Category: Aging

Pharmaceutical Entrepreneur Solomon Got Rich by Finding a Drug to Help His Son

(p. A19) Howard Solomon was building the pharmaceutical company Forest Laboratories, not by manufacturing drugs but by licensing them. In his search for deals in the United States and Europe, he learned about citalopram, a Danish antidepressant. He did not license it, though, believing the U.S. market was saturated with drugs to treat depression.

Then, in 1994, a family crisis intervened: His older son, the writer Andrew Solomon, had fallen into a deep depression. Mr. Solomon moved Andrew into his apartment on the Upper East Side of Manhattan and took weeks off from work to take care of him; . . . .

. . .

After two types of antidepressants were unable to help Andrew, a third did. His experience persuaded his father to make the deal a few years later for citalopram, which, under the name Celexa, became a billion-dollar drug for Forest Labs in the class of selective serotonin reuptake inhibitors, along with Prozac, Zoloft and Paxil.

. . .

Forest Labs was transformed by licensing Celexa from H. Lundbeck, the Danish company that developed it. But Lundbeck’s chief executive, Erik Sprunk-Jansen, was initially reluctant to speak to Mr. Solomon because licensing deals with some other U.S. companies had unraveled.

“Howard flew to Denmark to meet with him,” Phil Satow, a former executive vice president of Forest Labs, said in a phone interview. “Both were lovers of ballet, which became the common chord between them, and they developed a strong relationship.”

Celexa’s sales grew quickly, peaking at nearly $1.5 billion in 2003. Forest Labs then licensed Lexapro, an upgraded version of Celexa, which first reached $2 billion in sales in 2007.

. . .

His desire to work into his 80s was, he said, inspired by the example of Giuseppe Verdi.

“Growing up, he’d talk about Verdi writing ‘Falstaff’ in his 80s,” Andrew Solomon said. “‘Imagine that,’ he’d say, ‘in his 80s, he wrote some of the greatest music ever written.’ That was the path he hoped to follow.”

For the full obituary, see:

Richard Sandomir. “Howard Solomon, 94, Whose Business Feats Were Personal, Is Dead.” The New York Times (Wednesday, January 19, 2022): A19.

(Note: ellipses added.)

(Note: the online version of the obituary was updated Jan. 18, 2022, and has the title “Howard Solomon, 94, Dies; His Business Success Had a Personal Connection.”)

Larry King “Wanted to Stay Alive Forever”

(p. 23) King spent his life dodging death, resistant but haunted by its specter.

. . .

King took four human growth hormone pills every day, hoping they would buy him more time; . . . .

. . .

He deplored the idea of exiting the party while it was still going on, knowing he could never get back in. “Larry wanted to stay alive forever,” his best friend, Herb Cohen, told me. “He didn’t want to leave. He wouldn’t know who won the World Series.”

For the full obituary, see:

Jazmine Hughes. “Larry King.” The New York Times Magazine (Sunday, December 26, 2021): 22-23.

(Note: ellipses added.)

(Note: the online version of the obituary has the date Dec. 22, 2021, and has the title “Did Larry King’s Obsession With Death Fuel His ‘Indomitable’ Will to Live?”)

20 Startups Are Developing Senolytics to Slow Cell Senescence

(p. A17) Some species of tortoises, . . ., have a risk of death that doesn’t seem to change with age in adulthood. Though these wrinkly, lumbering beasts might not seem like ideal ambassadors for aging well, by the statistical definition of aging—how fast your risk of death increases with time—these tortoises hardly age at all.

. . .

A secret of the tortoises’ longevity is that their cells can divide more than twice as many times as human cells before becoming aged or “senescent.”

. . .

Already, therapies to combat cell senescence—senolytics—are undergoing human trials. Senescent cells build up in our bodies as we get older and seem to accelerate the aging process as they accumulate. Drugs and genetic modifications that periodically remove them have been shown to make mice biologically younger: They live longer and healthier than untreated mice, with stronger muscles and hearts; delayed cancer, cataracts and cognitive decline; and even plumper skin and thicker, glossier fur.

There are currently at least 20 startups trying to transfer senolytics from the lab to the clinic. These efforts target specific diseases in which senescent cells are known to be key villains. A company called Unity Biotechnology is targeting these cells to combat age-related sight loss, while a team including scientists at the Mayo Clinic who first demonstrated senolytics in mice is working to use the same drug cocktail to treat age-related lung fibrosis.

The average 80-year-old is suffering from five different diagnoses and taking a similar number of medications to treat them.

