Category: Aging

“Death Has Never Made Any Sense to Me”

(p. 10) . . . , Kinsley is intent on being wryly realistic about coping with illness and the terminal prospects ahead. He makes fun of a fellow boomer, Larry Ellison, the C.E.O. of Oracle, who has spent millions in a quest for eternal life, and who was quoted as saying, “Death has never made any sense to me.” Kinsley quips: “Actually the question is not whether death makes sense to Larry Ellison but whether Larry Ellison makes sense to death. And I’m afraid he does.”

For the full review, see:
PHILLIP LOPATE. “Senior Moments’.” The New York Times Book Review (Sun., APRIL 24, 2016): 10.
(Note: ellipsis added.)
(Note: the online version of the review has the date APRIL 18, 2016, and has the title “Michael Kinsley’s ‘Old Age: A Beginner’s Guide’.”)

The book under review, is:
Kinsley, Michael. Old Age: A Beginner’s Guide. New York: Tim Duggan Books, 2016.

Employers Less Likely to Hire Older Workers

(p. A3) Using a method of uncovering discrimination well known in economics, David Neumark, an economist at the University of California at Irvine, led a study that sent out 40,000 fake résumés to employers who had posted openings. Mr. Neumark and his co-authors found that résumés suggesting an applicant was 64 to 66 years old got a response 35 percent less often than résumés suggesting that the applicant was 29 to 31.
Labeling it discrimination is another matter, however. “The one thing that people always point out is that acceptability for age stereotyping is extremely high,” Mr. Neumark said. “The number of people who make age-related jokes are way more frequent than people who make race-related jokes. For whatever reason, the social stigma for age discrimination is really weak.”
Aside from fairness, evidence suggests that finding ways to keep older Americans working has benefits to the broader society: Working keeps older Americans happier, healthier and more mentally engaged. And forestalling retirement could relieve some of the pressure a large aging population places on this country’s social safety net.
“Governments all over the world are trying to figure how to get old people to stay at work longer,” Mr. Neumark said. “If we have discriminatory barriers, then all these reforms will be less effective.”

For the full story, see:
Quoctrung Bui. “As More Older People Look for Work, They Are Put Into ‘Old Person Jobs’.” The New York Times (Thurs., AUG. 18, 2016): A3.
(Note: the online version of the article has the title “More Older People Are Finding Work, but What Kind?”)

The Neumark paper mentioned above, is:
Neumark, David, Ian Burn, and Patrick Button. “Experimental Age Discrimination Evidence and the Heckman Critique.” American Economic Review 106, no. 5 (May 2016): 303-08.

Resveratrol Slows Alzheimer’s

(p. D1) A recent human study that suggested resveratrol could slow the progression of Alzheimer’s used a daily dose equivalent to the amount in about 1,000 bottles of red wine, says Scott Turner, director of the Memory Disorders Program at Georgetown University Medical Center, who led the study. Such high doses can lead to side effects such as nausea, vomiting and diarrhea.
Such side effects have caused past efforts to tap the health benefits of resveratrol to founder. GlaxoSmithKline PLC shelved a project to develop a resveratrol-based pill in 2010 after some clinical-trial patients developed kidney problems. The company, which had hoped to develop the drug as a treatment for a type of blood cancer, concluded that while resveratrol didn’t directly cause those problems, its side effects led to dehydration, which could exacerbate underlying kidney issues.
Now, scientists hope to overcome that problem by increasing the potency of resveratrol at more moderate doses. Researchers at the University of New South Wales, near Sydney, suspect the substance is more effective when accompanied by other ingredients found in red wine, which somehow promote its activity. They are developing a pill that combines puri-(p. D4)fied resveratrol with other compounds in wine in an effort to mimic the drink’s naturally-occurring synergies.
. . .
At the University of New South Wales, researchers have combined resveratrol with two other components of red wine: antioxidants and chelating agents, which have separately been shown also to have health benefits.
. . .
The researchers recently tried the combination in a small trial involving 50 people and found it increased the activity of a substance called NAD+ that plays a key role in maintaining healthy cells.

For the full story, see:
DENISE ROLAND. “Scientists Try to Put Red Wine in a Pill.” The Wall Street Journal (Tues., Aug. 2, 2016): D1 & D4.
(Note: ellipses added.)
(Note: the online version of the story has the date Aug. 1, 2016, and has the title “Scientists Get Closer to Harnessing the Health Benefits of Red Wine.”)

