Category: Entrepreneurship

ALS Drug Entrepreneurs Developed Idea in Dorm Room and Self-Funded the Early Development

(p. B3) An experimental drug slowed the paralyzing march of amyotrophic lateral sclerosis, or Lou Gehrig’s disease, in a clinical trial, according to researchers who say the results are a fresh sign that recent insights into the condition may soon bring new medicines.

. . .

The idea for the drug came to Amylyx Chief Executive Josh Cohen, he said, while he was a Brown University junior in 2012 and 2013 majoring in biomedical engineering and reading scientific papers on how neurons die.

Mr. Cohen told Mr. Klee, whom he had first met playing club tennis in college. Mr. Klee, a neuroscience major, spent the following night reading up on his friend’s idea.

“We did what most people in our generation do” when trying to learn about a topic, Mr. Klee said. “We went to the Internet. We Googled it.”

The research shed light on some molecular routes that neurodegeneration follows, which Mr. Cohen said sparked his interest in combining drugs that attacked two important pathways. The problem was, each drug alone hadn’t worked in studies.

Unfamiliar with both drug research and the industry, Messrs. Cohen and Klee sounded out experts, including Dr. Cudkowicz, to learn how to test their hypothesis in a laboratory, start a company and conduct testing in patients.

Their project took off after the pair scraped together $6,000 from personal savings and family donations to pay contract researchers in Finland, who found their combination drug worked in a petri dish.

Mr. Cohen took all his courses during his final year of college on Thursdays so he could devote the rest of the week to Amylyx.

Mr. Klee, who had moved to Cambridge, Mass., after graduating, took odd jobs coaching swimming, working as a research technician and participating in medical-research studies to earn money for the fledgling startup then based in his apartment.

The company, based in Cambridge, had three employees last March and seven today, but plans to add 100 employees next year.

For the full story, see:

Jonathan D. Rockoff. “ALS Drug Shows Promise in Study.” The Wall Street Journal (Tuesday, December 17, 2019): B3.

(Note: ellipsis added.)

(Note: the online version of the story has the same date as the print version, and has the title “ALS Drug Works in Study, Researchers Say.” The sentences quoted after the ellipsis above, appear in the online, but not in the print, version of the article.)

Entrepreneurs Dream of Transportation Breakthroughs

(p. A13) “Hop, Skip, Go” seems to be the result of an extended reporting trip, during which the authors chat with would-be game-changers from Los Angeles to Helsinki to Dubai to Guangzhou, offering futuristic punditry along the way.

. . .

The authors have tracked down entrepreneurs who are following their dreams of shaking up passenger transportation. In Shanghai, we meet Joseph Xie, whose Shanghai Quality Sensor Technology Corp. specializes in tiny semiconductors that sense light, sound and motion and have a wide application for autonomous vehicles, among other uses. In the Detroit area, R.J. Scaringe’s company, Rivian, aims to build electric cars and recently captured a $500 million investment from Ford. In Helsinki, an engineering student named Sonja Heikkilä wrote a thesis proposing a mobility app that would allow subscribers access to every sort of conveyance, from dockless scooters to rental cars. Mark Moore, a former NASA researcher now with an Uber venture called Uber Air, envisions small aircraft allowing users to fly over traffic jams within a decade.

For the full review, see:

Marc Levinson. “BOOKSHELF; Going Mobile.” The Wall Street Journal (Tuesday, December 3, 2019): A13.

(Note: ellipsis added.)

(Note: the online version of the review has the date Dec. 2, 2019, and has the title “BOOKSHELF; ‘Hop, Skip, Go’ Review: Going Mobile.”)

The book under review, is:

Rossant, John, and Stephen Baker. Hop, Skip, Go: How the Mobility Revolution Is Transforming Our Lives. New York: Harper Business, 2019.

Venture Capitalist Don Valentine Was Rare Early Backer of Apple

(p. A9) In the mid 1960s, Don Valentine had a hunch that startups using silicon semiconductors, then a new technology, would thrive. After failing to persuade his employer, Fairchild Semiconductor Corp., that it should invest in some of its more promising customers, Mr. Valentine decided to invest on his own.

His hobby became Sequoia Capital, which over the following five decades has built an unrivaled record of venture capital investing, betting early on Atari and Apple Inc. in the 1970s, Cisco Systems Inc. and Oracle Corp. in the 1980s, Yahoo! and Google in the 1990s, Airbnb Inc. and LinkedIn Corp. in the 2000s, and Stripe Inc., Square Inc. and WhatsApp this decade.

