Category: Books

Bezos’s Intuitions Drove Amazon’s Innovations

(p. 12) . . . Alexa, the voice coming out of my Echo, more or less is Jeff Bezos. He came up with the idea of a smart speaker in January 2011, back in the era of Google Plus and the iPod Shuffle. Bezos emailed his top deputies that month and declared, “We should build a $20 device with its brains in the cloud that’s completely controlled by our voice.”

For the next nearly four years, he obsessively micromanaged the project, pushing teams in Atlanta and Gdansk to make speech recognition seamless. He put in place a surreal testing protocol that involved hiring temps to spend days in empty apartments chattering away to silent speakers, and berated executives who told him it would take decades to develop speech recognition. He took home an early Echo prototype and when, in a moment of frustration, he told it to go “shoot yourself in the head,” it sent a wave of panic through the engineers who were listening in. He even came up with the idea for the LED ring on top, Stone writes, and with the name “Alexa” (in homage to the ancient library of Alexandria).

. . .

Amazon in the 2010s was an intensely personal venture, run by one of the wealthiest men in the world according to his own desires and reflecting his own personality.

. . .

Like Alexa, Amazon as a company seems to embody some of Bezos’ best personal qualities (his relentless drive to get you that package on time) and his worst (an “informal cruelty” that defines his company’s culture and requires that his factory workers and executives make personal sacrifices for corporate needs).

At Amazon, nearly every big decision comes down to a meeting with Bezos, at which his deputies hold their breaths, genuinely uncertain of whether he will berate them and tear up their proposals, or double their planned budgets. Some of his fixations, like his determination to create a smart speaker, are visionary.

. . .

It was, Stone writes, “a different style of innovation,” in which employees “worked backwards from Bezos’ intuition and were catering to his sometimes eclectic tastes (literally).”

For the full review, see:

Ben Smith. “Colossus.” The New York Times Book Review (Sunday, June 13, 2021): 12.

(Note: ellipses added.)

(Note: the online version of the review was updated June 17,, 2021, and has the title “To Understand Amazon, We Must Understand Jeff Bezos.”)

The book under review is:

Stone, Brad. Amazon Unbound: Jeff Bezos and the Invention of a Global Empire. New York: Simon & Schuster, 2021.

“Anti-Heroism Goes Too Far”

(p. 11) In “Extra Life,” Steven Johnson, a writer of popular books on science and technology, tells the stories behind what he calls, in an understatement, “one of the greatest achievements in the history of our species.” Starting in the second half of the 19th century, the average life span began to climb rapidly, giving humans not just extra life, but an extra life. In rich countries, life expectancy at birth hit 40 by 1880, 50 by 1900, 60 by 1930, 70 by 1960, and 80 by 2010.

. . .

It’s been a long time since the history of technology has been recounted as the triumph of plucky heroes, and Johnson’s stories reflect today’s more sophisticated understanding.

. . .

Sometimes the anti-heroism goes too far — Norman Borlaug, whose Green Revolution saved a billion lives, is unmentioned. But altogether, Johnson is a fine storyteller. Among his cast of characters are John Graunt (1620–74), the British haberdasher who studied mortality reports as a hobby and thereby invented epidemiology; Joseph Bazalgette (1819–91), the man behind “one of the 19th century’s greatest engineering achievements,” which you probably did not guess was the London sewers; “Moldy Mary” Hunt (1910–91), the Peoria bacteriologist who scoured fruit markets for the perfect rotten cantaloupe, the one with a strain of mold that enabled the mass production of penicillin; John Stapp (1910–99), who strapped himself into his invention, the rocket sled, and safely decelerated from 628 miles per hour to 0 in 1.4 seconds; and Dilip Mahalanabis, 86, the Indian pediatrician who discovered that a bit of salt and sugar dissolved in clean water could stop fatal diarrhea and thereby saved the lives of nearly 60 million people.

For the full review, see:

Steven Pinker. “Modern Miracle.” The New York Times Book Review (Sunday, June 13, 2021): 11.

(Note: ellipses added.)

(Note: the online version of the review has the date May [sic] 11, 2021, and has the title “How Humans Gained an ‘Extra Life’.”)

