“Anti-Heroism Goes Too Far”

(p. 11) In “Extra Life,” Steven Johnson, a writer of popular books on science and technology, tells the stories behind what he calls, in an understatement, “one of the greatest achievements in the history of our species.” Starting in the second half of the 19th century, the average life span began to climb rapidly, giving humans not just extra life, but an extra life. In rich countries, life expectancy at birth hit 40 by 1880, 50 by 1900, 60 by 1930, 70 by 1960, and 80 by 2010.

. . .

It’s been a long time since the history of technology has been recounted as the triumph of plucky heroes, and Johnson’s stories reflect today’s more sophisticated understanding.

. . .

Sometimes the anti-heroism goes too far — Norman Borlaug, whose Green Revolution saved a billion lives, is unmentioned. But altogether, Johnson is a fine storyteller. Among his cast of characters are John Graunt (1620–74), the British haberdasher who studied mortality reports as a hobby and thereby invented epidemiology; Joseph Bazalgette (1819–91), the man behind “one of the 19th century’s greatest engineering achievements,” which you probably did not guess was the London sewers; “Moldy Mary” Hunt (1910–91), the Peoria bacteriologist who scoured fruit markets for the perfect rotten cantaloupe, the one with a strain of mold that enabled the mass production of penicillin; John Stapp (1910–99), who strapped himself into his invention, the rocket sled, and safely decelerated from 628 miles per hour to 0 in 1.4 seconds; and Dilip Mahalanabis, 86, the Indian pediatrician who discovered that a bit of salt and sugar dissolved in clean water could stop fatal diarrhea and thereby saved the lives of nearly 60 million people.

For the full review, see:

Steven Pinker. “Modern Miracle.” The New York Times Book Review (Sunday, June 13, 2021): 11.

(Note: ellipses added.)

(Note: the online version of the review has the date May [sic] 11, 2021, and has the title “How Humans Gained an ‘Extra Life’.”)

The book under review is:

Johnson, Steven. Extra Life: A Short History of Living Longer. New York: Riverhead Books, 2021.

Risk Averse Family Firms with Large Cash Reserves Can Last 1,000 Years

Is longevity for firms a noble goal? Or do humans usually flourish more in the churn of creative destruction?

(p. B1) KYOTO, Japan — Naomi Hasegawa’s family sells toasted mochi out of a small, cedar-timbered shop next to a rambling old shrine in Kyoto. The family started the business to provide refreshments to weary travelers coming from across Japan to pray for pandemic relief — in the year 1000.

Now, more than a millennium later, a new disease has devastated the economy in the ancient capital, as its once reliable stream of tourists has evaporated. But Ms. Hasegawa is not concerned about her enterprise’s finances.

Like many businesses in Japan, her family’s shop, Ichiwa, takes the long view — albeit longer than most. By putting tradition and stability over profit and growth, Ichiwa has weathered wars, plagues, natural disasters, and the rise and fall of empires. Through it all, its rice flour cakes have remained the same.

Such enterprises may be less dynamic than those in other countries. But their resilience offers lessons for businesses in places like the United States, where the coronavirus has forced tens of thousands into bankruptcy.

“If you look at the economics textbooks, enterprises are supposed to be maximizing profits, scaling up their size, market share and growth rate. But these companies’ operating principles are completely different,” said Kenji Matsuoka, a professor emeritus of business at Ryukoku University in Kyoto.

(p. B5) “Their No. 1 priority is carrying on,” he added. “Each generation is like a runner in a relay race. What’s important is passing the baton.”

Japan is an old-business superpower. The country is home to more than 33,000 with at least 100 years of history — over 40 percent of the world’s total, according to a study by the Tokyo-based Research Institute of Centennial Management. Over 3,100 have been running for at least two centuries. Around 140 have existed for more than 500 years. And at least 19 claim to have been continuously operating since the first millennium.

. . .

The businesses, known as “shinise,” are a source of both pride and fascination.

. . .

