Category: Books

Monarch Butterflies Thrive on Poisonous Milkweed

(p. D5) The caterpillar of the monarch butterfly eats only milkweed, a poisonous plant that should kill it. The caterpillars thrive on the plant, even storing its toxins in their bodies as a defense against hungry birds.

For decades, scientists have marveled at this adaptation. On Thursday [Oct. 3, 2019 [sic]), a team of researchers announced they had pinpointed the key evolutionary steps that led to it.

Only three genetic mutations were necessary to turn the butterflies from vulnerable to resistant, the researchers reported in the journal Nature. They were able to introduce these mutations into fruit flies, and suddenly they were able to eat milkweed, too.

Biologists hailed it as a tour-de-force that harnessed gene-editing technology to unscramble a series of mutations evolving in some species and then test them in yet another.

“The gold standard is to directly test mutations in the organism,” said Joseph W. Thornton, an evolutionary biologist at the University of Chicago. The new study “finally elevates our standards.”

For the full story see:

Carl Zimmer. “MATTER; How Monarch Butterflies Evolved to Eat Poison.” The New York Times (Tuesday, October 8, 2019 [sic]): D5.

(Note: bracketed date added.)

(Note: the online version of the story was updated Oct. 3, 2019 [sic], and has the title “MATTER; These Butterflies Evolved to Eat Poison. How Could That Have Happened?”)

The article in Nature mentioned above is:

Karageorgi, Marianthi, Simon C. Groen, Fidan Sumbul, Julianne N. Pelaez, Kirsten I. Verster, Jessica M. Aguilar, Amy P. Hastings, Susan L. Bernstein, Teruyuki Matsunaga, Michael Astourian, Geno Guerra, Felix Rico, Susanne Dobler, Anurag A. Agrawal, and Noah K. Whiteman. “Genome Editing Retraces the Evolution of Toxin Resistance in the Monarch Butterfly.” Nature 574, no. 7778 (Oct. 2019): 409–12.

The “corresponding author” (often considered the primary author) of the article is Noah K. Whiteman, who has published a book that extensively discusses cases such as the monarch butterfly, where a creature has evolved the ability to consume or make use of chemicals that are poisonous to other creatures:

Whiteman, Noah. Most Delicious Poison: The Story of Nature’s Toxins―from Spices to Vices. New York: Little, Brown Spark, 2023.

Tax Universities to Offset Their Negative Externalities?

(p. A11) What can we do about the corruption of American higher education? Milton Friedman had an idea 20 years ago: Tax the schools rather than subsidize them. That reflected a change of heart. In “Capitalism and Freedom” (1960), he argued that college education had enough “positive externalities” to justify subsidies. But when I was researching a book in 2003, I emailed him (then 91) and asked if he still believed that.

He replied: “I have not changed my view that higher education has some positive externality, but I have become much more aware that it also has negative externalities. I am much more dubious than I was . . . that there is any justification at all for government subsidy of higher education. The spread of PC”—political correctness—“would seem to be a very strong negative externality, and certainly the 1960s student demonstrations were negative externalities. . . . A full analysis along those lines might lead you to conclude that higher education should be taxed to offset its negative externalities.”

For the full commentary, see:

Richard Vedder. “Harvard Should Pay Its Fair Share.” The Wall Street Journal (Saturday, Dec. 23, 2023): A11.

(Note: ellipses in original.)

(Note: the online version of the commentary has the date December 22, 2023, and has the same title as the print version.)

Friedman’s book mentioned above is:

Friedman, Milton. Capitalism and Freedom. Chicago: The University of Chicago Press, 1962.

Dick Nunis Was Resolved That Walt Disney’s “Dreams Would Live On”

(p. C3) When Disneyland opened in 1955, it was, in many ways, a disaster: There were rides out of service, restaurants that ran out of food, soft asphalt that consumed the heels of women’s shoes—all of it broadcast on national television.