The book under review is:

Johnson, Steven. Extra Life: A Short History of Living Longer. New York: Riverhead Books, 2021.

Warburg Focused on Cancer’s “Ravenous” Metabolizing of Sugars

(p. A15) Hours before Nazi Germany invaded the Soviet Union in 1941, SS leader Heinrich Himmler convened a perplexing meeting. He and his minions put aside preparations for the offensive to chitchat about a gay biochemist of Jewish descent in Berlin. Not to rage about the man, or plot his downfall—to the contrary, the Nazis believed this scientist could save the Reich, by ridding it of a threat they feared every bit as much as Jews, homosexuals and communists—the scourge of cancer.

That scientist, Otto Warburg, is the subject of “Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer–Diet Connection,” an eye-opening work by journalist Sam Apple.

. . .

There’s no doubt Warburg was brilliant—the greatest biochemist of his day—and in the 1930s he focused on cancer, a major concern of the Nazis. Cancer deaths skyrocketed 287% in Germany between 1876 and 1910, “making a quiet mockery of the extraordinary march of German science,” Mr. Apple notes. From the Führer down, Nazi leaders trembled at the disease, and they enacted surprisingly modern measures to fight cancer. They railed against cigarettes, encouraged women to examine their breasts for lumps and worked to eliminate pesticides and artificial preservatives in food.

In his lab, Warburg made seemingly fundamental discoveries about how cancer worked.

. . .

The second half of “Ravenous” shifts into the (somewhat tenuous) links between Warburg’s research and our modern understanding of cancer. The biochemical complexities get a bit gnarly—there’s a dizzying amount of detail, making it hard to follow the main thread on occasion. Among other things, Warburg discovered that cancer cells gobble up far more glucose (a sugar) than their nonmalignant neighbors—“eating like shipwrecked sailors,” Mr. Apple writes. Oddly, cancer cells also metabolize sugars through fermentation, in a manner analogous to yeast cells. Biochemically, fermentation is normally a backup power generator for human cells, used only when oxygen runs low. Warburg found that cancer cells were running the backup generator all the time.

. . .

. . ., it’s not clear how much credit Warburg deserves. I walked away from “Ravenous” thinking of Otto Warburg as a sort of Sigmund Freud of cancer research. Freud got One Big Thing right—that the unconscious drives much of human behavior. But he was wrong on nearly every detail. Similarly, Warburg explicitly rejected good evidence for the insulin-cancer link during his lifetime, among other blunders, making it tricky to uphold him as a pioneer of modern cancer research.

Nevertheless, history will show that Otto Warburg always insisted that cancer was intimately tied to metabolism. As one latter-day biologist noted, marveling over Warburg’s rehabilitation, “We found out that son of a bitch was right.”

For the full review, see:

Sam Kean. “BOOKSHELF; Untangling a Disease.” The Wall Street Journal (Wednesday, June 16, 2021): A15.

(Note: ellipses added.)

(Note: the online version of the review has the date June 15, 2021, and has the title “BOOKSHELF; ‘Ravenous’ Review: Untangling a Disease.”)

The book under review is:

Apple, Sam. Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection. New York: Liveright Publishing Corp., 2021.

“All Seasons Press” Will Publish Books Cancelled by Mainstream

(p. B4) Two veteran book-publishing executives have teamed up to launch a conservative publishing house called All Seasons Press LLC as ideological debates roil a book industry increasingly fueled by demand for political titles.

Louise Burke, the former president and publisher of Simon & Schuster’s Gallery Books Group, and Kate Hartson, whom Hachette Book Group dismissed as editorial director of its Center Street imprint earlier this year, said conservative authors are finding it harder to get published in the post-Trump era.

“I’m increasingly concerned and somewhat outraged about what’s going on in terms of free speech and free press,” said Ms. Burke, who retired in August 2017 after a 40-year career.

. . .

The company’s launch comes as some conservatives allege that much of the nation’s news media, publishers and mainstream social-media platforms are biased against them. They are looking to set up alternatives that they say better support free speech.

For the full story, see:

Jeffrey A. Trachtenberg. “Book Imprint to Serve Conservative Voices.” The Wall Street Journal (Wednesday, June 16, 2021): B4.

