RSV and Other Common Viruses Now Surge as Unintended Consequence of Covid-19 Masks, Distancing, and Lockdowns

(p. A6) Doctors in France are calling it the immunity debt: When people avoided each other during the pandemic, they failed to build up the immunity against viruses that comes from normal contact.

As regular life resumes, society may find payments on that debt coming due, in the form of worse-than-normal viral disease outbreaks.

. . .

Figures recently released in Japan show the profound effect exposure to viruses such as flu and RSV can have on a nation’s health.

Deaths caused by pneumonia—a common complication of viral infections—last year in Japan fell by more than 17,000, far outweighing the 3,466 deaths attributed to Covid-19. As a result, Japan’s overall mortality fell for the first time in more than a decade.

It may have been borrowing from the future by creating greater room for viruses to run rampant later. Robert Cohen, a professor at a pediatric research center near Paris called Activ, calls this “immunity debt.”

Dr. Cohen said the hygiene measures adopted during the pandemic bring “an immediate and indisputable benefit” because common illnesses have been suppressed. But at some point almost all children are going to get RS virus, chickenpox and viruses that cause colds, which could mean larger outbreaks when the bugs make up for lost time, he said.

For the full story see:

Miho Inada. “Common Viruses Make a Comeback.” The Wall Street Journal (Tuesday, June 29, 2021): A6.

(Note: ellipsis added.)

(Note: the online version of the story has the date June 28, 2021, and has the title “Post-Covid-19, World Risks an ‘Immunity Debt’.”)

Center-Left Biothreat Expert Says Many Scientists Rejected Wuhan Lab Origin, Not Due to Evidence, but Due to Trump

(p. A13) A few months before Covid-19 became a pandemic, Filippa Lentzos started reading about unusual flu cases in Wuhan, China. Ms. Lentzos, a social scientist who studies biological threats, belongs to an email group she describes as consisting of “ex-intelligence, bioweapons specialists, experts, former State Department diplomats” and others “who have worked in arms control, biological disarmament.”

As Chinese authorities struggled to contain the outbreak, she recalls, the expert circle asked questions about the pathogen’s origin: “Is this security related? Is it military? Is there something dodgy going on? What information are we not getting here?”

. . .

. . . in February 2020, a group of scientists had published a statement in the Lancet calling out “conspiracy theories suggesting that COVID-19 does not have a natural origin.” The New York Times and Washington Post dutifully attacked Mr. Cotton as unhinged. Media, with an assist from some virologists, dismissed the lab-leak theory as “debunked.”

Ms. Lentzos, who places her own politics on the Swiss “center left,” thought that conclusion premature and said so publicly. In May 2020, she published an article in the Bulletin of the Atomic Scientists weighing whether “safety lapses in the course of basic scientific research” caused the pandemic. While acknowledging there was, “as of yet, little concrete evidence,” she noted “several indications that collectively suggest this is a serious possibility that needs following up by the international community.”

. . .

The article barely made a ripple. “If you look at the argumentation that’s used today, it’s exactly the same basically as what I laid out, which was, accidents happen,” she says. “We know that they’re having questions around safety. We know they were doing this field work. We see videos where they’re in breach of standard biosafety protocol. We know China is manipulating the narrative, closing down information sources—all of that stuff. All of that is in there. But it didn’t get much traction.”

. . .

American liberals—including many scientists—conflated open-mindedness about the question with support for Mr. Trump. Ms. Lentzos was one of the few who could separate their distaste for him from their analysis of the pandemic.

. . .

The most significant problem came from the scientific community. “Some of the scientists in this area very quickly closed ranks,” she says, and partisanship wasn’t their only motive: “Like most things in life, there are power plays. There are agendas that are part of the scientific community. Just like any other community, there are strong vested interests. There were people that did not talk about this, because they feared for their careers. They feared for their grants.”

Ms. Lentzos counsels against idealizing scientists and in favor of “seeing science and scientific activity, and how the community works, not as this inner sacred sanctum that’s devoid of any conflicts of interests, or agendas, or any of that stuff, but seeing it as also a social activity, where there are good players and bad players.”

