Category: Books

Are We Right to Experiment on Animals to Save Humans?

I believe that higher animals feel emotions and maybe even have souls, so we should try to treat them humanely. I am deeply conflicted on how far animal experiments are justified in the pursuit of curing human diseases. Whenever possible, animal experiments should have the potential to benefit the animals in the experiments, as well as the human experimenters.

(p. A15) The “title characters” of Brandy Schillace’s admirable biography “Mr. Humble and Dr. Butcher: A Monkey’s Head, the Pope’s Neuroscientist, and the Quest to Transplant the Soul” were one and the same person: Robert J. White, a distinguished neurosurgeon, an accomplished neuroscientist and a man dedicated to searching for the means to transplant souls by transplanting the human brain. If this makes White sound macabre, Ms. Schillace’s account of his life, work and temperament is anything but. She deftly persuades the reader to take White seriously (he wasn’t even eccentric) and to ponder profound medical-scientific-philosophical issues. Best of all, the book is fascinating.

. . .

White felt it was his religious and medical duty to devise techniques for rescuing healthy brains from otherwise diseased and dying bodies. His solution was to transplant heads (containing their brains) onto cadavers that were brain dead but otherwise physiologically viable.

Before he could attempt such surgery on people, White experimented, mostly on monkeys, dozens of times, to ascertain and refine the necessary procedures. In March 1970 he succeeded in transplanting a monkey’s head onto another monkey’s body.

. . .

During the era in which White conducted his experiments, politicians, doctors, journalists and celebrities were becoming deeply and increasingly dismayed by scientific experiments on animals. White ran afoul of the animal-rights advocacy organization People for the Ethical Treatment of Animals (PETA) and was threatened by animal-rights extremists (he remained imperturbable). White prided himself on scrupulously avoiding harm to his animal subjects. But he didn’t believe that animals had souls: For him, Ms. Schillace writes, “the human was more than animal, and equating the two was not only wrong, it was dangerous.” One of White’s rejoinders to those who would halt animal experimentation was, to paraphrase: If you were a surgeon, how would you like to tell parents that their young child is going to die because the operation that might save him or her was impossible to perform, mainly because the necessary animal-dissection research that would have permitted it was forbidden by law or the medical canon of ethics? His foes never had a good answer.

For the full review, see:

Howard Schneider. “A Heart in the Right Place.” The Wall Street Journal (Monday, February 22, 2021): A15.

(Note: ellipses added; italics in original.)

(Note: the online version of the review has the date February 21, 2021, and has the title “Mr. Humble and Dr. Butcher’ Review: A Heart in the Right Place.”)

The book under review is:

Schillace, Brandy. Mr. Humble and Dr. Butcher: A Monkey’s Head, the Pope’s Neuroscientist, and the Quest to Transplant the Soul. New York: Simon & Schuster, 2021.

Cafe Hayek Quotes from Openness Book on Happiness

Posted by Arthur Diamond on Friday, April 2, 2021

Don Boudreaux quotes from my Openness to Creative Destruction book on Cafe Hayek, the blog he runs with Russ Roberts.

My book is:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.

Humans Excel at Finding and Using Patterns

(p. 9) At the end of the 20th century, scholars of human evolution proposed a thrilling idea: Humans were special and distinct from all other animals because of a sudden transformational change that occurred around 35,000 years ago. For millions of years our ancestors had trudged through existence with the same simple tool kit, yet in that special moment, there was a flowering of symbolism, of art, of complicated tool use. This was when the modern human mind was born. You could see its traces in the archaeological record.

. . .

In “The Pattern Seekers: How Autism Drives Human Invention,” Simon Baron-Cohen, a psychologist and the director of the Autism Research Center at Cambridge University, contributes a new version of this cognitive revolution. Baron-Cohen argues that humans split off from all other animals to become the “scientific and technological masters of our planet” because we evolved a unique piece of mental equipment that he calls the Systemizing Mechanism. It came into being between 70,000 and 100,000 years ago, and it led to the invention of pretty much everything, bows and arrows, pottery, agriculture, science, skateboards and so on.

. . .

