

In “Heavy Drinking: The Myth of Alcoholism as a Disease” (1988), Professor Fingarette all but accused the treatment industry of conspiring to profit from the conventional theory that alcoholism is a disease. He maintained that heavy use of alcohol is a “way of life,” that many heavy drinkers can choose to reduce their drinking to moderate levels, and that most definitions of the word “alcoholic” are phony.

“Some people can drink very heavily and get into no trouble whatsoever,” he told The New York Times in 1989.

. . .

At his death, he was completing an essay on how the dead continue to shape the lives of the living, a topic he had written about in “Death: Philosophical Soundings” (1996). . . .

“Never in my life will I experience death,” he wrote. “I will never know an end to my life, this life of mine right here on earth.” He added: “People hope never to know the end of consciousness. But why merely hope? It’s a certainty. They never will!”

For the full obituary, see:

Sam Roberts. “Herbert Fingarette, 97, Contrarian on Alcoholism.” The New York Times, First Section (Sunday, November 18, 2018 [sic]): 26.

(Note: ellipses added.)

(Note: the online version of the obituary has the date Nov. 15, 2018 [sic], and has the title “Herbert Fingarette, Contrarian Philosopher on Alcoholism, Dies at 97.”)

Fingarette’s book on alcoholism, mentioned above, is:

Fingarette, Herbert. Heavy Drinking: The Myth of Alcoholism as a Disease. Berkeley, CA: University of California Press, 1989.

Fingarette’s book on death, mentioned above, is:

Fingarette, Herbert. Death: Philosophical Soundings. Chicago: Open Court, 1999.

Our Brains Learn in a Process of Continuous Bayesian Updating

(p. A13) First articulated in the 18th century by a hobbyist-mathematician seeking to reason backward from effects to cause, Bayes’ theorem spent the better part of two centuries struggling for recognition and respect. Yet today, argues Tom Chivers in “Everything Is Predictable,” it can be seen as “perhaps the most important single equation in history.” It drives the logic of spam filters, artificial intelligence and possibly our own brains. . . .

At its core, the theorem provides a quantitative method for getting incrementally wiser by continuously updating what you think you know—your prior beliefs, which initially might be subjective—with new information. Your refined belief becomes the new prior, and the process repeats.

. . .

At times Mr. Chivers, a London-based science journalist who now writes for Semafor, seems overwhelmed by an admittedly complex subject, and his presentation lacks the clarity of Sharon Bertsch McGrayne’s “The Theory That Would Not Die” (2011). Yet he is onto something, since Bayes’ moment has clearly arrived. He notes that Bayesian reasoning is popular among “people who come from the new schools of data science—machine learning, Silicon Valley tech folks.” The mathematician Aubrey Clayton tells him that, in the cutting-edge realms of software engineering, “Bayesian methods are what you’d use.”

. . .

It’s notoriously difficult for most people to grasp problems in a structured Bayesian fashion. Suppose there is a test for a rare disease that is 99% accurate. You’d think that, if you tested positive, you’d probably have the disease. But when you figure in the prior—the fact that, for the average person (without specific risk factors), the chance of having a rare disease is incredibly low—then even a positive test means you’re still unlikely to have it. When quizzed by researchers, doctors consistently fail to consider prevalence—the relevant prior—in their interpretation of test results. Even so, Mr. Chivers insists, “our instinctive decision-making, from a Bayesian perspective, isn’t that bad.” And indeed, in practice, doctors quickly learn to favor common diagnoses over exotic possibilities.

. . .

Our brains work by making models of the world, Mr. Chivers reminds us, assessing how our expectations match what we earn from our senses, and then updating our perceptions accordingly. Deep down, it seems, we are all Bayesians.

For the full review, see:

David A. Shaywitz. “Thinking Prior to Thought.” The Wall Street Journal (Thursday, May 15, 2024): A13.

