Category: Books

In Middle Ages the Less Credentialed Offered “Daily Care,” While “Experts” Theorized

(p. 12) A new book about medieval views on medicine helps explain the Oby nuns’ contentment with the cheapness of their lives. In “Medieval Bodies: Life and Death in the Middle Ages,” the British art historian Jack Hartnell tackles a difficult phenomenon: the medieval embrace of medical “theories that have since been totally disproven to the point of absurdity but which nevertheless could not have seemed more vivid or logical in the Middle Ages.”

The doctors of Europe and the Mediterranean were not practical specialists but rather scholars of Greek and Roman natural philosophy, which taught a theory of nature composed of four basic elements (fire, water, earth, air). Each was associated with differing levels of moisture and heat. The human body contained four viscous liquids or “humors”: phlegm, blood, yellow bile and black bile. A doctor’s job was to correct an uneven humoral balance, drying up perceived wetness with spices or relieving an excess of heat with cooling herbs.

While experts promulgated theory, daily care was mostly administered by midwives, apothecaries, dentists and the odd entrepreneurial carpenter. A local barber might puncture your neck to drain three pints of blood if you complained of a headache.

For the full review see:

Josephine Livingstone. “Death by a Thousand Cuts.” The New York Times Book Review (Sunday, January 5, 2020 [sic]): 12.

(Note: the online version of the review has the date Nov. 19, 2019 [sic], and has the title “Bad Bishops, Bloodletting and a Plague of Caterpillars.”)

The book under review is:

Hartnell, Jack. Medieval Bodies: Life and Death in the Middle Ages. New York: W. W. Norton & Company, 2019.

“I’m Sick of It, I’m Leaving” Are First Words of Children in Primitive Village Routinely Eating Grubs and Starch Tasting Like “Gummy Mucous”

(p. C9) As she tended soldiers during the Crimean War, a British nurse found herself appalled by the wretched, vermin-infested conditions at the army’s hospital in Istanbul. She began collecting figures showing the devastating effects of the filth and the dramatic benefits of the sanitary improvements she implemented. Her presentation on the need for cleaner care facilities, published in 1858, led to reforms that ultimately saved millions of lives and increased life expectancy in the U.K. Florence Nightingale, it turns out, was a pioneering data scientist.

Data, when used to reveal the value of hospital hygiene or the harm of tobacco smoke, can be a vital force for good, as Tim Harford reminds us in “The Data Detective.”

. . .

Imprecise and inconsistent definitions are one source of confusion.  . . .  . . . “infant mortality,” a key data point for public health, varies depending on the specific time in fetal development when the line is drawn between a miscarriage and a tragically premature birth.

. . .

To learn from data, it’s essential to present it well. For her analysis after the Crimean War, Florence Nightingale created one of the first infographics, using shrewdly designed diagrams to tell a memorable story. From the outset, she regarded visually compelling data displays as indispensable to making her arguments.

. . .

An authentically open mind can make a difference, Mr. Harford says, noting that the top forecasters tend to be not experts but earnest learners who constantly take in new data while challenging and refining their hypotheses. Data, Mr. Harford concludes, can illuminate and inform as well as distract and deceive. It’s often maddeningly hard to know the difference, but it would be unforgivable not to try.

For the full review see:

Wade Davis. “To Hear a Dying Tongue.” The Wall Street Journal (Saturday, Aug. 10, 2019 [sic]): C9.

(Note: ellipses added.)

(Note: the online version of the review has the date Aug. 9, 2019 [sic], and has the title “‘A Death in the Rainforest’ Review: To Hear a Dying Tongue.”)

The book under review is:

Kulick, Don. A Death in the Rainforest: How a Language and a Way of Life Came to an End in Papua New Guinea. Chapel Hill, NC: Algonquin Books, 2019.

Noncredentialled Intense Outsider Duggan Brings Two Blockbuster Cancer Drugs to Market

(p. B11) There is a myth that making money in biotechnology stocks requires an advanced degree. But Bob Duggan, an avid surfer who never graduated from college, has proven that notion wrong. Twice.