Most of these old businesses are, like Ichiwa, small, family-run enterprises that deal in traditional goods and services. But some are among Japan’s most famous companies, including Nintendo, which got its start making playing cards 131 years ago, and the soy sauce brand Kikkoman, which has been around since 1917.

. . .

The Japanese companies that have endured the longest have often been defined by an aversion to risk — shaped in part by past crises — and an accumulation of large cash reserves.

It is a common trait among Japanese enterprises and part of the reason that the country has so far avoided the high bankruptcy rates of the United States during the pandemic. Even when they “make some profits,” said Tomohiro Ota, an analyst at Goldman Sachs, “they do not increase their capital expenditure.”

Large enterprises in particular keep substantial reserves to ensure that they can continue issuing paychecks and meet their other financial obligations in the event of an economic downturn or a crisis. But even smaller businesses tend to have low debt levels and an average of one to two months of operating expenses on hand, Mr. Ota said.

For the full story, see:

Ben Dooley and Hisako Ueno. “A Family Business Got Its Start In a Pandemic (1,000 Years Ago).” The New York Times (Saturday, December 5, 2020): B1 & B5.

(Note: ellipses added.)

(Note: the online version of the story was updated Jan. 7, 2021, and has the title “This Japanese Shop Is 1,020 Years Old. It Knows a Bit About Surviving Crises.”)

Older Americans Shifting to Entrepreneurship at Faster Pace

(p. B6) In April [2020], Dave Summers lost his job as director of digital media productions at the American Management Association, a casualty of layoffs brought on by the pandemic.

Mr. Summers, 60, swiftly launched his own business as a digital media producer, coach and animator who creates podcasts, webcasts and video blogs.

And in September, he and his wife, who teaches nursery school, moved from Danbury, Conn., to Maryville, Tenn., which they discovered while visiting their son in Nashville. “My new work is all virtual, so I can live anywhere,” he said. “Not only is it a cheaper place to live, we love hiking and the outdoors, and our new town is in the foothills of the Great Smoky Mountains.”

Droves of small businesses have been shuttered by the economic fallout of the coronavirus, but for Mr. Summers, starting a new one was the best option.

“I’m not sitting on a massive nest egg, so I need to work to keep afloat,” he said. “It’s also about being healthy and happy. I can’t just retire because underneath it all I’m creative, and I have to be busy doing stuff and helping people tell their stories.”

While the coronavirus pandemic is causing many older workers who have lost jobs, or who have been offered early retirement severance packages, to decide to leave the work force, others like Mr. Summers are shifting to entrepreneurship.

In fact, older Americans had already been starting new businesses at a fast rate. In 2019, research from the Kauffman Foundation, a nonpartisan group supporting entrepreneurship, found that more than 25 percent of new entrepreneurs were ages 55 to 64, up from about 15 percent in 1996.

Across the age spectrum, there has been a rise in new business start-ups since May [2020], according to the Census Bureau. The surge is likely “powered by newly unemployed individuals opting to start their own businesses, either by choice or out of necessity,” according to the Economic Innovation Group, a bipartisan public policy organization.

. . .

It turns out that the importance of entrepreneurship, or self-employment as a form of work, increases significantly with age, according to a report by Cal J. Halvorsen and Jacquelyn B. James of the Center on Aging & Work at Boston College.

According to the report: “While about one in six workers in their 50s are self-employed, nearly one in three are self-employed in their late 60s and more than 1 in 2 workers over the age of 80 are self-employed.

For the full story, see:

Kerry Hannon. “Older Americans Make a New Start in a Business of Their Own.” The New York Times (Friday, November 27, 2020): B6.

(Note: ellipsis, and bracketed year, added.)

(Note: the online version of the story has the date Oct. [sic] 21, 2020, and has the title “Making a New Start in a Business of Their Own.”)

Grandma Wong Waves a Union Jack as “a Symbol of the Rights Protected by the British Government”

(p. A11) HONG KONG — When protests swept Hong Kong last year, Alexandra Wong, better known as “Grandma Wong,” always seemed to be there. Day after day, she stood out among the hundreds of thousands of demonstrators as a small woman with short gray hair waving a large British flag.

