Nicholas Wade Highlighted That Early Email to Fauci Supported Lab-Leak Origin of Covid-19

Distinguished science journalist Nicholas Wade was one of the first and the few to early-on risk being canceled by providing evidence in favor of the lab-leak origin of Covid-19.

(p. A13) They told the world that the Covid-19 virus clearly couldn’t have been manipulated in the laboratory. But what they actually thought at first sight was that it had been.

The letter from five virologists published in Nature Medicine on March 17, 2020, was the single most influential statement in capturing the public narrative about the origin of SARS-CoV-2. Here was an authoritative statement from leading experts assuring the public that in terms of the virus’s origin “we do not believe that any type of laboratory-based scenario is plausible.”

But that’s the exact opposite of what these experts thought after taking their first look at the virus. A large batch of emails exchanged with Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, was made available this week to BuzzFeed and the Washington Post under the Freedom of Information Act. For the most part the emails concern meeting arrangements or messages from cranks and have been redacted of any meaningful information. But one significant email escaped the censor’s black marker.

On Jan. 31, 2020, shortly after the SARS-CoV-2 genome had been decoded, Kristian Andersen, the five virologists’ leader, emailed Dr. Fauci that there were “unusual features” in the virus. These took up only a small percentage of the genome, so that “one has to look really closely at all the sequences to see that some of the features (potentially) look engineered.”

Mr. Andersen went on to note that he and his team “all find the genome inconsistent with expectations from evolutionary theory.” It isn’t clear exactly what he meant by this striking phrase. But anything inconsistent with an evolutionary origin has to be man-made.

For the full commentary see:

Nicholas Wade. “Fauci Email Bolsters the Lab-Leak Theory.” The Wall Street Journal (Monday, June 5, 2021 [sic]): A13.

(Note: the online version of the commentary has the date June 4, 2021 [sic], and has the same title as the print version.)

Correll Managed Georgia-Pacific Well and Then Used Those Skills to Save a Failing Hospital

In my Openness book, I make the case for the many benefits of an economic system of innovative dynamism. One of the lesser, but still important, benefits was first identified by Joseph Schumpeter. He argued for a spillover effect of innovative dynamism. The skills, knowledge, and technologies created by innovative entrepreneurs in the for-profit sector of the economy, are also applied and imitated in the nonprofit and government sectors. So where there is innovative dynamism, not only is the market more creative and efficient, but both the nonprofit and the government sectors are more creative and efficient.

A good example may be Pete Correll who acted entrepreneurially as CEO of Georgia-Pacific to bring more stability to the business by acquiring the James River Corporation, maker of Quilted Northern, and guided the Georgia-Pacific firm through years of lawsuits over asbestos. He eventually sold Georgia-Pacific to Koch Industries, Inc. My impression is that Charles Koch then applied his market-based management system to make the Georgia-Pacific part of his business much more efficient and innovative. [Query: does Koch’s achievement undermine my claim that Pete Correll had acted entrepreneurially in his earlier management of Georgia-Pacific? Or can both Correll and Koch have been good manager/entrepreneurs, but in different ways at different times?]

But according to his obituary in the WSJ, his greatest achievement may have been in taking over a near-bankrupt Atlanta public (aka government) hospital, reorganizing it from government to nonprofit, and modernizing its management and technology.

Carrell’s obituary in the WSJ:

James R. Hagerty. “CEO Helped Save A Public Hospital.” The Wall Street Journal (Sat., June 5, 2021 [sic]): A9.

(Note: the online version of the WSJ obituary has the date June 2, 2021 [sic], and has the title “Retired CEO Saved an Atlanta Public Hospital.”)

For Charles Koch’s entrepreneurial market-based management system see:

Koch, Charles G. The Science of Success: How Market-Based Management Built the World’s Largest Private Company. Hoboken, NJ: Wiley & Sons, Inc., 2007.

My book mentioned in my initial comments is:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.