Little wonder, then, that there was trepidation as the Walt Disney company approached the 1971 opening of the far more ambitious Walt Disney World, especially as the word spread that it might not open in time. So, when Dick Nunis, the head of operations at the parks in Anaheim and Orlando, took control of the project, he was given carte blanche to do whatever it took to open the gates on Oct. 1.

. . .

Nunis, who died Dec. 13 [2023] at the age of 91, fired contractors who got in the way, held meetings at 5 a.m. and put signs up all over the property that said the park would open on Oct. 1. He made sure construction workers knew that their families were invited to the park a week before opening. He flew palm trees in on helicopters the night before the gates opened.

Not only did he understand the logistics of what it would take to hire thousands of employees, motivate construction workers and oversee the myriad details of opening a resort, he had worked closely with Walt Disney for a decade and knew how the company’s founder and creative visionary—who had been dead for almost five years—would have wanted it done.

“He understood the culture that Walt wanted there,” said Sandy Quinn, who started as marketing director of the resort years before it opened. “Walt didn’t want employees, he wanted a cast. He didn’t want customers, he wanted guests. They weren’t uniforms, they were costumes. And it was a mindset.”

Nunis didn’t just get the Magic Kingdom and the first phase of Disney World open as planned. He spent his 44-year career at Disney opening and overseeing parks around the world, and acting as a steward of Walt Disney’s philosophies as the company grew in the decades after his death in 1966.

. . .

“I had no idea at the time, but in those early years with Walt, he was looking for someone he could mentor by nurturing, challenging, and testing, to ensure that his ideals and those dreams would live on,” Nunis wrote in his memoir. “He was looking for an ‘apprentice.’ As that apprentice, my role and my life expanded beyond what I had ever imagined.”

. . .

Mary Nunis said that although the couple visited Walt Disney World on occasion after he retired, he didn’t walk the park as he had for the more than 40 years he was with the company, which she believed was because he wouldn’t be able to handle seeing something he wanted to change and not be able to change it. But he remained fiercely loyal to Walt Disney and his ideas.

“He just loved Walt Disney,” Mary Nunis said, “and knew that dream was what he wanted to try to maintain.”

For the full obituary, see:

Chris Kornelis. “Dick Nunis Got the Magic Kingdom Open.” The Wall Street Journal (Saturday, Jan. 6, 2024): A10.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary has the date January 5, 2024, and has the title “Dick Nunis, Walt Disney’s ‘Apprentice’ Who Got the Magic Kingdom Open, Dies at 91.”)

Nunis’s memoir, mentioned above, is:

Nunis, Dick. Walt’s Apprentice: Keeping the Disney Dream Alive. Los Angeles: Disney Editions, 2022.

Mountains Are Not Sublime if You Need a Plain to Survive

(p. 13) Most of the people who have lived on this planet since the invention of agriculture have been peasants.

. . .

The cultivators, it is often assumed, are dreadfully uncultivated. And this alleged lack of sophistication has made them fair game for every kind of depredation. The food they produce has been expropriated by their overlords, by marauding armies and by totalitarian states. They have been conscripted as cannon fodder; entangled in debt and dependency as sharecroppers and serfs; starved, sometimes deliberately, in famines and prisons; forcibly converted to their masters’ religions; herded onto collective farms and slaughtered mercilessly when they revolt.

. . .

. . . very few of the countless millions who have eked a living from the land left enduring accounts of their own lives.

“This,” Joyce wrote, “is a world of a very ancient form of silence, peasant silence, something enmeshed in cultures that are largely oral in nature.”

. . .

“The wild as our sublime,” he writes, “makes no sense to the peasant.” (Joyce cites a Polish peasant interviewed in the 1960s who said, “I like it where the plain is; when I was in America I saw a mountain, and this was an awful view.”)

. . .

Joyce shows how the supreme value of the peasant is generational survival: The great task is to hand on to the child the land the peasant has inherited, making one’s own existence a kind of interlude between past and future.

