Category: Science

“Unprecedented” and “Huge” Serendipitous Discovery of 60 Million Icefish Nests

(p. D3) As soon as the remotely operated camera glimpsed the bottom of the Weddell Sea, more than a thousand feet below the icy ceiling at the surface, Lilian Boehringer, a student researcher at the Alfred Wegener Institute in Germany, saw the icefish nests. The sandy craters dimpled the seafloor, each the size of a hula hoop and less than a foot apart. Each crater held a single, stolid icefish, dark pectoral fins outspread like bat wings over a clutch of eggs.

Aptly named icefishes thrive in waters just above freezing with enormous hearts and blood that runs clear as vodka. . . .

The sighting occurred in February 2021 in the camera room aboard a research ship, the Polarstern, which had come to the Weddell Sea to study other things, not icefish. It was 3 a.m. near Antarctica, meaning the sun was out but most of the ship was asleep. To Ms. Boehringer’s surprise, the camera kept transmitting pictures as it moved with the ship, revealing an uninterrupted horizon of icefish nests every 20 seconds.

. . .

The nests persisted for the entire four-hour dive, with a total of 16,160 recorded on camera. After two more dives by the camera, the scientists estimated the colony of Neopagetopsis ionah icefish stretched across 92 square miles of the serene Antarctic sea, totaling 60 million active nests. The researchers described the site — the largest fish breeding colony ever discovered — in a paper published Thursday in the journal Current Biology.

“Holy cow,” said C.-H. Christina Cheng, an evolutionary biologist at the University of Illinois-Urbana-Champaign, who was not involved with the research. “This is really unprecedented,” she said. “It is crazy dense. It is a major discovery.”

. . .

“The seafloor is not just barren and boring,” Dr. Purser said. “Such huge discoveries are still there to be made, even today in the 21st century.”

For the full story, see:

Sabrina Imbler. “Deep in Frigid Waters, Icefish Colonies Thrive.” The New York Times (Tuesday, January 18, 2022): D3.

(Note: ellipses added.)

(Note: the online version of the story has the date January 13, 2022, and has the title “‘Major Discovery’ Beneath Antarctic Seas: A Giant Icefish Breeding Colony.”)

Testing for Rare DNA Microdeletion Birth Defects Can Result in More False Positives Than True Positives

(p. 12) Between 2011 and 2013, a small California-based biotech company, Sequenom, tripled in size. The key to its success: MaterniT21, a new prenatal screening test that did remarkably well at detecting Down syndrome.

Older screening tests took months and required multiple blood tests. This new one generated fewer false positives with a single blood draw.

The test could also determine the sex of a fetus. It quickly became a hit. “You had people walking in saying, ‘I want this sex test,’” recalled Dr. Anjali Kaimal, a maternal-fetal medicine specialist at Massachusetts General Hospital.

Competitors began launching their own tests. Today, analyst estimates of the market’s size range from $600 million into the billions, and the number of women taking these tests is expected to double by 2025.

As companies began looking for ways to differentiate their products, many decided to start screening for more and rarer disorders. All the screenings could run on the same blood draw, and doctors already order many tests during short prenatal care visits, meaning some probably thought little of tacking on a few more.

For the testing company, however, adding microdeletions can double what an insurer pays — from an average of $695 for the basic tests to $1,349 for the expanded panel, according to the health data company Concert Genetics. (Patients whose insurance didn’t fully cover the tests describe being billed wildly different figures, ranging from a few hundred to thousands of dollars.)

But these conditions were so rare that there were few instances for the tests to find.

Take Natera, which ran 400,000 tests in 2020 for DiGeorge syndrome, a disorder associated with heart defects and intellectual disability.

That number of tests would be expected to identify about 200 cases of the disorder according to a Times analysis of the company’s studies. It would also generate at least an equal number of false positive results.

That is a best-case scenario based on Natera’s recent claim to have improved its algorithm. In clinical trials, its test (p. 13) generated three times as many false positives as true ones. The company’s four other microdeletion screenings, which it said were run at least 24,000 times in 2020, would be expected to find about eight true postitves and bewen 17 and 134 fase ones, according to the analysis.