Take Peter Daszak, the zoologist who organized the Lancet letter condemning lab-leak “conspiracy theories.” He had directed millions of dollars to the Wuhan Institute of Virology through his nonprofit, EcoHealth Alliance. A lab mistake that killed millions would be bad for his reputation. Other researchers have taken part in gain-of-function research, which can make viruses deadlier or easier to transmit. Who would permit, much less fund, such research if it proved so catastrophic? Yet researchers like Marion Koopmans, who oversees an institution that has conducted gain-of-function research, had an outsize voice in media. Both she and Mr. Daszak served on the World Health Organization’s origin investigation team.

. . .

Ms. Lentzos has experience working with United Nations agencies, including the World Health Organization. “It was incredibly exciting to finally go in. And then you become more disillusioned when you see how things operate, how things don’t operate,” she says. “Like any large organization, they are slow, and inflexible, and bureaucratic.”

For the full interview see:

Adam O’Neal, interviewer. “THE WEEKEND INTERVIEW; A Scientist Who Said No to Covid Groupthink.” The Wall Street Journal (Saturday, June 12, 2021): A13.

(Note: ellipses added.)

(Note: the online version of the interview has the date June 11, 2021, and has the same title as the print version.)

Dog Sniffs Identify Covid-19 Faster, Cheaper, and More Accurately than Antigen Tests

(p. A6) A growing body of research by scientists and dog trainers from the U.S. to the United Arab Emirates suggests that dogs can use their powerful sense of smell to sniff out Covid-19 infections, including in people without symptoms.

With more than 300 million scent receptors (compared with roughly five million in humans), dogs can do this with a high degree of accuracy by detecting compounds the human body releases in secretions like sweat and saliva as it reacts to the coronavirus, according to scientists.

Dogs have long been trained to detect odors associated with drugs or explosives and have also been used to identify diseases such as cancer, malaria and diabetes.

. . .

One dog can screen 250 to 300 people a day, according to the WHO.

Prof. Grandjean calculated that dog screenings in France could cost as little as one euro, equivalent to about $1.20, per person, as opposed to roughly €75 for a polymerase chain reaction, or PCR, test, a highly accurate test that involves a nasal swab.

. . .

Studies have shown that dogs can be trained to identify Covid-19 infections with roughly 82% to 99% sensitivity and 84% to 98% specificity, Prof. Grandjean said. A test’s sensitivity indicates its ability to correctly detect an infection, while its specificity shows how well it can avoid giving false positives.

Researchers at the University of Veterinary Medicine in Hannover, Germany, trained eight dogs for one week to detect respiratory secretions from infected patients with an average detection rate of 94%, according to a study published recently in the journal BMC Infectious Diseases

In a study of 21 dogs led by Prof. Grandjean, 15 of the animals were able to detect Covid-19 with a sensitivity of 90% or more, with six dogs showing a sensitivity of 71% to 87%. The study was published in April in the Open Access Journal of Veterinary Science and Research.

Such results mean dogs may be more precise than many rapid antigen tests, which correctly identify Covid-19 infections in an average of 72% of people showing symptoms and 58% of asymptomatic people, according to a recent review from Cochrane, a U.K.-based nonprofit that evaluates scientific research.

For the full story see:

Ruth Bender and Rachel Bachman. “Dogs Deployed to Sniff Out Covid.” The Wall Street Journal (Thursday, May 20, 2021): A6.

(Note: ellipses added.)

(Note: the online version of the story has the date May 19, 2021, and has the title “Your Next Covid-19 Test Could Be a Dog’s Sniff.”)

The articles mentioned in the passages above are:

Jendrny, Paula, Claudia Schulz, Friederike Twele, Sebastian Meller, Maren von Köckritz-Blickwede, Albertus Dominicus Marcellinus Erasmus Osterhaus, Janek Ebbers, Veronika Pilchová, Isabell Pink, Tobias Welte, Michael Peter Manns, Anahita Fathi, Christiane Ernst, Marylyn Martina Addo, Esther Schalke, and Holger Andreas Volk. “Scent Dog Identification of Samples from Covid-19 Patients – a Pilot Study.” BMC Infectious Diseases 20, no. 1 (2020). DOI:10.1186/s12879-020-05281-3