A recent article co-authored by Turner, related to the research summarized above, is:
Moussa, Charbel, Michaeline Hebron, Huang Xu, Jaeil Ahn, Robert A. Rissman, Paul S. Aisen, R. Scott Turner, Xu Huang, and R. Scott Turner. “Resveratrol Regulates Neuro-Inflammation and Induces Adaptive Immunity in Alzheimer’s Disease.” Journal of Neuroinflammation 14 (Jan. 3, 2017): 1-10.

U.S. Forest Service Killed “Prometheus,” World’s Oldest Tree

(p. D9) Great Basin’s . . . big draw–trees about as old as Egyptian hieroglyphics–sits at the top of the sky island in Wheeler Peak Bristlecone Grove.
. . .
At the grove, a stand of weather-battered bristlecone pines await, just as they have for between 3,000 and 4,000 years. With their knobby trunks and gnarled branches, the trees look like characters in an animated film’s enchanted forest, ready to burst into song. They often have only a small strip of bark, with the rest of the trunk bare, exposing the smooth, rich browns, yellows and grays in its fine grain.
At one time the oldest known tree in the world lived here. Its dignified appearance earned it the name Prometheus. In 1964, two decades before Great Basin became a national park, a researcher, trying to collect data about the area’s climate history, drilled into defenseless Prometheus (not knowing its exact age) to examine its rings. When his coring instrument got stuck, the Forest Service felled the tree to retrieve his tool– only to discover that the tree was 4,900 years old.
Oops.

For the full story, see:
JIM ROBBINS. “In a Strange Land; One of the country’s least-hyped nature preserves, Nevada’s Great Basin National Park has a weird, wild beauty all its own.” The Wall Street Journal (Sat., MARCH 11, 2017): D9.
(Note: ellipses added.)
(Note: the online version of the story has the date MARCH 9, 2017, and has the title “A Hike Through America’s Otherworldly Outback.”)

“More Women in Their 60s and 70s” Work in Fulfilling Jobs

(p. 1) Kay Abramowitz has been working, with a few breaks, since she was 14. Now 76, she is a partner in a law firm in Portland, Ore. — with no intention of stopping anytime soon. “Retirement or death is always on the horizon, but I have no plans,” she said. “I’m actually having way too much fun.”
The arc of women’s working lives is changing — reaching higher levels when they’re younger and stretching out much longer — according to two new analyses of census, earnings and retirement data that provide the most comprehensive look yet at women’s career paths.
. . .
Most striking, women have become significantly more likely to work into their 60s and even 70s, often full time, according to the analyses. And many of these women report that they do it because they enjoy it.
. . .
Nearly 30 percent of women 65 to 69 are working, up from 15 percent in the late 1980s, one of the analyses, by the Harvard economists Claudia Goldin and Lawrence Katz, found. Eighteen per-(p. 4)cent of women 70 to 74 work, up from 8 percent.
. . .
Of those still working, Ms. Goldin said, “They’re in occupations in which they really have an identity.” She added, “Women have more education, they’re in jobs that are more fulfilling, and they stay with them.” (Ms. Goldin happens to be an example of the phenomenon, as a 70-year-old professor and researcher.)

For the full story, see:
Claire Cain Miller. “With More Women Fulfilled by Work, Retirement Has to Wait.” The New York Times, First Section (Sun., FEB. 12, 2017): 1 & 4.
(Note: ellipses added.)
(Note: the online version of the article has the date FEB. 11, 2017, and has the title “More Women in Their 60s and 70s Are Having ‘Way Too Much Fun’ to Retire.”)

The paper by Goldin and Katz, mentioned above, is:
Goldin, Claudia, and Lawrence F. Katz. “Women Working Longer: Facts and Some Explanations.” NBER Working Paper #22607. National Bureau of Economic Research, Inc., Sept. 2016.

