Category: Entrepreneurship

Mice Genome Reprogrammed to Rejuvenate Organs and Extend Life

(p. A22) At the Salk Institute in La Jolla, Calif., scientists are trying to get time to run backward.
Biological time, that is. In the first attempt to reverse aging by reprogramming the genome, they have rejuvenated the organs of mice and lengthened their life spans by 30 percent. The technique, which requires genetic engineering, cannot be applied directly to people, but the achievement points toward better understanding of human aging and the possibility of rejuvenating human tissues by other means.
The Salk team’s discovery, reported in the Thursday issue of the journal Cell, is “novel and exciting,” said Jan Vijg, an expert on aging at the Albert Einstein College of Medicine in New York.
Leonard Guarente, who studies the biology of aging at M.I.T., said, “This is huge,” citing the novelty of the finding and the opportunity it creates to slow down, if not reverse, aging. “It’s a pretty remarkable finding, and if it holds up it could be quite important in the history of aging research,” Dr. Guarente said.
. . .
Ten years ago, the Japanese biologist Shinya Yamanaka amazed researchers by identifying four critical genes that reset the clock of the fertilized egg. The four genes are so powerful that they will reprogram even the genome of skin or intestinal cells back to the embryonic state.
. . .
Dr. Izpisua Belmonte believes these beneficial effects have been obtained by resetting the clock of the aging process. The clock is created by the epigenome, the system of proteins that clads the cell’s DNA and controls which genes are active and which are suppressed.
. . .
Dr. Izpisua Belmonte sees the epigenome as being like a manuscript that is continually edited. “At the end of life there are many marks and it is difficult for the cell to read them,” he said.
What the Yamanaka genes are doing in his mice, he believes, is eliminating the extra marks, thus reverting the cell to a more youthful state.
The Salk biologists “do indeed provide what I believe to be the first evidence that partial reprogramming of the genome ameliorated symptoms of tissue degeneration and improved regenerative capacity,” Dr. Vijg said.

For the full story, see:
NICHOLAS WADE. “Scientists Learn About Human Aging by Lengthening the Life Span of Mice.” The New York Times (Fri., DEC. 16, 2016): A22.
(Note: ellipses added.)
(Note: the online version of the story has the date DEC. 15, 2016, and has the title “Scientists Say the Clock of Aging May Be Reversible.”)

Doctors Lack Incentives to Use Best Ovarian Cancer Treatment

(p. 22) In 2006, the National Cancer Institute took the rare step of issuing a “clinical announcement,” a special alert it holds in reserve for advances so important that they should change medical practice.
In this case, the subject was ovarian cancer. A major study had just proved that pumping chemotherapy directly into the abdomen, along with the usual intravenous method, could add 16 months or more to women’s lives. Cancer experts agreed that medical practice should change — immediately.
Nearly a decade later, doctors report that fewer than half of ovarian cancer patients at American hospitals are receiving the abdominal treatment.
“It’s very unfortunate, but it’s the real world,” said Dr. Maurie Markman, the president of medicine and science at Cancer Treatment Centers of America. He added, “The word ‘tragic’ would be fair.”
Experts suggest a variety of reasons that the treatment is so underused: It is harder to administer than intravenous therapy, and some doctors may still doubt its benefits or think it is too toxic. Some may also see it as a drain on their income, because it is time-consuming and uses generic drugs on which oncologists make little money.

For the full story, see:
DENISE GRADY. “Ovarian Cancer Treatment Is Found Underused.” The New York Times (Tues., AUG. 4, 2015): A1 & A13.
(Note: the online version of the story has the date AUG. 3, 2015, and has the title “Effective Ovarian Cancer Treatment Is Underused, Study Finds.”)

Cuban Entrepreneurs Lost Faith in Fidel’s Revolution

(p. 22) Ihosvany Oscar Artiles Ferrer, 44, a veterinarian who worked in Camagüey but recently moved to Queens, said the lack of wholesalers to buy supplies from made it difficult to eke out a profit.
“The private business is like a handkerchief the government puts over everything to be able to say to the United Nations that in Cuba people own small businesses,” Mr. Artiles said.
“In the beginning, almost all of us were revolutionaries,” he added. “But now, we quit all that because we don’t believe in Fidel, in the revolution, in socialism or anything.”

