Many Long-Lived Ashkenazi Jews Did NOT Follow Usual Advice on Exercise, Diet, Sleep, and Social Connectivity

(p. B10) Louise Levy, who along with hundreds of others 95 and older was part of a study to understand how their genetic makeup led to their good physical and cognitive health during extremely long lives, died on July 17 [2023] in Greenwich, Conn. She was 112.

. . .

Mrs. Levy was one of more than 700 people, all 95 or older, recruited since 1998 to participate in a study by the Institute for Aging Research at the Albert Einstein School of Medicine in the Bronx to learn the genetic reasons for their unusually long, healthy lives.

“It’s not luck,” Dr. Nir Barzilai, an endocrinologist who directs the institute, said by phone. “They exceeded luck. The biggest answer is genetics.”

Using the blood and plasma of the test group, all Ashkenazi Jews — a comparatively homogeneous population whose genetic variations are easier to spot — the institute’s Longevity Genes Project has discovered gene mutations that are believed to be responsible for slowing the impact of aging on people like Mrs. Levy and protecting them against high cholesterol, heart disease, diabetes and Alzheimer’s disease.

“The most striking thing about them is they had a contraction of morbidity,” Dr. Barzilai said. “They are sick, as a group, for very little time at the end of their lives.”

He added, “Did they do what we know we should do — exercise, diet and sleep and have social connectivity? The answer is mostly no. Sixty percent were smoking. Less than 50 percent did much household activity or biking. Fifty percent were overweight or obese. Less than three percent were vegetarians. So they weren’t special in that sense.”

The goal of the research is the development of drugs that would imitate what the centenarians’ genes do to protect their health.

For the full obituary, see:

Richard Sandomir. “Louise Levy, 112, Longtime Subject in a Genetic Study of Human Longevity.” The New York Times (Saturday, July 29, 2023): B10.

(Note: ellipsis, and bracketed year, added.)

(Note: the online version of the obituary was updated July 31, 2023, and has the title “Louise Levy, Who Was Studied for Her Very Long Life, Is Dead at 112.”)

Independent Bookstores Shun Wuhan Book by Independent Robert F. Kennedy Jr.

I am generally not as skeptical of the safety and efficacy of vaccines as is Robert F. Kennedy Jr. But I strongly believe in the right to free speech. And I believe that truth in general, and truth in science in particular, advance fastest when we defend free speech and open discussion.

(p. B3) Independent presidential candidate Robert F. Kennedy Jr. is a member of the most famous political family in the U.S. and a bestselling author. But it may be hard to find his newest book at the local bookstore when it comes out next week [on Dec. 5, 2023].

Some booksellers have decided not to stock Kennedy’s latest, “The Wuhan Cover-Up and the Terrifying Bioweapons Arms Race,” citing concerns about the author’s past positions.

. . .

Kennedy expressed disappointment that independent bookstores may not be stocking his new book. “Independent bookstores are the traditional bulwarks against corporate propaganda and government censorship,” he said.

Kennedy, the nephew of the late president John F. Kennedy and son of the late attorney general and senator Robert F. Kennedy, has become a vocal critic of U.S. government agencies, in particular their response to the coronavirus pandemic.

. . .

In an interview, Kennedy, 69 years old, said he thinks “The Wuhan Cover-Up” will appeal to anybody interested in learning more about the origins of Covid-19 as well as foreign-policy issues.

. . .

The Federal Bureau of Investigation and Energy Department have said that a “laboratory-related incident” was most likely responsible for the pandemic, while other agencies believe natural infection was the cause.

For the full story, see:

Jeffrey A. Trachtenberg and Eliza Collins. “Small Bookstores Shun RFK Jr.’s Coming Book.” The Wall Street Journal (Wednesday, Nov. 29, 2023): B3.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the story has the date November 28, 2023, and has the title “Small Bookstores Shun Robert F. Kennedy Jr.’s Upcoming Book.”)

The book shunned by many independent bookstores is:

Kennedy, Robert F. , Jr. The Wuhan Cover-Up: And the Terrifying Bioweapons Arms Race. New York: Skyhorse Publishing, Inc., 2023.

Cancer “Vaccines Are Probably the Next Big Thing”

(p. A5) “Vaccines are probably the next big thing” in the quest to reduce cancer deaths, said Dr. Steve Lipkin, a medical geneticist at New York’s Weill Cornell Medicine, who is leading one effort funded by the National Cancer Institute. “We’re dedicating our lives to that.”