Then, during a few tumultuous days in August [2020] when the police fired tear gas in a subway station and protesters shut down the city’s airport, Ms. Wong, 64, suddenly vanished.

. . .

Ms. Wong said she had been detained while crossing the border between Hong Kong and Shenzhen on Aug. 14, and spent 15 days in administrative detention without being told of her crimes. Investigators grilled her about the protests, the British flag and whether she used violence, she said. They showed her photos of protesters and asked her if she knew them.

. . .

She was eventually released on a form of bail that prevented her from leaving Shenzhen.

. . .

Before she was released, she said, she was forced to say on video that she had not been abused while in custody, that she would not talk to the news media about her experience and that she would never protest again.

Last month, one full year after the initial bail period began, she was given the necessary paperwork allowing her to leave Shenzhen and return to Hong Kong.

. . .

For Ms. Wong, protesting now comes with greater risks. Waving a Union Jack — in her mind a symbol of the rights protected by the British government, not an endorsement of colonialism — has become “very dangerous,” she said. But detention has only strengthened her resolve for democracy.

Despite the pledges she made under duress, she continues to protest, and recently took the subway for an hour to the northeast corner of Hong Kong Island, where a trial is scheduled to begin for six young demonstrators charged with illegal assembly.

She walked to the courthouse carrying a handwritten sign: “Save HK Youths.”

For the full story, see:

Austin Ramzy. “After Vanishing in August, ‘Grandma Wong’ Returns to Hong Kong Protests.” The New York Times (Wednesday, November 11, 2020): A11.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story was updated Nov. 12, 2020, and has the title “Hong Kong Protest Icon Mysteriously Vanished. Then She Returned, Unbowed.”)


2,000-Year-Old Seeds Sprout “Long-Lost Judean Dates”

(p. A8) KETURA, Israel — The plump, golden-brown dates hanging in a bunch just above the sandy soil were finally ready to pick.

They had been slowly ripening in the desert heat for months. But the young tree on which they grew had a much more ancient history — sprouting from a 2,000-year-old seed retrieved from an archaeological site in the Judean wilderness.

. . .

These were the much-extolled but long-lost Judean dates, and the harvest this month was hailed as a modern miracle of science.

. . .

. . ., to bring something back to life from dormancy is so symbolic,” Dr. Sallon said. “To pollinate and produce these incredible dates is like a beam of light in a dark time.”

. . .

The research was peer reviewed and detailed in a paper published in February this year in Science Advances, a leading scientific journal.

For the full story, see:

Isabel Kershner. “Israel Dispatch: After 2,000 Years in the Wilderness, It’s a Date. And It’s Delicious.” The New York Times (Monday, September 7, 2020): A8.

(Note: ellipses added.)

(Note: the online version of the story has the same date as the print version, and has the title “Israel Dispatch: Aided by Modern Ingenuity, a Taste of Ancient Judean Dates.”)

The paper in Science Advances mentioned above is:

Sallon, Sarah, Emira Cherif, Nathalie Chabrillange, Elaine Solowey, Muriel Gros-Balthazard, Sarah Ivorra, Jean-Frédéric Terral, Markus Egli, and Frédérique Aberlenc. “Origins and Insights into the Historic Judean Date Palm Based on Genetic Analysis of Germinated Ancient Seeds and Morphometric Studies.” Science Advances 6, no. 6 (Feb. 5, 2020), DOI: 10.1126/sciadv.aax0384.

After Age 65, Men Lose More “Antibody-Producing B Cells” Than Women Lose

(p. B5) By examining gender-based distinctions in the immune system, cell structure, brain and other systems, researchers are discovering how and why men and women grow older in clearly different ways.

Their findings could help explain why Covid-19 has had a greater impact on older men than older women. A recent study found that men, after the age of 65, lost important antibody-producing B cells in the blood, while women didn’t.

“It was surprising,” said Duygu Ucar, an associate professor who led the study at the Jackson Laboratory for Genomic Medicine in Farmington, Conn. The research team also found that men, as they age, experience greater inflammation in their blood, which has been associated with severe cases of Covid-19.

