Author: Art Diamond

Poll Says Two-Thirds of Voters Wear Mask When Outside the House

(p. A4) . . . an overwhelming majority, 80%, feel that the country is spiraling out of control, according to a new Wall Street Journal/NBC News poll.

. . .

Roughly two-thirds of voters said they always wear a mask when they leave the house, compared with 21% who sometimes wear one and 15% who said they rarely or never do.

. . .

The Journal/NBC News poll surveyed 1,000 registered voters from May 28 through June 2. The margin of error was plus or minus 3.1 percentage points.

For the full story, see:

Michael C. Bender. “Nation Deeply Worried, Poll Finds.” The Wall Street Journal (Monday, June 8, 2020): A4.

(Note: ellipses added.)

(Note: the online version of the story has the date June 7, 2020, and has the title “Americans Are More Troubled by Police Actions in Killing of George Floyd Than by Violence at Protests, Poll Finds.” The last two sentences quoted above appear in the online, but not the print, version.)

Vaccine Progress Gives Hope That Pandemic Will Begin to End in September

(p. A1) In a medical research project nearly unrivaled in its ambition and scope, volunteers worldwide are rolling up their sleeves to receive experimental vaccines against the coronavirus — only months after the virus was identified.

Companies like Inovio and Pfizer have begun early tests of candidates in people to determine whether their vaccines are safe. Researchers at the University of Oxford in England are testing vaccines in human subjects, too, and say they could have one ready for emergency use as soon as September.

. . .

(p. A11) The coronavirus itself has turned out to be clumsy prey, a stable pathogen unlikely to mutate significantly and dodge a vaccine.

“It’s an easier target, which is terrific news,” said Michael Farzan, a virologist at Scripps Research in Jupiter, Fla.

An effective vaccine will be crucial to ending the pandemic, which has sickened at least 4.7 million worldwide and killed at least 324,000. Widespread immunity would reopen the door to lives without social distancing and face masks.

For the full story, see:

Carl Zimmer, Knvul Sheikh and Noah Weiland. “Tests Fuel Hope That Vaccine Is Months, Not Years, Away.” The New York Times (Thursday, May 21, 2020): A1 & A11.

(Note: ellipses added.)

(Note: the online version of the story was updated June [sic] 10, 2020 and has the title “A New Entry in the Race for a Coronavirus Vaccine: Hope.” The online versions says that the title of the New York print version is “Labs Step Up Race to Be First, Or Even 4th, to Find a Vaccine.” the title of my National print version was “Tests Fuel Hope That Vaccine Is Months, Not Years, Away.”)

For 12-Year-Old, 10 Hours a Day in Mine “Really Meant Freedom for Me”

(p. A15) For Jack Lawson, “ten hours a day in the dark prison below really meant freedom for me.” At age 12, this Northern England boy began full-time work down the local mine. His life underwent a transformation; there would be “no more drudgery at home.” Jack’s wages lifted him head and shoulders above his younger siblings and separated him in fundamental ways from the world of women. He received better food, clothing and considerably more social standing and respect within the family. He had become a breadwinner.

Rooted in firsthand accounts of life in the Victorian era, Emma Griffin’s “Bread Winner” is a compelling re-evaluation of the Victorian economy. Ms. Griffin, a professor at the University of East Anglia, investigates the personal relationships and family dynamics of around 700 working-class households from the 19th century, charting the challenges people faced and the choices they made. Their lives are revealed as unique personal voyages caught within broader currents.

“I didn’t mind going out to work,” wrote a woman named Bessie Wallis. “It was just that girls were so very inferior to boys. They were the breadwinners and they came first. They could always get work in one of the mines, starting off as a pony boy then working themselves up to rope-runners and trammers for the actual coal-hewers. Girls were nobodies. They could only go into domestic service.”

Putting the domestic back into the economy, Ms. Griffin addresses a longstanding imbalance in our understanding of Victorian life. By investigating how money and resources moved around the working-class family, she makes huge strides toward answering the disconcerting question of why an increasingly affluent country continued to fail to feed its children. There was, her account makes clear, a disappointingly long lag between the development of an industrialized lifestyle in Britain and the spread of its benefits throughout the population.

For the full review, see:

Ruth Goodman. “BOOKSHELF; Livings And Wages.” The Wall Street Journal (Monday, June 8, 2020): A15.