For the full review, see:

Fintan O’Toole. “Fanfare for the Common Man.” The New York Times Book Review (Sunday, March 10, 2024): 13.

(Note: ellipses added.)

(Note: the online version of the review was updated Feb. 28, 2024, and has the title “A Love Song to His Roots.”)

The book under review above is:

Joyce, Patrick. Remembering Peasants: A Personal History of a Vanished World. New York: Scribner, 2024.

“Troublemaker” Finally Convinced Peers That Hub Trees Distribute Resources to Kin

(p. C7) Over the years, Ms. Simard encountered no shortage of pushback. Government bureaucrats were reluctant to spend money on her recommendations. Her managers resisted changing their forestry models and perhaps “couldn’t listen to women,” labeling her a “troublemaker.” Fellow scientists challenged her research methods. This last may have originated in envy, but ultimately is an important part of the scientific process—after all, without stringent vetting, we might still believe that Vulcan is, indeed, a planet. Today Ms. Simard’s research is widely accepted. We now know that through fungal networks trees share resources, that mature trees (what she calls “hub trees” in her research, and “mother trees” when speaking to popular audiences) support seedlings, favor their kin and distribute resources, even in death. It’s a radical new understanding of plants.

For the full review, see:

Eugenia Bone. “Seeing the Forest.” The Wall Street Journal (Saturday, May 8, 2021 [sic]): C7.

(Note: the online version of the review has the date May 7, 2021 [sic], and has the title “‘Finding the Mother Tree’ Review: Seeing the Forest.”)

The book under review is:

Simard, Suzanne. Finding the Mother Tree: Discovering the Wisdom of the Forest. New York: Knopf, 2021.

Non-Drug Treatments Are Under-Studied Because They Are Hard to Patent, and Hard to Test in Randomized Clinical Trials

(p. C3) In particular, decades of research show that mental, physical and social stimulation is one of the potential ways to ward off Alzheimer’s disease.

. . .

All of these findings come from observational studies that look at people’s existing lifestyle and cognitive health, as opposed to providing them with a “lifestyle treatment” and then assessing cognitive outcomes. The gold standard in modern medicine is randomized, blind, placebo-controlled trials, which are more quantifiable and objective, and there have been few such trials of lifestyle treatments for dementia and Alzheimer’s.

Those that exist have shown disparate results. For example, a study published in the journal Applied Neuropsychology in 2003 found that while mental drills could train people to do better on specific tasks like recalling words from a list, the effect didn’t translate into overall cognitive improvement. Clinical trials on social engagement are currently lacking.

One reason why the cognitive benefits of lifestyle enrichment haven’t been sufficiently studied is that nonpharmacological treatments such as physical exercise can’t be easily patented, so pharmaceutical companies aren’t interested in investing. It’s also difficult to use placebos. In drug trials, a look-alike sugar pill and a test drug are randomly assigned to participants, but there’s no equivalent of a sugar pill for enrichment activities. Instead, the control group either receives no intervention, a fact that can’t be easily hidden to avoid bias, or they receive some other interventions that may have effects of their own and muddle trial results.

For the full essay, see:

Han Yu. “An Active Lifestyle Can Help To Ward Off Alzheimer’s.” The Wall Street Journal (Saturday, Feb. 27, 2021 [sic]): C3.

(Note: ellipsis added.)

(Note: the online version of the essay has the date February 25, 2021 [sic], and has the title “Can an Active Lifestyle Help Ward Off Alzheimer’s?”)

The essay quoted above is adapted from Yu’s book is:

Yu, Han. Mind Thief: The Story of Alzheimer’s. New York: Columbia University Press, 2021.

Chernow Channels McCloskey’s Index Card Advice

In her wonderful paper on how to research well and write clearly, Deirdre McCloskey suggests that we always carry with us a pack of 4 by 6 cards, so that we have them handy when we are hit by an epiphany or hear a relevant quote. (The suggestion probably also appears in the later book versions of her wonderful paper, but I do not have a copy handy to check.)