. . .

Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine, looked at the blood of men and women between the ages of 65 and 95 and found protein levels changed at different rates. Less change means more stability, he said. Men’s levels changed far more than women’s, with 600 significant changes versus 277 for women, according to the study, published in December.

“The female biology seems to be more stable than men’s,” says Dr. Barzilai, the author of “Age Later” who specializes in geroscience.

For the full story, see:

Clare Ansberry. “Women and Men Age Differently—-And in More Ways Than Just Longevity.” The Wall Street Journal (Wednesday, July 15, 2020): A13.

(Note: ellipsis added.)

(Note: the online version of the story has the date July 14, 2020, and has the title “Women and Men Age Differently—in More Ways Than Just Longevity.” The last couple of paragraphs quoted above, appeared in the online, but not the print, version of the article.)

The “recent study” mentioned above is:

Márquez, Eladio J., Cheng-han Chung, Radu Marches, Robert J. Rossi, Djamel Nehar-Belaid, Alper Eroglu, David J. Mellert, George A. Kuchel, Jacques Banchereau, and Duygu Ucar. “Sexual-Dimorphism in Human Immune System Aging.” Nature Communications 11, Article #751 (Feb. 6, 2020): 1-17.

The book by Barzilai, mentioned above, is:

Barzilai, Nir. Age Later: Health Span, Life Span, and the New Science of Longevity. New York: St. Martin’s Press, 2020.

Cancer Mortality Declines Mainly Due to Less Smoking and Better Lung Cancer Treatment

(p. A12) . . . the American Cancer Society reported that the United States had experienced the sharpest one-year drop in cancer death rate ever recorded, . . . .

. . .

The society’s latest annual report on cancer statistics, released on Wednesday, noted that the death rate had dropped steadily over 26 years, from 1991 to 2017. The largest single-year decline ever reported, when the rate fell 2.2 percent, occurred from 2016 to 2017.

. . .

Experts attributed the decline in mortality to reduced smoking rates and to advances in lung cancer treatment. New therapies for melanoma of the skin have also helped extend life for many people with metastatic disease, or cancer that has spread to other parts of the body.

For the full story, see:

Michael Levenson. “Cancer Death Fell Sharply, And Trump Took Credit.” The New York Times (Monday, January 13, 2020): A12.

(Note: ellipses added.)

(Note: the online version of the story has the date Jan. 12, 2020 and has the title “Trump Took Credit for Lower Cancer Death Rates. Advocates Say Not So Fast.” Where there was a minor wording difference between the print and online versions, the quotation above follows the online version. )

The report from the American Cancer Society, mentioned above, is:

Siegel, Rebecca L., Kimberly D. Miller, and Ahmedin Jemal. “Cancer Statistics, 2020.” CA: A Cancer Journal for Clinicians 70, no. 1 (2020): 7-30.

Those in Their 80s, Ceteris Paribus, Less Likely to Be Offered Bypass Surgery

(p. B6) A U.S. study out Wednesday finds that heart attack patients who turned 80 within the previous two weeks were less likely to get bypass surgery than those who were two weeks shy of that birthday, even though the age difference is less than a month.

Guidelines do not limit the operation after a certain age, but doctors may be mentally classifying people as being “in their 80s” and suddenly much riskier than those “in their 70s,” said the study leader, Dr. Anupam Jena of Harvard Medical School.

. . .

Death rates during the first two months after the heart attack were higher among those over 80, suggesting they might have been harmed by not being offered surgery, Jena said.

For the full story, see:

Marilynn Marchione / The Associated Press. “80 Is Not the New 70: Study Finds That Your Age May Bias Heart Care.” The Omaha World-Herald (Wednesday, February 20, 2020): 3A.

(Note: ellipsis added.)

(Note: the online version of the story has the same date as the print version, and has the title “80 Is Not the New 70: Age May Bias Heart Care, Study Finds.” Where there are slight differences in the wording of the online and print versions, the passages quoted above follow the online version.)