Senolytics are the vanguard but close behind are dozens of different ways to slow or reverse aging in the lab, ranging from drugs and diets to gene and stem cell therapies. These treatments intervene in the molecular, cellular and biological underpinnings of the aging process, from the smallest scale in our biology (damage to DNA and protein molecules) to the largest (dysfunction across the immune system). They are aimed at slowing down multiple aspects of the process and at wide-ranging rejuvenation.

There have been some high-profile failures in the field. One was resveratrol, found in grapes and other sources. A company working on resveratrol, Sirtris, was acquired by drug giant GSK for $720 million in 2008 but closed down five years later. The path from lab bench to pill is filled with obstacles, and we can expect further setbacks, but with so many different therapies and a deeper understanding of the biology of aging, at least some of the new ideas are likely to succeed.

For the full commentary, see:

Andrew Steele. “The Best Remedy for Our Diseases? Aging Less.” The Wall Street Journal (Saturday, April 10, 2021): A17.

(Note: ellipses added.)

(Note: the online version of the commentary was updated April 10, 2021, and has the same title as the print version.)

Steele’s commentary, quoted above, is related to his book:

Steele, Andrew. Ageless: The New Science of Getting Older without Getting Old. New York: Doubleday, 2021.

Carolyn Shoemaker Developed Tacit Knowledge of Presence of Comets and Asteroids

(p. B6) Carolyn Shoemaker, who for more than a decade managed a telescopic camera with her husband from a high-altitude observatory in California and became widely regarded, without academic training, as the world’s foremost detector of comets and asteroids, died on Aug. 13 [2021] at a hospital in Flagstaff, Ariz.

. . .

In the afternoons, Dr. Shoemaker would take the film they had used the previous night and develop it in a darkroom, then turn over the negatives to Ms. Shoemaker. Using a stereoscope, she would compare exposures of the same block of sky at different times. If anything moved against the relatively fixed background of stars, it would appear to float in the viewing device’s eyepiece.

Ms. Shoemaker was charged with discerning what was the grain of the film (and perhaps dust on it) and what was an actual image of light emitted by an object hurtling through space. “With time,” she wrote, “I saw fainter and fainter objects.”

It took a few years before she found her first new comet, in 1983. By 1994 she had discovered, in addition to hundreds of asteroids, 32 comets, a number considered by the United States Geological Survey and others to represent the world record at the time.

. . .

One comet, known as Shoemaker-Levy 9 (named in part for their associate David Levy), had stood out from the rest. Rather than making a lonely journey through the cosmic vacuum, Shoemaker-Levy 9 was on a collision course with Jupiter.

. . .

“Carolyn Shoemaker is one of the most revered and respected astronomers in history,” Jennifer Wiseman, a senior scientist overseeing the Hubble Space Telescope, said by phone. “Her discoveries, her tenacious care in how she did her work — those things have created a legacy and a reputation that has inspired people who have come into the field after her.”

. . .

. . . scientists still depend on methods that Ms. Shoemaker perfected.

“She and her colleagues set the stage for how to identify what we would call minor bodies in our solar system, such as comets and asteroids,” Dr. Wiseman said. “We still use the technique of looking for the relatively fast transverse motions of comets and asteroids in our own solar system, as compared to the slower or more fixed position of stars.”

For the full obituary, see:

Alex Traub. “Carolyn Shoemaker, 92, a Stargazer Who Spotted Comets and Asteroids.” The New York Times (Monday, September 6, 2021): B6.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary was updated Sept. 4, 2021, and has the title “Carolyn Shoemaker, Hunter of Comets and Asteroids, Dies at 92.”)

“Anti-Heroism Goes Too Far”

(p. 11) In “Extra Life,” Steven Johnson, a writer of popular books on science and technology, tells the stories behind what he calls, in an understatement, “one of the greatest achievements in the history of our species.” Starting in the second half of the 19th century, the average life span began to climb rapidly, giving humans not just extra life, but an extra life. In rich countries, life expectancy at birth hit 40 by 1880, 50 by 1900, 60 by 1930, 70 by 1960, and 80 by 2010.

. . .

It’s been a long time since the history of technology has been recounted as the triumph of plucky heroes, and Johnson’s stories reflect today’s more sophisticated understanding.

. . .