Mr. Valentine handed the reins to a new generation of investors in 1996, but the firm still operates in his image—as a team of hard-nosed investors willing to butt heads inside company boardrooms and who relentlessly question each other and those seeking their capital.

. . .

Atari founder Nolan Bushnell says Mr. Valentine was by far his best board member. “We fought like cats and dogs,” recalled Mr. Bushnell. “Steel sharpens steel. Every board meeting, he would ask me a question about my company that I didn’t know but I immediately knew that I should know it.”

Mr. Bushnell introduced Mr. Valentine to a young Atari employee named Steve Jobs, who had an idea for a personal computer but whom other investors wouldn’t back, in part because of his messy appearance.

Mr. Valentine said in the 2009 interview that one of Sequoia’s secrets was its Socratic method, in which partners constantly questioned one another. He recalled in the same interview that Mr. Jobs stood out as one of the “best interrogators” he ever saw. “Somehow or other, he knew what to focus on and how to build a sequence and series of questions that were additive to the answers.”

For the full obituary, see:

Rolfe Winkler. “Venture Capitalist Gave Entrepreneurs Tough Love.” The Wall Street Journal (Saturday, November 2, 2019): A9.

(Note: ellipsis added.)

(Note: the online version of the obituary has the date Oct. 27, 2019, and has the title “Venture Capital Pioneer Kept Entrepreneurs’ Egos in Check.”)

Amazon Enables Flourishing of Small Diverse Entrepreneurs

(p. A24) They are a religious community known for clinging to 18th-century fashions and mores — strict rules that keep men and women apart and constraints on attire, with men favoring black suits and formal hats and women in long sleeves and long skirts.

But when it comes to doing business, Hasidic Jews have become enamored with a distinctly 21st-century company: Amazon.

The ability to sell merchandise easily and relatively anonymously on Amazon has transformed the economies of Hasidic enclaves in Brooklyn, suburban New York and central New Jersey, communities where members prefer to keep to themselves and typically do not go to college, let alone graduate from business programs.

But Amazon allows Hasidim to start selling without much experience and without making the investments required by a brick-and-mortar store. It permits Hasidic sellers to deal with the public invisibly — almost entirely by mail, by email or through package-delivery firms.

“Amazon doesn’t ask for your résumé,” said Sam Friedman, a marketer who designs trade show exhibits and works with many Amazon sellers. “And your picture is not on your business. The investment is minimal. You can work out of your bedroom.”

. . .

If Amazon is fulfilling orders, the business may effectively be running on Sabbath and Jewish holidays, though how that is carried out is the subject of vigorous debate. With a Talmudic twist of logic, some Hasidic entrepreneurs take on a non-Jew as a presumptive partner, attributing profits made on the Sabbath to that person.

. . .

Mr. Friedman is . . . organizing a business, advertising and marketing expo in Brooklyn in December [2019] to help Hasidic merchants expand their online sales by contracting with experienced copy writers, web designers, videographers and other professionals whose occupations the Talmudic Sages never even dreamed of.

“We’re not college students,” Mr. Friedman said, “but the yeshiva makes us smart enough to figure things out.”

For the full story, see:

Joseph Berger. “Insular Hasidic Communities Embrace Selling on Amazon.” The New York Times (Thursday, October 17, 2019): A24.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story has the date Oct. 16, 2019, and has the title “How Amazon Has Transformed the Hasidic Economy.” The online version says that the article was on p. A26 of the New York edition. The article was on p. A24 of my National edition.)

Founding Entrepreneur Still Runs FedEx

Clayton Christensen plausibly argues that in the rare cases where an incumbent firm has been able to disrupt itself, it is almost always a firm where the founding entrepreneur is still running the firm.

(p. A1) MEMPHIS, Tenn.— Fred Smith bristles at any hint that FedEx Corp., the global delivery giant he built over four decades, could be disrupted by a player such as Amazon.com Inc.

. . .

FedEx’s 75-year-old chairman and chief executive, the man who pioneered the business of moving packages around the world at lightning speed, is confronting some of the greatest threats to the company he founded.

Global trade is slowing and tariff (p. A9) fights have companies rethinking supply chains. A key partner, the U.S. Postal Service, is struggling. Amazon has morphed from a customer into a competitor.

. . .