“Dr. Dyson’s Mind Burned Until the End”

(p. B12) Freeman J. Dyson, a mathematical prodigy who left his mark on subatomic physics before turning to messier subjects like Earth’s environmental future and the morality of war, died on Friday [February 28, 2020] at a hospital near Princeton, N.J. He was 96.

. . .

As a young graduate student at Cornell University in 1949, Dr. Dyson wrote a landmark paper — worthy, some colleagues thought, of a Nobel Prize — that deepened the understanding of how light interacts with matter to produce the palpable world. The theory the paper advanced, called quantum electrodynamics, or QED, ranks among the great achievements of modern science.

. . .

Dr. Dyson called himself a scientific heretic and warned against the temptation of confusing mathematical abstractions with ultimate truth.

. . .

Relishing the role of iconoclast, he confounded the scientific establishment by dismissing the consensus about the perils of man-made climate change as “tribal group-thinking.” He doubted the veracity of the climate models, and he exasperated experts with sanguine predictions they found rooted less in science than in wishfulness: Excess carbon in the air is good for plants, and global warming might forestall another ice age.

In a profile of Dr. Dyson in 2009 in The New York Times Magazine, his colleague Steven Weinberg, a Nobel laureate, observed, “I have the sense that when consensus is forming like ice hardening on a lake, Dyson will do his best to chip at the ice.”

Dr. Dyson’s distrust of mathematical models had earlier led him to challenge predictions that the debris from atomic warfare could blot out the sun and bring on a devastating nuclear winter. He said he wished that were true — because it would add to the psychological deterrents to nuclear war — but found the theory wanting.

For all his doubts about the ability of mortals to calculate anything so complex as the effects of climate change, he was confident enough in our toolmaking to propose a technological fix: If carbon dioxide levels became too high, forests of genetically altered trees could be planted to strip the excess molecules from the air. That would free scientists to confront problems he found more immediate, like the alleviation of poverty and the avoidance of war.

He considered himself an environmentalist. “I am a tree-hugger, in love with frogs and forests,” he wrote in 2015 in The Boston Globe. “More urgent and more real problems, such as the overfishing of the oceans and the destruction of wildlife habitat on land, are neglected, while the environmental activists waste their time and energy ranting about climate change.” That was, to say the least, a minority position.

. . .

Richard Feynman, a young professor at Cornell, had invented a novel method to describe the behavior of electrons and photons (and their antimatter equivalent, positrons). But two other physicists, Julian Schwinger and Sin-Itiro Tomonaga, had each independently devised a very different way. Each of these seemed to satisfy the requirements of both quantum mechanics and special relativity — two of nature’s acid tests. But which one was correct?

While crossing Nebraska on a Greyhound bus, Dr. Dyson was struck by an epiphany: The theories were mathematically equivalent — different ways of saying the same thing. The result was QED. Feynman called it “the jewel of physics — our proudest possession.”

. . .

Dr. Dyson’s mind burned until the end. In 2012, when he was 88, he collaborated with William H. Press on a paper about the prisoner’s dilemma, a mathematical concept important to understanding human behavior and the nature of evolution.

In his 90s, Dr. Dyson was still consulting for the government — on nuclear reactor design and the new gene-editing technology called CRISPR. In 2018, the year he turned 95, his book “Maker of Patterns: An Autobiography Through Letters” was published.

For the full obituary, see:

George Johnson. “Freeman Dyson, 96, Math Genius, Tech Visionary and Writer, Is Dead.” The New York Times (Saturday, February 29, 2020): B12.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the obituary has the date Feb. 28, 2020, and has the title “Freeman Dyson, Math Genius Turned Visionary Technologist, Dies at 96.”)

Rapamycin Will Be Tested to Extend Lifespan of Dogs

(p. 1A) SEATTLE (AP) — Can old dogs teach us new tricks? Scientists are looking for 10,000 pets for the largest-ever study of aging in canines. They hope to shed light on human longevity too.

The project will collect a pile of pooch data: vet records, DNA samples, gut microbes and information on food and walks. Five hundred dogs will test a pill that could slow the aging process.