(Note: the online version of the review has the date June 7, 2020, and has the title “BOOKSHELF; ‘Bread Winner’ Review: Livings and Wages.”)

The book reviewed above, is:

Griffin, Emma. Bread Winner: An Intimate History of the Victorian Economy. New Haven, CT: Yale University Press, 2020.

Anti-Hydroxychloroquine Lancet Study Retracted by Authors

(p. A7) Two major studies casting doubt on the ability of antimalaria drugs to treat Covid-19 patients based on data from a little-known Chicago company, Surgisphere Corp., were retracted Thursday [June 4, 2020].

The Lancet first pulled a study published late last month that found antimalarials provided no benefit as a treatment for Covid-19 infections while increasing the risk of heart problems and death. The New England Journal of Medicine then retracted a separate article, published in early May, that examined the impact of cardiovascular and blood-pressure drugs in Covid-19 patients.

. . .

Three of the Lancet paper’s authors said they decided to retract the paper after Surgisphere refused to share the full data set as part of a review triggered by concerns raised by outside researchers. The Lancet published a correction to the study on May 29.

“We always aspire to perform our research in accordance with the highest ethical and professional guidelines,” the authors, Drs. Mehra, Patel and Frank Ruschitzka said in a statement. “We can never forget the responsibility we have as researchers to scrupulously ensure that we rely on data sources that adhere to our high standards. Based on this development, we can no longer vouch for the veracity of the primary data sources.”

. . .

Following the study, the World Health Organization paused enrolling patients in clinical trials of hydroxychloroquine, although this week the organization said it resumed the trials.

In the days following publication of the study, however, other researchers began to raise questions about the Surgisphere data, first on social media and in emails, then in an open letter to The Lancet and the study’s authors. More than 100 researchers signed on to the letter.

For the full story, see:

Jared S. Hopkins and Russell Gold. “Antimalaria Drug Studies Are Retracted.” The Wall Street Journal (Friday, June 5, 2020): A7.

(Note: ellipses, and bracketed date, added. In the passages quoted above, where the online version differs from the print version, the quoted passages follow the online version.)

(Note: the online version of the story was updated June 5, 2020, and has the title “Hydroxychloroquine Studies Tied to Data Firm Surgisphere Retracted.”)

Ridley Quotes Petrovsky: “We Can’t Exclude the Possibility That This Came From a Laboratory Experiment”

(p. C3) What about the controversial claim that the virus may have originated in a laboratory? Both Ralph Baric’s team at the University of North Carolina at Chapel Hill and Shi Zhengli’s team at the Wuhan Institute of Virology have been working on SARS-like coronaviruses and testing their ability to infect human cells. They have for some years reported successful experiments in which they created new strains of the virus by manipulating the spike proteins that are now the focus of discovering the origin of SARS-CoV-2, and their research has included inserting furin cleavage sites.

The two teams made these so-called chimeric viruses in order to understand what makes viruses more or less dangerous and in the hope of being ready to protect people against a future SARS epidemic. In 2015 they published a joint experiment in which they combined parts of one mouse-adapted SARS-like coronavirus with a spike gene from a SARS-like coronavirus derived from Chinese bats.

In reporting their results, they expressed caution about continuing such risky experiments: “On the basis of these findings, scientific review panels may deem similar studies building chimeric viruses based on circulating strains too risky to pursue, as increased pathogenicity in mammalian models cannot be excluded.” They added: “The potential to prepare for and mitigate future outbreaks must be weighed against the risk of creating more dangerous pathogens.”

Nikolai Petrovsky and colleagues at Flinders University in Australia have found that SARS-CoV-2 has a higher affinity for human receptors than for any other animal species they tested, including pangolins and horseshoe bats. He suggests that this could have happened if the virus was being cultured in human cells, adding that “We can’t exclude the possibility that this came from a laboratory experiment.”

For the full commentary, see:

Matt Ridley. “So Where Did the Virus Come From?” The Wall Street Journal (Saturday, May 30, 2020): C3.

(Note: I corrected a misspelling of Petrovsky’s name.)

(Note: the online version of the commentary was the date May 29, 2020 and has the same title as the print version.)