Trump Is a Change Agent Because He Can Take the Ill Will of the Stagnationists

In an earlier blog entry I pondered Charlie Munger’s sage analysis that agents of change must often be willing to take the “ill will” aimed at them from the stagnationists who benefit from stasis. The stagnationists may be corrupt, or incompetent, or simply lack the imagination or the energy to do something in a better way.

Agents of change are scarce because most of us care a lot about what other people think of us. We experience psychic stress if we are systematically stigmatized, or even just ignored. Donald Trump may be capable of making major changes because, through temperament or resolve, he has found a way to shut out the psychic stress; a way to take the ill will.

Kessler’s commentary, quoted below, was published early in the pandemic, on Feb. 10, 2020. At that point Kessler believed that Trump’s success with the economy would get Trump re-elected. But as the months of 2020 rolled on, the pandemic increasingly hurt Trump’s prospects; hence the source of the pandemic still matters a lot, and whether the vaccine was intentionally delayed a few weeks, to release it just after the election, also still matters a lot.

A key question is whether Trump still has the core “agenda of tax cuts, deregulation and originalist judges” that Kessler believed was the Trump core agenda in 2016.

I hope yes, but fear no. In 2025 are tariffs and industrial policy part of the “distraction” (aka “MacGuffin”) Kessler posits, or are they part of Trump’s core agenda?

(p. A15) Is he a disease or a cure? Like him or hate him, there’s tons of spilled ink trying to assess President Trump’s governing style. To me, the key to understanding Trumpism is remembering why he was elected.

What do I mean? Voters chose Donald Trump as an antidote to the growing inflammation caused by the (OK, deep breath . . .) prosperity-crushing, speech-inhibiting, nanny state-building, carbon-obsessing, patriarchy-bashing, implicit bias-accusing, tokey-wokey, globalist, swamp-creature governing class—all perfectly embodied by the Democrats’ 2016 nominee. On taking office, Mr. Trump proceeded to hire smart people and create a massive diversion (tweets, border walls, tariffs) as a smokescreen to let them implement an agenda of tax cuts, deregulation and originalist judges.

Those reforms have left the market free to do its magic and got the economy grooving like it’s 1999. The daily Trump hurricane—like the commotion over the Chiefs from Kansas—makes the media focus on the all-powerful wizard while ignoring the policy makers behind the curtain.

Alfred Hitchcock called this kind of distraction a “MacGuffin”—something that moves the plot along and provides motivation for the characters, but is itself unimportant, insignificant or irrelevant. It can be a kind of sleight of hand, a distraction, and Mr. Trump uses his own public persona as a MacGuffin in precisely that way. The mobs decked in “Resist” jewelry fall for it every time.

For example, Sen. Bernie Sanders used his remarks during the Senate impeachment trial to point out that the media had documented some 16,200 alleged lies by President Trump. The MacGuffin worked! Mr. Sanders and his peers are focused on the president’s words, while most voters see the real plot unfolding in America—millions of jobs and rising wages.

The president’s success comes from his ability to shrug off critics.  . . .  Rather than cower at the criticism he faces from the mobs, he probably smirks and thinks to himself, “Yeah, I don’t believe in that” and tweets away.

That’s the only reaction that can withstand today’s far left, which has become increasingly self-righteous.

For the full commentary see:

Andy Kessler. “President Donald J. MacGuffin.” The Wall Street Journal (Monday, February 10, 2020 [sic]): A17.

(Note: ellipses added.)

(Note: the online version of the commentary has the date February 9, 2020 [sic], and has the same title as the print version.)

Stop Subsidizing Corn Growing to Reduce Corn Syrup Consumption and Make America Healthy Again

In a recent blog entry I discussed how consumption of corn syrup may increase obesity and how government subsidies to corn growing and quotas on the import of sugar, lead to increased consumption of corn syrup. In the entry below, I document brief comments by Robert F. Kennedy, Jr. on corn syrup.