Grandjean, Dominique, Dana Humaid Al Marzooqi, Clothilde Lecoq-Julien, Quentin Muzzin, Hamad Katir Al Hammadi, Guillaume Alvergnat, Kalthoom Mohammad Al Blooshi, Salah Khalifa Al Mazrouei, Mohammed Saeed Alhmoudi, Faisal Musleh Al Ahbabi, Yasser Saifallah Mohammed, Nasser Mohammed Alfalasi, Noor Majed Almheiri, Sumaya Mohamed Al Blooshi, and Loïc Desquilbet. “Use of Canine Olfactory Detection for Covid-19 Testing Study on U.A.E. Trained Detection Dog Sensitivity ” Open Access Journal of Veterinary Science & Research (OAJVSR) 6, no. 2 (May 2021). DOI: 10.23880/oajvsr-16000210.

Dinnes, J., J. J. Deeks, S. Berhane, M. Taylor, A. Adriano, C. Davenport, S. Dittrich, D. Emperador, Y. Takwoingi, J. Cunningham, and et al. “Rapid, Point‐of‐Care Antigen and Molecular‐Based Tests for Diagnosis of Sars‐Cov‐2 Infection.” Cochrane Database of Systematic Reviews, no. 3 (2021). DOI: 10.1002/14651858.CD013705.pub2

Slow FDA Feeds Skepticism of mRNA Covid-19 Vaccines

(p. A19) In December 2020, the F.D.A. approved the distribution of mRNA coronavirus vaccines made by Pfizer and Moderna under the agency’s emergency use authorization provision, which permits an accelerated approval process for medications and treatments during a public health emergency.

. . .

In theory, full approval should be imminent, since Pfizer applied for full approval in early May, and Moderna asked for full approval on June 1. This process is often long, requiring the agency to inspect manufacturing plants and review considerable amounts of documentation for vaccine production. But in this case, because of the urgency of the pandemic, the vaccine makers began to submit this material, called a biologics licensing application, in late 2020, and they’ve continued to submit more information. The F.D.A. has already reviewed some of the submissions and has provided feedback to the manufacturers. The emergency authorizations were granted more than six months ago. That’s more than ample time for the agency to conduct plant inspections and review the applications.

. . .

Fortunately, two doses of the mRNA vaccines appear to provide nearly full protection from Covid-related hospitalization and death, and the shots substantially reduce infections.

The lives and health of millions of Americans rest on the F.D.A.’s decision to fully license these vaccines.

For the full commentary see:

Eric J. Topol. “Vaccines Need Full Approval.” The New York Times (Monday, July 5, 2021): A19.

(Note: ellipses added.)

(Note: the online version of the commentary has the date June 1, 2021, and has the title “It’s Time for the F.D.A. to Fully Approve the mRNA Vaccines.”)

Evolution Did Not Design an Optimal Human Body

(p. A15) In Alex Bezzerides’s entertaining “Evolution Gone Wrong: The Curious Reasons Why Our Bodies Work (or Don’t),” the author’s quest is to determine the origins of the “aches and pains of the masses and why they happen”—not the mechanical causes of our maladies but the evolutionary ones.

. . .

. . ., according to Mr. Bezzerides, . . . four million years ago our ancestors transitioned from a fruit- and leaves-based diet to one of grasses and sedges. Their molars ballooned out to gargantuan proportions, which was not at first problematic, since their substantive jaws readily accommodated the newly enlarged teeth. But as humans controlled fire, learned to cook, became cooperative, and developed hunting techniques and an accompanying armamentarium of cutting implements, the requirement for robust dentition diminished. We were nevertheless stuck with the legacy of “a mouth full of large teeth.”

. . .

One requires no better evidence of our design’s lack of metaphysical oversight than the absurd configuration of our esophagus and trachea—so near each other as to invite trouble. A benign creator would surely have designed a respiratory system in a way that did not leave us in perpetual fear of choking. But once again this apparently bizarre arrangement results both from our evolutionary origins—the lungs began as an offshoot of the digestive system—and from the requirement for a descended larynx. This “clunky anatomical fault” may give us a fright every time a “hot dog takes a wrong turn at the intersection,” as Mr. Bezzerides writes, but it also facilitated the origin of human speech.

. . .

. . . , he has provided us with a timely reminder that we, as a species, may be outgrowing our evolutionary history and the biology we are constructed from. The emerging technology of genome writing may offer an opportunity to take human design back to first principles.