The manuscript co-authored by Petrovsky, and mentioned above, is reported in:

Sakshi Piplani, Puneet Kumar Singh, David A. Winkler, Nikolai Petrovsky. “In Silico Comparison of Spike Protein-Ace2 Binding Affinities across Species; Significance for the Possible Origin of the Sars-Cov-2 Virus.” May 13, 2020.

Like During the Great Depression, Wages May Now Be Sticky-Downward

Economists have sometimes claimed that the reason that the labor market did not quickly clear during the Great Depression, was that wages were sticky-downward. The result of sticky-downward wages can be long-term high levels of unemployment.

(p. 7) Much as now, in the Great Depression people were very focused on maintaining a “fair wage” in the face of economic distress. But this led to nationwide resistance to nominal wage cuts for anyone, even when retail prices were falling rapidly.

This appears to have had the unintended result of inducing employers, who could not afford to keep everyone working at their former wages, to lay off many people. The economists Harold L. Cole of the University of Pennsylvania and Lee E. Ohanian, of U.C.L.A., have shown that this may explain some of the extreme duration of Great Depression unemployment.

For the full commentary, see:

Robert J. Shiller. “ECONOMIC VIEW; Looking Back for Clues About What’s Ahead After the Pandemic.” The New York Times, SundayBusiness Section (Sunday, May 31, 2020): 7.

(Note: the online version of the commentary has the date May 29, 2020 and has the title “ECONOMIC VIEW; Why We Can’t Foresee the Pandemic’s Long-Term Effects.”)

The Cole and Ohanian paper mentioned above, is:

Cole, Harold L., and Lee E. Ohanian. “New Deal Policies and the Persistence of the Great Depression: A General Equilibrium Analysis.” Journal of Political Economy 112, no. 4 (Aug. 2004): 779–816.

Frustration of a Non-Expert Entrepreneur Inspired the Creation of Square

(p. B6) It was 2009, and Mr. McKelvey—a glassblower, computer scientist and serial entrepreneur—had lost a sale of one of his artworks because he couldn’t accept American Express cards. Though neither he nor Mr. Dorsey, now CEO of Square and Twitter Inc., knew much about the world of credit-card transactions, his frustration inspired the creation of Square’s signature white readers, a technology that would revolutionize payments by allowing anyone to accept a card with a smartphone or tablet.

In his new book, “The Innovation Stack,” Mr. McKelvey uses the story of Square’s early days, and its success in fending off a rival product from Amazon.com Inc., to encourage other potential founders with a dearth of credentials to fix unsolved problems and start novel businesses.

“If you’re going to do something that’s never been done, by definition, you cannot be an expert,” he said. “Take it from a glassblower who started a $30 billion payment company: You don’t have to be.”

. . .

“. . . there are no experts anymore. We’re living in a world without expertise, and that’s the world of the entrepreneur, like it or not.”

For the full interview, see:

Peter Rudegeair, interviewer. “Square’s Co-Founder Sees Openings in Recessions.” The Wall Street Journal (Tuesday, May 26, 2020): B6.

(Note: ellipses, and quotation marks around last two sentences, added.)

(Note: the online version of the television review has the date May 24, 2020, and has the same title “BOSS TALK; Square’s Co-Founder: A Recession Is a Great Time to Start a Company.” The first several paragraphs quoted above are from Pter Rudegeair’s introduction to his interview of Jim McKelvey. The last couple of sentences are from McKelvey’s response to the last question in the interview.)

The book, mentioned above in the introduction to the interview, is:

McKelvey, Jim. The Innovation Stack: Building an Unbeatable Business One Crazy Idea at a Time. New York: Portfolio, 2020.

Rigid Merged Health Systems Cause Slow Covid-19 Testing

(p. A1) When a stay-at-home order in March all but closed the revered labs of the gene-editing pioneer Jennifer Doudna, her team at the University of California, Berkeley dropped everything and started testing for the coronavirus.

They expected their institute to be inundated with samples since it was offering the service for free, with support from philanthropies. But there were few takers.

Instead, the scientists learned, many local hospitals and doctors’ offices continued sending samples to national laboratory companies — like LabCorp and Quest Diagnostics — even though, early on, patients had to wait a week or more for results. The bureaucratic hurdles of quickly switching to a new lab were just too high.

. . .

(p. A5) In normal times, scientists at the Innovative Genomics Institute at Berkeley spend their time advancing the gene-editing technology called Crispr that the lab’s founder, Dr. Doudna, is known for.