(p. A15) In my speech endorsing Donald Trump, I said we need to love our kids more than we hate each other. That means coming together to address common problems, and few are more urgent than the chronic-disease crisis. Americans are becoming sicker, beset by illnesses that our medical system isn’t addressing effectively.

. . .

Mr. Trump has made reforming broken institutions a cornerstone of his political life. He has become the voice of countless Americans who have been let down by our elites. He could unite the country by making it his priority to make America healthy again. Here are some specific policy ideas:

. . .

• Reform crop subsidies. They make corn, soybeans and wheat artificially cheap, so those crops end up in many processed forms. Soybean oil in the 1990s became a major source of American calories, and high-fructose corn syrup is everywhere.

For the full commentary see:

Robert F. Kennedy Jr. “Trump Can Make America Healthy Again.” The Wall Street Journal (Friday, Sept. 6, 2024): A15.

(Note: ellipses added.)

(Note: the online version of the commentary has the date September 5, 2024, and has the same title as the print version.)

The Classical Liberal Economist’s Current Job: Minimize the Harm from Tariffs, Maximize the Benefits from Deregulation and Downsizing Government

I used to run into Richard Burkhauser at economics meetings occasionally and always enjoyed talking with him and hearing about his research. I believe Richard’s activity in the first Trump administration makes sense: if tariffs are going to be imposed, do them in a way that minimizes the damage to the economy. Although not mentioned in the article quoted below, I am sure Richard also did what he could to further the part of Trump’s agenda that was positive for he economy: reducing regulations so entrepreneurs can innovate and create jobs, and downsizing the government so taxpayers can keep more of their earnings.

(p. 1) Partway through a panel discussion at a recent economics conference in San Francisco, Jason Furman, a former adviser to President Barack Obama, turned to Kimberly Clausing, a former member of the Biden administration and the author of a book extolling the virtues of free trade.

“Everyone in this room agrees with your book,” Mr. Furman said. “No one outside of this room agrees with your book.”

The academics and policy wonks gathered in the hotel conference room laughed, but the comment captured something real: After decades of helping to shape policy on weighty matters like taxes and health insurance, economists find that their influence is at a low ebb.

. . .

(p. 6) Mr. Trump, in his first term, had few economists in top roles, and perhaps the most prominent exception — Peter Navarro, a Harvard-trained economist who was an adviser on trade policy — held skeptical views on trade, particularly with China, that put him far outside the economic mainstream. (In a 2016 survey of academic economists, not a single respondent said putting tariffs on China to encourage domestic production would be a good idea.)

Economists who held more mainstream views had limited influence. Richard Burkhauser, a Cornell University professor who served on Mr. Trump’s Council of Economic Advisers, said he and his colleagues quickly understood that there was little point in trying to talk Mr. Trump out of imposing tariffs.

“The most forlorn economists at the C.E.A. specialized in trade,” he said. If they had tried to fight tariffs, he said, “that would have been the last meeting we were at.”

Instead, Mr. Burkhauser said, economists focused on a different question: If the administration was going to impose tariffs, how could it do them in the least painful way possible?

For the full story see:

Ben Casselman. “Economists See Influence Wane in Policy Circles.” The New York Times, SundayBusiness Section (Sun., January 12, 2025): 1 & 6.

(Note: ellipsis added.)

(Note: the online version of the story has the date Jan. 10, 2024, and has the title “Economists Are in the Wilderness. Can They Find a Way Back to Influence?”)

Not Every Fluoride Worry Is Anti-Science Misinformation

Emily Oster is an economist who believes that ordinary citizens are not uniformly stupid and ill-informed. Maybe they even have rights. So she suggests the public health authorities stop condescending and shouting commands and start offering the public nuanced information about varying levels of certainty and risk.

(p. 4) Robert F. Kennedy Jr. said this month that the new Trump administration would recommend removing fluoride from public water supplies. The suggestion that fluoride was unsafe was immediately criticized by many public health experts as anti-science misinformation.