(Note: the online version of the review has the date May 14, 2024, and has the title “‘Everything Is Predictable’ Review: The Secret of Bayes.” In the last quoted sentence I have replaced the word “earn” that appears in both the online and print versions, with the word “learn.”)

The book under review is:

Chivers, Tom. Everything Is Predictable: How Bayesian Statistics Explain Our World. New York: Atria/One Signal Publishers, 2024.

Techno-Optimist Claims AI Tools “Will Help Scientists Design Therapies Faster and Better”

(p. A13) It is said that triumphant Roman generals, to ensure that the rapture of victory didn’t go to their heads, would require a companion to whisper in their ear: “Remember, you are only a man.” Jamie Metzl worries that we may have learned all too well such lessons in humility. Given remarkable recent advances in technology—and the promise of more to come—we need to lean into our emerging godlike powers, he believes, and embrace the opportunity to shape the world into a better place. In “Superconvergence,” he sets out to show us how, after first helping us overcome our hesitations.

. . .

. . . the big advances will be in medicine—and indeed are already in evidence. Mr. Metzl points to the blisteringly fast development of the Covid-19 mRNA vaccine, from digital file to widespread immunization in less than a year; and to gene-editing technologies like Crispr. He cites the experience of Victoria Gray, a young woman from Mississippi who was suffering from sickle-cell disease until, in 2019, researchers in Nashville, Tenn., reinfused her with her own cells, which had been Crispr-edited; the treatment worked, liberating her from the disease’s tormenting pain and crippling fatigue. For Mr. Metzl, these are just the first intimations of a revolution to come. AI tools like DeepMind’s Alphafold, he says, will help scientists design therapies faster and better.

To get smarter about human health, though, AI will need more information, and here Mr. Metzl’s ebullience edges toward the willful suspension of disbelief. His imagined future of healthcare will require “collecting huge amounts of genetic and systems biology data in massive and searchable databases.” The details will include not only medical records and the results of laboratory tests but data from the sensors he anticipates will be everywhere—“bathrooms, bedrooms, and offices”—as information is hoovered up from “toilets, mirrors, computers, phones and other devices without the people even noticing.” While acknowledging that such a scenario sounds like “an authoritarian’s dream and a free person’s nightmare,” he suggests that the chance to catch disease early may offset the risks. This trade-off promises to be a tough sell.

More than many techno-optimists, Mr. Metzl seems to grasp the intricacy of biological systems; he notes that they are beyond our full understanding right now. Even so, a time will come when “the sophistication of our tools and understanding meets and then exceeds the complexity of biology.”

For the full review, see:

David A. Shaywitz. “Getting Better, Faster.” The Wall Street Journal (Thursday, July 11, 2024): A13.

(Note: the online version of the review has the date July 10, 2024, and has the title “‘Superconvergence’ Review: Getting Better, Faster.”)

The book under review is:

Metzl, Jamie. Superconvergence: How the Genetics, Biotech, and AI Revolutions Will Transform Our Lives, Work, and World. New York: Timber Press, 2024.

“Righteous Rage” Against “The Absence of a Cure”

The commentary quoted below advocates a productive rage against “the dying of the light” (Dylan Thomas); a sense of urgency.

(p. D6) Dr. Sacks, who recorded his heavenly highs and hellish lows in “A Leg to Stand On,” believes that those with a disability often oscillate between grateful rejoicing and bitter denouncing of their circumstances. The same dynamic may hold true for cancer patients. So how does one sustain the joy while avoiding the rancor?

There can be no simple answer, but I seek clues in works of art created by terminal cancer patients. Take, for example, the paintings of Hollis Sigler, which have been shown in hospitals across the country and collected in the volume “Hollis Sigler’s Breast Cancer Journal.”

. . .  She depicts a shocking lack of control in a painting with food and silverware unexpectedly flying from a table in a tornado of debris. The image reminds me of Dr. Benedict B. Benigno’s perspective on cancer: “If life is a banquet, then cancer takes away the knife and fork and pulls the chair out from under us.”