For the full story, see:

ARLA K. JOHNSON, Associated Press. “Vaccine Against Cancer Could Be Closer Than Ever.” Omaha World-Herald (Sunday, July 9, 2023): A11.

(Note: bracketed date added.)

(Note: the online version of the story was updated Nov 2, 2023, and has the title “The next big advance in cancer treatment could be a vaccine.”)

Biden’s Centrally Planned Cancer “Moonshot” Funds Surgery as Key to a Cure

(p. A5) WASHINGTON — President Joe Biden’s administration on Thursday [July 27, 2023] announced the first cancer-focused initiative under its advanced health research agency, aiming to help doctors more easily distinguish between cancerous cells and healthy tissue during surgery and improve outcomes for patients.

The administration’s Advanced Research Projects Agency for Health, or ARPA-H, is launching a Precision Surgical Interventions program, seeking ideas from the public and private sectors to explore how to dramatically improve cancer outcomes in the coming decades by developing better surgical interventions to treat the disease.

. . .

The initiative could markedly improve cancer treatments and make scientific breakthroughs that have as yet unknown applications, said Arati Prabhakar, director of the White House Office of Science and Technology.

“What’s true is that many cancer treatments still start with surgery,” she told The Associated Press in an interview. “So being really smart and attacking and developing new technology to make that first step better could really revolutionize how we are able to treat cancer for so many Americans.”

For the full story, see:

ZEKE MILLER Associated Press. “Cancer Research Initiative Part of Biden ‘Moonshot’.” Omaha World-Herald (Friday, July 28, 2023): A5.

(Note: ellipsis, and bracketed date, added.)

(Note: the online version of the story was updated Nov. 2, 2023, and has the title “Biden announces an advanced cancer research initiative as part of his ‘moonshot’ effort.”)

“Cochrane Reviews Are Often Referred to as Gold Standard Evidence in Medicine”

The credibility of Cochrane reviews matters. One of their most important reviews, that I cite in my in-progress work on clinical trials, suggests that results of randomized double-blind clinical trials, usually agree with results of observational studies on the same topic. This matters a lot, because observational studies can give us more and quicker actionable results, saving lives.

(p. A23) Cochrane reviews are often referred to as gold standard evidence in medicine because they aggregate results from many randomized trials to reach an overall conclusion — a great method for evaluating drugs, for example, which often are subjected to rigorous but small trials. Combining their results can lead to more confident conclusions.

. . .

. . . what we learn from the Cochrane review is that, especially before the pandemic, distributing masks didn’t lead people to wear them, which is why their effect on transmission couldn’t be confidently evaluated.

For the full commentary, see:

Zeynep Tufekci. “In Fact, the Science Is Clear That Masks Work.” The New York Times (Saturday, March 11, 2023): A23.

(Note: ellipses added.)

(Note: the online version of the commentary has the date March 10, 2023, and has the title “Here’s Why the Science Is Clear That Masks Work.”)

To Force Use of Organic Farming, Government Banned Chemical Fertilizers; A Ban Which “Devastated” Crops and “Destroyed the Farmers”

(p. A6) GALENBINDUNUWEWA, Sri Lanka—For more than half a century, Pahatha Mellange Jayaappu has tilled the field on his modest farm in Sri Lanka’s agricultural heartland, unswayed by recurrent political and economic turmoil.

Now the 71-year-old is just trying to eke out enough of a harvest to feed his family after an abrupt ban on chemical fertilizers last year devastated his crops. He says he has given up on planting for profit.

“We have lived through armed insurrections and bad government policies,” Mr. Jayaappu said. “This is the worst year I’ve ever seen. They have destroyed the farmers.”

Many Sri Lankans aren’t getting enough to eat, and farmers and agricultural experts say the food shortages are set to worsen. The government reversed the ban in November and promised fresh supplies of chemical fertilizers, but farmers said many received only a small amount, and too late for the current growing season.

. . .

The ban on imports of agricultural chemicals took effect in May 2021, and the rice harvest the following March was down 40%, according to government data. Prices soared. Sri Lanka, which had been largely self-sufficient in rice, was forced to use some of its fast-dwindling foreign reserves to import the key staple. Other crops, like tea, an important foreign-exchange earner, have also suffered. In May, the country defaulted on its external debt.

. . .

Mr. Wickremesinghe was installed by Parliament last month after his predecessor, Gotabaya Rajapaksa, fled the country and resigned in the face of mass protests over fuel shortages and food prices.  . . .