For the full review, see:

Adrian Woolfson. “BOOKSHELF; Our Fallible Bodies.” The Wall Street Journal (Tuesday, June 1, 2021): A15.

(Note: ellipses added.)

(Note: the online version of the review has the date May 31, 2021, and has the title “BOOKSHELF; ‘Evolution Gone Wrong’ Review: Our Fallible Bodies.”)

The book under review is:

Bezzerides, Alex. Evolution Gone Wrong: The Curious Reasons Why Our Bodies Work (or Don’t). Toronto, Canada: Hanover Square Press, 2021.

Men Are More Likely to Risk Their Lives for Others

(p. A15) “T” does what all superb popular science must do: It entertains as it educates.

. . .

Ultimately, “T” is a vigorous defense of the scientific method itself. Ms. Hooven summarizes: “Multiple independent sources of evidence can combine to strongly support a hypothesis, whether it’s about the cause of a rattle in your car, why your soufflé has collapsed, or why someone blocked you on Twitter. It’s just like that in science.”

. . .

. . . she’s emphatic that high T levels do not lead inexorably to rape and murder; mountains of data disprove this fallacy. She also gives testosterone its due: Men are far more likely “to put their lives on the line for others, and are massively overrepresented in the most dangerous occupations.” She lauds the men who protected her while she conducted fieldwork in the jungles; heroism, for her, thrives at the molecular level.

For the full review, see:

Hamilton Cain. “The Hormone of the Hour.” The Wall Street Journal (Tuesday, July 13, 2021): A15.

(Note: ellipses added.)

(Note: the online version of the review has the date July 12, 2021, and has the title “‘T’ Review: Hormone of the Hour.”)

The book under review is:

Hooven, Carole. T: The Story of Testosterone, the Hormone That Dominates and Divides Us. New York: Henry Holt and Co., 2021.

Auerbach Talked to Hikers, Skiers, and Divers to Advance Wilderness Medicine: “He Never Stopped”

(p. B10) Dr. Paul Auerbach, an emergency care physician who pioneered the field of wilderness medicine in the 1980s and then taught ways to heal people injured by the unpredictable, died on June 23 [2021] at his home in Los Altos, Calif.

. . .

Out in the wild, knowing how to treat a venomous snake bite or a gangrenous infection can mean the difference between life and death. In the 1970s, however, the specialized field of health care known as wilderness medicine was still in its infancy. Then Dr. Auerbach showed up.

A medical student at Duke University at the time, he went to work in 1975 with the Indian Health Service on a Native American reservation in Montana, and the experience was revelatory.

“We saw all kinds of cases that I would have never seen at Duke or frankly anywhere else except on the reservation,” Dr. Auerbach said in a recent interview given to Stanford University, where he worked for many years. “Snakebites. Drowning. Lightning strike.”

. . .

“I kept going back to literature to read, but there was no literature,” he said. “If I wanted to read about snake bites, I was all over the place. If I wanted to read about heat illness, I was all over the place. So I thought, ‘Huh, maybe I’ll do a book on wilderness medicine.’”

Dr. Auerbach started researching material for the book in 1978, when he began his medical residency at U.C.L.A., finding the time to do so despite grueling 12-hour hospital shifts. He collected information about how to treat burn wounds, hypothermia, frostbite and lightning injuries. He interviewed hikers, skiers and divers. And he assigned chapters to doctors who were passionate about the outdoors.

The resulting book, “Management of Wilderness and Environmental Emergencies,” which he edited with a colleague, Edward Geehr, was published in 1983 and is widely considered the definitive textbook in the field, with sections like “Protection From Blood-Feeding Arthropods” and “Aerospace Medicine: The Vertical Frontier.” Updated by Dr. Auerbach over 30 years, it is in its seventh edition and now titled “Auerbach’s Wilderness Medicine.”

. . .

Last year, shortly before he received his cancer diagnosis, the coronavirus pandemic began to take hold, and Dr. Auerbach decided to act.

“The minute it all first happened, he started working on disaster response,” his wife said. “Hospitals were running out of PPE. He was calling this person and that person to learn as much as he could. He wanted to find out how to design better masks and better ventilators. He never stopped.”