To document the ravages of metastatic breast cancer, Ms. Sigler, who died of the disease in 2001, used spacers between frames for prose on the dire statistics and facts she had learned. On the edges of the paintings, she recorded additional words from her journals and those of the poet and breast cancer activist Audre Lorde. Bitterness and rancor certainly get expressed in these testimonies, but righteous rage is channeled toward the real enemies: the absence of a cure, the lack of preventive measures, inadequate detection tools, degrading and injurious treatments, miserable mortality rates, contaminants in the environment.

. . .

Not repressing but directing her anger, Ms. Sigler managed, through her dazzling artistry, to contest and revise the poet W. H. Auden’s advice: “Let your last thinks all be thanks.”

For the full commentary see:

Susan Gubar. “Living With Cancer: Curses and Blessings.” The New York Times (Tuesday, July 21, 2015 [sic]): D6.

(Note: ellipses added.)

(Note: the online version of the commentary has the date July 16, 2015 [sic], and has the same title as the print version.)

The book of paintings by Hollis Sigler, mentioned above, is:

Sigler, Hollis, Susan M. Love, and James Yood. Hollis Sigler’s Breast Cancer Journal. New York: Hudson Hills Press, 1999.

During Black Death Only 7 of 21 Regions of Europe Had Catastrophic Decline in Agricultural Activity

(p. D4) In the mid-1300s, a species of bacteria spread by fleas and rats swept across Asia and Europe, causing deadly cases of bubonic plague. The “Black Death” is one of the most notorious pandemics in historical memory, with many experts estimating that it killed roughly 50 million Europeans, the majority of people across the continent.

“The data is sufficiently widespread and numerous to make it likely that the Black Death swept away around 60 percent of Europe’s population,” Ole Benedictow, a Norwegian historian and one of the leading experts on the plague, wrote in 2005. When Dr. Benedictow published “The Complete History of the Black Death” in 2021, he raised that estimate to 65 percent.

But those figures, based on historical documents from the time, greatly overestimate the true toll of the plague, according to a study published on Thursday [Feb. 10, 2022]. By analyzing ancient deposits of pollen as markers of agricultural activity, researchers from Germany found that the Black Death caused a patchwork of destruction. Some regions of Europe did indeed suffer devastating losses, but other regions held stable, and some even boomed.

. . .

Losing half the population would have turned many farms fallow. Without enough herders to tend livestock, pastures would have become overgrown. Shrubs and trees would have taken over, eventually replaced by mature forests.

If the Black Death did indeed cause such a shift, Dr. Izdebski and his colleagues reasoned, they should be able to see it in the species of pollen that survived from the Middle Ages. Every year, plants release vast amounts of pollen into the air, and some of it ends up on the bottom of lakes and wetlands. Buried in the mud, the grains can survive sometimes for centuries.

To see what pollen had to say about the Black Death, Dr. Izdebski and his colleagues picked out 261 sites across Europe — from Ireland and Spain in the west to Greece and Lithuania in the east — that held grains preserved from around 1250 to 1450.

In some regions, such as Greece and central Italy, the pollen told a story of devastation. Pollen from crops like wheat dwindled. Dandelions and other flowers in pastureland faded. Fast-growing trees like birch appeared, followed by slow-growing ones like oaks.

But that was hardly the rule across Europe. In fact, just seven out of 21 regions the researchers studied underwent a catastrophic shift. In other places, the pollen registered little change at all.

. . .

Monica Green, an independent historian based in Phoenix, speculated that the Black Death might have been caused by two strains of the bacteria Yersinia pestis, which could have caused different levels of devastation. Yersinia DNA collected from medieval skeletons hints at this possibility, she said.

In their study, Dr. Izdebski and his colleagues did not examine that possibility, but they did consider a number of other factors, including the climate and density of populations in different parts of Europe. But none accounted for the pattern they found.

“There is no simple explanation behind that, or even a combination of simple explanations,” Dr. Izdebski said.

. . .