But after the pandemic shut down the institute’s research in March, Dr. Doudna called for volunteers to redirect most of the labs’ work to coronavirus testing. The country was clamoring for more tests, after all, and her lab was full of researchers with the technical skills to make it happen.

Unlike many other major research institutions, Berkeley does not have a medical school or run its own hospital. So Dr. Urnov reached out to others in the area, who were still ordering from LabCorp and Quest, despite lengthy delays in processing results at the time.

“We would come to these entities and say, ‘Hi, we hear you have problems,’” Dr. Urnov recalled. “And they said, ‘Well, you have to basically work with our EHR,’” the acronym for electronic health records.

For the full story, see:

Katie Thomas. “In Testing Chaos, Some Labs Drowned While Others Sat Idle.” The New York Times (Friday, May 22, 2020): A1 & A5.

(Note: ellipsis added.)

(Note: the online version of the story has the date May 21, 2020 and has the title “These Labs Rushed to Test for Coronavirus. They Had Few Takers.”)

YouTube, Vimeo, and Twitter Censor Firm Working on Ultraviolet Covid-19 Cure

(p. A15) Early in the Covid-19 pandemic, Aytu BioScience made a commitment to find ways to help. One of those ways came through our newly formed relationship with a prominent Los Angeles hospital.

On April 20 [2020] we put out a press release titled “Aytu BioScience Signs Exclusive Global License with Cedars-Sinai for Potential Coronavirus Treatment.” The treatment is called Healight, and it was developed by research physicians at the hospital’s Medically Associated Science and Technology Program. The technology, which has been in development since 2016, uses ultraviolet light as an antimicrobial and is a promising potential treatment for Covid-19.

Aytu and Cedars-Sinai have engaged with the Food and Drug Administration to pursue a rapid path to human use through an Emergency Use Authorization. But hardly anyone noticed—until Thursday, when President Trump mused, “. . . supposing you brought the light inside the body . . .”

My team and I knew the president’s comments could trigger a backlash against the idea of UV light as a treatment, which might hinder our ability to get the word out. We decided to create a YouTube account, upload a video animation we had created, and tweet it out. It received some 50,000 views in 24 hours.

Then YouTube took it down. So did Vimeo. Twitter suspended our account. The narrative changed from whether UV light can be used to treat Covid-19 to “Aytu is being censored.”

For the full commentary, see:

Josh Disbrow. “Ultraviolet Light Takes Political Heat.” The Wall Street Journal (Tuesday, April 28, 2020): A15.

(Note: bracketed year added, ellipses in original.)

(Note: the online version of the commentary has the date April 27, 2020, and the title “An Experimental Ultraviolet Light Treatment for Covid-19 Takes Political Heat.”)

While Still “Dirt Poor,” Ulysses Grant Freed Slave Given to Him by His Father-in-Law

(p. 7) . . . like the Chernow book, “Grant” gives its subject his due for having fought ferociously as president against Southern Democrats, pursuing the Lincoln agenda, furthering the cause of Reconstruction, protecting blacks in the South and for crushing the Ku Klux Klan in the early 1870s.

He had been a champion of enslaved Americans long before the Emancipation Proclamation. Grant’s wife, Julia Dent, came from a slave-owning family; Grant’s father, Jesse, was a rabid abolitionist. While living with his in-laws, Grant invited the enmity of neighbors by laboring alongside his father-in-law’s field workers and, as explained by the writer Ta-Nehisi Coates, freeing the enslaved person his father-in-law had given him—thus relinquishing his greatest financial asset at a time when he was otherwise dirt poor. He later saw that black troops would be an asset to the North and used them to deadly effect.  . . .

For all its warfare and violence, eloquent interviews and gorgeous photographs, viewers will discover that the real star of “Grant” is the character of the subject himself.

For the full television review, see:

John Anderson. “TELEVISION REVIEW; A Warrior’s Wisdom and Weaknesses.” The Wall Street Journal (Friday, May 22, 2020): A13.

(Note: ellipses added.)

(Note: the online version of the television review has the date May 21, 2020, and has the same title “TELEVISION REVIEW; ‘Grant’ Review: The Wisdom and Weaknesses of a Warrior.”)

The book, mentioned above as the basis of the “Grant” television mini-series, is:

Chernow, Ron. Grant. New York: The Penguin Press, 2017.