(Note: ellipsis added.)

(Note: the online version of the story was updated June 15, 2021, and has the title “New Book Publisher Caters to Conservative Voices.”)

Government Cover Ups

(p. 230) It’s hard enough to find out about the things the universe prefers to keep hidden without our government, which somebody you know must have voted for, covering up what has already been found. Sometimes, of course, it hides things to save its own neck and sometimes seemingly just for the hell of it.

Norman Maclean’s musings, quoted above, are from his wonderful prize-winning account of the Mann Gulch fire in which Wag Dodge spontaneously invented a way to save his life from the wall of fire speeding toward him:

Maclean, Norman. Young Men and Fire. Chicago: University of Chicago Press, 2017 [first edition 1992].

The Promise of Gene Editing Is Greater Than the Peril

(p. C1) The Berkeley biochemist [Jennifer Doudna] had helped to invent a powerful new technology that made it possible to edit the human genome—an achievement that made her the recipient of a Nobel Prize in 2020. The innovation was based on a trick that bacteria have used for more than a billion years to fight off viruses, a talent very relevant to us humans these days. In their DNA, bacteria develop clustered, repeated sequences (what scientists call CRISPRs) that can recognize and then chop up viruses that attack them. Dr. Doudna and others adapted the system to create a tool that can edit DNA—opening up the potential for curing genetic diseases, creating healthier babies, inventing new vaccines, and helping humans to fight their own wars against viruses.

. . .

(p. C2) . . . the advances in CRISPR technology, combined with the havoc wrought by the Covid-19 pandemic, have pushed me to be more open to gene editing. I now see the promise of CRISPR more clearly than the peril. If we are wise in how we use it, biotechnology can make us more able to fend off lethal viruses and overcome serious genetic defects.

After millions of centuries during which evolution happened “naturally,” humans now can hack the code of life and engineer our own genetic futures. Or, for those who decry gene editing as “playing God,” let’s put it this way: Nature and nature’s God, in their wisdom, have evolved a species that can modify its own genome.

For the full commentary, see:

Walter Isaacson. “What Gene Editing Can Do for Humankind.” The Wall Street Journal (Saturday, Feb. 20, 2021): C1-C2.

(Note: ellipses, and bracketed name, added.)

(Note: the online version of the commentary has the date Feb. 19, 2021, and has the same title as the print version.)

Isaacson’s commentary is related to his book:

Isaacson, Walter. The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. New York: Simon & Schuster, 2021.

Lack of Competition Allows Carlsbad Medical Center to Sue Thousands of Patients

(p. D1) An examination of court records by The New York Times found almost 3,000 lawsuits filed by Carlsbad Medical Center against patients over medical debt since 2015, more than 500 of them through August of this year alone. Few hospitals sue so many patients so often.

. . .

Carlsbad Medical Center is not the only hospital to have filed reams of lawsuits over unpaid bills. In Memphis, Methodist Le Bonheur Healthcare, a nonprofit hospital, filed 8,300 lawsuits from 2014 through 2018, including some against its own em-(p. D6)ployees, according to an investigation by the journalism nonprofit groups ProPublica and MLK50.

. . .

People across the country are coping with soaring medical costs, opaque pricing and surprise bills, but these issues are felt acutely in one-hospital towns like Carlsbad, where residents have few options for care — and must pay whatever prices the hospital sets.

“Hospitals that have little competition can negotiate higher rates, because the insurer wants that hospital in their network,” said Sara Collins of the nonprofit Commonwealth Fund.

. . .

Carlsbad Medical Center is owned by Community Health Systems, a chain of hospitals based in Franklin, Tenn. An investigation in 2014 by the Santa Fe New Mexican newspaper found that the three hospitals charging the highest prices in the state were all owned by that chain.

In 2015, the company paid $98 million to the federal government to settle charges that it had inflated revenue by admitting patients unnecessarily. Community Health Systems admitted no wrongdoing.

. . .

There are alternative hospitals near Carlsbad, but the closest is more than 40 minutes away, in the town of Artesia — which residents may find too far to drive to in an emergency.

. . .