“What we show is that there are a number of factors, and it’s not easy to predict from the beginning which factors will matter,” he said, referring to how viruses can spread. “You cannot assume one mechanism to work everywhere the same way.”

For the full essay see:

Carl Zimmer. “Questioning the Toll Of a 1300s Pandemic.” The New York Times (Tuesday, February 15, 2022 [sic]): D4.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the essay was updated Feb. 15, 2022 [sic], and has the title “Did the ‘Black Death’ Really Kill Half of Europe? New Research Says No.”)

The book cited above as over-estimating the death toll of the Black Death is:

Benedictow, Ole J. The Complete History of the Black Death. Martlesham, UK: Boydell Press, 2021.

The academic article co-authored by Izdebski and mentioned above is:

Izdebski, A., P. Guzowski, R. Poniat, L. Masci, J. Palli, C. Vignola, M. Bauch, C. Cocozza, R. Fernandes, F. C. Ljungqvist, T. Newfield, A. Seim, D. Abel-Schaad, F. Alba-Sánchez, L. Björkman, A. Brauer, A. Brown, S. Czerwiński, A. Ejarque, M. Fiłoc, A. Florenzano, E. D. Fredh, R. Fyfe, N. Jasiunas, P. Kołaczek, K. Kouli, R. Kozáková, M. Kupryjanowicz, P. Lagerås, M. Lamentowicz, M. Lindbladh, J. A. López-Sáez, R. Luelmo-Lautenschlaeger, K. Marcisz, F. Mazier, S. Mensing, A. M. Mercuri, K. Milecka, Y. Miras, A. M. Noryśkiewicz, E. Novenko, M. Obremska, S. Panajiotidis, M. L. Papadopoulou, A. Pędziszewska, S. Pérez-Díaz, G. Piovesan, A. Pluskowski, P. Pokorny, A. Poska, T. Reitalu, M. Rösch, L. Sadori, C. Sá Ferreira, D. Sebag, M. Słowiński, M. Stančikaitė, N. Stivrins, I. Tunno, S. Veski, A. Wacnik, and A. Masi. “Palaeoecological Data Indicates Land-Use Changes across Europe Linked to Spatial Heterogeneity in Mortality During the Black Death Pandemic.” Nature Ecology & Evolution 6, no. 3 (March 2022): 297-306.

Akunin Bravely Says Russians “Obediently Follow” the “Paranoia” of a “Deranged Dictator”

(p. A4) Hundreds of Russians packed an auditorium in central London on a recent warm evening to listen as Boris Akunin, the author of a wildly popular detective series, told them that when it came to the Ukraine war, “I believe that the actions of the Russian Army are criminal.”

Mr. Akunin’s series, set in late czarist times, made him rich and famous, but outspoken statements like that one have made him more infamous of late back home in Russia. The Kremlin recently labeled the author — who went into self-imposed exile in London a decade ago — a “terrorist” and effectively banned his works.

When President Vladimir V. Putin ordered the invasion of Ukraine in February 2022, Mr. Akunin wrote on Facebook, “Russia is ruled by a psychologically deranged dictator and worst of all, it obediently follows his paranoia.” At that time, he began contemplating how cultural figures fleeing abroad might still reach their domestic audience and perhaps help to spur change at home. Being cut off from his own readers lent the project special urgency.

“I have to say, the amount of work and writing I’ve been doing over these two terrible years, never in my life have I written so much,” he told the audience members, who laughed when he said that a writing binge trumped a drinking binge. “It is a form of escapism.”

. . .

Born Grigory Chkhartishvili in Georgia, he grew up in Moscow, where his mother’s family were ardent Communists. As a boy, he once complained to his grandmother that he disliked porridge, and she told him: “You don’t have to like porridge, you have to eat it. You have to like Lenin and the Communist Party.”

. . .

Mr. Akunin’s lecture, on May 9 [2024], coincided with the release of the latest volume, “The Destruction and Resurrection of the Empire,” about the Lenin and Stalin years. His basic thesis is that Russia has considered centralized empire-building to be something sacred since the 15th century. The Ukraine war is Mr. Putin’s striving to do it again, he said.

