Ozempic Profits Poured into Massive Supercomputer Meant to Power AI for Future Drug Development

I think AI is currently being oversold. But I am very ignorant and could be wrong, so I favor a diversity of privately-funded bets on what will work to bring us future breakthrough innovations.

(p. B2) Two of the world’s most important companies are now in a partnership born from the success of their most revolutionary products. The supercomputer was built with technology from Nvidia—and money from the Novo Nordisk Foundation. The charitable organization has become supremely wealthy as the largest shareholder in Novo Nordisk, which means this project was made possible by the breakthrough drugs that have sent the Danish company’s stock price soaring.

To put it another way, it’s the first AI supercomputer funded by Ozempic.

It was named Gefion after the goddess of Norse mythology who turned her sons into oxen so they could plow the land that would become Denmark’s largest island.

. . .

Whatever you call it, Gefion is a beast. It is bigger than a basketball court. It weighs more than 30 tons. It took six months to manufacture and install. It also required an investment of $100 million.

. . .

When it’s fully operational, the AI supercomputer will be available to entrepreneurs, academics and scientists inside companies like Novo Nordisk, which stands to benefit from its help with drug discovery, protein design and digital biology.

For the full commentary see:

Ben Cohen. “It’s a Giant New Supercomputer That Might Transform an Entire Country.” The Wall Street Journal (Saturday, Nov. 2, 2024): B2.

(Note: ellipses added.)

(Note: the online version of the commentary has the date November 1, 2024, and has the title “Science of Success; The Giant Supercomputer Built to Transform an Entire Country—and Paid For by Ozempic.”)

Planners of Megaprojects Almost Always Over-Promise and Under-Deliver

(p. B5) Bent Flyvbjerg is an expert in the planning and management of “megaprojects,” his name for huge efforts that require at least $1 billion of investment: bridges, tunnels, office towers, airports, telescopes and even the Olympics. He’s spent decades wrapping his mind around the many ways megaprojects go wrong and the few ways to get them right, and he summarizes what he’s learned from his research and real-world experience in a new book called “How Big Things Get Done.”

Spoiler alert! Big things get done very badly.

They cost too much. They take too long. They fall too short of expectations too often. This is what Dr. Flyvbjerg calls the Iron Law of Megaprojects: “over budget, over time, under benefits, over and over again.”

The Iron Law of Megaprojects might sound familiar to anyone who has survived a home renovation. But when Dr. Flyvbjerg dug into the numbers, the financial overruns and time delays were more common than he expected. And worse. Much worse.

His seminal work on big projects can be distilled into three pitiful numbers:

• 47.9% are delivered on budget.

• 8.5% are delivered on budget and on time.

• 0.5% are delivered on budget, on time and with the projected benefits.

. . .

Humans are optimistic by nature and underestimate how long it takes to complete future tasks. It doesn’t seem to matter how many times we fall prey to this cognitive bias known as the planning fallacy. We can always ignore our previous mishaps and delude ourselves into believing this time will be different. We’re also subject to the power dynamics and competitive forces that complicate reality, since megaprojects don’t take place in controlled environments, and they are plagued by politics as much as psychology. Take funding, for example. “How do you get funding?” he said. “By making it look good on paper. You underestimate the cost so it looks cheaper, and you underestimate the schedule so it looks like you can do it faster.”

For the full review, see:

Ben Cohen. “SCIENCE OF SUCCESS; 99% of Big Projects Fail. Lego Is the Fix.” The Wall Street Journal (Saturday, February 4, 2023): B5.

(Note: ellipsis added.)

(Note: the online version of the review has the date February 2, 2023, and has the title “SCIENCE OF SUCCESS; 99% of Big Projects Fail. His Fix Starts With Legos.”)

The book under review is:

Flyvbjerg, Bent, and Dan Gardner. How Big Things Get Done: The Surprising Factors That Determine the Fate of Every Project, from Home Renovations to Space Exploration and Everything in Between. New York: Currency, 2023.

“Climate Change Has Been Good for Us”

(p. A1) SLINDE, Norway—Perched on a steep slope overlooking the country’s largest fiord, tidy rows of vines spread on the frosted ground underneath towering pine trees.

On the 61st parallel—the latitude of Anchorage, Alaska— Bjorn Bergum’s vineyard is set to become the world’s northernmost commercial wine estate, a testimony to how global warming is disrupting century-old landscapes, traditions and oenological preconceptions.

