Aging – Page 12 – artdiamondblog.com

Affluent Are More Likely to Work During Retirement

That the affluent are more than twice as likely to work past retirement, may be a sign that the better paying jobs are also the more satisfying jobs.

(p. B9) But retirement isn’t for everyone. Affluent individuals are more than twice as likely as other people to keep working in retirement, according to a July survey by Bank of America’s Merrill Lynch and Age Wave, a research firm based in Emeryville, Calif., that specializes in aging populations.

Some 33% of retirees with $1 million to $5 million in assets are working, as are 29% of those with more than $5 million. Most say they do so because they want to, not because they have to, according to the survey.
Half of affluent working retirees have shifted to a different line of work, most often because of greater flexibility of scheduling, the opportunity to experience new things, and the pursuit of a passion or interest, the survey found.
The results show how important it is to consider what you will do with your time and to think hard about whether that will be satisfying.

For the full commentary, see:
LIZ MOYER. “Can You Afford to Retire Early?” The Wall Street Journal (Sat., Aug. 2, 2014): B7 & B9.
(Note: the online version of the commentary has the date Aug. 1, 2014.)

To FDA Aging Is Not a Disease, So FDA Will Not Approve Drugs that Extend Life

(p. D1) Some of the top researchers on aging in the country are trying to get an unusual clinical trial up and running.
. . .
The trial aims to test the drug metformin, a common medication often used to treat Type 2 diabetes, and see if it can delay or prevent other chronic diseases. (The project is being called Targeting/Taming Aging With Metformin, or TAME.) Metformin isn’t necessarily more promising than other drugs that have shown signs of extending life and reducing age-related chronic diseases. But metformin has been widely and safely used for more than 60 years, has very few side effects and is inexpensive.
The scientists say that if TAME is a well-designed, large-scale study, the Food and Drug Administration might be persuaded to consider aging as an indication, or preventable condition, a move that could spur drug makers to target factors that contribute to aging.
. . .
(p. D4) Fighting each major disease of old age separately isn’t winnable, said S. Jay Olshansky, another TAME project planner and a professor at the school of public health at the University of Illinois at Chicago. “We lower the risk of heart disease, somebody lives long enough to get cancer. If we reduce the risk of cancer, somebody lives long enough to get Alzheimer’s disease.”
“We are suggesting that the time has arrived to attack them all by going after the biological process of aging,” Dr. Olshansky said.
Sandy Walsh, an FDA spokeswoman, said the agency’s perspective has long been that “aging” isn’t a disease. “We clearly have approved drugs that treat consequences of aging,” she said. Although the FDA currently is inclined to treat diseases prevalent in older people as separate medical conditions, “if someone in the drug-development industry found something that treated all of these, we might revisit our thinking.”

For the full story, see:
SUMATHI REDDY. “To Grow Old Without Disease.” The Wall Street Journal (Tues., March 17, 2015): D1 & D4.
(Note: ellipses added.)
(Note: the online version of the story has the date March 16, 2015, and has the title “Scientists’ New Goal: Growing Old Without Disease.”)

Longevity and Frugality Allow More Happiness Through New “Second Act” Jobs

(p. B7) Research suggests that happiness over the course of our lives is U-shaped, with our satisfaction deteriorating through our 20s and 30s, hitting bottom in our 40s and then bouncing back from there.
What causes the decline in our happiness during our early adult years? We don’t know for sure. It might be the stress of juggling work and home life, or it could be the gradual realization that we won’t fulfill all of our youthful ambitions.
But for some, midlife dissatisfaction may reflect growing disenchantment with their chosen career. The good news: Today, thanks to our longer life expectancy, we have time for a second act.
In fact, that second act may be necessary if we are laid off. Our new career could prove more fulfilling, but it might come with a smaller paycheck.
This is a reason to start saving as soon as we enter the workforce. If we do that, we likely will have the financial flexibility to swap into a less lucrative job. What if we haven’t been good savers? We may be stuck in a job we have come to hate.

For the full commentary, see:
JONATHAN CLEMENTS. “Can You Afford a Long Life?” The Wall Street Journal (Sat., APRIL 25, 2015): B7.
(Note: the online version of the commentary has the date APRIL 23, 2015, and has the title “What Long Life Spans Mean for Your Money and Career.”)