. . .

In May [2024], he introduced an online platform where writers, filmmakers, theater directors, musicians and other artists could stream their work, charging viewers a small fee. He also expanded the website for selling his books to include many other authors banned in Russia. After he refused to stop selling “Heritage,” a new novel by the best-selling author Vladimir Sorokin, also living in exile, the site was blocked in Russia in late June.

For the full story see:

Neil MacFarquhar. “Exiled in London, but Still Focused on His Russian Audience.” The New York Times (Monday, July 15, 2024): A4.

(Note: ellipses, and bracketed years, added.)

(Note: the online version of the story has the date July 14, 2024, and has the title “From Exile in London, a Crime Novelist Works to Transform Russia.”)

Conservatives Are Better Than Liberals at “the Separation of Facts from Feelings”

(p. A13) I don’t know who’s going to win the presidential election, and neither do you. Neither, for that matter, does Nate Silver, notwithstanding his reputation as a political prognosticator. He is more accurately characterized as a forecaster, which is to say that he deals in probabilities, not outright predictions.

. . .

. . . since I first encountered his work in 2009, Mr. Silver has always struck me as an honest practitioner. Although he describes himself as a “center-left liberal,” he frequently provokes antagonism from fellow liberals when his data and analysis point in directions they’d rather not go.

. . .

Mr. Silver’s career as a political pundit is something of an accident. After earning a bachelor’s degree in economics at the University of Chicago in 2000, he went to work as a KPMG consultant. Bored with his job, he started playing online poker, at first for fun. He says he “eventually deposited money at a real-money site and ran it up from 25 bucks to 15,000 bucks.” He quit KPMG and got a part-time job writing about baseball statistics, but 80% of his income came from poker winnings.

Then in 2006 Congress passed the Unlawful Internet Gambling Enforcement Act, which effectively banned online poker by making it unlawful for the sites to accept payments. “That killed my livelihood,” Mr. Silver says. “I started following politics. I had more time on my hands. I also wanted to see the people behind the bill ousted from office, which they were.” Its primary sponsor, Rep. Jim Leach (R., Iowa), lost his bid for a 16th term.

Mr. Silver still plays poker semiprofessionally—in person—and has earned $855,800 in tournaments, according to the Hendon Mob database. He has a new book out next week, “On the Edge: The Art of Risking Everything,” in which he interviews professional gamblers, venture capitalists, adventurers and others known for their “mastery of risk” and develops a philosophical framework around their insights.

The book touches only lightly on politics, but some of its concepts have obvious application. One of them is “decoupling,” which means, roughly, thinking with analytical detachment, including the separation of facts from feelings. Journalists used to call it objectivity, an aspiration that has fallen out of fashion in recent decades, especially in the Trump era.

A failure to decouple explains the widespread denial of Mr. Biden’s decline in the months before his withdrawal. Clear evidence became mistakable when distorted through the lenses of partisanship, ideology and antipathy toward Mr. Trump. There is no reason to believe people on the left are intrinsically more prone to this sort of error, but Mr. Silver thinks that “liberal bubbles are bigger than conservative bubbles.” Domination of big cities and influential institutions makes it easier for those on the left simply to ignore opposing views.

For the full interview see:

James Taranto. “The Weekend Interview; President Kamala Harris? What Are the Odds?” The Wall Street Journal (Saturday, Aug 10, 2024): A13.

(Note: ellipses added.)

(Note: the online version of the interview has the date August 9, 2024, and has the same title as the print version.)

The “new book” by Silver mentioned above is:

Silver, Nate. On the Edge: The Art of Risking Everything. New York: The Penguin Press, 2024.

In “An Entrenched Echo Chamber” the Highly Credentialed Slow Progress Toward an Alzheimer’s Cure

Centralized research funding (often centralized by government agencies) reduces the pluralism of ideas and methods that often lead to breakthrough innovations. The story of Alzheimer’s research, quoted below, is a dramatic case-in-point.