For the full story, see:

Sarah Kliff and Aatish Bhatia. “Prenatal Tests for Rare Defects Often Produce False Positives.” The New York Times, First Section (Sunday, January 2, 2022): 1 & 12-13.

(Note: the online version of the story has the date Jan. 1, 2022, and has the title “When They Warn of Rare Disorders, These Prenatal Tests Are Usually Wrong.” The last three paragraphs above appear in the online version, but not in this form in the print version. In the print version, the information in the last three paragraphs quoted above, appears mostly as part of an extended graphic.)

Bret Baier Documents How Fauci and Collins Dishonestly Dismissed the Hypothesis That COVID-19 Originated in Wuhan Lab

Bret Baier gave a serious report on the substantial and growing evidence that Anthony Fauci, Francis Collins, and other “experts” and officials lied, early and intentionally, in their dismissal of the likely Wuhan lab origin of Covid-19. (The report aired on Bret Baer’s “Special Report” nightly news program on Tues., January 25, 2022 on Fox News.)

“Unexpected” Discovery of Large “Pristine” Coral Reef “Unscathed by Climate Change”

(p. A7) An underwater mapping project recently took an unexpected twist off the coast of Tahiti, where deep sea explorers said this week that they had discovered a sprawling coral reef resembling a bed of roses that appeared to be largely unscathed by climate change.

Extending for about three kilometers (1.86 miles), the reef is remarkably well preserved and is among the largest ever found at its depth, according to those involved in the mapping project sponsored by UNESCO, the U.N. Educational, Scientific and Cultural Organization.

Some even described the condition of the reef, hidden at depths between 30 meters (about 100 feet) and 100 meters in the crystalline waters of the South Pacific, as “pristine.”

Alexis Rosenfeld, an underwater photographer from Marseille, France, said on Thursday that the reef lived up to what he had envisioned when he first explored it shortly after its discovery in November [2021].

. . .

John Jackson, a film director with 1 Ocean who is involved with the project, compared the reef’s shape to lacework. In an interview on Thursday [January 20, 2022], he said that significant work remained when it came to underwater exploration, pointing out that only about 20 percent of the world’s seabeds had been mapped.

For the full story, see:

Neil Vigdor. “‘Pristine’ Coral Reef Resembling Bed of Roses Is Found Off the Coast of Tahiti.” The New York Times (Saturday, January 22, 2022): A7.

(Note: ellipsis, and bracketed year and date, added.)

(Note: the online version of the story has the date Jan. 20, 2022, and has the title “Sprawling Coral Reef Resembling Roses Is Discovered Off Tahiti.”)

Mars Can Be Terraformed to Reduce Costs of Colonization

(p. D5) Since joining NASA in 1980, Jim Green has seen it all. He has helped the space agency understand Earth’s magnetic field, explore the outer solar system and search for life on Mars. As the new year arrived on Saturday, he bade farewell to the agency.

Over the past four decades, which includes 12 years as the director of NASA’s planetary science division and the last three years as its chief scientist, he has shaped much of NASA’s scientific inquiry, overseeing missions across the solar system and contributing to more than 100 scientific papers across a range of topics. While specializing in Earth’s magnetic field and plasma waves early in his career, he went on to diversify his research portfolio.

. . .

Ahead of a December [2021] meeting of the American Geophysical Union in New Orleans, Dr. Green spoke about some of this wide-ranging work and the search for life in the solar system. Below are edited and condensed excerpts from our interview.

. . .

    You’ve previously suggested it might be possible to terraform Mars by placing a giant magnetic shield between the planet and the sun, which would stop the sun from stripping its atmosphere, allowing the planet to trap more heat and warm its climate to make it habitable. Is that really doable?

Yeah, it’s doable. Stop the stripping, and the pressure is going to increase. Mars is going to start terraforming itself. That’s what we want: the planet to participate in this any way it can. When the pressure goes up, the temperature goes up.

The first level of terraforming is at 60 millibars, a factor of 10 from where we are now. That’s called the Armstrong limit, where your blood doesn’t boil if you walked out on the surface. If you didn’t need a spacesuit, you could have much more flexibility and mobility. The higher temperature and pressure enable you to begin the process of growing plants in the soils.