Artesia General has no debt-collection suits against patients on record since 2015. Neither does Presbyterian Hospital in Albuquerque — which, at 450 licensed beds, is almost four times as large as the hospital in Carlsbad.

By contrast, other hospitals owned by Community Health Systems in New Mexico also regularly file suits over unpaid bills. Lea Regional Medical Center in Hobbs has filed almost 2,000 such suits since 2015. Mountain View Regional Medical Center in Las Cruces has filed about 2,000 suits against patients in that time; almost half of them came just this year.

In Carlsbad, these lawsuits flood the docket. District Judge Lisa Riley, who has been on the bench in Eddy County since 2011, estimated that about one-third of all civil cases that come across her desk involve unpaid medical debt.

. . .

She, too, was a target of the hospital before she became a judge. Her husband had been disputing emergency room charges when the hospital sued; the case was resolved and dismissed. (Judge Riley would not comment further, citing ethics restrictions that prohibit judges from making statements about matters that might appear in court.)

Judge Riley’s case and others from Carlsbad appear in an upcoming book called “The Price We Pay,” by Dr. Marty Makary, a surgeon at Johns Hopkins University who studies the costs of American health care and led the study of hospital suits in Virginia.

Debt collection is common in the health care industry, he said, but lawsuits are a traumatic way to force patients to pay. Normally hospitals simply refer unpaid bills to debt collectors; fewer file lawsuits and then garnish wages or place liens on homes.

In his study of Virginia, 36 percent of hospitals garnished the wages of patients owing money, with 10 percent doing so frequently. (Even his own institution, however, has come under fire for suing the poor.)

When seeking payment for medical bills, “Collections agencies may harass you with phone calls,” Dr. Makary said. “They may send a note to your credit bureau, but they’re not reaching into your paycheck.”

Many of these patients are low-paid workers with little savings. Dr. Makary’s study found that Walmart was the most common employer of those whose wages were garnished over medical bills. “These are hardworking Americans who did nothing wrong,” he said.

The cost of care differs from institution to institution, partly because hospitals have broad discretion in setting prices. Charges for the same services vary widely, even when hospitals have similar patient demographics, and the amounts billed have little relationship to quality.

If you are a hospital executive, “you could charge whatever you want,” said Dr. Makary. “You could charge $1 million for an X-ray.”

For the full story, see:

Laura Beil. “Proficient At Healing, And Suing.” The New York Times (Tuesday, September 3, 2019): D1 & D6.

(Note: ellipses added.)

(Note: the online version of the story was updated Dec. 2, 2019, and has the title “As Patients Struggle With Bills, Hospital Sues Thousands.”)

The Makary book mentioned above is:

Makary, Marty. The Price We Pay: What Broke American Health Care–and How to Fix It. New York: Bloomsbury Publishing, 2019.

Can the Methods of ACT UP Bring Quicker Cures for Other Maladies?

Amar Bhidé has a thought-provoking article in which he asks the public choice question of how to overcome government regulators who slow the development of breakthrough drugs. He holds up, as a main example to ponder, the AIDs ACT UP movement that is often given credit for winning concessions from the FDA that spurred the availability of a drug cocktail that greatly extended and improved the lives of AIDs patients. The passages quoted below are from a review of a book that may be a promising source for learning more about what ACT UP did and how they did it.

(p. C3) In her 2012 book, “The Gentrification of the Mind,” Sarah Schulman delved into the silence still surrounding AIDS in America.

. . .

Schulman has gone from witness to a sort of living archive. She is a former member of AIDS Coalition to Unleash Power, the influential direct-action group committed to ending AIDS. Her new book, “Let the Record Show,” is based on 17 years of interviews she conducted with nearly 200 members of the organization.

. . .

The effect is rather like standing in the middle of that large room, where anyone could speak up and share an idea. Everyone is talking; small stories branch off, coalesce pages later. Speakers shade in one another’s stories, offer another angle, disagree passionately. You turn a page, and the same people have their arms linked together at a protest. Shadows start to fall; in squares of gray text, deaths are marked, moments for remembrance. So many people leave the room.

. . .

This is not reverent, definitive history. This is a tactician’s bible.