A secondary related lesson from the story quoted below is that Dr. Thambisetty, one of the outsiders struggling to make a difference, is trying to evade the enormous costs of mandated phase 3 clinical trials, by only investigating drugs that already have been approved by the FDA for use against other conditions. With his severely limited funding, and the huge costs of mandated phase 3 clinical trials, this may be a shrewd strategy for Thambisetty, but notice that by following it, he will never explore all the as-yet-unapproved chemicals that might include the best magic bullet against Alzheimer’s.)

(p. A25) What if a preposterous failed treatment for Covid-19 — the arthritis drug hydroxychloroquine — could successfully treat another dreaded disease, Alzheimer’s?

Dr. Madhav Thambisetty, a neurologist at the National Institute on Aging, thinks the drug’s suppression of inflammation, commonly associated with neurodegenerative disorders, might provide surprising benefits for dementia.

It’s an intriguing idea. Unfortunately, we won’t know for quite a while, if ever, whether Dr. Thambisetty is right. That’s because unconventional ideas that do not offer fealty to the dominant approach to study and treat Alzheimer’s — what’s known as the amyloid hypothesis — often find themselves starved for funds and scientific mind share.

Such shortsighted rigidity may have slowed progress toward a cure — a tragedy for a disease projected to affect more than 11 million people in the United States by 2040.

. . .

. . ., in 2006, an animal experiment published in the journal Nature identified a specific type of amyloid protein as the first substance found in brain tissue to directly cause symptoms associated with Alzheimer’s. Top scientists called it a breakthrough that provided a key target for treatments. The paper became one of the most cited in the field, and funds to explore similar proteins skyrocketed.

. . .

In 2022, my investigation in Science showed evidence that the famous 2006 experiment that helped push forward the amyloid hypothesis used falsified data. On June 24 [2024], after most of its authors conceded technical images were doctored, the paper was finally retracted.

. . .

In reporting for my forthcoming book about the disturbing state of play in Alzheimer’s research, I’ve spoken to many scientists pursuing alternatives. Dr. Thambisetty, for example, compares brain tissues from people who died in their 30s or 40s with and without genetic risk factors for Alzheimer’s. He then compares these findings to tissues from deceased Alzheimer’s patients and people who didn’t have the disease. Where changes overlap, drug targets might emerge. Rather than develop new drugs through lab and animal testing, followed by clinical trials that cost vast sums — a process that can take decades — he examines treatments already approved as reasonably safe and effective for other conditions. Patent protections have lapsed for many, making them inexpensive.

Experiments have also begun to test the weight-loss drug semaglutide (sold as Wegovy, among other brands). Researchers hope that results due in 2026 will show that its anti-inflammatory effects — like Dr. Thambisetty’s idea about hydroxychloroquine — slow cognitive decline.

Ruth Itzhaki, a research scientist at the University of Oxford, stirred curiosity in the 1990s when she shared evidence tying Alzheimer’s to herpesvirus — a scourge spread by oral or genital contact and often resulting in painful infections. For years, powerful promoters of the amyloid hypothesis ignored or dismissed the infection hypothesis for Alzheimer’s, effectively rendering it invisible, Dr. Itzhaki said with exasperation. Research suggests that viruses may hide undetected in organs, including the brain, for years, causing symptoms divergent from the original infection.

. . .

Sometimes a disease stems from a single clear-cut origin, such as genetic mutations that cause deadly sickle cell disease. “But very few diseases of aging have just one cause. It’s just not logical,” said Dr. Matthew Schrag, a neurologist at Vanderbilt University Medical Center. Working independently of his university, he discovered the 2006 research image manipulations.

. . .

“There is an entrenched echo chamber that involves a lot of big names,” Dr. Schrag said. “It’s time for the field to move on.”