Mr. Rajapaksa billed the ban as a nationwide shift to organic farming, but agricultural experts say that requires a yearslong transition. Opposition lawmakers said cutting off imports of fertilizer, which the government heavily subsidizes for farmers, was a shortsighted attempt to hold on to foreign reserves.

. . .

Farmers complained that the organic fertilizers that came on the market after the ban took effect were poor quality, full of material that wasn’t fully decomposed. And the haste of the ban left insufficient time to make their own compost, or learn how to farm organically.

For the full story, see:

Shan Li and Philip Wen. “Sri Lanka’s Farmers Struggle to Survive.” The Wall Street Journal (Saturday, August 20, 2022): A6.

(Note: ellipses added.)

(Note: the online version of the story was updated Aug. 19, 2022, and has the title “Sri Lanka’s Farmers Struggle to Feed the Country—and Themselves.”)

Experienced Nurses Can Be Disciplined If They Use Hunches from Clinical Observations to Override AI Protocols

(p. A1) Melissa Beebe, an oncology nurse, relies on her observation skills to make life-or-death decisions. A sleepy patient with dilated pupils could have had a hemorrhagic stroke. An elderly patient with foul-smelling breath could have an abdominal obstruction.

So when an alert said her patient in the oncology unit of UC Davis Medical Center had sepsis, she was sure it was wrong. “I’ve been working with cancer patients for 15 years so I know a septic patient when I see one,” she said. “I knew this patient wasn’t septic.”

The alert correlates elevated white blood cell count with septic infection. It wouldn’t take into account that this particular patient had leukemia, which can cause similar blood counts. The algorithm, which was based on artificial intelligence, triggers the alert when it detects patterns that match previous patients with sepsis. The algorithm didn’t explain (p. A9) its decision.

Hospital rules require nurses to follow protocols when a patient is flagged for sepsis. While Beebe can override the AI model if she gets doctor approval, she said she faces disciplinary action if she’s wrong. So she followed orders and drew blood from the patient, even though that could expose him to infection and run up his bill. “When an algorithm says, ‘Your patient looks septic,’ I can’t know why. I just have to do it,” said Beebe, who is a representative of the California Nurses Association union at the hospital.

As she suspected, the algorithm was wrong. “I’m not demonizing technology,” she said. “But I feel moral distress when I know the right thing to do and I can’t do it.”

. . .

In a survey of 1,042 registered nurses published this month by National Nurses United, a union, 24% of respondents said they had been prompted by a clinical algorithm to make choices they believed “were not in the best interest of patients based on their clinical judgment and scope of practice” about issues such as patient care and staffing.” Of those, 17% said they were permitted to override the decision, while 31% weren’t allowed and 34% said they needed doctor or supervisor’s permission.

. . .

Jeff Breslin, a registered nurse at Sparrow Hospital in Lansing, Mich., has been working at the Level 1 trauma center since 1995. He helps train new nurses and students on what signs to look for to assess and treat a critically ill or severely injured patient quickly.

“You get to a point in the profession where you can walk into a patient’s room, look at them and know this patient is in trouble,” he said. While their vital signs might be normal, “there are thousands of things we need to take into account,” he said. “Does he exhibit signs of confusion, difficulty breathing, a feeling of impending doom, or that something isn’t right?”

. . .

Nurses often describe their ability to sense a patient’s deterioration in emotional terms. “Nurses call it a ‘hunch,’ ” said Cato, the University of Pennsylvania professor who is also a data scientist and former nurse. “It’s something that causes them to increase surveillance of the patient.”

. . .

At UC Davis earlier this spring, Beebe, the oncology nurse, was treating a patient suffering from a bone cancer called myeloid leukemia. The condition fills the bones with cancer cells, “they’re almost swelling with cancer,” she said, causing excruciating pain. Seeing the patient wince, Beebe called his doctor to lobby for a stronger, longer-lasting pain killer. He agreed and prescribed one, which was scheduled to begin five hours later.

To bridge the gap, Beebe wanted to give the patient oxycodone. “I tell them, ‘Anytime you’re in pain, don’t keep quiet. I want to know.’ There’s a trust that builds,” she said.

When she started in oncology, nurses could give patients pain medication at their discretion, based on patient symptoms, within a doctor’s parameters. They gave up authority when the hospital changed its policies and adopted a tool that automated medication administration with bar-code scanners a few years ago.

In its statement, UC Davis said the medication tool exists as a second-check to help prevent human error. “Any nurse who doesn’t believe they are acting in the patient’s best interests…has an ethical and professional obligation to escalate those concerns immediately,” the hospital said.