But there’s a real danger to painting everyone with concerns about fluoride as a conspiracy theorist. It’s not that we should remove fluoride from tap water (we shouldn’t), but fluoride is a complex topic, and glossing over that complexity — as public health experts and agencies often do — leaves people understandably skeptical.

Public health agencies typically tell people what to do and what not to do, but they don’t regularly explain why — or why people might hear something different from others. They also often fail to prioritize. In the end, advice for a range of topics is delivered with the same level of confidence and, seemingly, the same level of urgency. The problem is that when people find one piece of guidance is overstated, they may begin to distrust everything.

. . .

Deservedly or not, public health authorities lost a lot of trust, especially during the pandemic, and they have struggled to get it back. This has left an opening for others. The reaction from public health officials often seems to be to yell the same thing, only more loudly. This isn’t working.

For the full commentary see:

Emily Oster. “How to Talk About Fluoride, Vaccines and Raw Milk.” The New York Times, SundayOpinion Section (Sun., November 17, 2024): 4.

(Note: ellipsis added.)

(Note: the online version of the commentary has the date Nov. 13, 2024, and has the title “There’s a Better Way to Talk About Fluoride, Vaccines and Raw Milk.”)

Medical Entrepreneur Fired for Nimbly Pivoting to Get Job Done

Back in early 2021, the Moderna vaccine was not yet widely available. Protocols mandated who could get the scarce shots, prioritizing health care workers, senior citizens, and those with severe diseases. Each vial contained enough for 10 doses, but the doses had to be given with six hours, before the vaccine spoiled. On Dec. 29 Dr. Hasan Gokal, a Pakistani immigrant, worked at the county’s first vaccination event, set up for health care workers. Near the end of the scheduled event a health care worker showed up and a nurse punctured a new vial to give the worker the shot.

Now, what to do with the remaining nine doses? He got on the phone and drove around seeking and finding several senior citizens who wanted the vaccine. Exhausted with a half-hour until the vaccine expired, he gave the final dose to his wife, who had pulmonary sarcoidosis, which was indicated in the protocols as a qualification for the vaccine.

Dr. Gokal’s supervisor and the director of human resources then fired Dr. Gokal:

The officials maintained that he had violated protocol and should have returned the remaining doses to the office or thrown them away, the doctor recalled. He also said that one of the officials startled him by questioning the lack of “equity” among those he had vaccinated.

“Are you suggesting that there were too many Indian names in that group?” Dr. Gokal said he asked.

Exactly, he said he was told. (Barry 2021, p. A5)

A couple of weeks later, the county district attorney charged Dr. Gokal with theft of doses of the vaccine.

Dr. Gokal acted as a medical entrepreneur. His job was to save lives by administering the vaccine. He nimbly pivoted in a difficult situation. For that he was punished–fired and charged with a crime.

The growing promulgation and enforcement of protocols limit physicians from acting as mission-oriented entrepreneurs. They are limited in their use of judgement based on their own experiences, they are limited in innovating, and sometimes they are even limited in using all of a scarce vaccine. These limits may be part of the reason that so many physicians today experience frustration and burn-out.

[As of the time of the writing of the NYT article cited below, Dr. Gokal remained fired from his job, and still was in legal jeopardy.]

My source for the facts of Dr. Gokal’s case, is the NYT article:

Dan Barry. “Racing the Clock, a Doctor Gave Out the Vaccine.” The New York Times (Thurs., February 11, 2021 [sic]): A1 & A5.

(Note: the online version of the NYT article was updated June 23, 2023 [sic], and has the title “The Vaccine Had to Be Used. He Used It. He Was Fired.”)

NBER Study Asserts That High-Risk Medicare Beneficiaries Are Clueless

I have looked at the National Bureau of Economic Research (NBER) paper mentioned below, and suspect (and hope) that its key findings are wrong. I do not believe that people are always rational and well-informed. But I do believe that people have incentives to be rational and well-informed, especially on crucial issues related to their health.