For the full story, see:
FRANCES ROBLES. “Stay or Go? Cuban Entrepreneurs Are Divided on Where to Stake Futures.” The New York Times (Tues., MARCH 22, 2016): 22.
(Note: the online version of the story has the date MARCH 21, 2016, and has the title “Stay or Go? Cuban Entrepreneurs Divided on Where to Stake Futures.”)

Firm Success May Depend on Being Allowed to Create Corporate Culture Through Hiring

(p. B1) After submitting an online application, completing a video interview and meeting with a hiring manager, the last thing standing between many applicants and a job at G Adventures Inc. is a roughly two-foot-deep ball pit similar to what you might find at a Chuck E. Cheese’s.
Candidates remove their shoes and join three of the Toronto-based tour company’s employees, who spin a wheel with questions such as, “What’s a signature dance move and will you demonstrate it?”
Sitting in a pool of plastic balls seemingly has little to do with selling package tours, but company founder Bruce Poon Tip says it reveals a lot about who will be successful at the 2,000-employee company.
Culture is “like a tribal thing for us,” he says. Lately, many companies seem to agree.
Employers are finding new ways to assess job candidates’ cultural suitability as they seek hires who fit in from day one. While few go as far as G Adventures, companies such as Salesforce.com Inc. have experimented with tapping “cultural ambassadors” to evaluate finalists for jobs in other departments. Zappos.com Inc. gives company veterans veto power over hires who might not fit in with its staff–even if those hires have the right skills for the job.
Though employment experts warn that fuzzy criteria such as culture fit may permit bias in the hiring process and result in a lack of diversity, companies say culture often determines who succeeds or fails in their workplace.

For the full commentary, see:
RACHEL FEINTZEIG. “‘Culture Fit’ May Be Key to Your Next Job.” The Wall Street Journal (Weds., Oct. 12, 2016): B1 & B6.
(Note: the online version of the commentary has the title “Culture Fit’ May Be the Key to Your Next Job.”)

Complex Regulations Stifle Innovation

(p. A15) In “The Innovation Illusion” . . . [Fredrik Erixon and Björn Weigel] argue that “there is too little breakthrough innovation . . . and the capitalist system that used to promote eccentricity and embrace ingenuity all too often produces mediocrity.”
The authors identify four factors that have made Western capitalism “dull and hidebound.” The first is “gray capital,” the money held by entities such as investment institutions, which are often just intermediaries for other investors. Their shareholders, say the authors, tend to focus on short-term outcomes, a perspective that makes company managers reluctant to invest in the research and development that is the lifeblood of the new. The authors’ second villain is “corporate managerialism,” which breeds a “custodian corporate culture” that searches for certainty and control instead of “fast and radical innovation.”
A third villain is globalization, though the authors have a novel complaint: The global economy, they say, has given rise to large firms that are more interested in protecting their turf than pursuing path-breaking ideas. Finally, they decry “complex regulation” for injecting uncertainty into corporate investment and thus stifling the emergence of new ideas and new products.
Echoing the views of Northwestern economist Robert Gordon, Messrs. Erixon and Weigel lament the paucity of big-bang innovation, writing that “the advertised technologies for the future underwhelm.” They wonder why there hasn’t been more progress in all sorts of realms, from the engineering of flying cars to the curing of cancer. Responding to those who worry that robots will drive up unemployment, they say that the real concern should be “an innovation famine rather than an innovation feast.”

For the full review, see:

MATTHEW REES. “BOOKSHELF; Bending the Arc of History.” The Wall Street Journal (Tues., December 13, 2016): A15.
(Note: first ellipsis added; second ellipsis in original.)
(Note: the online version of the review has the date Dec. 12, 2016,)

The book under review, is:
Erixon, Fredrik, and Björn Weigel. The Innovation Illusion: How So Little Is Created by So Many Working So Hard. New Haven, CN: Yale University Press, 2016.