Before giving the oxycodone, Beebe scanned the bar code. The system denied permission, adhering to the doctor’s earlier instructions to begin the longer-acting pain meds five hours later. “The computer doesn’t know the patient is in out-of-control pain,” she said.

Still, she didn’t act. “I know if I give the medication, I’m technically giving medication without an order and I can be disciplined,” she said. She watched her patient grimace in pain while she held the pain pill in her hand.

For the full story, see:

Lisa Bannon. “Nurses Clash With AI Over Patient Care.” The Wall Street Journal (Friday, June 16, 2023): A1 & A9.

(Note: ellipses added.)

(Note: the online version of the story has the date June 15, 2023, and has the title “When AI Overrules the Nurses Caring for You.”)

Lister Used Data, Results, and Amiability to Convince Physicians to Sterilize Hands, Scalpels, and Wounds

(p. C6) What was the most dangerous place in the vast territories of the British Empire in the 19th century? Was it the savage savannas of Zululand? Perhaps the frozen wastes of the Northwest Passage, or the treacherous high passes of the Hindu Kush?

To judge from “The Butchering Art,” a fine and long overdue biography of the great physician Joseph Lister by Lindsey Fitzharris, the answer might be a much more domestic corner of empire: the Victorian teaching hospital.

. . .

Infection rates plummeted when Lister used carbolic acid to wash hands and scalpels, to dress wounds, and to sterilize sutures. He even sprayed it into the air of the operating room. But other physicians were skeptical and bitterly resisted the notion that their sloppy and unhygienic practices were the cause of so many deaths.

. . .

Lister won over his opponents, not with bile and rhetoric but with a relentless focus on data and results, coupled with his innate amiability. He paid particular attention to audiences of medical students, perhaps anticipating Max Planck’s observation that bitter disciples of old dogmas are never won over by new theories, they simply die off and are replaced by a new generation.

The modesty and compassion of Lister would have been remarkable in any man, let alone a surgeon. His patients and students adored him. Lister taught his residents that “every patient, even the most degraded, should be treated with the same care and regard as though he were the Prince of Wales himself.” After he drained a young girl’s knee abscess, the girl showed him her doll, which was missing a leg. As Ms. Fitzharris writes, “The girl fumbled around under her pillow and—much to Lister’s amusement—produced the severed limb.” Lister called for needle and thread and “stitched the limb back onto the doll and with quiet delight handed it back to the little girl.”

For the full review, see:

John J. Ross. “BOOKSHELF; The Butchering Art.” The Wall Street Journal (Saturday, Oct. 14, 2017): C6.

(Note: ellipses added.)

(Note: the online version of the review has the date Oct. 13, 2017, and has the title “BOOKSHELF; Review: ‘The Butchering Art’ Resurrects Joseph Lister.”)

The book under review is:

Fitzharris, Lindsey. The Butchering Art: Joseph Lister’s Quest to Transform the Grisly World of Victorian Medicine. New York: Farrar, Straus and Giroux, 2017.

The reviewer repeats the plausible but debunked view of Planck that old scientists do not change their views. The debunking occurs in:

Diamond, Arthur M., Jr. “Age and the Acceptance of Cliometrics.” Journal of Economic History 40, no. 4 (Dec. 1980): 838-41.

Hull, David L. , Peter D. Tessner, and Arthur M. Diamond, Jr. “Planck’s Principle: Do Younger Scientists Accept New Scientific Ideas with Greater Alacrity Than Older Scientists?” Science 202 (Nov. 17, 1978): 717-23.

Stimulant Ephedrine Was Known and Used in Bronze Age

Ephedrine currently has a variety of medical uses, including as a decongestant.

(p. A4) Bronze Age humans have been credited with a number of civilizational advancements: the invention of irrigation, the wheel, writing systems and the ability to forge weapons and tools from the durable metal that lends the era its name.

Now, strands of human hair discovered in an ancient burial cave in Spain suggest another novelty: a proclivity for consuming psychoactive drugs.

. . .

The findings, published Thursday [April 6, 2023] in Scientific Reports of the journal Nature, provide the first direct evidence that ancient Europeans consumed psychoactive drugs much like their pre-Columbian brethren in Mesoamerica, the researchers said.

Elisa Guerra-Doce, the lead author of the study, said researchers were stunned by the results, especially because the cave interiors yielded no detectable signs of the drugs’ presence. A chemical analysis of the hair revealed evidence of three alkaloid substances known to produce altered states of consciousness: ephedrine, atropine and scopolamine.