(p. C11) Mr. Chernow usually spends about twice as much time researching a book as writing it. He types up his research on a computer, so that he has it backed up, and then prints out the individual entries on paper with perforated edges that he can tear into 4-by-6-inch cards. (He was inspired to use index cards by Vladimir Nabokov, who wrote his novels on them.) He then files the cards chronologically and indexes them. His research on Grant fills some 25,000 cards packed into 22 boxes, all stacked up in the office of his Brooklyn brownstone under a big abstract painting.

For the full interview, see:

Alexandra Wolfe. “WEEKEND CONFIDENTIAL; Ron Chernow.” The Wall Street Journal (Saturday, Sept. 16, 2017 [sic]): C11.

(Note: the online version of the interview has the date Sept. 15, 2017 [sic], and has the title “WEEKEND CONFIDENTIAL; Ron Chernow’s New Chapter: Ulysses S. Grant.”)

The main Chernow book discussed in the interview is:

Chernow, Ron. Grant. New York: The Penguin Press, 2017.

McCloskey’s wonderful paper, mentioned above, is:

McCloskey, Deirdre. “Economical Writing.” Economic Inquiry 23, no. 2 (April 1985): 187-222.

Private-Sector Experimentation Versus Washington Inertia in the Fight for Longer Life

(p. A15) Amid today’s technological wizardry, it’s easy to forget that several decades have passed since a single innovation has dramatically raised the quality of life for millions of people. Summoning a car with one’s phone is nifty, but it pales in comparison with discovering penicillin or electrifying cities. Artificial intelligence is being heralded as the next big thing, but a cluster of scientists, technologists and investors are aiming higher. In the vernacular of Silicon Valley, where many of them are based, their goal is nothing less than disrupting death, and their story is at the center of “Immortality, Inc.” by science journalist Chip Walter.

. . .

That is the backdrop to Mr. Walter’s absorbing story, which he begins with a visit to Alcor, the Arizona-based organization that says it preserves corpses at minus 124 degrees Celsius “in an attempt to maintain brain viability after the heart stops.” (Current “patients” include baseball legend Ted Williams.) While this life-extending strategy, known as “cryonics,” is often ridiculed, the individuals profiled in “Immortality, Inc.” are high-status, highly regarded figures whose initiatives can’t be easily dismissed. What links them, writes Mr. Walter, is that “they are all troublemakers at heart.” They believe that the “conventional approaches” of most medical researchers and practitioners are, “at the very least, misguided.”

. . .

While “Immortality, Inc.” is focused on aging and the efforts to defy it, the book is also a gripping chronicle of private-sector experimentation and ingenuity in the face of inertia in Washington. “As recently as five years ago,” Mr. Walter writes, “the great pashas at [the National Institutes of Health] . . . looked upon aging research as largely crackpot.” He faults the Food and Drug Administration for refusing to classify aging as a disease. As a result, clinical trials—the foundation of medical research—can’t be conducted.

For the full review, see:

Matthew Rees. “BOOKSHELF; Birthdays Without End.” The Wall Street Journal (Monday, Jan. 27, 2020 [sic]): A15.

(Note: ellipses between paragraphs, added; ellipsis within paragraph, in original.)

(Note: the online version of the review has the date Jan. 26, 2020 [sic], and has the title “BOOKSHELF; ‘Immortality, Inc.’ Review: Birthdays Without End.”)

The book under review is:

Walter, Chip. Immortality, Inc.: Renegade Science, Silicon Valley Billions, and the Quest to Live Forever. Washington, D.C.: National Geographic, 2020.

Physicians Are Neither Trained Nor Paid to Express the “Medical Heresy” that Good Health Depends on Good Nutrition

(p. A17) Amazingly, medical schools in the United States focus very little on nutrition. The topic, according to one study, gets less than 1% of the classroom time that aspiring physicians are required to sit through over four years—even though the foods and beverages people ingest are far and away, in America, the biggest drivers of disease.