117 Year Old Said “Her Life Seemed Rather Short”

(p. A10) Misao Okawa, the world’s oldest person, died Wednesday, a few weeks after celebrating her 117th birthday.
. . .
Ms. Okawa, . . . , said at her recent birthday celebration that her life seemed rather short.

For the full story, see:
THE ASSOCIATED PRESS. “WORLD BRIEFING; Japan: Weeks After a Birthday, the World’s Oldest Person Dies.” The New York Times (Thurs., APRIL 2, 2015): A10.
(Note: ellipses added.)
(Note: the online version of the story has the date APRIL 1, 2015.)

26 Different Drugs Lengthen Healthy Life Span in Mice

(p. F5) For thousands of years, people have sought to escape or outrun their mortality with potions, pills and elixirs, often blended with heavy doses of hope and will.
In the “Epic of Gilgamesh,” a Mesopotamian king searched for the secret of immortality after the death of his best friend. At least three Chinese emperors in the Tang dynasty died after consuming treatments containing lead and mercury that they hoped would make them immortal. In the late 19th century, a French-American physiologist seemed to have found the elixir of life by injecting the elderly and himself with extracts from animal testicles.
. . .
“By targeting fundamental aging processes, we might be able to delay the major age-related chronic diseases instead of picking them off one at time,” said Dr. James Kirkland, a professor of aging research and head of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic. “For example, we don’t want to have situation where we, say, cure cancer and then people die six months later of Alzheimer’s disease or a stroke. It would be better to delay all of these things together.”
This is where the field known as the biology of aging is moving — to develop drugs that will increase life span and what researchers refer to as health span, the period of life when people are able to live independently and free from disease.
Dr. Kirkland said that at least six drugs had been written up in peer-reviewed journals and that he knew of about 20 others that appear to affect life span or health span in mice. The goal is to see if those benefits can be translated into humans to increase their longevity, “to find interventions that we can use in people that might, say, make a person who’s 90 feel like they’re 60 or a person who’s 70 feel like they’re 40 or 50.”
Other researchers are studying centenarians, seeking to understand whether certain genes have carried them past 100 years old and kept them in good health.

For the full story, see:
TRACEY SAMUELSON. “Science (and Quacks) vs. the Aging Process.” The New York Times (Weds., Nov. 19, 2014): F5.
(Note: ellipsis added.)
(Note: the online version of the story has the date NOV. 18, 2014.)

Solution to Problems of Retirement: Don’t Retire

(p. A13) Unsurprisingly, one response to the retirement challenge is: Don’t do it. Not, at least, until you really must. As Mr. Farrell argues (with plenty of supporting evidence), there is no magic element of personal doom attached to one’s 65th birthday or whatever age is believed to separate honest labor from a twilight of idleness. If you like what you do well enough, can perform your tasks competently and could use the income, why not keep working? The satisfactions of work are too often unrecognized in the popular imagination. Without it, a lot people wouldn’t know what to do.
And the longer you work, of course, the more money you will have when you eventually do retire, a strategy that works to the good of society too, since your paychecks will be contributing to FICA and will help keep the system running.

For the full review, see:
GEOFFREY NORMAN. “BOOKSHELF; Second Acts After 65; People who could be playing golf and doting on their grandchildren are starting businesses. One senior launched a coffee house in Detroit.” The Wall Street Journal (Weds., Sept. 24, 2014): A13.
(Note: the online version of the review has the date Sept. 23, 2014, and has the title “BOOKSHELF; Book Review: ‘Unretirement’ by Chris Farrell; People who could be playing golf and doting on their grandchildren are starting businesses. One senior launched a coffee house in Detroit.”)

The book under review is:
Farrell, Chris. Unretirement: How Baby Boomers Are Changing the Way We Think About Work, Community, and the Good Life. New York: Bloomsbury Press, 2014.

