Category: Entrepreneurship

Since Adderall Is “Highly Regulated” Pharmacies and Patients Can’t “Quickly Pivot” in Response to Scarcity

(p. A13) The Food and Drug Administration has declared a nationwide shortage of Adderall, a medication used to treat A.D.H.D. that has had surging demand in recent years.

. . .

Adderall, which contains the stimulant amphetamine, is a controlled substance and highly regulated, so it is difficult for pharmacies to quickly pivot and carry new brands, analysts said.

. . .

While a number of companies make Adderall and generic versions, pharmacies may find it difficult to pivot to other suppliers because of amphetamine’s status as a controlled substance that typically includes restrictions on its use and monitoring of prescription orders. Any given pharmacy might risk raising red flags with the Drug Enforcement Administration by doubling its supply, said Erin Fox, an expert on drug shortages at the University of Utah.

“With a controlled substance, it’s harder for patients to call around and find a pharmacy that has product for them,” Ms. Fox said.

For the full story, see:

Christina Jewett. “F.D.A. Confirms Widespread Shortages of Adderall.” The New York Times (Friday, October 14, 2022): A13.

(Note: ellipses added.)

(Note: the online version of the story has the date Oct. 13, 2022, and has the title “F.D.A. Confirms Wide Shortage of Adderall.”)

Musk’s Private Starlink Infrastructure “Played a Crucial Role” in Saving Ukraine

(p. A6) KYIV, Ukraine—Elon Musk backtracked on his complaints over the cost of funding Starlink internet terminals in Ukraine and said his company would continue to pay for them, as explosions rocked the Russian-held city of Donetsk in eastern Ukraine on Sunday [Oct. 16, 2022].

Mr. Musk, the billionaire chief executive of SpaceX and Tesla, pledged to continue funding the Starlink service for Ukraine just a day after he said SpaceX couldn’t finance the service indefinitely on its own.

“The hell with it,” Mr. Musk tweeted on Saturday. “Even though Starlink is still losing money & other companies are getting billions of taxpayer $, we’ll just keep funding Ukraine govt for free.”

The 20,000 Starlink terminals estimated to be in operation across Ukraine have played a crucial role in maintaining the country’s communications during the war and are deployed at hundreds of Ukrainian military outposts where they allow commanders to call in artillery strikes or coordinate operations in areas where cell service is jammed by Russia.

For the full story, see:

Matthew Luxmoore. “Musk Says SpaceX to Cover Starlink Costs in Ukraine.” The Wall Street Journal (Monday, Oct. 17, 2022): A6.

(Note: ellipsis, and bracketed date, added.)

(Note: the online version of the story was updated Oct. 16, 2022, and has the title “Elon Musk Says SpaceX Will Continue to Cover Starlink Costs in Ukraine.”)

Environmentalists Ignore “The Unintended Impacts of Policies”

(p. A1) Nicole Kramaritsch of Roxbury, N.J., has 46 bags just sitting in her garage. Brian Otto has 101 of them, so many that he’s considering sewing them into blackout curtains for his baby’s bedroom. (So far, that idea has gone nowhere.) Lili Mannuzza in Whippany has 74.

“I don’t know what to do with all these bags,” she said.

The mountains of bags are an unintended consequence of New Jersey’s strict new bag ban in supermarkets. It went into effect in May and prohibits not only plastic bags but paper bags as well. The well-intentioned law seeks to cut down on waste and single-use plastics, but for many people who rely on grocery delivery and curbside pickup services their orders now come in heavy-duty reusable shopping bags — lots and lots of them, week after week.

While nearly a dozen states nationwide have implemented restrictions on single-use plastic bags, New Jersey is the only one to ban paper bags because of their environmental impact. The law also bans polystyrene foam food containers and cups, and restricts restaurants from handing out plastic straws unless they’re requested.

Emily Gonyou, 22, a gig worker in Roselle Park who provides shopping services for people (p. A11) through Instacart, said she was surprised when she learned the delivery company had no special plans for accommodating the ban. “They pretty much said, ‘OK, do exactly what you’re doing, but with reusable bags,’” she said.

Ms. Gonyou said she goes through up to 50 reusable bags a day, many of which, she suspects, could end up in the garbage.