Because of the knowledge gap, doctors routinely miss opportunities to counsel their patients on the connection between nutrition and health—thus allowing bad eating habits to keep doing major damage. This failure is one of many indictments that Robert Lustig, a physician, brings against America’s medical-nutritional establishment in “Metabolical,” a wide-ranging polemic that covers the misdeeds of food and beverage companies and the misinformation that, in his view, contributes to the undermining of health.

. . .

Dr. Lustig’s real complaint is with “ultra-processed” products, which account for 58% of Americans’ calorie intake. Such products—candy, crackers, deli meat, frozen pizzas, fruit juices—are increasingly found not just in supermarkets and restaurants but virtually everywhere: movie theaters, hardware stores, gas stations, even health clubs. They’re typically mass produced, have a long shelf life and offer low nutritional quality.

How low? Dr. Lustig characterizes these products as “poison” more than two dozen times. To validate the claim, he describes in detail how the dominant features of such foods—high in sugar but also teeming with nitrates and refined carbohydrates—lead to cancer and other chronic diseases like diabetes and heart disease. Roughly 60% of Americans are afflicted with such diseases today (up from 30% in 1980). Relatedly, unhealthy eating has contributed to the decline in U.S. life expectancy in recent years.

That doctors don’t do more to steer their patients away from such hazards is only part of Dr. Lustig’s attack on the medical profession. He believes that, on the whole, doctors are “parochial,” taking their cues mostly from other doctors and thus succumbing to herd thinking. He worries that too many elements in their professional world—research, clinical meetings, webinars—are underwritten by Big Pharma and that the little nutrition science they know is compromised by studies that are sponsored by food companies. He says that doctors “don’t listen” to their patients and prefer to reach for the “quickest and easiest form of treatment,” whether it works or not, in part because insurance companies have limited the length of patient visits. “Talking about lifestyle changes takes time that we don’t have—because that’s how we’ve been trained and how we get paid.”

. . .

Dr. Lustig says that his book is “both my act of contrition to you, the public, and my act of medical disobedience to the medical establishment.” He hints that he could write such a book only after retiring from clinical practice—at the University of California, San Francisco (where he is an emeritus professor)—because “no ivory tower academic bastion would want to take credit for the ‘medical heresy’ that you’ll find sandwiched within these pages.”

For the full review, see:

Matthew Rees. “BOOKSHELF; Is It Something I Ate?” The Wall Street Journal (Monday, May 10, 2021 [sic]): A17.

(Note: ellipses added.)

(Note: the online version of the review has the date May 9, 2021 [sic], and has the title “BOOKSHELF; ‘Metabolical’ Review: Is It Something I Ate?”)

The book under review is:

Lustig, Robert H. Metabolical: The Lure and the Lies of Processed Food, Nutrition, and Modern Medicine. New York: Harper, 2021.

The Cholera and Bubonic Plague Vaccination Campaigns of Waldemar Haffkine Count as Evidence of “the Benevolence of British Medical Imperialism”

(p. C7) “In the end, all history is natural history,” writes Simon Schama in “Foreign Bodies: Pandemics, Vaccines and the Health of Nations.” The author, a wide-ranging historian and an engaging television host, reconciles the weight of medical detail with the light-footed pleasures of narrative discovery. His book profiles some of the unsung miracle workers of modern vaccination, and offers a subtle rumination on borders political and biological.

. . .

Inoculation, Mr. Schama writes, became a “serious big business” in commercial England, despite the inoculators’ inability to understand how (p. C8) it worked, and despite Tory suspicions that the procedure meant “new-fangled,” possibly Jewish, interference in the divine plan. In 1764, the Italian medical professor Angelo Gatti published an impassioned defense of inoculation that demolished humoral theory. Mr. Schama calls Gatti an “unsung visionary of the Enlightenment.” His work was a boon to public health, though his findings met resistance in France, where the prerevolutionary medical establishment was more concerned with protecting its authority.

. . .