Tech Firms Rally Their Customers to Fight Restrictive Regulations

(p. A23) The nasty battle between Uber and the administration of Mayor Bill de Blasio over New York City’s proposed cap on livery vehicles has ended, at least for now, with the city and the ride-hailing giant agreeing to postpone a decision pending a “traffic study.” There’s no doubt who won, though. The mayor underestimated his opponent and was forced to retreat.
It wasn’t just conventional pressure — ads, money, lobbying — that caught the mayor off guard. Uber mobilized its customers, leveraging the power of its app to prompt a populist social-media assault, all in support of a $50 billion corporation. The company added a “de Blasio’s Uber” feature so that every time New Yorkers logged on to order a car, they were reminded of the mayor’s threat (“NO CARS — SEE WHY”) and were sent directly to a petition opposing the new rules. Users were also offered free Uber rides to a June 30 rally at City Hall. Eventually, the mayor and the City Council received 17,000 emails in opposition. Just as Uber has offloaded most costs of operating a taxi onto its drivers, the company uses its customers to do much of its political heavy lifting.
Uber’s earlier strategy to win entry into the Portland, Ore., market followed a similar pattern. When the city wasn’t allowing the company to operate taxis, Uber exploited rules that allowed it to act as a delivery company, and distributed free ice cream around town. Using data on these deliveries, the firm shrewdly recruited recipients as pro-Uber citizen lobbyists, pressuring local officials to allow their cars to pick up passengers. It worked.
Many tech firms now recognize the organizing power of their user networks, and are weaponizing their apps to achieve political ends. Lyft embedded tools on its site to mobilize users in support of less restrictive regulations. Airbnb provided funding for the “Fair to Share” campaign in the Bay Area, which lobbies to allow short-term housing rentals, and is currently hiring “community organizers” to amplify the voices of home-sharing supporters. Amazon’s “Readers United” was an effort to gain customer backing during its acrimonious dispute with the publisher Hachette. Emails from eBay prodded users to fight online sales-tax legislation.

For the full commentary, see:
EDWARD T. WALKER. “The Uber-ization of Activism.” The New York Times (Fri., AUG. 7, 2015): A23.
(Note: the online version of the commentary has the date AUG. 6, 2015.)

Where Fidelistas Miss Mr. Hershey’s Company Town

(p. A9) This small town on Cuba’s northern coast is steeped in memory and wistfulness, a kind of living monument to the intertwined histories of the United States and Cuba and to the successes and failures of Fidel Castro’s social revolution.
The town dates to 1916, when Milton S. Hershey, the American chocolate baron, visited Cuba for the first time and decided to buy sugar plantations and mills on the island to supply his growing chocolate empire in Pennsylvania. On land east of Havana, he built a large sugar refinery and an adjoining village — a model town like his creation in Hershey, Pa. — to house his workers and their families.
He named the place Hershey.
The village would come to include about 160 homes — the most elegant made of stone, the more modest of wooden planks — built along a grid of streets and each with tidy yards and front porches in the style common in the growing suburbs of the United States. It also had a public school, a medical clinic, shops, a movie theater, a golf course, social clubs and a baseball stadium where a Hershey-sponsored team played its home games, residents said.
The factory became one of the most productive sugar refineries in the country, if not in all of Latin America, and the village was the envy of surrounding towns, which lacked the standard of living that Mr. Hershey bestowed on his namesake settlement.
. . .
“I’m a Fidelista, entirely in favor of the revolution,” declared Meraldo Nojas Sutil, 78, who moved to Hershey when he was 11 and worked in the plant during the 1960s and ’70s. “But slowly the town is deteriorating.”
Many residents do not hesitate to draw a contrast between the current state of the town and the way that it looked when “Mr. Hershey,” as he is invariably called here, was the boss.
Residents seem amused by, if not proud of, the ties to the United States.
Most still use the village’s original name, pronounced locally as “AIR-see.” And Hershey signs still hang at the town’s train station, a romantic nod to a bygone era, though perhaps also a symbol of hope that the past — at least, certain aspects of it — will again become the present.