Sometimes the anti-heroism goes too far — Norman Borlaug, whose Green Revolution saved a billion lives, is unmentioned. But altogether, Johnson is a fine storyteller. Among his cast of characters are John Graunt (1620–74), the British haberdasher who studied mortality reports as a hobby and thereby invented epidemiology; Joseph Bazalgette (1819–91), the man behind “one of the 19th century’s greatest engineering achievements,” which you probably did not guess was the London sewers; “Moldy Mary” Hunt (1910–91), the Peoria bacteriologist who scoured fruit markets for the perfect rotten cantaloupe, the one with a strain of mold that enabled the mass production of penicillin; John Stapp (1910–99), who strapped himself into his invention, the rocket sled, and safely decelerated from 628 miles per hour to 0 in 1.4 seconds; and Dilip Mahalanabis, 86, the Indian pediatrician who discovered that a bit of salt and sugar dissolved in clean water could stop fatal diarrhea and thereby saved the lives of nearly 60 million people.

For the full review, see:

Steven Pinker. “Modern Miracle.” The New York Times Book Review (Sunday, June 13, 2021): 11.

(Note: ellipses added.)

(Note: the online version of the review has the date May [sic] 11, 2021, and has the title “How Humans Gained an ‘Extra Life’.”)

The book under review is:

Johnson, Steven. Extra Life: A Short History of Living Longer. New York: Riverhead Books, 2021.

Risk Averse Family Firms with Large Cash Reserves Can Last 1,000 Years

Is longevity for firms a noble goal? Or do humans usually flourish more in the churn of creative destruction?

(p. B1) KYOTO, Japan — Naomi Hasegawa’s family sells toasted mochi out of a small, cedar-timbered shop next to a rambling old shrine in Kyoto. The family started the business to provide refreshments to weary travelers coming from across Japan to pray for pandemic relief — in the year 1000.

Now, more than a millennium later, a new disease has devastated the economy in the ancient capital, as its once reliable stream of tourists has evaporated. But Ms. Hasegawa is not concerned about her enterprise’s finances.

Like many businesses in Japan, her family’s shop, Ichiwa, takes the long view — albeit longer than most. By putting tradition and stability over profit and growth, Ichiwa has weathered wars, plagues, natural disasters, and the rise and fall of empires. Through it all, its rice flour cakes have remained the same.

Such enterprises may be less dynamic than those in other countries. But their resilience offers lessons for businesses in places like the United States, where the coronavirus has forced tens of thousands into bankruptcy.

“If you look at the economics textbooks, enterprises are supposed to be maximizing profits, scaling up their size, market share and growth rate. But these companies’ operating principles are completely different,” said Kenji Matsuoka, a professor emeritus of business at Ryukoku University in Kyoto.

(p. B5) “Their No. 1 priority is carrying on,” he added. “Each generation is like a runner in a relay race. What’s important is passing the baton.”

Japan is an old-business superpower. The country is home to more than 33,000 with at least 100 years of history — over 40 percent of the world’s total, according to a study by the Tokyo-based Research Institute of Centennial Management. Over 3,100 have been running for at least two centuries. Around 140 have existed for more than 500 years. And at least 19 claim to have been continuously operating since the first millennium.

. . .

The businesses, known as “shinise,” are a source of both pride and fascination.

. . .

Most of these old businesses are, like Ichiwa, small, family-run enterprises that deal in traditional goods and services. But some are among Japan’s most famous companies, including Nintendo, which got its start making playing cards 131 years ago, and the soy sauce brand Kikkoman, which has been around since 1917.

. . .

The Japanese companies that have endured the longest have often been defined by an aversion to risk — shaped in part by past crises — and an accumulation of large cash reserves.

It is a common trait among Japanese enterprises and part of the reason that the country has so far avoided the high bankruptcy rates of the United States during the pandemic. Even when they “make some profits,” said Tomohiro Ota, an analyst at Goldman Sachs, “they do not increase their capital expenditure.”

Large enterprises in particular keep substantial reserves to ensure that they can continue issuing paychecks and meet their other financial obligations in the event of an economic downturn or a crisis. But even smaller businesses tend to have low debt levels and an average of one to two months of operating expenses on hand, Mr. Ota said.

For the full story, see:

Ben Dooley and Hisako Ueno. “A Family Business Got Its Start In a Pandemic (1,000 Years Ago).” The New York Times (Saturday, December 5, 2020): B1 & B5.

(Note: ellipses added.)

(Note: the online version of the story was updated Jan. 7, 2021, and has the title “This Japanese Shop Is 1,020 Years Old. It Knows a Bit About Surviving Crises.”)

Older Americans Shifting to Entrepreneurship at Faster Pace

(p. B6) In April [2020], Dave Summers lost his job as director of digital media productions at the American Management Association, a casualty of layoffs brought on by the pandemic.

Mr. Summers, 60, swiftly launched his own business as a digital media producer, coach and animator who creates podcasts, webcasts and video blogs.