The organizational brilliance of ACT UP emerged out of necessity. The group was founded in 1987, incited by Larry Kramer’s famous call to action. The members were infected, their lovers were sick and dying. There wasn’t time to obsess over process, to contest every comma in a letter. The anarchistic framework asked only that members be “committed to direct action to end the AIDS crisis.”

. . .

When Schulman herself returns to the individual, it is to think again about the figure of the bystander. Why did these particular people rise to the moment and not others?

What thread connected an H.I.V.-positive stockbroker, a retired chemist from Queens, addicts, art students, lifelong activists, people who just happened to be in the next room at the center and wandered in, What was going on in there? For some it was their first experience of gay community; for others it was where they went when the community began to vanish. All of them became autodidacts in drug research, policy, media relations.

For the full review, see:

Parul Sehgal. “Remembering Those Who Stood Up.” The New York Times (Wednesday, May 5, 2021): C3.

(Note: ellipses added. In the original, the words NOT italicized above, were the only words that WERE italicized.)

(Note: the online version of the review has the date May 4, 2021, and has the title “A New Testament to the Fury and Beauty of Activism During the AIDS Crisis.”)

The book under review is:

Schulman, Sarah. Let the Record Show: A Political History of ACT UP New York, 1987-1993. New York: Farrar, Straus and Giroux, 2021.

The article mentioned above by Bhidé is:

Bhidé, Amar. “Constraining Knowledge: Traditions and Rules That Limit Medical Innovation.” Critical Review 29, no. 1 (Jan. 2017): 1-33.

“Legions of Good People” Are Willing to Pay a Price “to Speak the Truth”

(p. A9) . . . in February 1986 . . . a presidential commission was investigating the explosion of the Challenger space shuttle, which killed all seven crew members a few weeks earlier.

Mr. McDonald was an engineer for the maker of the solid-fuel booster rockets. During a hearing, he believed an official of the National Aeronautics and Space Administration was glossing over a prelaunch debate on whether to proceed despite unusually cold temperatures in Cape Canaveral, Fla.

Seated in the background, Mr. McDonald waved his hands for attention and then stood up. He told the commission that he and other engineers had warned that low temperatures might cause a failure of synthetic rubber O-ring seals in the rocket’s joints. The commission later found that such a failure was responsible for the explosion and that NASA had brushed aside a warning that could have saved the astronauts.

. . .

Mr. McDonald’s uninvited testimony was a shock to the commission appointed by President Ronald Reagan. In his memoir, “Truth, Lies and O-Rings,” the engineer recalled the reaction from William P. Rogers, chairman of the commission:

“Who in the hell are you?”

. . .

Mr. Rogers thanked Mr. McDonald and other engineers for giving their side of the story.

. . .

At work, however, Mr. McDonald was at times ostracized by colleagues who accused him of undermining the company’s aerospace business. Morton Thiokol moved him out of his space shuttle duties in what he considered a demotion.

. . .

“I never considered myself a hero for doing my job in the best manner that I knew how and telling the truth about it,” he wrote, adding that “there are legions of good people out there every day defending their professional opinions and willing to speak the truth at some risk to their own job security. They just haven’t been involved in such a high-profile news making event like me.”

For the full obituary, see:

James R. Hagerty. “Engineer Exposed Space Shuttle Risks.” The Wall Street Journal (Saturday, April 3, 2021): A9.

(Note: ellipses added.)

(Note: the online version of the obituary has the date March 30, 2021, and has the title “Rocket Engineer Blew the Whistle on NASA After the Challenger Disaster.”)

The McDonald memoir mentioned above is:

McDonald, Allan J., and James R. Hansen. Truth, Lies, and O-Rings: Inside the Space Shuttle Challenger Disaster. Gainesville, FL: University Press of Florida, 2018..


“If It’s Consensus, It Isn’t Science”

(p. C9) . . . science itself is not conducted by polls, regardless of how often we are urged to heed a “scientific consensus” on climate. As the science-trained novelist Michael Crichton summarized in a famous 2003 lecture at Caltech: “If it’s consensus, it isn’t science. If it’s science, it isn’t consensus. Period.” Mr. Koonin says much the same in “Unsettled.”