For the full story, see:
KIRK SEMPLE. “CAMILO CIENFUEGOS JOURNAL; Past Is Bittersweet in Cuban Town That Hershey Built.” The New York Times (Thurs., DEC. 7, 2016): A9.
(Note: ellipsis added.)
(Note: the online version of the article has the date DEC. 7, 2016, and has the title “CAMILO CIENFUEGOS JOURNAL; In Cuban Town That Hershey Built, Memories Both Bitter and Sweet.”)

Science Can Learn Much from Outliers “Who Are Naturally Different”

(p. 1) Abby Solomon suffers from a one-in-a-billion genetic syndrome: After just about an hour without food, she begins to starve. She sleeps in snatches. In her dreams she gorges on French fries. But as soon as she wakes up and nibbles a few bites, she feels full, so she ends up consuming very few calories. At 5 feet 10 inches tall, she weighs 99 pounds.
Now 21 years old, she is one of the few people in the world to survive into adulthood with neonatal progeroid syndrome, a condition that results from damage to the FBN1 gene.
. . .
(p. 6) Dr. Chopra told me that, as far as medical science is concerned, Abby Solomon is worth thousands of the rest of us.
. . .
“Nothing comes close to starting with people who are naturally different,” he said. This is why he searches out patients at the extreme ends of the spectrum — those who are wired to weigh 80 pounds or 380 pounds. He said, “We have the opportunity to help a bigger swath of humanity when we learn from these outliers.”
In 2013, after hearing about Ms. Solomon’s unusual condition from another patient, he asked her to visit his clinic. Ms. Solomon warned him that she would be able to carry on a conversation for only 15 minutes before she needed to snack on chips or a cookie. That remark inspired a revelation. Dr. Chopra realized that “she had to eat small, sugary meals all day to stay alive, because her body was constantly running out of glucose,” he said.
The clue led Dr. Chopra and his colleagues to their discovery of the blood-sugar-regulating hormone, which they named asprosin. Ms. Solomon’s natural asprosin deficiency keeps her on the brink of starvation, but Dr. Chopra’s hope is that an artificial compound that blocks asprosin could be used as a treatment for obesity. He and his team have already tested such a compound on mice, and found that it can reverse insulin resistance and weight gain.

For the full commentary, see:
PAGAN KENNEDY. “The Thin Gene.” The New York Times, SundayReview Section (Sun., NOV. 27, 2016): 1 & 6.
(Note: ellipses added.)
(Note: the online version of the commentary has the date NOV. 25, 2016.)

Not All Old Ideas Should Be Recycled

(p. C16) “What is true in the consumer tech industry is true in science and other fields of thinking,” Mr. Poole elaborates. “The story of human understanding is not a gradual, stately accumulation of facts” but rather “a wild roller-coaster ride full of loops and switchbacks.”
Horses, for example, are once again being used in warfare in the Middle East. Vinyl records are back after losing out to digital CDs and internet streaming. Leeches, whose use was once considered a barbaric medieval practice, are now an FDA-approved “medical device” for cleaning wounds. Bicycles are making a comeback as a popular and efficient means of moving about in large, crowded cities. Blimps are starting to compete with helicopters for moving heavy cargo.
. . .
To understand this process of rediscovery–“old is the new new”–we need to abandon the myth of progress as something that results from a rejection of all that is old.
Still, not all old ideas will return reconfigured into new and useful ones, and it is here where readers may find room for disagreement, despite Mr. Poole’s many caveats.
. . .
That there are many unsolved mysteries in science does not always mean that we should turn to the past for insight. Sometimes–usually, in fact–the bad ideas rejected by science belong in the graveyard. Phlogiston, miasma, spontaneous generation, the luminiferous aether–wrong, wrong, wrong and wrong.
Nevertheless, those notions–and many others that Mr. Poole surveys in this thought-provoking book–were wrong in ways that led scientists toward a better understanding, and the middle chapters of “Rethink” elegantly recount these stories. Going forward, Mr. Poole ends by suggesting that we adopt a “view from tomorrow” in which we “try to consider an idea free of the moral weight that attaches to it in particular historical circumstances” and that “we could try to get into the habit of deferring judgments about ideas more generally” in order to keep an open mind. On the flip side, skeptics should not rush to dismiss a consensus idea as wrong just because consensus science is not always right. Most of today’s ideas gained consensus in the first place for a very good reason: evidence. Do you know what we call alternative science with evidence? Science.