Here’s how the mechanism works: Humans alone observe the world and ask questions that demand why, how and what. They answer their questions by looking for if-and-then patterns, such as, if I boil an egg for eight minutes, then the yolk will be hard, and if I boil an egg for four minutes, then the yolk will be soft. They use those patterns to build theories, which they then repeatedly test, looking always for systems to further employ and exploit.

Grand theories aside, Baron-Cohen is at his most striking when he writes about people with autism, like Jonah, who was slow to talk but who taught himself to read. When Jonah eventually learned to speak, he used language less as a tool for communication than as a system for categorizing the world around him. As a young child, he was endlessly fascinated by how things worked, and he spent hours experimenting, like flipping a light switch on and off to test and retest its effect. At school he showed great brilliance in his observations about the natural world, he was a “born pattern seeker,” but at the same time he was taunted by other children for being so different. In group reading time, which he hated, he would shut his eyes and put his fingers in his ears. Jonah’s weekend hobby as a young man was helping fishermen locate shoals by being able to read the signs from surface waves. Yet despite his incredible talents, Jonah was lonely and frustrated because he couldn’t find a job that would allow him to live an independent life. Baron-Cohen argues with feeling and conviction that society must do a better job of making room for people like Jonah, and that it will benefit enormously when it does.

For the full review, see:

Christine Kenneally. “Systematizers.” The New York Times Book Review (Sunday, December 20, 2020): 9.

(Note: ellipses added.)

(Note: the online version of the review was updated Dec. 9, 2020, and has the title “Does Autism Hold the Key to What Makes Humans Special?.”)

The book under review is:

Baron-Cohen, Simon. The Pattern Seekers: How Autism Drives Human Invention. New York: Basic Books, 2020.

Vaccine Immunity, Plus Natural Immunity from Getting Covid-19, Equals Herd Immunity Soon

The author of the passages I quote below is a surgeon and professor at the Johns Hopkins School of Medicine and has authored The Price We Pay, which I recently read. It is a disturbing, eye-opening, excellent account of why the costs of drugs are high and rising.

(p. A17) Anthony Fauci has been saying that the country needs to vaccinate 70% to 85% of the population to reach herd immunity from Covid-19. But he inexplicably ignores natural immunity. If you account for previous infections, herd immunity is likely close at hand.

. . .

Dr. Fauci’s vaccination-only path to herd immunity has significantly influenced the national conversation. KNBC-TV in Los Angeles has a county-by-county vaccine tracker showing a bar graph of the percentage of Californians vaccinated, with the zone 70% to 85% labeled “herd immunity.” Currently, it’s at 26%. The false construct does create a greater urgency for everyone to get vaccinated. But it also creates false justification for continued excessive restrictions on freedom. And it raises the possibility that authorities are misallocating the limited vaccine supply by failing to direct it toward people without natural antibodies.

. . .

Some experts claim they don’t talk about natural immunity because we shouldn’t trust it. But a recent Public Health England study found that less than 1% of 6,614 healthcare workers who had Covid-19 developed a reinfection within five months—even though many of them work with Covid patients. Other experts believe natural immunity is powerful. “Natural immunity after Covid-19 infection is likely lifelong, extrapolating from data on other coronaviruses that cause severe illness, SARS and MERS,” says Monica Gandhi, an infectious-disease physician and professor at the University of California.

For the full commentary, see:

Marty Makary. “Herd Immunity Is Near, Despite Fauci’s Denial.” The Wall Street Journal (Thursday, March 25, 2021): A17.

(Note: ellipses added.)

(Note: the online version of the commentary has the date March 24, 2021, and has the same title as the print version.)

The Makary book praised above is:

Makary, Marty. The Price We Pay: What Broke American Health Care–and How to Fix It. New York: Bloomsbury Publishing, 2019.

Chinese Atlases Are Shrugging

(p. B4) SINGAPORE—Chinese e-commerce company Pinduoduo Inc.’s founder and chairman, Colin Huang, stepped down from the company on Wednesday [March 17, 2021], even as the five-year-old company overtook Alibaba Group Holding Ltd. to become the country’s largest e-commerce company by annual active buyers.