Duggan’s latest investment, Summit Therapeutics SMMT 9.25%increase; green up pointing triangle, has become one of the industry’s greatest bets in recent years. The stock is up more than 1,000% in the past 12 months thanks to data from a late-stage trial that showed that its drug, Ivonescimab, beat Merck’s blockbuster cancer drug Keytruda in patients with a form of lung cancer. Duggan, who was already a billionaire before the Summit investment, is now worth about $16 billion, according to Forbes data.

There is much still to be worked out with the drug, which Summit licensed from Chinese biotech Akeso in 2022. For starters, investors are eager to see how it performs in global trials outside of China. What is remarkable about Summit’s success so far, though, is that this isn’t even Duggan’s first time making billions in biotech.

About 20 years ago, Duggan, a member of the Church of Scientology, began acquiring shares in a little-known biotech company called Pharmacyclics. He was drawn to the company’s cancer drug Xcytrin because of a personal loss: his son’s death from brain cancer. Pharmacyclics ultimately dropped the development of Xcytrin after multiple setbacks but went on to develop leukemia blockbuster Imbruvica. In 2015, AbbVie paid $21 billion for the company.

. . .

Nathan Vardi, author of “For Blood and Money,” which chronicles the development of Imbruvica and a competitor molecule, says that during his research he noticed that many people in biotech circles thought Duggan simply got lucky. While luck certainly plays a big role in the binary world of drug development, few would stick to that argument now.

So what is his secret? One thing Vardi points to is the ability to know when to retreat and when to go all in on an investment. “Duggan has a lifetime of experience making big bets with his own money on the line and figuring out when to hold or fold,” he wrote in an email. “Nobody gets these things completely right, but I think we have to admit he’s doing really well.”

Duggan, who built successful businesses in baking and robotics before jumping into biotechnology, suggests that the naivete of an outsider, combined with the intensity he brings to whatever he does, allowed him to try unconventional things. Nathan Vardi, author of “For Blood and Money,” which chronicles the development of Imbruvica and a competitor molecule, says that during his research he noticed that many people in biotech circles thought Duggan simply got lucky. While luck certainly plays a big role in the binary world of drug development, few would stick to that argument now.

So what is his secret? One thing Vardi points to is the ability to know when to retreat and when to go all in on an investment. “Duggan has a lifetime of experience making big bets with his own money on the line and figuring out when to hold or fold,” he wrote in an email. “Nobody gets these things completely right, but I think we have to admit he’s doing really well.”

Duggan, who built successful businesses in baking and robotics before jumping into biotechnology, suggests that the naivete of an outsider, combined with the intensity he brings to whatever he does, allowed him to try unconventional things.

For the full commentary see:

David Wainer. “Heard on the Street; An Outsider Crashes the Biotech Party.” The Wall Street Journal (Saturday, Sept. 24, 2024): B11.

(Note: ellipsis added.)

(Note: the online version of the commentary has the date September 23, 2024, and has the title “Heard on the Street; How a Surfer Who Never Finished College Became a Biotech Billionaire.” The sentence starting with “Léon Bottou” appears in the online, but not the print, version. Where there are small differences between the versions, the passages quoted above follow the online version.)

The book by Vardi mentioned above is:

Vardi, Nathan. For Blood and Money: Billionaires, Biotech, and the Quest for a Blockbuster Drug. New York: W. W. Norton & Company, 2023.

Rationality-Defender Stigler Saw Voting as Irrational, but Did It Anyway

Nobel Prize winner George Stigler contributed to the Public Choice literature and was a staunch defender of rationality. One example would be his paper with Gary Becker, “De Gustibus Non Est Disputandum.” One popular, much discussed conclusion of some public choice theorists is that it is irrational to vote. The argument goes that the marginal effect of one vote is almost always miniscule, so the expected benefit to the voter is equally miniscule. On the other hand, the time and effort it takes to vote are always more than miniscule. So the expected costs of voting exceed the expected benefits. Ergo it is irrational to vote. When I was a graduate student, taking courses in philosophy and economics, and for a couple of years as a post-doctoral fellow, I frequently stopped by the office of the Journal of Political Economy where Stigler was an editor. I believe it was there that I heard Stigler, definitely on an election day, say “Here I go to do something irrational.”

Stigler is well-known for his humorous biting comments. These could be tough on others. But this story shows that they also could be directed at himself.