The NBER paper says that given a modest increase in the price of a crucial drug (e.g., a statin), high-risk patients (e.g., with severe arteriosclerosis) will often stop taking the crucial drug, being “unaware of these risks.” I suspect that the policy conclusion that many will draw from the NBER paper is: don’t raise Medicare drug prices.

If the authors are right that high-risk Medicare beneficiaries are clueless, an alternative policy conclusion is: give the beneficiaries a clue.

(p. 7) The high cost of drugs can force some seniors to make difficult choices between paying for medications or other household expenses.

A . . . study by the National Bureau of Economic Research found that when Medicare beneficiaries’ out-of-pocket drug costs jump, there is a significant drop in the number of patients who fill prescriptions and an increase in mortality.

For the full commentary see:

Mark Miller. “Steps for Coping With Medicare’s Rising Costs.” The New York Times, SundayBusiness Section (Sun., December 26, 2021 [sic]): 7.

(Note: ellipsis added.)

(Note: the online version of the commentary has the date Dec. 22, 2021 [sic], and has the title “How to Cope With Medicare’s Rising Costs.”)

A revised version of the National Bureau of Economic Research paper mentioned above is:

Chandra, Amitabh, Evan Flack, and Ziad Obermeyer. “The Health Costs of Cost-Sharing.” National Bureau of Economic Research Working Paper #28439, Feb. 2024.

Gig Work Enables Free Agent Entrepreneurship

In my Openness book, I distinguish between free agent entrepreneurs and innovative entrepreneurs. Free agent entrepreneurs are there own boss, doing what has been done before. Innovative entrepreneurs are their own boss, doing what is new. Of course the distinction is not sharp–a continuum.

Recent research, summarized in the WSJ, suggests that gig work can ease entry into free agent entrepreneurship. Gig work is flexible–the gig worker has time when they need it, to work on their entrepreneurial venture. Gig work also can generate capital and give experience in self-management.

A higher percent of gig workers become entrepreneurs than similar employed workers, and they do so, on average, at a slightly younger age.

Those who want to regulate gig work, and thereby make it less common, should remember how gig work benefits aspiring entrepreneus.

The WSJ article mentioned above is:

Lisa Ward. “Gig Workers Show More Enterprise, Study Finds.” The Wall Street Journal (Thurs., May 8, 2025): A11.

(Note: the online version of the WSJ article has the date May 5, 2025, and has the title “Want to Start a Business? Maybe Begin by Being a Gig Worker.”)

The academic working paper summarized in the WSJ article is:

Denes, Matthew R., Spyridon Lagaras, and Margarita Tsoutsoura. “Entrepreneurship and the Gig Economy: Evidence from U.S. Tax Returns.” In National Bureau of Economic Research Working Paper #33347, Jan. 2025.

My book mentioned in my initial comments is:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.

We Need Market-Tested Innovation to Cure the Sadly Chaotic, Inefficient, Dishonest, and Unfair Organ Transplant System

The government contracts with, and ‘supervises,’ a network of nonprofits in a sadly chaotic, inefficient, dishonest, and unfair system to allocate scarce transplant organs. The government has set up perverse incentives, with unintended consequences, by telling the nonprofits that they will be evaluated on the basis of not wasting organs; those evaluated badly will not have their contracts renewed. So they have an incentive to get the organs out the door quickly, even if they do not go to patients higher on the waiting list. Hospitals know they will be evaluated on the basis of how many transplanted patients survive at least a year. So they have an incentive to reject below average organs, and, when they get above average organs, to ignore the waiting list, in order to transplant them into the most healthy patients.

The result is that the sickest and those who have waited the longest are frequently skipped over, instead of receiving the organ when it is their turn.