For the full review, see:

MICHAEL SHERMER. “Everything Old Is New Again.” The Wall Street Journal (Sat., December 10, 2016): C16.
(Note: ellipses added.)
(Note: the online version of the review has the date Dec. 9, 2016, and has the title “Electric Cars Are Old News.”)

The book under review, is:
Poole, Steven. Rethink: The Surprising History of New Ideas. New York: Scribner, 2016.

Entrepreneur Hires for Perseverance

Max Levchin, who is quoted below, is an entrepreneur who played an important role in the early days of PayPal.

(p. 2) How do you think your parents and grandparents influenced your leadership style today?

My grandmother was exceptionally formative. She basically was willpower personified. If she wanted something to happen, it would happen. She had this walk-through-walls style where you did not ask for permission or forgiveness; you just did what you needed to get it done. I still judge some of my decisions based on: What would Grandma decide? Was I sufficiently tenacious or not enough?
And one thing I have found over the years is that in hiring, the dominant characteristic I select for is this sense of perseverance in really tough situations. It’s like the difference between endurance athletes and sprinters. I think it is a really good predictor for how people behave under severe stress.
Working in a start-up means there is a baseline of stress with occasional spikes. There are people who are really good at handling spikes. In fact, most people are really good at handling spikes. But normal isn’t normal. There is constant stress. And so I look for endurance athletes, in the business sense.

For the full interview, see:
ADAM BRYANT. “Corner Office; Looking for Signs of Endurance.” The New York Times, SundayBusiness Section (Sun., December 11, 2016): 2.
(Note: bold in original.)
(Note: the online version of the interview has the date DEC. 9, 2016, and has the title “Corner Office; Max Levchin of Affirm: Seeking the Endurance Athletes of Business.” The bold words are Adam Bryant’s question; the non-bold words are Max Levchin’s answer.)

Uber Fights Regulations by Asking Forgiveness, Not Permission

(p. B3) For seven years, Uber’s stance on complying with regulations has been consistent: Ask forgiveness, not permission.
On Friday [December 16, 2016], the ride-hailing company stuck to that position. It said it had no intention of ending a new test of its self-driving vehicles in San Francisco, even though California regulators had said the service was illegal because Uber had not obtained the necessary permits. Uber said its self-driving cars were still on the road and picking up passengers.
The dispute is rooted in Uber’s refusal to seek a permit from the California Department of Motor Vehicles, which would allow it to test autonomous vehicles under certain conditions. Companies like Google, Tesla Motors and Mercedes-Benz have all gotten such permits.
Uber officials contend that under the letter of California law, the company does not need a permit because the motor vehicles department defines autonomous vehicles as those that drive “without the active physical control or monitoring of a natural person.” Uber said its modified, self-driving Volvo XC90s require human oversight, and therefore do not fit California’s definition of an autonomous vehicle.
. . .
The episode serves the latest volley in Uber’s war with local and state regulators — not only in the United States, but in many of the more than 70 countries in which the company operates. Uber has previously grappled with the authorities in California over safety concerns. And Otto, the self-driving trucking start-up founded by Mr. Levandowski and acquired by Uber in August, has flouted state laws in Nevada in the past.

For the full story, see:
MIKE ISAAC. “Uber Defies California Officials Over Self-Driving Cars.” The New York Times (Sat., December 17, 2016): B3.
(Note: ellipsis, and bracketed date, added.)
(Note: the online version of the story has the date DEC. 16, 2016, and has the title “Uber Defies California Regulators With Self-Driving Car Service.”)