I do not know if anyone has fully solved the paradox of the irrationality of voting. I guess you would have to say something about how the effects of all good people ceasing to vote would be far from marginal and far from good.

I once mentioned to distinguished Public Choice theorist Dwight Lee that a positive result of the personal benefits of voting being miniscule to a voter, is that the voter was freed from voting their personal narrow self-interest, and could vote their conscience about what served the general good. (Maybe something like what Rawls hoped for behind his “veil of ignorance” in A Theory of Justice.) I believe that Dwight told me that he already published a paper that expressed this positive result, but I never took the time to look for that paper.

Refrigeration Preserves Three-Quarters of Food Americans Eat

(p. 10) Consider the improbable fact of the supermarket banana. In “Frostbite,” an exploration of the vast system known as the cold chain, the journalist Nicola Twilley follows the banana through a “seamless network of thermal control.” This series of refrigerated trucks, rail cars, shipping containers and warehouses ends in the ripening room, with its temperature gauges and gas immersion baths, all to meet our demand for ripe tropical fruit in all seasons. “Produce is a labor of love,” a warehouse owner tells her. “I tell people that working here is like a face tattoo — you’ve got to be really sure you want it.”

Twilley is a food and health reporter who has studied cold and refrigeration for many years.

. . .

The home refrigerator is barely a century old. Twilley is shown how simple it is to build one, and then tells us just why it took so long to figure out. Early efforts were bent toward making ice with giant and dangerous machinery; breakthroughs in the use of vacuum pumps and compressors “cut out the middleman” of the ice itself.

. . .

One story leads into another. A technology invented to dry photographic film at Eastman Kodak led first to the extraction of fish oil and, eventually, bagged salad.

. . .

. . .; I found this book hard to put down. The startling statistics — the cold chain preserves almost three-quarters of the food Americans eat; American households open the fridge door an average of 107 times a day — separate tales of unsung scientists. We meet the self-taught engineer Fred Jones, who invented the first mobile mechanical refrigeration unit, expanding the speed and size of the cold chain. Twilley also introduces the physicist Barbara Pratt, who perfected the refrigerated shipping container by traveling the world in one.

For the full review see:

Sallie Tisdale. “Freeze Frame.” The New York Times Book Review (Sunday, August 4, 2024): 9.

(Note: ellipses added.)

(Note: the online version of the review has the date June 24, 2024, and has the title “Have Refrigerators Spoiled Everything?”)

The book under review is:

Twilley, Nicola. Frostbite: How Refrigeration Changed Our Food, Our Planet, and Ourselves. New York: Penguin Press, 2024.

Europeans Tire of Costly and Ineffective Climate Transition Policies

(p. A15) The 2015 Paris Agreement aspired to “reduce the risks and impacts of climate change” by eliminating greenhouse-gas emissions in the latter half of this century. The centerpiece of the strategy was a global transition to low-emission energy systems.

. . .

U.S. and European governments are trying to induce an energy transition by building or expanding organizations and programs favoring particular “clean” technologies, including wind and solar generation, carbon capture, hydrogen production and vehicle electrification. Promoting technological innovation is a worthy endeavor, but such efforts face serious challenges as costs and disruptions grow without tangible progress in reducing local, let alone global, emissions. Retreats from aggressive goals are already under way in Europe, with clear signs of mandate fatigue. The climbdown will be slower in the U.S., where subsidies create constituencies that make it more difficult to reverse course.

. . . It means that today’s ineffective, inefficient, and ill-considered climate-mitigation strategies will be abandoned, making room for a more thoughtful and informed approach to responsibly providing for the world’s energy needs.

For the full commentary see:

Steven E. Koonin. “The ‘Climate Crisis’ Fades Out.” The Wall Street Journal (Tuesday, June 11, 2024): A15.

(Note: ellipses added.)

(Note: the online version of the commentary has the date June 10, 2024, and has the same title as the print version.)

Koonin’s commentary, quoted above, is related to his book:

Koonin, Steven E. Unsettled: What Climate Science Tells Us, What It Doesn’t, and Why It Matters. Dallas, TX: BenBella Books, 2021.