Why don’t we try something bold–allow for-profit entrepreneurs to engage in medical institutional innovation? For instance, if we allow it, one medical entrepreneurs might purchase from willing donors the right to allocate their organs if and when they become available. Another medical entrepreneur might set up an institution appealing to donors who do not want to be paid, but do want a guarantee that their organs will go to the poor at no charge.

In retailing Walmart and Amazon have different models, but both made major logistical innovations. We need a Walmart and an Amazon of organ transplantation. We need market-tested innovation (as Deirdre McCloskey might say).

Allowing some donors to be paid will reduce the scarcity of organs, which is the most basic constraint on this issue. Innovative medical entrepreneurs may find other ways to loosen this most basic constraint, such as mechanical organs, regrowing human organs from stem cells, and growing transplantable organs in pigs.

(p. A1) For decades, fairness has been the guiding principle of the American organ transplant system. Its bedrock, a national registry, operates under strict federal rules meant to ensure that donated organs are offered to the patients who need them most, in careful order of priority.

But today, officials regularly ignore the rankings, leapfrogging over hundreds or even thousands of people when they give out kidneys, livers, lungs and hearts. These organs often go to recipients who are not as sick, have not been waiting nearly as long and, in some cases, are not on the list at all, a New York Times investigation found.

Last year, officials skipped patients on the (p. A10) waiting lists for nearly 20 percent of transplants from deceased donors, six times as often as a few years earlier. It is a profound shift in the transplant system, whose promise of equality has become increasingly warped by expediency and favoritism.

Under government pressure to place more organs, the nonprofit organizations that manage donations are routinely prioritizing ease over fairness. They use shortcuts to steer organs to selected hospitals, which jockey to get better access than their competitors.

. . .

The Times analyzed more than 500,000 transplants performed since 2004 and found that procurement organizations regularly ignore waiting lists even when distributing higher-quality organs. Last year, 37 percent of the kidneys allocated outside the normal process were scored as above-average. Other organs are not scored in the same way, but donor age is often used as a proxy for quality, and data shows there is little difference in the age of organs allocated normally compared with those that are not.

And while many people in the transplant community believe ignoring lists is reducing organ wastage, there is no evidence that is true, according to an unreleased report by a group of doctors and researchers asked by the transplant system last year to study the practice.

. . .

In 2020, procurement organizations felt under attack. Congress was criticizing them for letting too many organs go to waste. Regulators moved to give each organization a grade and, starting in 2026, fire the lowest performers.

They scrambled to respond. They assigned more staff to hospitals to identify donors, grew more aggressive with families and recovered more organs from older or sicker donors.

Those steps increased donations and transplants, dozens of employees said. Both hit record highs last year, when there were 41,115 transplants.

At the same time, the organizations increasingly used a shortcut known as an open offer. Open offers are remarkably efficient — officials choose a hospital and allow it to put the organ into any patient.

. . .

Some procurement organizations sidestep the list because they believe it helps them place more organs. But it can also help their bottom lines.

In 2021, the South Carolina procurement organization phased out its allocation team and handed the task to workers who were already managing donors, testing organs and helping with surgeries. As a workaround, three former employees said, executives created a spreadsheet with preferred doctors’ phone numbers.

If the employees were too busy to do allocation, they said, they were told to give open offers to those doctors.

“They’d tell me to get rid of the organs quickly, so I could be done,” said Aron Knorr, one of the former workers, who said the directive made him uncomfortable.

. . .

Dr. Alghidak Salama, who led South Florida’s organization until August [2024], said open offers were financially beneficial: When organizations distribute organs, they are paid a set fee by receiving hospitals, regardless of what costs they incur. Speeding up allocation (p. A11) saves money on staffing.

. . .

When hospitals get open offers, they often give organs to patients who are healthier than others needing transplants, The Times found. For example, 80 percent of all donated hearts in recent years went to patients sick enough to be hospitalized, records show. But when lists were skipped, it was less than 40 percent.