Compared to single-use plastics, the more durable reusable bags are better for the environment only if they are actually reused. According to Shelie Miller, a professor at the University of Michigan School for Environment and Sustainability, a typical reusable bag, manufactured from polypropylene, must be used at least 10 times to account for the additional energy and material required to make it. For cotton totes, that number is much higher.

. . .

Dr. Miller said the bag situation in New Jersey was emblematic of a lot of environmental policies. “If we don’t pay attention to the unintended impacts of policies such as the plastic waste ban, we run into the potential of playing environmental Whac-a-Mole,” she said. “We solve one environmental problem only to create or exacerbate another problem.”

For the full story, see:

Clare Toeniskoetter. “New Jersey Bag Ban’s Unforeseen Consequence: Too Many Bags.” The New York Times (Friday, September 2, 2022): A1 & A11.

(Note: ellipsis added.)

(Note: the online version of the story has the date Sept. 1, 2022, and has the title “Why Do Some People in New Jersey Suddenly Have Bags and Bags of Bags?”)

Regulators Slowed Development of Moderna Vaccine

How much credit for the Covid vaccines goes to government and how much to entrepreneurs? Loftus’s book focuses on Moderna, and makes the case that government deserves considerable credit, mostly for early funding. A case can be made that at least as much focus should be given to BioNTech. If BioNTech had been the focus, that case might have been harder to make.

(p. C5) In late 2019, just weeks before the world heard of Covid-19, scientists from the National Institute of Allergy and Infectious Diseases visited the new manufacturing plant of a small, 9-year-old biotechnology company called Moderna. The company’s leaders boasted that the new plant in Norwood, Mass., could make a batch of a newly designed vaccine in 60 days—rapid by standard timelines that usually take 12 months or more.

. . .

One Friday afternoon in August [2020], the company was expecting delivery of large air-handling units to help expand production at its factory. Moderna had hired construction cranes to lift the tractor-trailer-sized units onto the roof of its plant. But delivery was delayed because the supplier lacked all the state permits needed to transport oversize cargo from the Midwest to Massachusetts. If the units didn’t get there by Sunday, Moderna would lose the cranes and a week of production.

Frantic, Moderna executives called Warp Speed officials. They gave the job to an Army colonel, who leaned on state officials, who in turn sent state police with sirens blaring to escort the delivery to their state line and then hand off the convoy to a new escort. The precious cargo rolled into Moderna’s plant on Sunday morning, in time for the cranes.

The much larger and older Pfizer, meanwhile, mostly opted out of Operation Warp Speed for fear it would slow the company down. As for Moderna’s collaboration, it generated enough friction to make the company’s chief medical officer during 2020, Tal Zaks, question at times whether it was worth it to accept the federal assistance.

Dr. Zaks had wanted to use a private contract research organization to run the whole trial, but NIAID officials wanted their clinical-trial network involved. Eventually, Dr. Zaks backed off, and both entities participated. “I realized we were at an impasse, and I was the embodiment of the impasse,” Dr. Zaks said.

Next, when Moderna’s 30,000-person study began enrolling volunteers in July 2020, the subjects weren’t racially diverse enough. Moncef Slaoui, who led Warp Speed’s vaccine efforts, and Dr. Fauci began holding Saturday Zoom calls with Mr. Bancel and other Moderna leaders to “help coax and advise Moderna how to get the percentage of minorities up to a reasonable level,” Dr. Fauci recalled.

Drs. Fauci and Slaoui wanted Moderna to slow down overall enrollment, to give time to find more people of color. Moderna executives resisted at first. “That was very tense,” Dr. Slaoui said. “Voices went up, and emotions were very high.” Moderna ultimately agreed, and the effort worked, but it cost the trial about an extra three weeks. Later, Mr. Bancel called the decision to slow enrollment “one of the hardest decisions I made this year.”

For the full essay, see:

Peter Loftus. “The Partnership That Made the First U.S. Covid Vaccine.” The Wall Street Journal (Saturday, July 30, 2022): C5.

(Note: ellipsis, and bracketed year, added.)

(Note: the online version of the essay has the date July 29, 2022, and has the same title as the print version.)

The essay quoted above is an adaptation from Loftus’s book:

Loftus, Peter. The Messenger: Moderna, the Vaccine, and the Business Gamble That Changed the World. Boston: Harvard Business Review Press, 2022.