And in September, he and his wife, who teaches nursery school, moved from Danbury, Conn., to Maryville, Tenn., which they discovered while visiting their son in Nashville. “My new work is all virtual, so I can live anywhere,” he said. “Not only is it a cheaper place to live, we love hiking and the outdoors, and our new town is in the foothills of the Great Smoky Mountains.”

Droves of small businesses have been shuttered by the economic fallout of the coronavirus, but for Mr. Summers, starting a new one was the best option.

“I’m not sitting on a massive nest egg, so I need to work to keep afloat,” he said. “It’s also about being healthy and happy. I can’t just retire because underneath it all I’m creative, and I have to be busy doing stuff and helping people tell their stories.”

While the coronavirus pandemic is causing many older workers who have lost jobs, or who have been offered early retirement severance packages, to decide to leave the work force, others like Mr. Summers are shifting to entrepreneurship.

In fact, older Americans had already been starting new businesses at a fast rate. In 2019, research from the Kauffman Foundation, a nonpartisan group supporting entrepreneurship, found that more than 25 percent of new entrepreneurs were ages 55 to 64, up from about 15 percent in 1996.

Across the age spectrum, there has been a rise in new business start-ups since May [2020], according to the Census Bureau. The surge is likely “powered by newly unemployed individuals opting to start their own businesses, either by choice or out of necessity,” according to the Economic Innovation Group, a bipartisan public policy organization.

. . .

It turns out that the importance of entrepreneurship, or self-employment as a form of work, increases significantly with age, according to a report by Cal J. Halvorsen and Jacquelyn B. James of the Center on Aging & Work at Boston College.

According to the report: “While about one in six workers in their 50s are self-employed, nearly one in three are self-employed in their late 60s and more than 1 in 2 workers over the age of 80 are self-employed.

For the full story, see:

Kerry Hannon. “Older Americans Make a New Start in a Business of Their Own.” The New York Times (Friday, November 27, 2020): B6.

(Note: ellipsis, and bracketed year, added.)

(Note: the online version of the story has the date Oct. [sic] 21, 2020, and has the title “Making a New Start in a Business of Their Own.”)

Grandma Wong Waves a Union Jack as “a Symbol of the Rights Protected by the British Government”

(p. A11) HONG KONG — When protests swept Hong Kong last year, Alexandra Wong, better known as “Grandma Wong,” always seemed to be there. Day after day, she stood out among the hundreds of thousands of demonstrators as a small woman with short gray hair waving a large British flag.

Then, during a few tumultuous days in August [2020] when the police fired tear gas in a subway station and protesters shut down the city’s airport, Ms. Wong, 64, suddenly vanished.

. . .

Ms. Wong said she had been detained while crossing the border between Hong Kong and Shenzhen on Aug. 14, and spent 15 days in administrative detention without being told of her crimes. Investigators grilled her about the protests, the British flag and whether she used violence, she said. They showed her photos of protesters and asked her if she knew them.

. . .

She was eventually released on a form of bail that prevented her from leaving Shenzhen.

. . .

Before she was released, she said, she was forced to say on video that she had not been abused while in custody, that she would not talk to the news media about her experience and that she would never protest again.

Last month, one full year after the initial bail period began, she was given the necessary paperwork allowing her to leave Shenzhen and return to Hong Kong.

. . .

For Ms. Wong, protesting now comes with greater risks. Waving a Union Jack — in her mind a symbol of the rights protected by the British government, not an endorsement of colonialism — has become “very dangerous,” she said. But detention has only strengthened her resolve for democracy.

Despite the pledges she made under duress, she continues to protest, and recently took the subway for an hour to the northeast corner of Hong Kong Island, where a trial is scheduled to begin for six young demonstrators charged with illegal assembly.

She walked to the courthouse carrying a handwritten sign: “Save HK Youths.”

For the full story, see:

Austin Ramzy. “After Vanishing in August, ‘Grandma Wong’ Returns to Hong Kong Protests.” The New York Times (Wednesday, November 11, 2020): A11.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story was updated Nov. 12, 2020, and has the title “Hong Kong Protest Icon Mysteriously Vanished. Then She Returned, Unbowed.”)


2,000-Year-Old Seeds Sprout “Long-Lost Judean Dates”

(p. A8) KETURA, Israel — The plump, golden-brown dates hanging in a bunch just above the sandy soil were finally ready to pick.

They had been slowly ripening in the desert heat for months. But the young tree on which they grew had a much more ancient history — sprouting from a 2,000-year-old seed retrieved from an archaeological site in the Judean wilderness.

. . .

These were the much-extolled but long-lost Judean dates, and the harvest this month was hailed as a modern miracle of science.

. . .