Healthier patients are likelier to help transplant centers perform well on one of their most important benchmarks: the percentage of patients who survive a year after surgery. The government monitors that rate, as do insurers, which can decline to pay low-performing hospitals.

. . .

Federal regulators have known since 2022 that more people were being skipped, according to meeting notes obtained by The Times. But until last week, they had done little to address it.

The U.S. Centers for Medicare & Medicaid Services monitors hospitals and procurement organizations. The Health Resources and Services Administration tracks the system overall. But for years, they deferred to UNOS.

Records show that when the system’s oversight committee reviews instances of bypassed patients, it closes more than 99.5 percent of cases without action, usually concluding that the organ was at risk of going to waste. In the last five years, the committee has never gone further than sending “notices of noncompliance,” the mildest action it can take.

“The oversight is almost nonexistent, and that’s been true basically forever,” said Dr. Seth Karp, a Vanderbilt University surgeon who served on the committee, which he noted is largely made up of transplant doctors and procurement officials policing themselves.

For the full story see:

Brian M. Rosenthal, Mark Hansen and Jeremy White. “Organ Transplant System ‘in Chaos’ As Waiting Lists Are Ignored.” The New York Times (Monday, March 10, 2025): A1 & A10-A11.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story has the date Feb. 26, 2025, and has the same title as the print version.)

Fraudulently Doctored Images and “Suspect Data” in Many Leading Cancer Research Papers

Charles Piller in his Doctored paints a damning picture of doctored images and suspect data rampant in the leading scientific literature on Alzheimer’s disease. Not only were leading scientists guilty of fraud, but the key institutions of scientific research (journals, universities, and government grant-making agencies) failing their oversight duty, and when outsiders stepped in to provide oversight, delayed and minimized their responses. Practicing and turning a blind eye to fraud matters, since Alzheimer’s patients are depending on this research. And researchers who do not commit fraud suffer because they appear to have worse research records than those compiled by the fraudsters. So the honest get worse academic appointments and fewer grants.

After reading Doctored I was depressed, but I at least hoped that this pathology was limited to this one (albeit an important one) area of medical research. But in the article quoted below, evidence is presented that there is substantial similar doctored images and suspect data in the field of cancer research.

A side issue in the quoted article is worth highlighting. In the absence of credible oversight from the institutions tasked with oversight, oversight is being done by competent volunteers, with the aid of A.I. These volunteers do not receive compensation for their work, and in fact are probably pay a price for it, since they alienate powerful scientists and scientific institutions. But if science is a search for truth, and truth matters for cures, they are doing a service to us all, and especially to those who suffer from major diseases such as Alsheimer’s and cancer.

On the connection with the Doctored book, it is worth noting that the article quotes Dr. Matthew Schrag, who is the most important source in Doctored. The article also quoted Elisabeth Bik, who does not have an MD like Schrag but has a PhD in microbiology, and who is another important source in Doctored.

(p. A1) The stomach cancer study was shot through with suspicious data. Identical constellations of cells were said to depict separate experiments on wholly different biological lineages. Photos of tumor-stricken mice, used to show that a drug reduced cancer growth, had been featured in two previous papers describing other treatments.

Problems with the study were severe enough that its publisher, after finding that the paper violated ethics guidelines, formally withdrew it within a few months of its publication in 2021. The study was then wiped from the internet, leaving behind a barren web page that said nothing about the reasons for its removal.

As it turned out, the flawed study was part of a pattern. Since 2008, two of its authors — Dr. Sam S. Yoon, chief of a cancer surgery division at Columbia University’s medical center, and a more junior cancer biologist — have collaborated with a rotating cast of researchers on a combined 26 articles that a British scientific sleuth has publicly flagged for containing suspect data. A medical journal retracted one of them this month after inquiries from The New York Times.

Memorial Sloan Kettering Cancer Center, where Dr. Yoon worked when much of the research was done, is now investigating the studies. Columbia’s medical center declined to comment on specific allegations, saying only that it reviews “any concerns about scientific integrity brought to our attention.”