Periodic Fasting May Reduce Inflammation That Causes Multiple Maladies

(p. A15) Mr. Hendricks sees fasting as a way of combating a range of ailments. (“Surgery without a scalpel” was how some doctors once described the practice.) He cites studies showing fasting to be effective against arthritis, hypertension and fibromyalgia, among other afflictions. The medical logic in these cases is that fasting reduces inflammation—the source of multiple maladies—while promoting insulin sensitivity, stimulating DNA repair and generating antioxidants that neutralize a harmful molecule known as reactive oxygen species. Mr. Hendricks argues that fasting leads to better outcomes from chemotherapy, too—by causing healthy cells to go dormant and avoid the treatment’s toxic chemicals.

And, yes, fasting triggers weight loss. The fasting Mr. Hendricks has in mind is periodic, its frequency and duration varying from person to person.

. . .

A theme running through “The Oldest Cure in the World” is the author’s exasperation with the American approach to practicing medicine. Few physicians, he notes, are knowledgeable about fasting, despite the benefits it provides. He favorably profiles two researchers—Valter Longo and Satchin Panda, at the University of Southern California and the Salk Institute, respectively—who have conducted ground-breaking studies on the value of restrictive food consumption.

The book’s most compelling story features an infant who in 1993 started having daily seizures after his first birthday. Neither medications nor brain surgery provided significant relief. Pediatric neurologists told the parents that their son, Charlie, faced a life of mental and physical retardation.

Charlie’s father discovered an obscure clinic at Johns Hopkins University that offered a treatment that involved brief fasting followed by a high-fat, ketogenic diet. The family’s neurologist dismissed the treatment as unworkable, but the family tried it anyway. On the second day of Charlie’s fast, the seizures stopped. Over time, his physical and mental development returned to normal, and he has grown up to be as healthy as his siblings. Later research has shown that fasting and a high-fat diet is a potent method for reducing seizures in epileptic children.

For the full review, see:

Matthew Rees. “BOOKSHELF; No First Helpings.” The Wall Street Journal (Friday, October 7, 2022): A15.

(Note: ellipsis added.)

(Note: the online version of the review has the date October 6, 2022, and has the title “BOOKSHELF; ‘The Oldest Cure in the World’ Review: No First Helpings.”)

The book under review is:

Hendricks, Steve. The Oldest Cure in the World: Adventures in the Art and Science of Fasting. New York: Harry N. Abrams, 2022.

Steve Case Sees “Local Knowledge” as a Plus for Entrepreneurs Outside of Silicon Valley

(p. A15) Steve Case, a co-founder of AOL, was one of the early internet pioneers. But he is not a creature of Silicon Valley. AOL, he points out in “The Rise of the Rest: How Entrepreneurs in Surprising Places Are Building the New American Dream,” was based in the Washington, D.C., area, and many of the early tech firms, like Dell, were not started in Silicon Valley. Hence his conviction that successful entrepreneurship can happen anywhere.

. . .

Mr. Case reckons that we are entering a new phase of tech innovation. Success now requires not only software ingenuity but also industry expertise. If true, we could be due for a wave of local entrepreneurs because these are the people who are aware of the problems their communities face. Now that tech workers can work anywhere, local knowledge and expertise will be at a premium.

. . .

. . . [A] firm that Mr. Case discusses is Catalyte, a software company based in Baltimore. Founder Michael Rosenbaum was convinced that “potential talent was being overlooked by a system that valued pedigree over innate ability” and devised a hiring approach that would ignore traditional résumé points and instead match employees “according to their abilities and potential, which would be determined through carefully calibrated metrics and AI design.” To that end, Mr. Rosenbaum decided to launch his startup in Baltimore, “a postindustrial city . . . with a large, dislocated population of workers who were not connected to the future job opportunities.” His methods paid off, resulting in a diverse workforce and one that produced “off the charts” performance results.

According to Mr. Case, spurring regional entrepreneurship requires leaning on universities and building more “innovation districts.” But these zones, which contain startups, business incubators and investment funds that support one another, have a mixed record. He sees government involvement as crucial but doesn’t contend with its past failures . . .