. . ., to bring something back to life from dormancy is so symbolic,” Dr. Sallon said. “To pollinate and produce these incredible dates is like a beam of light in a dark time.”

. . .

The research was peer reviewed and detailed in a paper published in February this year in Science Advances, a leading scientific journal.

For the full story, see:

Isabel Kershner. “Israel Dispatch: After 2,000 Years in the Wilderness, It’s a Date. And It’s Delicious.” The New York Times (Monday, September 7, 2020): A8.

(Note: ellipses added.)

(Note: the online version of the story has the same date as the print version, and has the title “Israel Dispatch: Aided by Modern Ingenuity, a Taste of Ancient Judean Dates.”)

The paper in Science Advances mentioned above is:

Sallon, Sarah, Emira Cherif, Nathalie Chabrillange, Elaine Solowey, Muriel Gros-Balthazard, Sarah Ivorra, Jean-Frédéric Terral, Markus Egli, and Frédérique Aberlenc. “Origins and Insights into the Historic Judean Date Palm Based on Genetic Analysis of Germinated Ancient Seeds and Morphometric Studies.” Science Advances 6, no. 6 (Feb. 5, 2020), DOI: 10.1126/sciadv.aax0384.

After Age 65, Men Lose More “Antibody-Producing B Cells” Than Women Lose

(p. B5) By examining gender-based distinctions in the immune system, cell structure, brain and other systems, researchers are discovering how and why men and women grow older in clearly different ways.

Their findings could help explain why Covid-19 has had a greater impact on older men than older women. A recent study found that men, after the age of 65, lost important antibody-producing B cells in the blood, while women didn’t.

“It was surprising,” said Duygu Ucar, an associate professor who led the study at the Jackson Laboratory for Genomic Medicine in Farmington, Conn. The research team also found that men, as they age, experience greater inflammation in their blood, which has been associated with severe cases of Covid-19.

. . .

Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine, looked at the blood of men and women between the ages of 65 and 95 and found protein levels changed at different rates. Less change means more stability, he said. Men’s levels changed far more than women’s, with 600 significant changes versus 277 for women, according to the study, published in December.

“The female biology seems to be more stable than men’s,” says Dr. Barzilai, the author of “Age Later” who specializes in geroscience.

For the full story, see:

Clare Ansberry. “Women and Men Age Differently—-And in More Ways Than Just Longevity.” The Wall Street Journal (Wednesday, July 15, 2020): A13.

(Note: ellipsis added.)

(Note: the online version of the story has the date July 14, 2020, and has the title “Women and Men Age Differently—in More Ways Than Just Longevity.” The last couple of paragraphs quoted above, appeared in the online, but not the print, version of the article.)

The “recent study” mentioned above is:

Márquez, Eladio J., Cheng-han Chung, Radu Marches, Robert J. Rossi, Djamel Nehar-Belaid, Alper Eroglu, David J. Mellert, George A. Kuchel, Jacques Banchereau, and Duygu Ucar. “Sexual-Dimorphism in Human Immune System Aging.” Nature Communications 11, Article #751 (Feb. 6, 2020): 1-17.

The book by Barzilai, mentioned above, is:

Barzilai, Nir. Age Later: Health Span, Life Span, and the New Science of Longevity. New York: St. Martin’s Press, 2020.

Cancer Mortality Declines Mainly Due to Less Smoking and Better Lung Cancer Treatment

(p. A12) . . . the American Cancer Society reported that the United States had experienced the sharpest one-year drop in cancer death rate ever recorded, . . . .

. . .

The society’s latest annual report on cancer statistics, released on Wednesday, noted that the death rate had dropped steadily over 26 years, from 1991 to 2017. The largest single-year decline ever reported, when the rate fell 2.2 percent, occurred from 2016 to 2017.

. . .

Experts attributed the decline in mortality to reduced smoking rates and to advances in lung cancer treatment. New therapies for melanoma of the skin have also helped extend life for many people with metastatic disease, or cancer that has spread to other parts of the body.

For the full story, see:

Michael Levenson. “Cancer Death Fell Sharply, And Trump Took Credit.” The New York Times (Monday, January 13, 2020): A12.

(Note: ellipses added.)

(Note: the online version of the story has the date Jan. 12, 2020 and has the title “Trump Took Credit for Lower Cancer Death Rates. Advocates Say Not So Fast.” Where there was a minor wording difference between the print and online versions, the quotation above follows the online version. )

The report from the American Cancer Society, mentioned above, is:

Siegel, Rebecca L., Kimberly D. Miller, and Ahmedin Jemal. “Cancer Statistics, 2020.” CA: A Cancer Journal for Clinicians 70, no. 1 (2020): 7-30.