. . .

As for “denying,” Mr. Koonin makes it clear, on the book’s first page, that “it’s true that the globe is warming, and that humans are exerting a warming influence upon it.”

The heart of the science debate, however, isn’t about whether the globe is warmer or whether humanity contributed. The important questions are about the magnitude of civilization’s contribution and the speed of changes; and, derivatively, about the urgency and scale of governmental response. Mr. Koonin thinks most readers will be surprised at what the data show. I dare say they will.

As Mr Koonin illustrates, tornado frequency and severity are also not trending up; nor are the number and severity of droughts. The extent of global fires has been trending significantly downward. The rate of sea-level rise has not accelerated. Global crop yields are rising, not falling. And while global atmospheric CO2 levels are obviously higher now than two centuries ago, they’re not at any record planetary high—they’re at a low that has only been seen once before in the past 500 million years.

. . .

Mr. Koonin’s science credentials are impeccable—unlike, say, those of one well-known Swedish teenager to whom the media affords great attention on climate matters. He has been a professor of physics at Caltech and served as the top scientist in Barack Obama’s Energy Department. The book is copiously referenced and relies on widely accepted government documents.

. . .

Never have so many spent so much public money on the basis of claims that are so unsettled.

For the full review, see:

Mark P. Mills. “The ‘Consensus’ On Climate.” The Wall Street Journal (Monday, April 26, 2021): C9.

(Note: ellipses added.)

(Note: the online version of the review has the date April 25, 2021, and has the title “‘Unsettled’ Review: The ‘Consensus’ On Climate.”)

The book under review is:

Koonin, Steven E. Unsettled: What Climate Science Tells Us, What It Doesn’t, and Why It Matters. Dallas, TX: BenBella Books, 2021.

Illuminators Were in MORE Demand AFTER the Arrival of the Printing Press

(p. C9) In “The Bookseller of Florence,” Ross King relates the fascinating story of a bookstore run by Vespasiano da Bisticci, a Florentine born in 1422, whose shop on the Via dei Librai, or Street of Booksellers, sat at the center of Florence’s golden age and its valiant recovery of ancient knowledge.

. . .

Before long, Vespasiano established a bookshop selling beautifully made manuscripts of newly fashionable Roman classics for prosperous clients. He was well placed: Florence, “the new Athens on the Arno,” was a city where an astounding seven of 10 citizens could read.

. . .

Vespasiano’s life straddled two eras. Before the dawn of movable type in Europe, readers relied on manuscripts, painstakingly copied by hand with goosequills on parchment made from animal skins. After, they flocked to buy cheaper books printed on presses. Meanwhile, scribes either became early adopters—trading their inkpots for composing sticks—or found themselves surprisingly busy rubricating and illuminating innumerable books rolling off the new presses. By the time the presses made their way south of the Alps, Vespasiano was in his early 30s and, for whatever reason, chose not to embrace the new technology.

Printing came to Florence later than elsewhere, possibly due in part to Vespasiano, who continued to sell only books copied out on parchment. Still, competition from printed books began to tell on his sales. Then, just when it seemed he might be edged out of the market, there arrived a redeeming commission by the count of Urbino, Federico da Montefeltro, for “the finest library since antiquity,” one that would keep Vespasiano’s team of dozens of scribes and illuminators busy for nearly a decade, well into the era of the printing press. Montefeltro, a wealthy mercenary—who at the age of 15 had seized a fortress long believed impregnable—was also a bookish man, like many in the Renaissance. He retained five men to read to him as he ate, and even a poet to sing his praises. Among the many books created for his library was Vespasiano’s masterpiece, the Urbino Bible, one of the most lavish illustrated books of all time.

For the full review, see:

Ernest Hilbert. “Wise Men Fished There.” The Wall Street Journal (Saturday, April 24, 2021): C9.

(Note: ellipses added.)

(Note: the online version of the review has the date April 15, 2021, and has the title “‘The Bookseller of Florence’ Review: Manuscripts and Medicis.”)

The book under review is:

King, Ross. The Bookseller of Florence: The Story of the Manuscripts That Illuminated the Renaissance. New York: Atlantic Monthly Press, 2021.