Florence Nightingale Used Early Infographics to Improve Hospital Hygiene

(p. A15) As she tended soldiers during the Crimean War, a British nurse found herself appalled by the wretched, vermin-infested conditions at the army’s hospital in Istanbul. She began collecting figures showing the devastating effects of the filth and the dramatic benefits of the sanitary improvements she implemented. Her presentation on the need for cleaner care facilities, published in 1858, led to reforms that ultimately saved millions of lives and increased life expectancy in the U.K. Florence Nightingale, it turns out, was a pioneering data scientist.

Data, when used to reveal the value of hospital hygiene or the harm of tobacco smoke, can be a vital force for good, as Tim Harford reminds us in “The Data Detective.”

. . .

Imprecise and inconsistent definitions are one source of confusion.  . . .  . . . “infant mortality,” a key data point for public health, varies depending on the specific time in fetal development when the line is drawn between a miscarriage and a tragically premature birth.

. . .

To learn from data, it’s essential to present it well. For her analysis after the Crimean War, Florence Nightingale created one of the first infographics, using shrewdly designed diagrams to tell a memorable story. From the outset, she regarded visually compelling data displays as indispensable to making her arguments.

. . .

An authentically open mind can make a difference, Mr. Harford says, noting that the top forecasters tend to be not experts but earnest learners who constantly take in new data while challenging and refining their hypotheses. Data, Mr. Harford concludes, can illuminate and inform as well as distract and deceive. It’s often maddeningly hard to know the difference, but it would be unforgivable not to try.

For the full review see:

David A. Shaywitz. “Bookshelf; Broadly Informed, Easily Misled.” The Wall Street Journal (Friday, Jan. 29, 2021 [sic]): A15.

(Note: ellipses added.)

(Note: the online version of the review has the date January 28, 2021 [sic], and has the title “Bookshelf; ‘The Data Detective’ Review: Broadly Informed, Easily Misled.”)

The book under review is:

Harford, Tim. The Data Detective: Ten Easy Rules to Make Sense of Statistics. New York: Riverhead Books, 2021.

The Dynamic Renewal of artdiamondblog.com

In my Openness to Creative Destruction book I claim that we flourish through dynamism. But sometimes I do not practice what I preach. I fear that may be true with artdiamondblog.com. So I have spent some time pondering changes in my blog that I hope will on balance make it more useful to readers, and also free some of my time for my current main project, a book on Less Costs, More Cures: Unbinding Medical Entrepreneurs.

The Benefits and Opportunity Cost of My Current Blog:

Sone entries preserve some important examples that otherwise might be hard to find or to document.

Some entries help inform readers (and publishers) about my articles and books.

But time spent editing entries could be spent on my next book, or on writing op-eds, or on researching academic papers.

Conclusion:

I believe that the time I spend on my blog has produced value. But I also believe that the time could produce greater value if I re-directed some of it to my main project, the book Less Costs, More Cures. I also believe that it will have more value if a higher percent of the blog entries are related to the new book. (As Aaron and any other regular readers of the blog know, over the past year or two I have already moved in the direction of a higher percent of blog entries being relevant to Less Costs, More Cures.)

I have spent time preserving and sorting articles that I will now toss. Painful, but I long taught that sunk costs really are sunk, and I should practice what I preached.

In addition to content renewal, I also plan to implement some process renewal. Some of this will be trial and error. The content and process ideas below are not an exhaustive list.

Blog Renewal:

For some entries, instead of the past substantial quotations, I will just provide a citation and a couple of sentence summary. This will take less of my time, and so will have less opportunity cost. For some of the entries this change may also make it clearer to the reader why I think the cited article is important.

For articles related to Less Costs, More Cures, I will sometimes continue the past “readers digest” format for entries, where I explicitly quote particularly apt or important portions of the article. But I will less frequently do so for articles that support contentious points that I made in Openness.

I plan to occasionally add entries that provide meaningful and/or entertaining anecdotes or vignettes from my life as an academic. I hope these will not take much time, and that some may be useful to future historians of thought.

For articles to blog, I will try harder to seek out those that will stand the test of time–not depreciate quickly. These would tend to be meaningful stories, not statistics, or short-term accounts about particular firms or executives.