“There is no doubt,” Mr. Bergum says. “Climate change has been good for us.”

. . .

(p. A9) “First we take Scandinavia, then the world,” says Erik Lindås, head of Norway’s nascent winegrowers association. “It’s motivating to work when people think you can’t make it. People laughed at English wine 15 years ago but they are not laughing anymore.”

Denmark and Sweden are commercially producing wines that have won international awards, while Britain and Belgium are experiencing a viticultural renaissance. Vintners in Germany, which has a proud winemaking tradition in the south, are exploring new terroirs farther north.

. . .

The northerners have a replique to southern arguments about boreal vineyards’ lack of tradition: During the so-called Medieval Climate Optimum, a warm spell from the ninth century to the 13th, winemaking thrived as far up as northern England and the Baltics.

Professor Hans R. Schultz, who studies climate change’s effects on viticulture at Germany’s Geisenheim University, says global warming is pulling the winemaking economy northward. In Germany’s terroirs, which used to lose entire harvests to cold spells, every vintage since 1987 was better than the previous, he says.

For the full story, see:

Bojan Pancevski. “New Wines Invade From Viking Terroir.” The Wall Street Journal (Wednesday, October 30, 2019): A1 & A9.

(Note: ellipses added; italics in original.)

(Note: the online version of the story has the date Oct. 29, 2019, and has the title “Chateau Viking: Climate Change Makes Northern Wine a Reality.”)

Denmark Drones Saving Lives

(p. B1) Mr. McLinden is a member of a group of middle-aged emergency workers taking part in a trial to jump-start the use of unmanned aircraft by Europe’s emergency services. The goal is to give the region a head start over the United States and elsewhere in using drones to tackle real-world emergencies.
The “drone school” builds on Europe’s worldwide lead in giving public groups and companies relatively free rein to experiment with unmanned aircraft. If everything goes as planned, the project’s backers hope government agencies in Europe and farther afield can piggyback on the experiences, helping to transform drones from recreational toys to lifesaving tools.
“For us, this technology is a game-changer,” said Mr. McLinden, who traveled to Copenhagen (p. B4) for a three-day training course with two colleagues from the Mid and West Wales Fire and Rescue Service. They will start offering 24/7 drone support — allowing colleagues, for example, to monitor accidents from 300 feet above — across central Wales later this month.
“Drones aren’t going to replace what we do,” Mr. McLinden added. “But anything that we can do to give our crews an advantage, that’s great.”
. . .
In a somewhat stuffy classroom at a disused fire station in Copenhagen, Thomas Sylvest gave advice to Mr. McLinden and others from his two years of flying. As Denmark’s first, and so far only, emergency service drone pilot, Mr. Sylvest has responded to things as varied as missing person cases and fires, often receiving calls late at night.
Mr. Sylvest, a fast-talking 50-year-old, offered tips on how best to share videos streamed directly from drones to commanders on the ground. During a recent fire in downtown Copenhagen, Mr. Sylvest said, he was able to beam high-definition images from high above, allowing his bosses to judge if a building’s walls would collapse (they did not). And when the police called him out last year after a man was reported missing, he flew his drone along a stretch of train tracks to guide colleagues on where best to look. (The man was found.)

For the full story, see:
MARK SCOTT. “Emergency Workers Turn to Drones to Save Lives.” The New York Times (Mon., JUNE 20, 2016): B1 & B4.
(Note: ellipsis added.)
(Note: the online version of the commentary has the date JUNE 19, 2016, and has the title “Europe’s Emergency Workers Turn to Drones to Save Lives.”)

“A Fairy Tale About a Lonely Candle that Wants to Be Lighted”

TallowCandleManuscript2013-01-01.jpeg “A newly found manuscript of a fairy tale by Hans Christian Andersen, which has been located in Odense, is pictured in the State Archives in Copenhagen, Denmark, Wednesday, Dec. 12, 2012. The story of ‘The Tallow Candle’ might have been written about 1823, when he was 18 year old.” Source of caption and photo: http://www.ctvnews.ca/entertainment/new-found-tale-of-a-lonely-candle-could-be-early-work-of-hc-andersen-1.1077533#ixzz2GmTQNcFvhttp://www.ctvnews.ca/polopoly_fs/1.1077539!/

(p. C2) A fairy tale about a lonely candle that wants to be lighted had been languishing in a box in Denmark’s National Archives for many years. In October it was discovered by a retired historian, who now believes it is one of the first fairy tales ever written by Hans Christian Andersen.
. . .
The six-page manuscript, called “Tallow Candle,” is dedicated to a vicar’s widow named Bunkeflod who lived across the street from Andersen’s home. Ejnar Stig Askgaard, a Hans Christian Andersen expert, said the work was probably one of Andersen’s earliest.