Mr. Smith, a former Marine officer and decorated Vietnam War veteran, started FedEx in 1971 and has been CEO for nearly its whole history. The billionaire was preparing to hand over the reins, but he extended his stay after two top executives, including his heir apparent, abruptly left.

That has left Mr. Smith, who remains one of FedEx’s biggest shareholders, to revamp the business. He started with divorcing Amazon.

For years, Amazon has been building up its logistics operations to handle more deliveries itself. The online retailing giant added tractor-trailers, hundreds of sorting centers and dozens of cargo planes to carry millions of its packages. It now delivers nearly half its orders, compared with less than 15% in 2017, according to estimates from research firm Rakuten Intelligence.

In February [2019], Amazon noted in its annual report that it views companies in “transportation and logistics services” among its rivals.

“They had never done that before that day,” Mr. Smith said. “So we took it seriously.”

For the full story, see:

Paul Ziobro. “FedEx Chief Reinvents Firm He Founded.” The Wall Street Journal (Friday, October 18, 2019): A1 & A9.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story has the date Oct. 17, 2019, and has the title “Fred Smith Created FedEx. Now He Has to Reinvent It.”)

Muyembe Had Knowledge of an Ebola Cure Before Clinical Trial

(p. A1) In a medical breakthrough that compares to the use of penicillin for war wounds, two new drugs are saving lives from the virus and helping uncover tools against other deadly infectious diseases. They were proven effective in a gold-standard clinical trial conducted by an international coalition of doctors and researchers in the middle of armed violence.

. . .

(p. A10) Dr. Muyembe set out on his path to an Ebola treatment during the 1995 outbreak. He transferred blood from five survivors to eight patients, hoping that the antibodies that kept some people alive would keep others from dying. Seven of the patients who received the blood transfusion recovered.

He published the results in a scientific journal in 1999. Other researchers said the study was small and had failed to include a control group, a comparison set of patients who weren’t given the treatment, to fully test its efficacy.

For the full story, see:

Betsy McKay. “From a War Zone Came an Unexpected Cure for Ebola.” The Wall Street Journal (Thursday, October 31, 2019): A1 & A10.

(Note: ellipsis added.)

(Note: the online version of the story has the date Oct. 30, 2019, and has the title “‘Ebola Is Now a Disease We Can Treat.’ How a Cure Emerged From a War Zone.”)

“Proud” Entrepreneurs’ “Joy Was Palpable”

(p. A13) People of all backgrounds are starting to see how they can participate in our wonderful free-market system. They’re innovating, creating jobs and lifting themselves and others up.

I was fortunate to come to that same realization as a young man. Although I had always aspired to be financially successful, my role models in Nebraska City, Neb., of the 1940s and ’50s were mainly doctors, dentists and attorneys in town. There was nothing to point me toward founding a discount brokerage firm, as I ultimately did with Ameritrade. Luckily, on my father’s advice, I took a job as a credit reporter for Dun & Bradstreet.

It wasn’t a high-paying or respected job, but it meant I spent my days driving from business to business in Nebraska and Iowa, interviewing entrepreneurs about their balance sheets. Those business owners shared proud stories of how they built their companies. Their joy was palpable. Had I not received that education in the field, I might never have become an entrepreneur.

For the full commentary, see:

Joe Ricketts. “In Praise of Today’s Entrepreneurs.” The Wall Street Journal (Tuesday, November 5, 2019): A13.

(Note: the online version of the commentary has the date Nov. 10, 2019, and has the title “Big Business Is Overcharging You $5,000 a Year.”)

Ricketts’s commentary is related to his book:

Ricketts, Joe. The Harder You Work, the Luckier You Get: An Entrepreneur’s Memoir. New York, NY: Simon & Schuster, 2019.

YouTube Archives Can Reduce the Pain from Missing What Has Been Creatively Destroyed

(p. 10) When Robb Alvey, an amusement park fanatic, heard that Universal Studios Orlando was shuttering its beloved “Jaws”-themed ride in 2012, he made sure to grab a front-row seat for the closing day.

Using a hand-held digital camera, he filmed the six-minute boat ride: from the skipper Jacob welcoming passengers; to the “mayday” distress call; to the first sighting of the prosthetic shark; to the grenade launchers and exploding fireballs; and, finally, to the “high-voltage” cable that fries the animatronic beast.