I will stop blogging so much on issues that are important, but where a strong and growing minority are presenting similar information. Three such issues would be environmental optimism, anti-D.E.I., and anti-Chinese-Communist violation of rights. For example, on the environment, we may be approaching a tipping point. Even The New York Times, sometimes in front page articles, has been explaining the potential of geoengineering (though still with the obligatory politically correct nod to the anti-growth/anti-technology environmentalists). [See: Gelles, David. “Can We Engineer Our Way Out of a Climate Crisis?” The New York Times, First Section (Sunday, March 31, 2024): 1 & 12-13; Gelles, David. “Scientist Wants to Block Sunlight to Cool Earth.” The New York Times (Sunday, Aug. 4, 2024): 1 & 18-19; Plumer, Brad, and Raymond Zhong. “Bold Plan Would Turn the World’s Oceans into Carbon Busters.” The New York Times (Monday, Sept. 23, 2024): A1 & A12-A13; and Gelles, David. “Renegades of Silicon Valley Pollute the Sky to Save the Planet.” The New York Times (Monday, Sept. 30, 2024): B1-B2.]

Welcome Your Comments:

Although I hope that my blog has been useful, and I have ideas about how it might have been useful, I rarely have empirical evidence. So I will be grateful if you let me know if any of it has been useful to you. I also will be grateful if you let me know what you think about my plans for renewal, and what suggestions you have for improvement (especially suggestions that do not cost me much time or effort ;).

You can respond within my blog as a comment to this entry or you can email me at amdiamond@cox.net. (Or if you have one of my other email addresses, use what you already have.)

Facing Death in a Seaplane Accident, Bertrand Russell’s Thoughts Were Not Philosophical: “I Thought the Water Was Cold”

For a year or two in grad school at Chicago, I was a member of a Bertrand Russell book club. I didn’t like Russell’s politics, but I did like his down-to-earth clarity, his sense of humor, and his optimistic defense of secular humanism.

(p. 10) “I am human, and consider nothing human alien to me”: The famous line from the Roman playwright Terence, written more than two millenniums ago, is easy to assert but hard to live by, at least with any consistency. The attitude it suggests is adamantly open-minded and resolutely pluralist: Even the most annoying, the most confounding, the most atrocious example of anyone’s behavior is necessarily part of the human experience. There are points of connection between all of us weirdos, no matter how different we are. Michel de Montaigne liked the line so much that he had the Latin original — Homo sum, humani nihil a me alienum puto — inscribed on a ceiling joist in his library.

. . .

Humanism, . . ., has always had to negotiate between noble ideals of humanity and the peculiarities of actual humans. Paradox and ambiguity aren’t to be rejected but embraced. “Dispute and contradiction, not veneration and obedience, are the essence of intellectual life,” Bakewell writes.

. . .

. . ., Bakewell practices what she preaches — or, since preaching would be anathema to a humanist, she does what she suggests. She puts her entire self into this book, linking philosophical reflections with vibrant anecdotes. She delights in the paradoxical and the particular, reminding us that every human being contains multitudes.

This can lead her to some wonderful asides.  . . .  When Bertrand Russell was in a seaplane accident in Norway and a journalist called him afterward to ask whether his brush with death had led him to think about such high-flown concepts as mysticism and logic, he said no, it had not. “I thought the water was cold.”

For the full review see:

Jennifer Szalai. “Oh, the Humanity.” The New York Times Book Review (Sunday, April 16, 2023 [sic]): 10.

(Note: ellipses added.)

(Note: the online version of the review has the date March 29, 2023 [sic], and has the title “The Tricky Thing With Humanism, This Book Implies, Is Humans.” In the original, the Latin phrase in the first quoted paragraph is in italics.)

The book under review is:

Bakewell, Sarah. Humanly Possible: Seven Hundred Years of Humanist Freethinking, Inquiry, and Hope. New York: Penguin Press, 2023.

What Inspired Steve Jobs and Who Steve Jobs Inspired

(p. A13) Katie Cotton, who as Apple’s longtime communications chief guarded the media’s access to Steve Jobs, the company’s visionary co-founder, and helped organize the introduction of many of his products, died on April 6 [2023] in Redwood City, Calif.

. . .