There are several scenarios on how to do the magnetic shield. I’m trying to get a paper out I’ve been working on for about two years. It’s not going to be well received. The planetary community does not like the idea of terraforming anything. But you know. I think we can change Venus, too, with a physical shield that reflects light. We create a shield, and the whole temperature starts going down.

For the full story, see:

Jonathan O’Callaghan, interviewer. “Inhabiting Mars? He Calls It ‘Doable.’” The New York Times (Tuesday, January 4, 2022): D5.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story has the date Jan. 2, 2021, and has the title “NASA’s Retiring Top Scientist Says We Can Terraform Mars and Maybe Venus, Too.” The first three paragraphs, and the block-indented sentence and question, are by the interviewer Jonathan O’Callaghan. The answer after the question is by Jim Green.)

Musk Wants to Use His Billions “to Get Humanity to Mars”

(p. B1) In the negotiations over President Biden’s infrastructure bill, Senator Ron Wyden, Democrat of Oregon and chairman of the Finance Committee, proposed the idea of a tax on billionaires specifically. Thursday morning, Mr. Biden announced his framework for paying for the bill, which promised additional taxes on the income of “the wealthiest 0.02 percent of Americans.”

Mr. Wyden’s proposed tax will likely never make it into law.

. . .

(p. B5) Elon Musk, in a tweet, seemed to come out against the proposal. “Eventually, they run out of other people’s money and then they come for you,” he wrote. It is fairly safe to say that Mr. Musk will never run out of money. A back-of-the-envelope calculation from Forbes’s real-time net worth tracker suggests that he could spend $1 million a year for 100,000 years and still have more money than Bill Gates, with an estimated $136.2 billion.

. . .

Abigail Disney, granddaughter of Roy Disney and a longtime critic of income inequality, said in an interview that she believes the immense displays of wealth by the country’s richest during the pandemic — particularly the ostentatiousness of last summer’s space race — helped foster a serious discussion about the tax burdens on billionaires.

. . .

In comments denouncing the proposed billionaire tax, Mr. Manchin described the ultrawealthy as people who “create a lot of jobs and invest a lot of money and give a lot to philanthropic pursuits.”

That was an implicit endorsement of the idea, often repeated in discussions around high-net worth giving, that regular people pay taxes while rich people pursue philanthropy, giving not to the Treasury but to their preferred causes. “My plan is to use the money to get humanity to Mars and preserve the light of consciousness,” Mr. Musk said in a subsequent tweet in response to the tax proposal.

“That idea that ‘it’s my money and I should decide what to do with it’ is very dominant, and it goes along with the culture of individualism that allows people to feel that they’ve done this on their own and haven’t benefited from social goods like roads and education and laws,” Professor Sherman said.

Ms. Disney, who is an active member of the Patriotic Millionaires, said she sees that thinking as a primary obstacle to raising taxes on the richest Americans. “Billionaires may be brilliant — and I don’t doubt Elon Musk’s I.Q. — but they don’t do anything on their own,” she said. She also questioned the prevailing wisdom among the country’s wealthiest that they know best and the government shouldn’t be trusted with their money.

“The last time I was in the Bay Area, I went walking in the marina and saw seven consecutive boats named after characters from Ayn Rand,” Ms. Disney said. “They need to come to their senses.”

For the full story, see:

Nicholas Kulish, Ephrat Livni and Emma Goldberg. “Billionaires Of America Are Thriving.” The New York Times (Friday, October 29, 2021): B1 & B5.

(Note: ellipses added.)

(Note: the online version of the story was updated Nov. 2, 2021, and has the title “Who Are America’s Billionaires, Anyway?”)

Proof Vikings Were in North America 1,000 Years Ago

(p. A8) A new look at wooden artifacts found amid the ruins of an ancient homestead shows that Vikings had crossed the Atlantic Ocean and settled in North America as far back as 1021—exactly 1,000 years ago and almost five centuries before Columbus’s famous voyage.

. . .

To pinpoint the year that Vikings occupied the site, the scientists scoured the ancient settlement for wooden artifacts, hoping to find any made from trees that had grown during an unusually intense burst of cosmic radiation known to have occurred in the year 993.

. . .

Using the carbon spike as a reference point, they counted the tree rings in each specimen until they reached the bark, indicating the year the tree was cut down—in this case 1021.