Mr. Huang, 41 years old, is resigning as China’s powerful internet sector comes under growing government scrutiny. His resignation follows another departure from a major company in the sector: Financial-tech giant Ant Group Co.’s Chief Executive Simon Hu stepped down earlier this month.

. . .

Beijing in recent months has been moving to rein in China’s powerful internet sector including e-commerce companies. Among the hardest hit has been Alibaba, which is under antitrust probe; its fintech affiliate Ant, whose initial public offering was canceled in November [2020]; and its founder Jack Ma.

This month, Chinese regulators fined Pinduoduo, alongside several other e-commerce companies, alleging anticompetitive practices.

For the full story, see:

Keith Zhai. “Head of China’s Giant E-Commerce Firm Quits.” The Wall Street Journal (Thursday, March 18, 2021): B4.

(Note: ellipsis, and bracketed dates, added.)

(Note: the online version of the story was updated March 17, 2021, and has the title “Pinduoduo Founder Colin Huang Steps Down From Company.”)

The fictional version is:

Rand, Ayn. Atlas Shrugged. New York: Random House, 1957.

Freireich on Chemo-Cocktail Cure for Childhood Leukemia: “I Thought About It and I Knew It Would Work”

(p. A20) Dr. Emil Freireich, a renowned cancer doctor and relentless researcher who helped devise treatments for childhood leukemia that transformed the lives of patients thought to have little hope of survival, died on Feb. 1 [2021] at the University of Texas MD Anderson Cancer Center in Houston, where he had worked since 1965.

. . .

When Dr. Freireich (pronounced FRY-rike) started work at the N.C.I., in Bethesda, Md., in 1955, acute childhood leukemia was considered a death sentence. Entering the ward where the children were being treated, he recalled their hemorrhaging because their blood had virtually no platelets, the disc-shaped cells that clot blood.

. . .

Dr. Freireich, a hematologist and oncologist, tested his hypothesis that the lack of platelets was causing the hemorrhaging by mixing some of his own blood with some of the children’s.

“Would it behave normally?” he said in interview for an N.C.I. oral history project in 1997. “Sure enough, it did.”

Further testing, done to persuade his skeptics at the cancer institute, proved him right.

. . .

. . . Dr. Freireich’s most important and most enduring achievement was in using a combination of drugs to send leukemia into remission. He explored options in chemotherapy with several N.C.I. colleagues, including Dr. Emil Frei III, who was known as Tom.

They made an aggressive assault on childhood leukemia by devising a cocktail of four drugs that would be administered simultaneously — a technique similar to the three-drug regimen used to treat tuberculosis — so that each one would attack a different aspect of the physiology of the cancer cells.

“It was crazy,” Dr. Freireich told Mr. Gladwell. “But smart and correct. I thought about it and I knew it would work. It was like the platelets. It had to work!”

But not without peril and concern. Some of the children nearly died from the drugs. Critics called Dr. Freireich inhumane for experimenting with his young patients.

“Instead, 90 percent went into remission immediately,” he told USA Today in 2015. “It was magical.” But temporary. One round of the cocktail was not enough to eliminate all the cancer, so Dr. Freireich and his team treated them with the drugs monthly for more than a year.

. . .

Dr. Freireich compared his early fight to cure childhood leukemia to being in a battle in which he and the N.C.I. team had an alliance that was “forged under fire.”

To cure cancer, he added: “Motivate people and give them the opportunity. People are innately motivated. Nobody likes to be lazy and do nothing. Everybody wants to be significant.”

For the full obituary, see:

Richard Sandomir. “Emil Freireich, 93, Pioneering Researcher and Cancer Doctor, Is Dead.” The New York Times (Saturday, February 13, 2021): A20.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary was updated Feb. 8, 2021, and has the title “Emil Freireich, Groundbreaking Cancer Researcher, Dies at 93.”)

Malcolm Gladwell devoted a chapter to Freireich in Gladwell’s book:

Gladwell, Malcolm. David and Goliath: Underdogs, Misfits, and the Art of Battling Giants. New York, NY: Little, Brown and Company, 2013.