Fitness Can Improve Even After Age 100

(p. D4) At the age of 105, the French amateur cyclist and world-record holder Robert Marchand is more aerobically fit than most 50-year-olds — and appears to be getting even fitter as he ages, according to a revelatory new study of his physiology.
The study, which appeared in December in The Journal of Applied Physiology, may help to rewrite scientific expectations of how our bodies age and what is possible for any of us athletically, no matter how old we are.
. . .
Conventional wisdom in exercise science suggests that it is very difficult to significantly add to aerobic fitness after middle age. In general, VO2 max, a measure of how well our bodies can use oxygen and the most widely accepted scientific indicator of fitness, begins to decline after about age 50, even if we frequently exercise.
But Dr. Billat had found that if older athletes exercised intensely, they could increase their VO2 max. She had never tested this method on a centenarian, however.
. . .
These data strongly suggest that “we can improve VO2 max and performance at every age,” Dr. Billat says.

For the full story, see:
GRETCHEN REYNOLDS. “Phys Ed; Lessons from a 105-Year-Old.” The New York Times (Tues., FEB. 14, 2017): D4.
(Note: ellipses added.)
(Note: the online version of the article has the date FEB. 8, 2017, and has the title “Phys Ed; Lessons on Aging Well, From a 105-Year-Old Cyclist.”)

The academic article mentioned in the passages quoted above, is:
Billat, Véronique, Gilles Dhonneur, Laurence Mille-Hamard, Laurence Le Moyec, Iman Momken, Thierry Launay, Jean Pierre Koralsztein, and Sophie Besse. “Case Studies in Physiology: Maximal Oxygen Consumption and Performance in a Centenarian Cyclist.” Journal of Applied Physiology 122 (2017): 430-34.

Mice Genome Reprogrammed to Rejuvenate Organs and Extend Life

(p. A22) At the Salk Institute in La Jolla, Calif., scientists are trying to get time to run backward.
Biological time, that is. In the first attempt to reverse aging by reprogramming the genome, they have rejuvenated the organs of mice and lengthened their life spans by 30 percent. The technique, which requires genetic engineering, cannot be applied directly to people, but the achievement points toward better understanding of human aging and the possibility of rejuvenating human tissues by other means.
The Salk team’s discovery, reported in the Thursday issue of the journal Cell, is “novel and exciting,” said Jan Vijg, an expert on aging at the Albert Einstein College of Medicine in New York.
Leonard Guarente, who studies the biology of aging at M.I.T., said, “This is huge,” citing the novelty of the finding and the opportunity it creates to slow down, if not reverse, aging. “It’s a pretty remarkable finding, and if it holds up it could be quite important in the history of aging research,” Dr. Guarente said.
. . .
Ten years ago, the Japanese biologist Shinya Yamanaka amazed researchers by identifying four critical genes that reset the clock of the fertilized egg. The four genes are so powerful that they will reprogram even the genome of skin or intestinal cells back to the embryonic state.
. . .
Dr. Izpisua Belmonte believes these beneficial effects have been obtained by resetting the clock of the aging process. The clock is created by the epigenome, the system of proteins that clads the cell’s DNA and controls which genes are active and which are suppressed.
. . .
Dr. Izpisua Belmonte sees the epigenome as being like a manuscript that is continually edited. “At the end of life there are many marks and it is difficult for the cell to read them,” he said.
What the Yamanaka genes are doing in his mice, he believes, is eliminating the extra marks, thus reverting the cell to a more youthful state.
The Salk biologists “do indeed provide what I believe to be the first evidence that partial reprogramming of the genome ameliorated symptoms of tissue degeneration and improved regenerative capacity,” Dr. Vijg said.

For the full story, see:
NICHOLAS WADE. “Scientists Learn About Human Aging by Lengthening the Life Span of Mice.” The New York Times (Fri., DEC. 16, 2016): A22.
(Note: ellipses added.)
(Note: the online version of the story has the date DEC. 15, 2016, and has the title “Scientists Say the Clock of Aging May Be Reversible.”)

More Live to 100, and Those Who Do, Are Living Even Longer

(p. A13) There were 72,197 of them in 2014, up from 50,281 in 2000, according to the report by the Centers for Disease Control and Prevention. In 1980, they numbered about 15,000.
Even demographers seemed impressed. “There is certainly a wow factor here, that there are this many people in the United States over 100 years old,” said William H. Frey, the senior demographer at the Brookings Institution. “Not so long ago in our society, this was somewhat rare.”
Not only are there more centenarians, but they are living even longer. Death rates declined for all demographic groups of centenarians — white, black, Hispanic, female, male — in the six years ending in 2014, the report said.
Women, who typically live longer than men, accounted for the overwhelming majority of centenarians in 2014: more than 80 percent.