For the full obituary, see:

Alex Vadukul. “Dr. Paul Auerbach, 70, Who Pioneered Treatment of Wilderness Emergencies.” The New York Times, First Section (Tuesday, July 20, 2021): B10.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary has the date July 19, 2021, and has the title “Dr. Paul Auerbach, Father of Wilderness Medicine, Dies at 70.”)

The latest edition of Auerbach’s book is:

Auerbach, Paul S., Tracy A. Cushing, and N. Stuart Harris, eds. Auerbach’s Wilderness Medicine. 7th ed. 2 vols. Philadelphia, PA: Elsevier, 2017.

Global Freedom Has Declined for 15 Straight Years

(p. A4) Freedom House, a nonpartisan organization dedicated to promoting freedom and democracy, reports that freedom across the globe has declined for 15 straight years, a trend that accelerated last year. “The long democratic recession is deepening,” Freedom House says.

. . .

Democracy is messy, but in an authoritarian system the problem is the lack of messiness. Cults of personality develop, opposing voices with potentially good ideas are squelched, healthy debates and innovative thoughts are blocked. In a new piece in Foreign Affairs magazine, China expert Jude Blanchette notes this risk for Mr. Xi in China: “Paeans to the greatness of ‘Xi Jinping Thought’ may strike outsiders as merely curious or even comical, but they have a genuinely deleterious effect on the quality of decision-making and information flows within the (Communist) party.”

At least China has done a good job of managing its economy. Elsewhere, authoritarian systems have produced a plundering of national resources, corruption and a general mismanagement of the economy.

For the full commentary, see:

Gerald F. Seib. “Autocrats Show Staying Power, for Now.” The Wall Street Journal (Tuesday, July 13, 2021): A4.

(Note: ellipsis added.)

(Note: the online version of the commentary has the date July 12, 2021, and has the title “Cuba’s Unrest Frames World’s Big Struggle: Dictators vs. Democracies.”)

Choppin at Hughes Medical Institute Hired Good Scientists and Let Them Pursue Hunches and Serendipitous Insights

(p. A27) Purnell Choppin, whose research on how viruses multiply helped lay the foundation for today’s fight against the Covid-19 pandemic, died on July 3 [2021] at his home in Washington, one day shy of his 92nd birthday.

. . .

Dr. Choppin (pronounced show-PAN) focused on measles and influenza, but his research, and the methods he developed to conduct it, proved critical for later work on other viruses, including severe acute respiratory syndrome coronavirus 2, the virus behind the Covid-19 pandemic, said David Baltimore, an emeritus professor of biology at the California Institute of Technology and a winner of the 1975 Nobel Prize in Physiology or Medicine.

“The issue of how viruses infect cells was very much on his mind, and the mechanisms he worked out studying influenza were central to thinking about coronaviruses,” Dr. Baltimore said. “Thanks to his work and that of so many others, when the pandemic hit, we were able to formulate questions about the virus in quite precise terms.”

Dr. Choppin was equally well known as an administrator, first at Rockefeller and then at the Howard Hughes Medical Institute, which hired him in 1985 as its chief medical officer. He later ran the institute for 12 years, turning it from a modest-size research organization into a global research powerhouse.

. . .

With a calm, easygoing demeanor that disguised a fierce, visionary ambition, Dr. Choppin took an innovative approach to funding. Unlike other institutions, which provide grants for specific projects, he focused on identifying top researchers and then showering them with money and resources. Even better, he did not ask them to move to the institute, in Chevy Chase, Md. — they could stay where they were and let the Hughes largesse come to them.

. . .

While Dr. Choppin was sometimes criticized for making safe bets on established scientists who probably didn’t need his help, he made no apologies, and had the track record to prove the soundness of his approach: Dozens of Hughes researchers had gone on to become members of the National Academy of Sciences, and six won the Nobel Prize.

“We bet on people who look like they are going to be winners,” he told The Washington Post in 1988. “You look for originality. How they pick a problem and stick to it. Their instinct for the scientific jugular.”

For the full obituary, see:

Clay Risen. “Purnell Choppin, 91, Researcher Who Focused on Viruses.” The New York Times, First Section (Sunday, July 25, 2021): 27.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary has the date July 23, 2021, and has the title “Purnell Choppin, 91, Dies; Researcher Laid Groundwork for Pandemic Fight.”)