For the full review, see:

Allison Schrager. “BOOKSHELF; Startups Across America.” The Wall Street Journal (Monday, Sept. 12, 2022): A15.

(Note: ellipses between paragraphs, and at the start or end of a paragraph, added; ellipsis within paragraph, in original. Bracketed word also added.)

(Note: the online version of the review has the date September 11, 2022, and has the title “BOOKSHELF; ‘The Rise of the Rest’ Review: Startups Across America.”)

The book under review is:

Case, Steve. The Rise of the Rest: How Entrepreneurs in Surprising Places Are Building the New American Dream. New York: Avid Reader Press, 2022.

To Avoid “Misconduct” Starbucks Asks “That All Future Elections Be Conducted Fully in Person”

(p. B5) As the union drive at Starbucks stores accelerates, Starbucks has ratcheted up its efforts to push back on the campaign, asking on Monday [Sept. 15, 2022] that the National Labor Relations Board investigate allegations of misconduct during a union vote in the Kansas City area.

Starbucks, in a letter to the labor board, asked that the agency investigate reports by an N.L.R.B. employee that there was unfair coordination between the agency and the union, specifically that several employees were given special voting arrangements and that the N.L.R.B. provided confidential real-time election results to the union. The company asked that the agency suspend all elections until the allegations could be investigated. In addition, Starbucks asked that all future elections be conducted fully in person.

For the full story, see:

Emma Goldberg. “Citing Misconduct Claims, Starbucks Asks to Halt Union Elections.” The New York Times (Tuesday, August 16, 2022): B5.

(Note: bracketed date added.)

(Note: the online version has the date Aug. 15, 2022, and has the title “Starbucks Asks for a Suspension of Union Elections.”)

Shy and “Docile” Raccoons May Be “More Likely to Learn”

(p. D3) Despite their reputation, little is known about why raccoons are so good at urban living.

Over the past few years, researchers have taken to the streets of Laramie, Wyo., to uncover the raccoons’ secrets, adapting a cognitive test designed for captive animals so that it can be deployed in the wild.

Preliminary findings suggest that the most docile animals learned to use the testing devices more easily than bolder, more aggressive ones did, a result that has implications for our relationship with urban wildlife. The study was published on Thursday [Sept. 22, 2022] in the Journal of Experimental Biology.

. . .

Dr. Stanton’s team . . . wanted to know if certain characteristics made a raccoon more likely to excel on the test. They noted each animal’s behavior throughout the trapping and tagging process and found that individual raccoons reacted differently to the stress of being captured: Some were aggressive, hissing at the researchers, whereas others were quiet in their traps.

The scientists had expected that bolder raccoons would be more likely to interact with the testing devices. “But this isn’t what we found,” Dr. Stanton said.

Instead, the docile raccoons were more likely to learn how the devices work. The surprising discovery has implications for how cities deal with raccoons.

Urban wildlife management tends to focus on aggressive animals that may be confronting people and their pets, noted Sarah Benson-Amram, a behavioral ecologist at the University of British Columbia and a co-author of the study. By neglecting the docile animals, we may be increasing the proportion of problem-solving raccoons living in cities.

“Maybe they’re the ones who are learning how to open up the chicken coops and steal your chickens or break into your attic,” Dr. Benson-Amram said.

The results of the study add to a growing body of research suggesting animals that aren’t as aggressive or stressed by the presence of people may also have cognitive skills that help them thrive in urban areas.

“This is perhaps the first step towards domestication,” said Benjamin Geffroy, a biologist at the University of Montpellier in France. “Now we need to know more about what comes first, docility or cognitive abilities.”

. . .

Working with captive raccoons has convinced Dr. Benson-Amram that they actually enjoy cognitive challenges. “We give them problems, and even when there’s no reward, they just keep going for it,” she said.

Raccoons in urban environments can also be remarkably persistent, said Suzanne MacDonald, an animal behavior scientist at York University in Toronto. For one study, she put an open can of cat food in a trash bin, secured the lid with a bungee cord and deployed it in backyards to see how raccoons would react.

“I had one female spend like eight hours trying to get in,” Dr. MacDonald said. “And she did.”

For the full story, see:

Betsy Mason. “Shy Raccoons May Have an Edge in Learning.” The New York Times (Tuesday, September 27, 2022): D3.