Dr. Yoon, who has said his research could lead to better cancer treatments, did not answer repeated questions. Attempts to speak to the other researcher, Changhwan Yoon, an associate research scientist at Columbia, were also unsuccessful.

The allegations were aired in recent months in online comments on a science forum and in a blog post by Sholto David, an independent molecular biologist. He has ferreted out problems in a raft of high-profile cancer research, including dozens of papers at a Harvard cancer center that were subsequently referred for retractions or corrections.

From his flat in Wales, Dr. David pores over published images of cells, tumors and mice in his spare (p. A17) time and then reports slip-ups, trying to close the gap between people’s regard for academic research and the sometimes shoddier realities of the profession.

. . .

Armed with A.I.-powered detection tools, scientists and bloggers have recently exposed a growing body of such questionable research, like the faulty papers at Harvard’s Dana-Farber Cancer Institute and studies by Stanford’s president that led to his resignation last year.

But those high-profile cases were merely the tip of the iceberg, experts said. A deeper pool of unreliable research has gone unaddressed for years, shielded in part by powerful scientific publishers driven to put out huge volumes of studies while avoiding the reputational damage of retracting them publicly.

The quiet removal of the 2021 stomach cancer study from Dr. Yoon’s lab, a copy of which was reviewed by The Times, illustrates how that system of scientific publishing has helped enable faulty research, experts said. In some cases, critical medical fields have remained seeded with erroneous studies.

“The journals do the bare minimum,” said Elisabeth Bik, a microbiologist and image expert who described Dr. Yoon’s papers as showing a worrisome pattern of copied or doctored data. “There’s no oversight.”

. . .

Dr. Yoon, a stomach cancer specialist and a proponent of robotic surgery, kept climbing the academic ranks, bringing his junior researcher along with him. In September 2021, around the time the study was published, he joined Columbia, which celebrated his prolific research output in a news release. His work was financed in part by half a million dollars in federal research money that year, adding to a career haul of nearly $5 million in federal funds.

. . .

The researchers’ suspicious publications stretch back 16 years. Over time, relatively minor image copies in papers by Dr. Yoon gave way to more serious discrepancies in studies he collaborated on with Changhwan Yoon, Dr. David said. The pair, who are not related, began publishing articles together around 2013.

But neither their employers nor their publishers seemed to start investigating their work until this past fall, when Dr. David published his initial findings on For Better Science, a blog, and notified Memorial Sloan Kettering, Columbia and the journals. Memorial Sloan Kettering said it began its investigation then.

. . .

A proliferation of medical journals, they said, has helped fuel demand for ever more research articles. But those same journals, many of them operated by multibillion-dollar publishing companies, often respond slowly or do nothing at all once one of those articles is shown to contain copied data. Journals retract papers at a fraction of the rate at which they publish ones with problems.

. . .

“There are examples in this set that raise pretty serious red flags for the possibility of misconduct,” said Dr. Matthew Schrag, a Vanderbilt University neurologist who commented as part of his outside work on research integrity.

. . .

Experts said the handling of the article was symptomatic of a tendency on the part of scientific publishers to obscure reports of lapses.

“This is typical, sweeping-things-under-the-rug kind of nonsense,” said Dr. Ivan Oransky, co-founder of Retraction Watch, which keeps a database of 47,000-plus retracted papers. “This is not good for the scientific record, to put it mildly.”

For the full story, see:

Benjamin Mueller. “Cancer Doctor Is in Spotlight Over Bad Data.” The New York Times. (Fri., February 16, 2024): A1 & A17.

(Note: ellipses added.)

(Note: the online version has the date Feb. 15, 2024 [sic], and has the title “A Columbia Surgeon’s Study Was Pulled. He Kept Publishing Flawed Data.”)

Piller’s book mentioned in my initial comments is:

Piller, Charles. Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s. New York: Atria/One Signal Publishers, 2025.