For the full story, see:
CAROL VOGEL. “Discovery of Story Is Like a Fairy Tale.” The Wall Street Journal (Fri., December 14, 2012): C2.
(Note: ellipsis and underline added; bold in original.)
(Note: the online version of the story has the date December 13, 2012, and has the title “Like a Fairy Tale: Hans Christian Andersen Story Is Found in a Box.”)
(Note: the words underlined by me above, were in the online, but not the print, version of the article.)

“The Government Wants to Decide What We Eat”

PuddingBannedDenmark2011-07-19.jpg “A rule against selling food with added vitamins and minerals, like canned pudding, prompted the removal of several popular products from Abigail’s, a shop in Copenhagen.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A6) COPENHAGEN — For the last seven years, Marianne Orum has owned a narrow store in a charming street in the heart of this Danish capital.

A sign advertises “British and South African Food and Drink.”
The shelves are lined with products familiar to most Americans, like Betty Crocker Pancake Mix, but also more exotic items, like Heinz’s Taste of Home Delightful Spotted Dick Pudding in cans, and bottles of Harviestoun Old Engine Oil porter.
But in January Ms. Orum got a phone call from government food inspectors. Tipped off by a competitor, they told her she was selling products that were fortified with vitamins or minerals, and such products require government approval, which she did not have, so she would have to take them off the shelves.
The culprits were Ovaltine; a shredded wheat cereal called Shreddies; a malt drink called Horlicks; and Marmite, the curiously popular yeast byproduct that functions in England as a sandwich spread, snack or base for a soup (just add boiling water), and is sometimes known as tar-in-the-jar.
“That’s four products in one go,” said Ms. Orum, clearly angered. “That’s a lot for a small company.”
Application for approval, she said, costs almost $1,700 per product, and time for approval can run up to six months or more; the fee is not refunded if the product is rejected.
“It’s a strange thing, this attitude in Denmark,” she said, in a tone of exasperation. “The government wants to decide what we eat and not.”

For the full story, see:
JOHN TAGLIABUE. “COPENHAGEN JOURNAL; Extra Vitamins? A Great Idea, Except in Denmark.” The New York Times (Fri., June 17, 2011): A6.
(Note: the online version of the story was dated June 16, 2011.)

Denmark (Yes, Sanctimoniously ‘Green’ Denmark) Seeks to Exploit the BENEFITS of Global Warming

(p. A7) Denmark plans to lay claim to parts of the North Pole and other areas in the Arctic, where melting ice is uncovering new shipping routes, fishing grounds and drilling opportunities for oil and gas, a leaked government document showed Tuesday.

For the full story, see:
THE ASSOCIATED PRESS. “WORLD BRIEFING | EUROPE; Denmark: Leaked Document Reveals Plans to Claim Parts of the North Pole.” The New York Times (Weds., May 18, 2011): A7.
(Note: the online version of the story is dated May 17, 2011.)

Thousands Waited Hours in Subzero Cold Trying to Enter Global Warming Conference (“This Is What UN Efficiency Looks Like”)

(p. A10) As dozens of developing countries threatened to walk out of the Copenhagen climate-change summit, thousands of NGOs, journalists, lawyers, activists were still trying to get in.

The thousands queued from the early morning into the afternoon on Monday to register for the summit but found themselves in a line that barely budged for most of the day. Only those who already had accreditation — obtained during the first week of the summit or over the weekend — were let in; the rest braved subzero temperatures for some glimpse of a breakthrough.
Would-be attendees chanted “Let us in!” to Danish policemen ringing the Bella Center.
United Nations officials announced at one point that the process of accreditation would stop at 6 p.m. today, prompting boos and catcalls and cries of “shame” from those in line. One sign declared: “This is what UN efficiency looks like.”

For the full story, see:
Guy Chazan. “Copenhagen Dispatches; Some Walk Out of Gathering, But Many More Want In.” The Wall Street Jounal (Tues., December 15, 2009): A10.
(Note: the online version of the commentary had the title “Thousands Line Up for Climate Conference” and the date December 14, 2009.)