For the full commentary see:

Charles Piller. “All the Alzheimer’s Research We Didn’t Do.” The New York Times (Friday, July 12, 2024): A25.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the commentary has the date July 7, 2024, and has the same title as the print version. Where there are a couple of small differences in wording, the passages quoted above follow the online version.)

Piller’s paper in Science, mentioned above, is:

Piller, Charles. “Blots on a Field?” Science 377, no. 6604 (July 2022): 358-63.

Piller’s commentary is related to his forthcoming book:

Piller, Charles. Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s. New York: Atria/One Signal Publishers, Forthcoming on February 4, 2025.

Black American Woman Professor of Cinema Says “You Can Love” Gone with the Wind

(p. C5) The handsome Tudor Revival mansion set on a shaded lot in the bustling heart of Atlanta has long been known as the Margaret Mitchell House. Yet, in truth, Mitchell’s time there — a span of seven years, during which she wrote “Gone With the Wind” — was confined to a 650-square-foot first-floor apartment she so lovingly named “The Dump.”

Over time, Mitchell and the property she never owned would become inextricable. Visitors wanted to step into the cramped quarters where Mitchell, an unemployed former newspaper reporter, created a sprawling saga that came to define the antebellum South in the popular imagination.

. . .

“We’re not trying to label her,” said Sheffield Hale, the president and chief executive of Atlanta History Center, the museum and research center that has overseen operations of the house since 2004. “We’re not trying to praise or denigrate her. There’s a whole lot of non-Confederate gray in this exhibit.”

. . .

. . ., the director John Ridley, the screenwriter behind the 2013 Oscar-winning film “12 Years a Slave,” wrote an essay in The Los Angeles Times in which he urged the streamer HBO Max to remove the film from its platform before reintroducing it with more context for viewers.

“The movie had the very best talents in Hollywood at that time working together to sentimentalize a history that never was,” he wrote.

HBO acquiesced, pulling the film and then restoring it with a four-minute introduction that outlined its value and its flaws, and an explanation of why suppressing the film was not the right solution.

. . .

The book, published in 1936, was a critical and commercial success, winning a Pulitzer Prize and selling nearly a million copies within six months. Readers were enthralled with the travails of the protagonist, Scarlett O’Hara, from the start of the Civil War through the turmoil of Reconstruction.

“People had been dealing with really hard times,” Haley said, referring to the Great Depression. She added, “The story is about redemption and it’s about a character going through a war and coming out on the other side and ‘Never be hungry again.’”

. . .

. . . for all of the reappraising, visitors may come away with the sense that both the pride and the pain the story inspired were justified, said Stephane Dunn, a professor of cinema, television and emerging media studies at Morehouse College in Atlanta, who advised the exhibit’s curators.

“You can love it,” Dunn said.

She still does.

“I mean, I am a Black American woman, right?” she said. “I did not think slavery was romantic, but I found Scarlett fascinating. I found the costumes fascinating. I found in Mammy her strength, and she was not invisible in any scene she was in.”

“Gone With the Wind” has waned in popularity as an understanding of American history has evolved. But by the time visitors reach the end of the exhibit, organizers said, the hope is that they will understand how the story came to be and why it resonated.

“Because that helps us look at the stories we’re telling today,” Haley said, “to see if there are areas where we could stand to expand our perspectives.”

For the full story see:

Rick Rojas. “Pride and Pain Under One Roof.” The New York Times (Saturday, July 13, 2024): C5.

(Note: ellipses added.)

(Note: the online version of the story has the date July 12, 2024, and has the title “At Margaret Mitchell’s House, ‘Gone With the Wind’ Gets a Rewrite.”)

The book is:

Mitchell, Margaret. Gone with the Wind. New York: Vintage Classics, 2020 (1st ed. 1936).

In the City of 38 Atlases “The Citizens Ate as if They Would Die the Next Day, and Built as if They Would Live Forever”

(p. D3) Of all the punishments chronicled in Greek mythology, none were as heavy-handed as the one that Zeus meted out to Atlas. Having led the Titans in their losing battle with the Olympian gods for control of the heavens, Atlas was condemned to bear the sky aloft for eternity.