“What we learn will potentially be good for dogs and has great potential to translate to human health,” said project co-director Daniel Promislow of the University of Washington School of Medicine.

. . .

(p. 2A) Dogs weighing at least 40 pounds will be eligible for an experiment with rapamycin, now taken by humans to prevent rejection of transplanted kidneys. The drug has extended lifespan in mice. A small safety study in dogs found no dangerous side effects, said project co-director Matt Kaeberlein of the University of Washington.

For the full story, see:

Carla K. Johnson of The Associated Press. “Needed: 10,000 Dogs for Project That Could Also Benefit Humans.” Omaha World-Herald (Thursday, Nov. 15, 2019): 1A-2A.

(Note: ellipsis added.)

(Note: the online version of the story has the date Nov. 17 [sic], 2019, and has the title “Old dogs, new tricks: 10,000 pets needed for science.”)

“Rejuvenate Bio” Startup Succeeds in Using Gene Therapy to Fight Age-Related Diseases in Mice

The online PNAS article mentioned below includes the information that one of the article’s referees was Aubrey de Grey, Cambridge scientist, and co-author of The End of Aging. Aubrey de Grey has been arguing for many years that anti-aging research will only take-off when proof-of-concept is achieved with mice. The PNAS article summarized below, appears to provide that proof-of-concept.

(p. A13) North Grafton, Mass.

A Cavalier King Charles spaniel named Shadow was at the front lines of a new approach to gene therapy.

Earlier this month, 7-year-old Shadow was the first dog to be screened at Tufts University for a pilot study attempting to use gene therapy to treat a type of heart disease that often afflicts aging cavaliers.

It’s part of a novel approach to gene therapy that has successfully treated age-related ailments in mice. Now it is being studied in dogs, with eventual hopes to test it in humans.

Researchers reported their success in mice in a study published Monday [Nov. 4, 2019] in the journal PNAS. They treated four age-related diseases in mice using genetic therapy: heart and kidney failure, Type 2 diabetes and obesity. On average, the mice experienced a 58% increase in heart function, a 75% reduction in kidney degradation, and normalized weight and blood-sugar levels in mice fed a high-fat diet, the study found.

. . .

What’s interesting about the new research in mice is that it is broader—targeting not a single rare defect, but common age-related ailments. The experiments injected mice with DNA to create an extra copy of a healthy gene, expressing more healthy material in cells linked to common diseases of aging.

The goal of the biotech company behind the mice study, Rejuvenate Bio —which sprang from research out of the lab of Harvard geneticist George Church, who is a co-founder—is to treat multiple aging-related diseases in dogs. It recently started working with Tufts University’s Cummings School of Veterinary Medicine on the dog pilot. If successful in dogs, the company hopes to treat similar human diseases but says that will take a lot more resources and time.

The firm says it expects the cost of dog genetic therapies would be similar to dog cancer treatments, including surgery, which range from about $500 to $8,000.

. . .

Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York City, praised the PNAS study as a proof of concept . . .

For the full story, see:

Sumathi Reddy. “YOUR HEALTH; Gene Therapy Targets Aging.” The Wall Street Journal (Tuesday, Nov. 4, 2019): A13.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the story has the date Nov. 4, 2019, and has the title “YOUR HEALTH; A New Approach to Gene Therapy—Now In Dogs, Maybe Later In Humans.”)

The PNAS article, summarized in the passages quoted above, is:

Davidsohn, Noah, Matthew Pezzone, Andyna Vernet, Amanda Graveline, Daniel Oliver, Shimyn Slomovic, Sukanya Punthambaker, Xiaoming Sun, Ronglih Liao, Joseph V. Bonventre, and George M. Church. “A Single Combination Gene Therapy Treats Multiple Age-Related Diseases.” Proceedings of the National Academy of Sciences (PNAS) (Nov. 4, 2019): https://doi.org/10.1073/pnas.1910073116.

The book co-authored by Aubrey de Grey, and mentioned way above, is:

de Grey, Aubrey, and Michael Rae. Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime. New York: St. Martin’s Press, 2007.