When the Green Pedalers Went Home, the Grid Powered the Christmas Tree

CopenhagenPedalPoweredXmasTree2010-01-23.jpg

“The pedal-powered Christmas tree at City Hall Square.” Source of caption: the print version of the WSJ article quoted and cited below. Source of photo (which appeared in the print, but not the online, version of the WSJ article quoted and cited below): http://www.chriskeam.com/blog/uploaded_images/Copenhagen-Xmas-tree-792971.jpg

(p. A16) Copenhagen has splashed out on every kind of green widget to shore up its environmental credentials as host of the world’s biggest climate change conference in years. Most of the emissions-free wizardry is familiar, such as electric cars. Here’s one you may not have seen yet: An extra “green” Christmas tree.

At the Danish capital’s City Hall Square, 15 to 20 volunteers can sit on stationary bikes located around a massive, decorated tree and pedal away to keep it light, at least during the day. The bikes are connected to electrical tie-ups that ultimately power hundreds of lights on the tree.
. . .
Late at night, the big tree continues to sparkle–but thanks to traditional power outlets, not pedal power–once the volunteers have gone home.

For the full story, see:
Spencer Swartz. “Copenhagen Dispatches: Pedal Power: Copenhagen Lights Christmas Tree With Bikes.” The Wall Street Journal (Weds., December 16, 2009): A16.
(Note: the title of the online version of the article is “Pedal Power: Copenhagen Lights Christmas Tree With Bikes” and is dated December 15, 2009.)
(Note: ellipsis added.)

Green Danes Embrace Hot Air Escaping Through Open Doors

PedalPoweredSmoothies2010-01-16.jpg“Environmental displays in Copenhagen’s City Hall Square include pedal-powered smoothies.” Source of caption and photo: online version of the NYT article quoted and cited below.

I mainly liked the article cited below for the photo displayed above.
But there also was this bit, showing that beyond some silly green pretensions, not all is rotten in Denmark:

(p. A11) . . . , cracks in Copenhagen’s green facade were easy to spot on Friday at the nearby Stroget, a popular car-free shopping area in the city center. In the late afternoon every shop door was propped open, sending clouds of heated air into the chilly street.

Some cities impose fines on shopkeepers who allow excess energy to escape through open doors.
But Jan Michael Hansen, the executive director of Copenhagen City Center, an organization representing shops along the three-quarter-mile-long corridor, was nonplused. A closed door keeps customers away, which is bad for business, he explained.
He seemed puzzled that the visitor brought it up. “I have never had an inquiry like this before,” he said.

For the full story, see:
TOM ZELLER Jr. and ANDREW C. REVKIN. “Reporter’s Notebook; Global and Local Concerns Meet in ‘Hopenhagen’.” The New York Times (Fri., December 10, 2009): A11.
(Note: the online version of the article is dated December 10, 2009.)
(Note: ellipsis added.)

Copenhagen Global Warming Performer Asks for More Summer “Because It’s Too Cold to Be Out Here”

(p. 12) . . . a small contingent of climate skeptics and libertarians opposed to caps on heat-trapping carbon dioxide emissions derided the United Nations talks.

“We want to be able to live our lives like we’ve always led them before — as free citizens in free democracies,” said David Pontoppidan, a graduate student in sociology at the University of Copenhagen, who addressed passers-by through a megaphone over the chatter of two helicopters hovering far above. “We want free debate; we want to be able to be taken seriously even though we don’t agree with the U.N.”
. . .
Leading the march from the square this afternoon, a man in blue coveralls, with vaudevillian face paint and a faux Cyrano nose, could be seen sweeping the street and peering into a rolling trash bin painted to resemble the planet. It emitted plumes of white dust and mournful musical notes.
“This is our comment on global warming,” said the sweeper, Jens Kloft, a Danish performance artist. “We want to have an international compromise on global warming — a better climate, but two more months of summer in Denmark please. Because it’s too cold to be out here.”

For the full story, see:
TOM ZELLER Jr. “Thousands March in Copenhagen, Calling for Action.” The New York Times, First Section (Sun., December 13, 2009): 12.
(Note: the last two paragraphs quoted above are from the print version; the NYT deleted them from the online version. Also, the first paragraph quoted, is from the print version of that paragraph, and not the shortened online version. The online version of the article is dated Sat., December 12, 2009.)
(Note: ellipses added.)