Moss Revived After 1,500 Years

(p. D3) Typically, plants break down into organic matter as they become permafrost. Looking at the ancient moss from Signy Island, however, Dr. Convey and his colleagues wondered if, after centuries of frozen darkness, it could grow again.
It was an unlikely idea. Scientists had not managed to revive moss that had been frozen for more than 20 years. Still, Dr. Convey thought it would be interesting to try. “It was just kite-flying,” he said.
The scientists put a core of Signy permafrost under a lamp in a lab in Britain and misted it from time to time with water. After a few weeks, the moss was sending up new green growth.
The deepest layer in which the resuscitated moss grew was three and a half feet below the surface. Based on radiocarbon tests, as they report in the journal Current Biology, the revived moss turned out to be more than 1,500 years old. It’s been in a state of suspended animation, in other words, since the age of King Arthur.
. . .
In some cases, organisms may naturally revive after thousands of years without scientists’ help. And it’s possible that they play an important role in their ecosystems.
At the end of each ice age, for example, retreating glaciers leave behind bare ground that develops into new ecosystems. Dr. Convey wonders if moss, and perhaps other species, may survive under the ice for thousands of years and revive when the glaciers melt. “That gives you a very different way of understanding the biodiversity of a region,” he said.
While cloning mammoths remains speculative, reviving dormant organisms is now passing out of its proof-of-concept stage. The research could lead to using revival to help bolster endangered species.
“You could use whatever is stored in ice or sediment as a sort of backup for biodiversity,” said Luisa Orsini of the University of Birmingham in England. But, she said, “one has to be really, really careful introducing something from the past.”

For the full story, see:
Carl Zimmer. “MATTER; A Growth Spurt at 1,500 Years Old.” The New York Times (Tues., MARCH 18, 2014): D3.
(Note: ellipsis added.)
(Note: the online version of the story has the date MARCH 17, 2014.)

The academic paper reporting the research summarized above, is:
Roads, Esme, Royce E. Longton, and Peter Convey. “Millennial Timescale Regeneration in a Moss from Antarctica.” Current Biology 24, no. 6 (March 17, 2014): R222-R223.

Drugs May Rebuild Muscle in Frail Elderly

(p. B1) In 1997, scientist Se-Jin Lee genetically engineered “Mighty Mice” with twice as much muscle as regular rodents. Now, pharmaceutical companies are using his discovery to make drugs that could help elderly patients walk again and rebuild muscle in a range of diseases.
. . .
“I am very optimistic about these new drugs,” says Dr. Lee, a professor of molecular biology at Johns Hopkins University in Baltimore, who isn’t involved in any of the drug trials. “The fact that they’re so far along means to me they must have seen effects.”
Myostatin is a naturally occurring protein that curbs muscle growth. The drugs act by blocking it, or blocking the sites where it is detected in the body, potentially rebuilding muscle.

For the full story, see:
HESTER PLUMRIDGE and MARTA FALCONI. “Drugs Aim to Treat Frailty in Aging.” The Wall Street Journal (Mon., April 28, 2014): B1-B2.
(Note: ellipsis added.)
(Note: the second paragraph quoted above is divided into two mini-paragraphs in the online, but not in the print, version.)
(Note: the online version of the story has the date April 27, 2014, and has the title “Drugs Aim to Help Elderly Rebuild Muscle.”)

Proof-of-Concept: Life Can Be Very Long

“Rare Eucalyptus (species redacted for protection) (13,000 years old; New South Wales, Australia). This critically endangered eucalyptus is around 13,000 years old, and one of fewer than five individuals of its kind left on the planet. The species name might hint too heavily at its location, so it has been redacted.” Source of caption and photo: online version of the WSJ article quoted and cited below.

(p. C12) Photographer Rachel Sussman has spent the past decade looking for the oldest things alive. . . . She documents 30 of those organisms in her new book, “The Oldest Living Things in the World” (University of Chicago Press, $45).

For the full, brief, review, see:
Alexandra Wolfe. “EXHIBIT; The 2,000-Year-Old Plant.” The Wall Street Journal (Sat., April 26, 2014): C12.
(Note: ellipsis added.)
(Note: the online version of the review has the date April 25, 2014, and has the title “EXHIBIT; The 2,000-Year-Old Plant.”)

The book under review is:
Sussman, Rachel. The Oldest Living Things in the World. Chicago: University of Chicago Press, 2014.