For the full story, see:

Robert Lee Hotz. “Viking Artifacts Pinpoint Europeans.” The Wall Street Journal (Thursday, October 21, 2021): A8.

(Note: ellipses added.)

(Note: the online version of the story has the date October 20, 2021, and has the title “Viking Artifacts Give Precise Date for Europeans’ Earliest Presence in North America.”)

Virtual Reality (VR) Used to Better See Cancer Cell Mutations

(p. R3) Chemist and entrepreneur Jackie von Salm recently walked inside a receptor in the brain to inspect a new drug compound. As she looked at the brightly colored, cascading ribbons around her, she noted something: Part of the atomic structure, a series of thick, orange rods and hexagons, jutted toward her in an odd way, suggesting that the compound, a derivative of the psychedelic DMT, might be effective at treating addiction without having hallucinogenic effects.

“This is weird,” says Dr. von Salm, the co-founder and chief scientific officer of Psilera Inc., a Tampa, Fla.-based company working to turn psychedelics into treatments for addiction, neurodegenerative diseases and mood disorders. “But it might be really unique and special.”

The odd positioning of the compound might be the right shape to latch onto serotonin receptors in the brain that are involved with hallucination and addiction. That insight was possible thanks to a technology more closely associated with gamers than scientists: Virtual reality.

Dr. von Salm is one of a growing number of drug-discovery researchers who are using VR to see, in new ways, the molecules they have long studied on computer screens. Their goal is to investigate subtle changes in the distance, shape and chemical properties of atomic structures that could give them clues about how well a drug might work and speed up the drug-discovery process.

. . .

Since 2018, cancer researchers at the University of California San Francisco have been using VR to better understand the genetic mutations in cancer cells that might make a patient resistant to treatment. For example, in VR, it was clear that the reason a drug didn’t bind properly to its protein target in the cancer cell was because of the movement of a portion of the protein called the P-loop. The movement was caused by a mutation in the target.

On a computer monitor, it was difficult to see the tiny change in the movement. “When there are changes like that, the VR is critical,” says Beth Apsel Winger, a hematologist and oncologist at the university’s department of pediatrics.

For the full commentary, see:

Sara Castellanos. “VR Rx.” The Wall Street Journal (Friday, Sept. 10, 2021): R3.

(Note: ellipsis added.)

(Note: the online version of the commentary has the date September 7, 2021, and has the title “Virtual Reality Puts Drug Researchers Inside the Molecules They Study.”)

Absence of Covid-19 in 9,000 Chinese Samples from Late 2019 Supports Lab-Leak Theory

(p. A17) Where did Covid-19 come from? The answer can be found in the SARS-CoV-2 virus itself. To get to the truth, we need only unleash the power of science.

Based on experience with SARS-1 in 2003 and MERS in 2012, we know that many people are infected by a host animal long before a coronavirus mutates to the point where it can jump from human to human. An extensive data set from late 2019—more than 9,000 hospital samples—is available of people exhibiting flulike (thus Covid-like) symptoms in China’s Hubei and Shaanxi provinces before the epidemic started. Based on SARS-1 and MERS, the natural zoonotic theory predicts 100 to 400 Covid infections would be found in those samples. The lab-leak hypothesis, of course, predicts zero. If the novel coronavirus were engineered by scientists pursuing gain-of-function research, there would be no instances of community infection until it escaped from the laboratory. The World Health Organization investigation analyzed those stored samples and found zero pre-pandemic infections. This is powerful evidence favoring the lab-leak theory.

Within months of the SARS-1 and MERS outbreaks, scientists found animals that had hosted the viruses before they made the jump to humans. More than 80% of the animals in affected markets were infected with a coronavirus. In an influential March 2020 paper in Nature Medicine, Kristian Andersen and co-authors implied that a host animal for SARS-CoV-2 would soon be found. If the virus had been cooked up in a lab, of course, there would be no host animal to find.

Chinese scientists searched for a host in early 2020, testing more than 80,000 animals from 209 species, including wild, domesticated and market animals. As the WHO investigation reported, not a single animal infected with SARS-CoV-2 was found. This finding strongly favors the lab-leak theory. We can only wonder if the results would have been different if the animals tested had included the humanized mice kept at the Wuhan Institute of Virology.