And of all the temples built during the ancient Greek empire, none enlisted more Atlases than the one dedicated to the Olympic Zeus in Akragas, a city-state now called Agrigento, on the southwest coast of Sicily. Atop massive half-columns, 38 Atlases, each 25 feet tall and carved from limestone, seemingly held up the architrave — the main beam that rests on the capitals of columns — with their bent arms.

The Doric temple — the world’s largest — was built to commemorate the victory over Carthage at the battle of Himera in 480 B.C.; it survives today as a heap of tumbled pillars and blocks of stone at the Valley of the Temples archaeological park. Only one of its Atlases, or telamones, remains even semi-intact. It stands on display in the Regional Archaeological Museum, badly weathered and footless but upright.

This past summer the park’s director, Roberto Sciarratta, announced he had commissioned a colossal statue, a sort of Franken-Atlas, to mark the founding of Akragas 2,600 years ago.

. . .

The lyric poet Pindar described Akragas as the most beautiful city “inhabited by mortals,” and the philosopher Empedocles, a native son, is said to have remarked that the citizens ate as if they would die the next day, and built as if they would live forever.

. . .

Nowadays, a copy of the museum’s Atlas, cobbled together in the 1970s, lounges near the rubble, roped off from the public. “Many visitors believe the Atlas on the ground is authentic,” said Leonardo Guarnieri, a park spokesman, with a shrug worthy of Ayn Rand. “It is not authentic.”

He added that the hands of the new golem Atlas would be unencumbered. That ought to take a load off his shoulders.

For the full story see:

Franz Lidz. “Renewable Resources of the Ancients.” The New York Times (Tuesday, October 6, 2020 [sic]): D3.

(Note: ellipses added.)

(Note: the online version of the story has the date Oct. 5, 2020 [sic], and has the title “From the Rubble of Atlases, a Colossus Will Rise.”)

The obscure mention of Ayn Rand near the end of the passages quoted above invites the cognoscenti to remember:

Rand, Ayn. Atlas Shrugged. New York: Random House, 1957.

Unlike DNA, RNA Has “Catalytic Power”

(p. 8) In the early 1980s, when I was much younger and most of the promise of RNA was still unimagined, I set up my lab at the University of Colorado, Boulder. After two years of false leads and frustration, my research group discovered that the RNA we’d been studying had catalytic power. This means that the RNA could cut and join biochemical bonds all by itself — the sort of activity that had been thought to be the sole purview of protein enzymes. This gave us a tantalizing glimpse at our deepest origins: If RNA could both hold information and orchestrate the assembly of molecules, it was very likely that the first living things to spring out of the primordial ooze were RNA-based organisms.

. . .

RNA discoveries have led to new therapies, such as the use of antisense RNA to help treat children afflicted with the devastating disease spinal muscular atrophy. The mRNA vaccines, which saved millions of lives during the Covid pandemic, are being reformulated to attack other diseases, including some cancers. RNA research may also be helping us rewrite the future; the genetic scissors that give CRISPR its breathtaking power to edit genes are guided to their sites of action by RNAs.

Although most scientists now agree on RNA’s bright promise, we are still only beginning to unlock its potential. Consider, for instance, that some 75 percent of the human genome consists of dark matter that is copied into RNAs of unknown function. While some researchers have dismissed this dark matter as junk or noise, I expect it will be the source of even more exciting breakthroughs.

For the full essay see:

Thomas Cech. “Move Aside, DNA. RNA Has Arrived.” The New York Times, SundayOpinion Section (Sunday, June 2, 2024): 8.

(Note: ellipses added.)

(Note: the online version of the essay has the date May 29, 2024, and has the title “The Long-Overlooked Molecule That Will Define a Generation of Science.”)

The essay quoted above was adapted from the author’s book:

Cech, Thomas R. The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets. New York: W. W. Norton & Company, 2024.