Mr. Alvey, 49, who lives in Orlando, Fla., and runs a website called Theme Park Review, uploaded the footage to YouTube. Seven years later, the video has been viewed more than 160 million times.

. . .

That longing for expired rides is certain to increase in coming years, as America’s theme parks are renovated: In August, Disney announced that Epcot will undergo yet another major overhaul, while Universal Orlando recently revealed plans for a massive new park called Epic Universe.

And when parks make big changes, the charmingly antiquated rides are often first to go. In 2014, Walt Disney World shuttered its Studio Backlot Tour, a behind-the-scenes look at movie production, to make room for “Star Wars”: Galaxy’s Edge, a blockbuster attraction that opened this year.

“The backlot tour was over two hours long, and took up a big part of your day, but it showed you every aspect of filmmaking,” said Alicia Stella, 37, a journalist who covers theme parks on her website Orlando ParkStop. “I miss those kinds of attractions. A lot of the new ones are fast-paced thrill rides.”

Such expansions are a reminder that the parks are in a constant state of evolution, which makes the archivists’ efforts all the more crucial: You never know when your favorite ride could close for good.

For the full story, see:

Brian Raftery. “The Ride Has Ended, but It Still Goes On.” The New York Times, SundayStyles Section (Sunday, November 3, 2019): 10.

(Note: ellipsis added.)

(Note: the online version of the story has the date Nov. 2, 2019, and has the title “Where ‘Jaws,’ the Ride, Lives Forever.”)

Entrepreneur Hopes to Turn Jellyfish from Turtle Food into Tourist Attraction

(p. A7) In a rare marine lake on a hatchet-shaped atoll in Indonesia, four species of jellyfish have evolved in isolation and lost their ability to sting humans. There are believed to be millions of these benign jellyfish in Kakaban Lake, which has become a popular spot for tourists intrepid enough to reach the remote archipelago known as the Derawan Islands.

. . .

While the jellyfish continue to thrive on Kakaban, the island has just two human inhabitants, . . .

. . .

About 4,000 people, mostly Muslim, live on nearby Maratua, the largest of the Derawan islands.

. . .

Maratua has at least two marine lakes. One, Haji Buang, once had jellyfish to rival Kakaban Lake. But about five years ago, its owner, Hartono, thought he could make some quick cash by raising more than 30 hawksbill sea turtles in the lake.

Only after he put the turtles in the water did he discover that it would be illegal to sell their shells because the species is critically endangered.

The hawksbills, which feed on jellyfish, have nearly exterminated the lake’s population.

“Now I regret it,” said Mr. Hartono, 62. “There used to be more jellyfish than in Kakaban Lake, but we didn’t realize this could be a tourist area.”

Mr. Hartono said he was contemplating how to catch the turtles so he could return them to the sea — with the hope that the jellyfish population would recover.

For the full story, see:

Richard C. Paddock. “INDONESIA DISPATCH; A Harmless Jellyfish Fears Humanity’s Sting.” The New York Times (Monday, November 4, 2019): A7.

(Note: ellipses added.)

(Note: the online version of the story has the same date as the print version, and has the title “INDONESIA DISPATCH; A Lake With Stingless Jellyfish and Hints of Hotter Seas.”)

Does Musk Want to Reach Mars or Conspicuously Consume Real Estate?

In my book Openness to Creative Destruction, I describe and praise those who I call “project entrepreneurs.” These are innovative entrepreneurs, like Walt Disney and Cyrus Field, who are motivated primarily by a desire to bring their project into the world, rather than a desire for conspicuous personal consumption. I have been unsure whether to count Elon Musk as a project entrepreneur. The evidence quoted below suggests the answer is “no.”

(p. M1) Over the last seven years, Mr. Musk and limited-liability companies tied to him have amassed a cluster of six houses on two streets in the “lower” and “mid” areas of the Bel-Air neighborhood of Los Angeles, a celebrity-filled, leafy enclave near the Hotel Bel-Air.

Those buys—plus a grand, 100-year-old estate in Northern California near the headquarters of Tesla, the electric car concern he heads—means Mr. Musk or LLCs with ties to him have spent around $100 million on seven properties.

For the full story, see:

Nancy Keates. “Elon Musk’s Big Buyout.” The Wall Street Journal (Friday, December 6, 2019): M1 & M6.

(Note: the online version of the story has the date Dec. 5, 2019, and has the title “Elon Musk Buys Out the Neighbors.”)

My book, mentioned at the top, is:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.