Video of Diamond Q&A on Innovation Unbound Posted to YouTube

On 3/17/21 Derek Yonai posted my 3/16/21 live Q&A session related to my “Innovation Unbound” lecture that was recorded on 3/1/21 and posted on 3/9/21. Some of my lecture and some of my answers in the Q&A, were related to my book:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.

Journalism on the Left: “Nobody Censored What We Wrote”

(p. D7) James Ridgeway, an investigative reporter who exposed corporate dirty tricks, the secrets of environmental polluters and the horrors of solitary confinement in the nation’s prison systems, died on Saturday [Feb. 13, 2021] in Washington.

. . .

Mr. Ridgeway focused on the nation’s 2,200 public and private institutions of higher learning in “The Closed Corporation: American Universities in Crisis” (1968). The book contended that colleges and universities, hiding behind tax exemptions and interlocked with private corporations and government agencies, were riddled with conflicts of interest in a corrupt system of profiteering.

“Ridgeway notes that 50 years ago, the universities were run by social reformers and scholars,” H.L. Nieburg wrote in a review for The Times, “while today they are operated by teams of middle-management executives more involved with pyramiding financial holdings and keeping faculty in line than in undergraduates.”

. . .

In 2012, after the death of Alex Cockburn, with whom he had shared a column in The Voice, Mr. Ridgeway wrote in Mother Jones: “We did our reporting in a way that most people in the press would die for. Nobody censored what we wrote. Nobody messed with how things were written, or dreamed of questioning a political opinion.”

For the full obituary, see:

Robert D. McFadden. “James Ridgeway, a Journalist Who Attacked Skulduggery, Is Dead at 84.” The New York Times (Monday, February 15, 2021): D7.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the obituary has the date Feb. 14, 2021, and has the title “James Ridgeway, Hard-Hitting Investigative Journalist, Dies at 84.”)

James Ridgeway’s book on higher education was:

Ridgeway, James. The Closed Corporation: American Universities in Crisis. New York: Random House, 1968.

Diamond’s Innovation Unbound Lecture Posted to YouTube

Dr. Derek Yonai of the Koch Center for Leadership and Ethics posted on Tues., March 9, 2021 my half-hour lecture on how regulations bind innovators. The lecture is related to my book:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.

“Solar Geoengineering” Is “a Test of Our Technological Ingenuity”

(p. C6) . . . humans have been so successful at changing the environment that we have become the dominant influence on the natural world. According to Elizabeth Kolbert’s new book, “Under a White Sky,” how we proceed is, in one sense, full of possibility, a test of our technological ingenuity and derring-do, . . .

. . .

Kolbert is a writer for The New Yorker, where parts of this book originally appeared. Her narrative voice is steady and restrained — the better, it sometimes seems, to allow an unadorned reality to show through, its contours unimpeded by frantic alarmism or baroque turns of phrase. The people she meets are trying to reverse the course of man-made environmental disaster, whether that might involve electrifying a river, shooting diamond dust into the stratosphere or genetically modifying a species to extinction. She says that the “strongest argument” in favor of some of the most fantastical sounding measures tends to be a sober realism: “What’s the alternative?”

The biggest and most urgent of the impending cataclysms involves climate change. Mitigation efforts — reducing emissions — won’t do anything to alleviate the greenhouse gases that are already trapping heat on our planet. The title of Kolbert’s book comes from one possible side-effect of “solar geoengineering” (or “solar radiation management,” in what’s supposed to be the less scary parlance). Spraying light-reflective particles into the atmosphere will make blue skies look white.

For the full review, see:

Szalai, Jennifer. “BOOKS OF THE TIMES: Exploring All Measures to Save the Environment.” The New York Times (Thursday, February 11, 2021): C6.

(Note: ellipses added.)

(Note: the online version of the review has the date Feb. 10, 2021, and has the title “BOOKS OF THE TIMES: Electrified Rivers and Other Attempts to Save the Environment.”)

The book under review is:

Kolbert, Elizabeth. Under a White Sky: The Nature of the Future. New York: Crown, 2021.