The compounds themselves are produced by flora native to Minorca. Atropine and scopolamine, powerful hallucinogens, can be found in plants in the nightshade family, among them mandrake, henbane and thorn apple. Ephedrine, a stimulant, can be extracted from joint pine.

“These findings are so singular,” said Ms. Guerra-Doce, an expert in the anthropology of intoxication at the University of Valladolid in Spain. “Sometimes when people think about drugs, they think it’s a modern practice. These results tell a different story.”

. . .

The three compounds have a long history of human use. Ephedrine is a stimulant that provides bursts of energy and mental clarity, and it can stave off sleepiness. Atropine and scopolamine are powerful deliriants that can produce hallucinations and out-of-body experiences.

For the full story, see:

Andrew Jacobs. “Scientists See Bronze Age In New Light: It Was Trippy.” The New York Times (Friday, April 7, 2023): A4.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the story has the date April 6, 2023, and has the title “Tripping in the Bronze Age.”)

The academic paper mentioned in the passage quoted above is:

Guerra-Doce, E., C. Rihuete-Herrada, R. Micó, R. Risch, V. Lull, and H. M. Niemeyer. “Direct Evidence of the Use of Multiple Drugs in Bronze Age Menorca (Western Mediterranean) from Human Hair Analysis.” Scientific Reports 13, no. 1 (April 6, 2023): article #4782.

“Flowers Never Bend, With the Rainfall”

Sometimes when I am in a dark mood I wonder how you keep moving forward when you do not know how much time is left. Some seek an answer in religion. I am more open to a kind of stoicism combined with the other gift of Prometheus: blind hope.

(p. 3) A few months into treatment, I realized that Josh might not make it to the next spring, when we would normally visit my extended family in Greece. I told Dr. Sara that I would like to take my husband to Greece, because he might not get the chance again.

. . .

My diary reminds me that while we were there, I asked Josh what he would do differently in life. “Not get cancer,” he said.

. . .

As for me, I kept hearing the lyrics to a Simon and Garfunkel song in my head: “So, I’ll continue to continue to pretend, my life will never end, and flowers never bend, with the rainfall.” It was my soundtrack.

For the full commentary, see:

Anemona Hartocollis. “My Husband’s Doctor, Onscreen.” The New York Times, SundayStyles Section (Sunday, November 20, 2022): 1-3.

(Note: the online version of the commentary was updated June 20, 2023 [sic], and has the title “Cancer, My Husband’s Doctor, and Catherine Deneuve.”)

Some High Performers Find Ways to Avoid Accumulating Microstresses

(p. C5) Have you had days that exhaust you extraordinarily without any particular reason why?

. . .

There’s a common but little-understood reason for that exhaustion. We call it “microstress”—brief, frequent moments of everyday tension that accumulate and impede us even though we don’t register them.

. . .

One study published in the journal Biological Psychology in 2015 found that exposure to social stress within two hours of a meal leads your body to metabolize the food in a way that adds 104 calories on average. “If this happens daily, that’s 11 pounds gained per year,” noted Lisa Feldman Barrett, a psychology professor at Northeastern University and author of “Seven and a Half Lessons About the Brain.”

. . .

In our research, we observed that some of the high performers—a small subset that we came to call the “Ten Percenters”—were much better at coping with microstress than the rest of those we studied, and perhaps than the rest of us, too. What do they do differently?

. . .

. . ., they’re better at removing themselves from interactions that generate microstress in their lives, whether or not they realize the dynamic. Ten Percenters are more likely to shape these interactions by dealing with simmering disagreements head-on or by limiting such contacts.

. . .

Our Ten Percenters were also thoughtful about not creating the kinds of conditions that cause microstress for others. Think about what happens—to both of you—when you push your child too hard on their grades and it comes back in the form of a rebellious attitude. Or the stress you may create as a manager by unnecessarily shifting expectations. Stopping this cycle helps to prevent microstress from boomeranging back on us.

For the full essay, see:

Rob Cross and Karen Dillon. “Combating the ‘Microstress’ That Causes Burnout.” The Wall Street Journal (Saturday, April 22, 2023): C5.

(Note: ellipses added.)

(Note: the online version of the essay has the date April 21, 2023, and has the same title as the print version.)

The essay quoted above is adapted from Cross and Dillon’s book:

Cross, Rob, and Karen Dillon. The Microstress Effect: How Little Things Pile Up and Create Big Problems—and What to Do About It. Boston, MA: Harvard Business Review Press, 2023.