For the full commentary, see:

Richard Muller and Steven Quay. “Science Closes In on Covid’s Origins.” The Wall Street Journal (Wednesday, Oct. 6, 2021): A17.

(Note: the online version of the commentary has the date October 5, 2021, and has the same title as the print version.)

Carolyn Shoemaker Developed Tacit Knowledge of Presence of Comets and Asteroids

(p. B6) Carolyn Shoemaker, who for more than a decade managed a telescopic camera with her husband from a high-altitude observatory in California and became widely regarded, without academic training, as the world’s foremost detector of comets and asteroids, died on Aug. 13 [2021] at a hospital in Flagstaff, Ariz.

. . .

In the afternoons, Dr. Shoemaker would take the film they had used the previous night and develop it in a darkroom, then turn over the negatives to Ms. Shoemaker. Using a stereoscope, she would compare exposures of the same block of sky at different times. If anything moved against the relatively fixed background of stars, it would appear to float in the viewing device’s eyepiece.

Ms. Shoemaker was charged with discerning what was the grain of the film (and perhaps dust on it) and what was an actual image of light emitted by an object hurtling through space. “With time,” she wrote, “I saw fainter and fainter objects.”

It took a few years before she found her first new comet, in 1983. By 1994 she had discovered, in addition to hundreds of asteroids, 32 comets, a number considered by the United States Geological Survey and others to represent the world record at the time.

. . .

One comet, known as Shoemaker-Levy 9 (named in part for their associate David Levy), had stood out from the rest. Rather than making a lonely journey through the cosmic vacuum, Shoemaker-Levy 9 was on a collision course with Jupiter.

. . .

“Carolyn Shoemaker is one of the most revered and respected astronomers in history,” Jennifer Wiseman, a senior scientist overseeing the Hubble Space Telescope, said by phone. “Her discoveries, her tenacious care in how she did her work — those things have created a legacy and a reputation that has inspired people who have come into the field after her.”

. . .

. . . scientists still depend on methods that Ms. Shoemaker perfected.

“She and her colleagues set the stage for how to identify what we would call minor bodies in our solar system, such as comets and asteroids,” Dr. Wiseman said. “We still use the technique of looking for the relatively fast transverse motions of comets and asteroids in our own solar system, as compared to the slower or more fixed position of stars.”

For the full obituary, see:

Alex Traub. “Carolyn Shoemaker, 92, a Stargazer Who Spotted Comets and Asteroids.” The New York Times (Monday, September 6, 2021): B6.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary was updated Sept. 4, 2021, and has the title “Carolyn Shoemaker, Hunter of Comets and Asteroids, Dies at 92.”)

China Removed Gene Sequences from NIH Data Base Related to Covid-19 Origin

(p. A3) Chinese researchers directed the U.S. National Institutes of Health to delete gene sequences of early Covid-19 cases from a key scientific database, raising concerns that scientists studying the origin of the pandemic may lack access to key pieces of information.

. . .

The removal of the sequencing data is described in a new paper posted online Tuesday by Jesse Bloom, a virologist at the Fred Hutchinson Cancer Research Center in Seattle. The paper, which hasn’t been peer reviewed, says the missing data include sequences from virus samples collected in the Chinese city of Wuhan in January and February of 2020 from patients hospitalized with or suspected of having Covid-19.

. . .

. . . Dr. Bloom said their removal sows doubts about China’s transparency in the continuing investigation into the origin of the pandemic.

Some other scientists agreed.

“It makes us wonder if there are other sequences like these that have been purged,” said Vaughn S. Cooper, a University of Pittsburgh evolutionary biologist who wasn’t involved in the new paper and said he hasn’t studied the deleted sequences himself.

For the full story see:

Amy Dockser Marcus, Betsy McKay and Drew Hinshaw. “Covid-19 Gene Data Removed at NIH.” The Wall Street Journal (Thursday, June 24, 2021): A3.

(Note: ellipses added.)

(Note: the online version of the story was updated June 23, 2021, and has the title “Chinese Covid-19 Gene Data That Could Have Aided Pandemic Research Removed From NIH Database.”)