Category: Books

Curing Cancer Requires Enabling Serendipity, Not a Centrally Planned War

Happy Accidents is a wonderful book on serendipitous discovery that I ran across serendipitously. I had never heard of the author, but was interested in serendipity, so I started to collect books that Amazon says have something to do with serendipity. I let Happy Accidents sit on my shelf for about four years before starting to read.
The author is a retired, distinguished physician. The book is mainly a compendium of cases where major medical advances resulted from chance discoveries. Of course, the discoveries usually required more than just good luck. They usually required that someone was alert to the unexpected, and was willing to work in order to turn the unexpected into a cure. Their efforts are often made all the harder because of resistance from powerful incumbent “experts” and institutions. Often the discoveries go against the current theory, and are discovered by underfunded marginal outsiders.
Meyers points out that the centrally planned War on Cancer has cost the taxpayer a lot of money, and has largely failed to achieve its intended and predicted results. The reason is that you cannot centrally plan serendipity.
During the next several weeks, I will be quoting some of Meyers’ more revealing examples or thought-provoking comments.

Book discussed:
Meyers, Morton A. Happy Accidents: Serendipity in Modern Medical Breakthroughs. New York: Arcade Publishing, 2007.

Similarities Between Lucretius and Galileo

(p. 254) Like Lucretius, Galileo defended the oneness of the celestial and terrestrial world: there was no essential difference, he claimed, between the nature of the sun and the planets and the nature of the earth and its inhabitants. Like Lucretius, he believed that everything in the universe could be understood through the same disciplined use of observation and reason. Like Lucretius, he insisted on the testimony of the senses, against, if necessary, the orthodox claims of authority. Like Lucretius, he sought to work through this testimony toward a rational comprehension of the hidden structures of all things. And like Lucretius, he was convinced that these structures were by nature constituted by what he called “minims” or minimal particles, that is, constituted by a limited repertory of atoms combined in innumerable ways.

Source:
Greenblatt, Stephen. The Swerve: How the World Became Modern. New York: W. W. Norton & Company, 2011.

Under Communism People Felt They Had No Control Over Their Lives

(p. C4) “When people have to talk about Communism,” they tend to employ passive, impersonal constructions, as if they “had no influence on anything and were unwilling to take personal responsibility,” he notes in one typically observant passage. “Thus, in a situation where someone ought to say: ‘I was afraid to talk about it,’ ‘I hadn’t the courage to ask about it,’ or ‘I had no idea about it,’ they say: ‘There was no talk about it.’ ‘Nothing was known about it.’ ‘That wasn’t asked about.’ “

For the full review, see:
LARRY ROHTER. “Understanding the Land Where ‘Kafkaesque’ Was Born.” The New York Times (Mon., June 23, 2014): C4.
(Note: the online version of the review has the date June 22, 2014.)

The book being reviewed is:
Szczygiel, Mariusz. Gottland: Mostly True Stories from Half of Czechoslovakia. Translated by Antonia Lloyd-Jones. Brooklyn, NY: Melville House, 2014.

Cardinal Explained to Emperor that It Is OK to Lie to Heretics

Notwithstanding the assurances that the pope, the council, and the emperor had given him, Hus was almost immediately vilified and denied the opportunity to speak in public. On November 28, barely three weeks after he arrived, he was arrested on order of the cardinals and taken to the prison of a Dominican monastery on the banks of the Rhine. There he was thrown into an underground cell through which all the filth of the monastery was discharged. When he fell seriously ill, he asked that an advocate be appointed to defend his cause, but he was told that, according to canon law, no one could plead the cause of a man charged with heresy. In the face of protests from Hus and his Bohemian supporters about the apparent violation of his safe-conduct, the emperor chose not to intervene. He was, it was said, uncomfortable about what seemed a violation of his word, but an English cardinal had reportedly reassured him that “no faith need be kept with heretics.”

Source:
Greenblatt, Stephen. The Swerve: How the World Became Modern. New York: W. W. Norton & Company, 2011.
(Note: this quote is from somewhere on pp. 167-168; I bought the Kindle version which does not give page numbers correctly and I can’t recover pages on this one from Google books; I would guess it is all on p. 168.)

“Et La Liberté!”

(p. C7) [A] milestone in the diary comes in 1943 when [Guéhenno’s] students are drafted into compulsory work service in Germany; many escape to Spain or join resistance groups. Nor was Guéhenno exempt from the repression. That same year he was demoted by the Vichy education minister to the rank of a beginning instructor, assigned to teach 17 hours of class a week rather than the usual six and faced with supervising hundreds of students. “Stammering with fatigue,” he wondered how he would have time to keep his diary going. But he cheered up whenever he contemplated how many of the authors in his curriculum were bona fide revolutionaries: “Voltaire, Rousseau, Diderot, Danton, Robespierre, Chénier, Hugo, Michelet …, I have nothing to discuss but suspects.” He liked to end his class sessions by shouting “Et la liberté!”