“Bristlecone Pine (White Mountains, California). Bristlecone pines are the oldest unitary organisms in the world, known to surpass 5,000 years in age. In the 1960s, a then-grad student cut down what would have been the oldest known tree in the world while retrieving a lost coring bit. A cross section of that tree was placed in a Nevada casino.” Source of caption and photo: online version of the WSJ review quoted and cited above.

30,000 Year Old Virus Revived from Permafrost

(p. D5) From Siberian permafrost more than 30,000 years old, [French and Russian researchers] have revived a virus that’s new to science.
“To pull out a virus that’s 30,000 years old and actually grow it, that’s pretty impressive,” said Scott O. Rogers of Bowling Green State University who was not involved in the research. “This goes well beyond what anyone else has done.”
. . .
Measuring 1.5 micrometers long, the viruses are 25 percent bigger than any virus previously found.
. . .
“Sixty percent of its gene content doesn’t resemble anything on earth,” Dr. Abergel said. She and her colleagues suspect that pithoviruses may be parasitic survivors of life forms that were very common early in the history of life.
. . .
“Its potential implications for evolutionary theory and health are quite astonishing,” said Eske Willerslev, an evolutionary biologist at the University of Copenhagen.

For the full story, see:
Carl Zimmer. “Out of Siberian Ice, a Virus Revived.” The New York Times (Tues., MARCH 4, 2014): D5.
(Note: ellipses, and bracketed words, added.)
(Note: the online version of the story has the date MARCH 3, 2014.)

Aging Brains May Be Slower Because They Have More Data to Search Through

(p. D3) In a paper published in Topics in Cognitive Science, a team of linguistic researchers from the University of Tübingen in Germany used advanced learning models to search enormous databases of words and phrases.
Since educated older people generally know more words than younger people, simply by virtue of having been around longer, the experiment simulates what an older brain has to do to retrieve a word. And when the researchers incorporated that difference into the models, the aging “deficits” largely disappeared.
“What shocked me, to be honest, is that for the first half of the time we were doing this project, I totally bought into the idea of age-related cognitive decline in healthy adults,” the lead author, Michael Ramscar, said by email. But the simulations, he added, “fit so well to human data that it slowly forced me to entertain this idea that I didn’t need to invoke decline at all.”
. . .
Scientists who study thinking and memory often make a broad distinction between “fluid” and “crystallized” intelligence. The former includes short-term memory, like holding a phone number in mind, analytical reasoning, and the ability to tune out distractions, like ambient conversation. The latter is accumulated knowledge, vocabulary and expertise.
“In essence, what Ramscar’s group is arguing is that an increase in crystallized intelligence can account for a decrease in fluid intelligence,” said Zach Hambrick, a psychologist at Michigan State University. In a variety of experiments, Dr. Hambrick and Timothy A. Salthouse of the University of Virginia have shown that crystallized knowledge (as measured by New York Times crosswords, for example) climbs sharply between ages 20 and 50 and then plateaus, even as the fluid kind (like analytical reasoning) is dropping steadily — by more than 50 percent between ages 20 and 70 in some studies. “To know for sure whether the one affects the other, ideally we’d need to see it in human studies over time,” Dr. Hambrick said.

For the full commentary, see:
BENEDICT CAREY. “MIND; Older Mind May Just Be a Fuller Mind.” The New York Times (Tues., JANUARY 28, 2014): D3.
(Note: ellipsis added.)
(Note: the online version of the commentary has the date JANUARY 27, 2014, and has the title “MIND; The Older Mind May Just Be a Fuller Mind.”)

The Ramscar article mentioned above is:
Ramscar, Michael, Peter Hendrix, Cyrus Shaoul, Petar Milin, and Harald Baayen. “The Myth of Cognitive Decline: Non-Linear Dynamics of Lifelong Learning.” Topics in Cognitive Science 6, no. 1 (Jan. 2014): 5-42.

One of the papers by Hambrick and Salthouse that discusses crystallized knowledge is:
Hambrick, David Z., and Timothy A. Salthouse. “Predictors of Crossword Puzzle Proficiency and Moderators of Age-Cognition Relations.” Journal of Experimental Psychology, General 128, no. 2 (June 1999): 131-64.