(p. C8) Mr. Schama alights on the story of Waldemar Haffkine, the Odessa-born Jew who created vaccines against cholera and bubonic plague. In 1892, Haffkine inoculated himself against cholera with the vaccine he had developed at the Institut Pasteur in Paris. He went on to inoculate thousands of Indians, and so effectively that his campaigns served as, in Mr. Schama’s words, “an advertisement for the benevolence of British medical imperialism.”

. . .

The author notes the contrast between the facts of Haffkine’s achievements and the response of the British establishment, with its modern echoes of the medieval fantasy that Jews were “demonic instigators of mass death.” Yet Mr. Schama’s skepticism of authority only extends so far. It would have been instructive to learn why, when Covid-19 appeared, the WHO concurred with Voltaire that the Chinese were “the wisest and best governed people in the world” and advised liberal democracies to emulate China’s lockdowns.

Haffkine’s colleague Ernest Hanbury Hankin once wrote an essay called “The Mental Limitations of the Expert.” Mr. Schama’s conclusion shows the limitations of our expert class, which appears not to understand the breach of public trust caused by the politicization of Covid policy and the suppression of public debate. You do not have to be “far right” to distrust mandatory mRNA vaccination. As Mr. Schama shows, the health of the body politic depends on scientific inquiry.

For the full review, see:

Dominic Green. “Protecting the Body Politic.” The Wall Street Journal (Saturday, Sept. 23, 2023): C7-C8.

(Note: ellipses added.)

(Note: the online version of the review has the date September 22, 2023, and has the title “‘Foreign Bodies’ Review: Migrant Microbes, Human Borders.”)

The book under review is:

Schama, Simon. Foreign Bodies: Pandemics, Vaccines, and the Health of Nations. New York: Ecco Press, 2023.

Burning One’s Own Book Is Protected by the Right of Free Expression

(p. C6) There are few sights as alarming as a book set alight. Igniting the printed word in order to destroy the ideas contained therein runs counter to our notions of enlightenment, deliberation and reason. It can also carry a message of contempt for those who consider the burned book sacred. But while there’s no need to condone book burning and plenty of reasons to condemn it, it shouldn’t be punished by law.

That principle is now in jeopardy in Denmark, which has witnessed more than 170 anti-Muslim demonstrations in recent years, including a number of public Quran burnings. In response, lawmakers have introduced a bill to criminalize “improper treatment of objects of significant religious importance.” Offenders would face up to two years in prison. In announcing the proposed law, the Danish government cited the problem of being “seen in large parts of the world as a country that facilitates insulting and denigrating actions against other countries and religions.”

The move marks a reversal from the Danes’ approach in 2005, when the publication of cartoons depicting the Muslim Prophet Muhammad in a Danish newspaper sparked worldwide violence. Then the Danish government stood firm in its defense of free expression, rejecting calls to censor—or even censure—the paper.

. . .

The Danish government insists that its proposal is merely a “targeted intervention,” claiming it will “not change the fact that we must maintain very broad freedom of expression in Denmark.”

. . .

Yet by treating religious sensitivities as inviolate, the measure risks legitimizing the notion that vengeance may be warranted against those perceived to have denigrated the sacred.

. . .

The impulse to outlaw expression that creates unease, offense and uproar is not unique to Denmark. Censors around the world designate speech as dangerous and subversive in order to silence it. Denmark needs to reassure Muslims that it is committed to keeping them safe, protected and respected. It should do that by upholding rather than betraying the country’s core commitment to free expression and human rights.

For the full commentary, see:

Suzanne Nossel. “Book-Burning Bans Are the Wrong Way to Fight Religious Hatred.” The Wall Street Journal (Saturday, Sept. 23, 2023): C6.

(Note: ellipses added.)

(Note: the online version of the commentary has the date September 21, 2023, and has the same title as the print version.)

Nossel’s essay, quoted above, is related to her book:

Nossel, Suzanne. Dare to Speak: Defending Free Speech for All. New York: Dey Street Books, 2020.