Ms. Cotton . . . chose which reporters could speak to Mr. Jobs (even though he would occasionally speak, on his own, to journalists he knew well). In 1997, she invited a Newsweek reporter, Katie Hafner, to watch, along with Mr. Jobs, the first commercial in Apple’s new “Think Different” advertising campaign.

A tribute to “the crazy ones, the misfits, the rebels and the troublemakers,” a narrator intoned as the commercial opened with a still picture of Mr. Jobs holding an apple in his left hand; it continued with clips of people who changed the world, among them Albert Einstein, Pablo Picasso, John Lennon, the Rev. Dr. Martin Luther King Jr., Thomas Edison and Muhammad Ali.

“I looked over and Steve was crying,” Ms. Hafner, who wrote about Apple for Newsweek and later for The Times, said in a phone interview. “I looked at Katie, and I couldn’t tell if she was moved or feeling triumphant — I don’t know — but I was filled with admiration for her, because she knew how to play this and to give me access.”

. . .

After Mr. Jobs died, the advertising agency TBWA/Media Arts Lab screened a proposed commercial for Ms. Cotton and two other Apple executives.

“It’s sad when a founder dies,” the commercial began, as recounted by the journalist Tripp Mickle (who now covers the tech industry for The Times) in “After Steve: How Apple Became a Trillion-Dollar Company and Lost Its Soul” (2022). “You wonder if you can make it without him. Should you put your brave face on for the world, or just be honest?”

When it finished, Ms. Cotton was weeping.

“We can’t run this,” she said. They never did.

For the full obituary see:

Richard Sandomir. “Katie Cotton, 57, Media Vice President at Apple Who Had Jobs’s Back.” The New York Times, First Section (Sunday, May 7, 2023 [sic]): 30.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary has the date May 4, 2023 [sic], and has the title “Katie Cotton, Who Helped Raise Apple’s Profile, Dies at 57.” The online version says that the print version is on p. 28. In my national print version, the obituary is on p. 30.)

The book by Mickle mentioned above is:

Mickle, Tripp. After Steve: How Apple Became a Trillion-Dollar Company and Lost Its Soul. New York: William Morrow, 2022.

A Founding Manager (aka Project Entrepreneur) Has the Motivation, Knowledge, and Power to Keep His Firm Innovative

In my Openness book, I discuss “project entrepreneurs” who overlap considerably with what is called “founder mode” in the commentary quoted below.

(p. B4) People like Elon Musk and Steve Jobs at times seemed to have a je ne sais quoi that allowed them to act and behave as leaders of their companies in ways that would have tripped up mere mortals.

This past week, Silicon Valley put a name to it: “Founder Mode.”

It’s a term coined by Paul Graham, co-founder of Y Combinator, an influential startup incubator in the San Francisco Bay Area. He wrote an essay this month gaining a lot of attention in tech circles that pits his “Founder Mode” against what he calls “Manager Mode.”

Graham tries to put his finger on the special relationship entrepreneurs have with their companies that he argues outsiders just lack.

. . .

In a podcast late last year, Chesky, who co-founded Airbnb originally as AirBed and Breakfast, talked about the three traits he said better equip a company’s founder over an outside manager.

“They’re the biological parent—you can love something but when you’re the biological parent of something, like, it came from you, it is you, there’s a deep passion and love,” Chesky said. “The second thing a founder has is they have the permission…like I can’t tell another child what to do but if they were my child I probably could.”

This empowers a founder to make dramatic changes, such as rebranding.

And finally, according to Chesky, a founder knows how the company was built in the first place. “You know how to rebuild it, you know the freezing temperature of a company, you know at what temperature it melts,” he said.

. . .

Before publishing his essay, Graham ran it by a few tech titans, including Musk. After it was published, Musk weighed in on X with his own endorsement: “Worth reading.”

For the full commentary see:

Tim Higgins. “Micromanaging Is Cool Again in Tech.” The Wall Street Journal (Monday, Sept. 9, 2024): B4.

(Note: ellipses between paragraphs added; ellipsis within paragraph in original.)

(Note: the online version of the commentary has the date September 7, 2024, and has the title “With ‘Founder Mode,’ Silicon Valley Makes Micromanaging Cool.” The French phrase is italicized in the print version.)

My book, mentioned above, is:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.