For the full story, see:
SABRINA TAVERNISE. “Centenarians Proliferate, and Live Longer.” The New York Times (Thurs., JAN. 21, 2016): A13.

The Octopus, Though Intelligent, Only Lives for Two Years

(p. C5) Around 600 million years ago there lived in the sea a small unprepossessing worm, virtually eyeless and brainless. For some reason this species split into two, thus seeding the vast zoological groupings of the vertebrates and the invertebrates. On one branch sit the mammals; on the other sit the molluscs (and many others). Among these two groups, two notable creatures eye each other warily: the human and the octopus. They have no common ancestor apart from that lowly worm, yet there is a strange affinity, a bond almost. For they are both evolutionary experiments in intelligence–pockets of genius in a vast ocean (sorry!) of biological mediocrity.
In “Other Minds,” Peter Godfrey-Smith, a philosopher at CUNY and an avid scuba diver, has given us a smoothly written and captivating account of the octopus and its brethren, as observed by humans. He celebrates the cephalopods: the octopus, the squid and the cuttlefish. He stresses their dissimilarity to us and other mammals, but he also wants us to appreciate what we have in common. Just as eyes have evolved independently in many lineages, so have intelligent minds. From those mindless worms, via two separate evolutionary paths, to the glories of consciousness and curiosity–we are brothers in big brains.
. . .
(p. C6) Mr. Godfrey-Smith mixes the scientific with the personal, giving us lively descriptions of his dives to “Octopolis,” a site off the east coast of Australia at which octopuses gather. There they make their dens in piles of scallop shells. He also reproduces some excellent photographs of the octopuses and other cephalopods he has observed in his submerged city. It is with a jolt, then, that he announces the average life span of the cephalopod: one to two years. That’s it: That marvelous complex body, the large brain, lively mind and amazing Technicolor skin–all over so quickly. There are boring little fish that live for 200 years, and the closely related nautilus can live for 20 years, but the octopus has only a year or two to enjoy its uniqueness. Mr. Godfrey-Smith speculates that the brevity results from a lifestyle that forces the animal to reach reproductive age as soon as possible, given the problem of predators such as whales or large fish.
Whatever the biological reason for such a brief life, it is a melancholy fact.
. . .
What is it like to be an octopus? It’s not easy to say, but I speculate soft, malleable, brimming with sensation, vivid, expressive, exciting, complicated, tragic and determined. They make good, if brief, use of their portion of consciousness. They must live by the evolutionary laws that have created them, but there is an inner being that makes the best of its lot. Though it’s easy to think of octopuses as alien, a better view is that they are our cousins in biological destiny–spirits in a material world.

For the full review, see:
COLIN MCGINN. “Experiments in Intelligence.” The Wall Street Journal (Sat., December 3, 2016): C5-C6.
(Note: ellipses added.)
(Note: the online version of the review has the date Dec. 4 [sic], 2016, and has the title “Our Noble Cousin: The Octopus.”)

The book under review, is:
Godfrey-Smith, Peter. Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness. New York: Farrar, Straus and Giroux, 2016.

Superagers Engage in “Strenuous Mental Effort”

(p. 10) Why do some older people remain mentally nimble while others decline? “Superagers” (a term coined by the neurologist Marsel Mesulam) are those whose memory and attention isn’t merely above average for their age, but is actually on par with healthy, active 25-year-olds.
. . .
Of course, the big question is: How do you become a superager? Which activities, if any, will increase your chances of remaining mentally sharp into old age? We’re still studying this question, but our best answer at the moment is: work hard at something. Many labs have observed that these critical brain regions increase in activity when people perform difficult tasks, whether the effort is physical or mental. You can therefore help keep these regions thick and healthy through vigorous exercise and bouts of strenuous mental effort. My father-in-law, for example, swims every day and plays tournament bridge.
The road to superaging is difficult, though, because these brain regions have another intriguing property: When they increase in activity, you tend to feel pretty bad — tired, stymied, frustrated. Think about the last time you grappled with a math problem or pushed yourself to your physical limits. Hard work makes you feel bad in the moment. The Marine Corps has a motto that embodies this principle: “Pain is weakness leaving the body.” That is, the discomfort of exertion means you’re building muscle and discipline. Superagers are like Marines: They excel at pushing past the temporary unpleasantness of intense effort. Studies suggest that the result is a more youthful brain that helps maintain a sharper memory and a greater ability to pay attention.