(Note: ellipses, and bracketed date, added.)

(Note: the online version has the date Sept. 22, 2022, and has the title “Shy Raccoons Are Better Learners Than Bold Ones, Study Finds.”)

The article in the Journal of Experimental Biology mentioned above is:

Stanton, Lauren A., Eli S. Bridge, Joost Huizinga, and Sarah Benson-Amram. “Environmental, Individual and Social Traits of Free-Ranging Raccoons Influence Performance in Cognitive Testing.” Journal of Experimental Biology 225, no. 18 (2022) DOI: 10.1242/jeb.243726.

“The Car Emancipated the Masses”

(p. 11) Ear-shredding noise, toxic air, interminable traffic jams, chaos and death — all the result of untrammeled population expansion. Is this a description of a contemporary urban nightmare? Not quite: We’re talking about 19th-century London, although the situation in Paris and other major cities wasn’t much better. And the cause of all this misery was … the horse.

As recounted by Bryan Appleyard in his compelling new book, “The Car,” by 1900 the 50,000 horses required to meet London’s transportation needs deposited 500 tons of excrement daily. Hooves and carriage wheels threw up curtains of fetid muck. Accidents caused by mechanical failures and spooked animals were often fatal to passengers, drivers and the horses themselves. New York City employed 130,000 horses and predictions were made that by 1930 that city’s streets would be piled three stories high with dung. Yet another dire prophecy fallen victim to the continuity fallacy — the belief that a current trend will endure forever.

Things change because when problems arise, people work at solving them, and sometimes they arrive at solutions. The answer to the psychosocial and physical degradation brought on by too many people employing too many horses in the burgeoning Industrial Age was, of course, the development of the motor vehicle. Specifically, one powered by the internal combustion engine.

. . .

For all the carping and finger-pointing leveled at traditional automobiles — much of which Appleyard acknowledges as valid — he is unabashed about his appreciation for the most important machine in human history. As he points out, “The car emancipated the masses far more effectively than any political ideology; that it did so at a cost should not obliterate the importance of that freedom.”

Well said. Vroom.

For the full review, see:

Jonathan Kellerman. “Auto Erotica.” The New York Times Book Review (Sunday, September 25, 2022): 11.

(Note: ellipsis added.)

(Note: the online version of the review was updated Sept. 23, 2022, and has the title “How the Car Created the Modern World.”)

The book under review is:

Appleyard, Bryan. The Car: The Rise and Fall of the Machine That Made the Modern World. New York: Pegasus Books, 2022.

Flexible Entrepreneurial Rancher Uses Beavers “As Furry Weapons of Climate Resilience” to Create Water Storage

(p. A1) As global warming intensifies droughts, floods and wildfires, Mr. Smith has become one of a growing number of ranchers, scientists and other “beaver believers” who see the creatures not only as helpers, but as furry weapons of climate resilience.

Last year, when Nevada suffered one of the worst droughts on record, beaver pools kept his cattle with enough water. When rains came strangely hard and fast, the vast network of dams slowed a torrent of water raging down the mountain, protecting his hay crop. And with the beavers’ help, creeks have widened into wetlands that run through the sagebrush desert, cleaning water, birthing new meadows and creating a buffer against wildfires.

. . .

(p. A15) . . . Mr. Smith decided to try a different approach to cattle management, moving them around his land and letting them spend less time around the creeks. That allowed shrubs and trees to grow in along the banks, making the whole area more stable. Eventually, if the beaver dams did give way, they would do so at the center, and the surge of water would stay in the channel.

. . .

Part of what has made the partnership successful is Mr. Smith’s flexibility. For example, beavers have completely rerouted one section of creek. But Mr. Smith doesn’t see the change as good or bad, “just different.” The most important thing, he said, is how much water they’re storing on the land.

Now more than ever, he said, “water is liquid gold.”

For the full story, see:

Catrin Einhorn and Niki Chan Wylie. “A Nevada Rancher Made a Truce With Beavers, and It Paid Off.” The New York Times (Tuesday, September 6, 2022): A1 & A15.

(Note: ellipses, and bracketed year, added.)

(Note: the online version was updated Sept. 14, 2022, and has the title “It Was War. Then, a Rancher’s Truce With Some Pesky Beavers Paid Off.”)