Omaha’s “Boutique” Quarantine Unit Looked Backward to Ebola, Not Forward to Covid-19

(p. C1) Quarantine can be lifesaving; it can also be dangerous, an exercise of extraordinary power in the name of disease control, a presumption of guilt instead of innocence.

In “Until Proven Safe,” a new book about quarantine’s past and future, Geoff Manaugh and Nicola Twilley do an impressively judicious job of explaining exactly why fears of quarantine are understandable and historically justified, . . .

. . .

(p. C6) What becomes clear in “Until Proven Safe” is that it’s a lot easier to tell someone else to just shut up and submit to quarantine than to do it yourself. Any exercise of such formidable power also opens up the possibility of abuse. The book includes historical examples of disease control measures getting mapped onto existing prejudices. In 1900, a cordon sanitaire in San Francisco’s Chinatown zigzagged around white-owned businesses; . . .

. . .

Quarantine infrastructures tend to be tailored to the previous epidemic, instead of anticipating whatever is to come. A shiny new federal quarantine facility in Omaha — the first constructed in the United States in more than a century — was finished in January 2020, just in time to receive 15 American passengers from the coronavirus-infested Diamond Princess cruise ship. This National Quarantine Unit has a grand total of 20 beds. It offers a “boutique experience” ideally suited to managing one or two patients at a time after they have had potential exposure to, say, Ebola. The facility can’t do much to help contain a raging pandemic. As Manaugh and Twilley point out, the first American evacuation flight out of Wuhan alone carried 195 passengers.

For the full review, see:

Jennifer Szalai. “BOOKS OF THE TIMES; You Can’t Leave Unless We Say So.” The New York Times (Tuesday, July 27, 2021): C1 & C6.

(Note: ellipses added.)

(Note: the online version of the review has the date July 26, 2021, and has the title “BOOKS OF THE TIMES; The Extraordinary History (and Likely Busy Future) of Quarantine.”)

The book under review is:

Twilley, Nicola, and Geoff Manaugh. Until Proven Safe: The History and Future of Quarantine. New York: Farrar, Strauss and Giroux, 2021.

Lack of Full FDA Vaccine Approval Discourages Use

(p. A12) Even as President Biden, the C.D.C. and virtually the entire scientific community are urging — pleading with, even — Americans to get vaccinated, the government has not formally approved any vaccine. The Food and Drug Administration has instead given only “emergency use authorization” to the shots from Moderna, Pfizer and Johnson & Johnson. That’s a temporary form of approval that allows people to receive shots while the agency continues to study their effectiveness and safety.

The difference between emergency authorization and full approval matters.

. . .

The situation also feeds uncertainty and skepticism among some Americans who have not yet gotten a shot. Those skeptics, as Matthew Yglesias of Substack wrote yesterday, are effectively taking the F.D.A. at its word. The F.D.A. leaders’ official position is that “they don’t have enough safety data yet,” Yglesias noted.

. . .

. . ., public health officials made highly technical statements about masks that many people interpreted as discouragement from wearing them. These statements ignored the many reasons to believe that masks could make a difference (like their longtime popularity in Asia to prevent the spread of viruses) and focused instead on the absence of studies showing that masks specifically prevented the spread of Covid.

Later, officials insisted that they were merely “following the data.” In truth, though, they were basing their advice on a narrow reading of the data — . . . .

. . .

Think of it this way: In the highly unlikely event that the evidence were to change radically — if, say, the vaccines began causing serious side effects about 18 months after people had received a shot — Americans would not react by feeling confident in the F.D.A. and grateful for its caution. They would be outraged that Woodcock and other top officials had urged people to get vaccinated.

The combination means that the F.D.A.’s lack of formal approval has few benefits and large costs: The agency has neither protected its reputation for extreme caution nor maximized the number of Americans who have been protected from Covid. “In my mind, it’s the No. 1 issue in American public health,” Topol told me. “If we got F.D.A. approval, we could get another 20 million vaccinated,” he estimated.

For the full commentary, see:

David Leonhardt. “Why, After Months of Shots, Are None Approved?.” The New York Times (Thursday, July 22, 2021): A12.

(Note: ellipses added.)

(Note: the online version of the commentary has the date July 21, 2021, and has the title “Why Aren’t the Vaccines Approved?”)