For the full commentary, see:
LISA FELDMAN BARRETT. “Gray Matter; How to Become a ‘Superager’.” The New York Times, SundayReview Section (Sun., January 1, 2017): 10.
(Note: ellipsis added.)
(Note: the online version of the commentary has the date DEC. 31, 2016.)

The passages quoted above are related to Barrett’s academic paper:
Sun, Felicia W., Michael R. Stepanovic, Joseph Andreano, Lisa Feldman Barrett, Alexandra Touroutoglou, and Bradford C. Dickerson. “Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks Contributes to Youthful Memory in Superaging.” The Journal of Neuroscience 36, no. 37 (Sept. 14, 2016): 9659-9668.

Complex Labor Rules Reduce Work Choices for Older Workers

(p. B4) CALL them boomerang retirees: people who exit gracefully after their career at a company, then return shortly afterward to work there part time.
More and more companies are establishing formal programs to facilitate this, for reasons that benefit both the employer and the retiree. Leaving a satisfying job cold-turkey for a life of leisure can be an abrupt jolt to people accustomed to feeling purposeful, earning money and enjoying their colleagues. From the corporate perspective, it is useful to have experienced hands who can train younger people, pass along institutional wisdom and work with fewer strings attached.
“People in the U.S. define themselves by their work, and they like their co-workers,” said Roselyn Feinsod, senior partner in the retirement practice at the human resources firm Aon Hewitt, the human resources consultancy. Thus, unlike many retirees from past generations, people from both the blue-collar and white-collar sectors are more eager to retain ties to the familiar working world that they enjoyed (and sometimes loathed).
. . .
. . . , Atlantic Health Systems of Morristown, N.J., is among the growing ranks of employers that sponsor a formal program to invite retirees back into the work force, for no more than 1,000 hours a year. The company’s Alumni Club — formerly known as the 1,000 Hour Club — was established in 2006, and about 300 Atlantic Health retirees are currently on the company’s payroll in various capacities. “They’re engaged employees; they’re productive,” said Lesley Meyer, Atlantic Systems’ manager of corporate human resources. “They’re a stable talent pool.”
. . .
Most boomerang retirees return to work after an informal negotiation with a former boss. Programs like the one at Atlantic Systems are still relatively rare — for instance, about 8 percent of the 463 companies surveyed by the Society for Human Resource Management in 2015 had one — but they are on the rise.
They are also tricky to run: Establishing a boomerang retiree program involves a substantial commitment of resources, including systems for navigating complex labor market rules and pension law. Most returning retirees must wait several months before they can come back, and are often limited to that 1,000 hours a year. Companies are increasingly turning to outside staffing firms to manage the nuts and bolts.
. . .
It was a phone call from her former manager that lured Pat Waller, who spent 39 years as an intensive care nurse for Atlantic Health before retiring in 2005 at age 66, back to the work force part time. She joined the Alumni Club in 2007 after the hospital where she had worked, Morristown Medical Center in Morristown, N.J., applied to qualify as a federal center of excellence in knee and hip surgery; her former boss wondered if she would help gather data. Absolutely, she answered.
Since then, Ms. Waller has worked on several projects for Atlantic Health, gigs that easily give her the time to travel with her husband and see her six grandchildren.
Now that she is 77, Ms. Waller works mostly from home, sometimes three to four days a week and other times one to two, depending on the project, “I always said when I was at work I learned something every day,” she said. “Since I’ve come back, I feel the same way.”

For the full story, see:
CHRISTOPHER FARRELL. “Boomerang Boom: Firms Tapping Skills of the Recently Retired.” The New York Times (Sat., December 17, 2016): B4.
(Note: ellipses added.)
(Note: the online version of the story has the date DEC. 16, 2016, and has the title “Retiring; Boomerang Boom: More Firms Tapping the Skills of the Recently Retired.”)