For the full review, see:
Alice Kaplan. “Shedding Light on Nazi-Occupied Paris.” The New York Times (Thurs., JUNE 26, 2014): C7.
(Note: ellipsis in original; words in brackets were added.)
(Note: the online version of the review has the date JUNE 25, 2014.)

The book being reviewed is:
Guéhenno, Jean. Diary of the Dark Years, 1940-1944: Collaboration, Resistance, and Daily Life in Occupied Paris. Translated by David Ball. New York: Oxford University Press, 2014.

Conservatives Still Read Books, Despite Book Industry Slump

(p. B1) Of all the headaches of her current book tour — the declining sales, the constant travel, the interviews that generated unkind headlines about her family’s wealth — this one may sting Hillary Rodham Clinton the most: Her memoir, “Hard Choices,” has just been toppled from its spot on the best-seller list by a sensational Clinton account by her longtime antagonist Edward Klein.
. . .
. . . : the conservative book-buying public, . . . has continued to generate sales despite the industry’s overall slump, . . .

For the full story, see:
AMY CHOZICK and ALEXANDRA ALTER. “A Provocateur’s Book on Clinton Overtakes Her Memoir in Sales.” The New York Times (Fri., July 11, 2014): B1 & B6.
(Note: ellipses added.)
(Note: the online version of the article has the date JULY 10, 2014, and has the title “A Provocateur’s Book on Hillary Clinton Overtakes Her Memoir in Sales.”)

Future Pope Showed an Interest in the “Higher Forms of Piracy”

(p. 158) A decade older than his apostolic secretary Poggio, Baldassare Cossa had been born on the small volcanic island of Procida, near Naples. His noble family held the island as its personal possession, the hidden coves and well-defended fortress evidently well suited to the principal family occupation, piracy. The occupation was a dangerous one: two of his brothers were eventually captured and condemned to death. Their sentence was commuted, after much pulling of strings, to imprisonment. It was said by his enemies that the young Cossa participated in the family business, owed to it his lifelong habit of wakefulness at night, and learned from it his basic assumptions about the world.
Procida was far too small a stage for Baldassare’s talents. Energetic and astute, he early displayed an interest in what we might call higher forms of piracy. He studied jurisprudence at the University of Bologna–in Italy it was legal studies rather than theology that best prepared one for a career in the Church–where he obtained doctorates in both civil and canon law. At his graduation ceremony, a colorful affair in which the successful candidate was conducted in triumph through the town, Cossa was asked what he was going to do now. He answered,” To be Pope.”

Source:
Greenblatt, Stephen. The Swerve: How the World Became Modern. New York: W. W. Norton & Company, 2011.

Established Companies Are Not Structured for Exponential Growth

(p. A13) Why are large tech companies losing the ability to innovate? Entrepreneur and author Salim Ismail studies the new generation of “exponential corporations,” enterprises that grow 10 times faster than the average rate. He believes that established companies simply aren’t structured for this kind of speed. So their only choice is to buy those companies that can still innovate rapidly.
If Mr. Ismail is correct–and the current dynamic in Silicon Valley suggests that he may be–we’re on the brink of a major restructuring of business strategy, venture capital and almost every part of the high-tech world. It may be time to stop waiting for famous tech companies to roll out the hottest new product and start investing in startups that can sell their innovations to big companies. Tech appears to be evolving into a different kind of field: one that is, paradoxically, more static at the top but also more dependent on entrepreneurship than ever before.

For the full commentary, see:
MICHAEL S. MALONE. “An Innovation Slowdown at the Tech Giants; Seen anything new and big lately from Cisco, Yahoo or even Twitter?” The Wall Street Journal (Weds., July 2, 2014): A13.
(Note: the online version of the commentary has the date July 1, 2014.)

The Ismail research mentioned above, is discussed further in:
Ismail, Salim, Mike Malone, and Yuri van Geest. Exponential Organizations: Why New Organizations Are Ten Times Better, Faster, Cheaper Than Yours (and What to Do About It). New York: Diversion Books, 2014.

Poggio Helped Invent Italics Script

(p. 115) What Poggio accomplished, in collaboration with a few others, remains startling. They took Carolingian minuscule–a scribal innovation of the ninth-century court of Charlemagne–and transformed it into the script they used for copying manuscripts and writing letters. This script in turn served as the basis for the development of italics. They were then in effect the inventors of the script we still think of as at once the clearest, the simplest, and the most elegant written representation of our words. It is difficult to take in the full effect without seeing it for oneself, for example, in the manuscripts preserved in the Laurentian Library in Florence: the smooth bound volumes of vellum, still creamy white after more than five hundred years, (p. 116) contain page after page of perfectly beautiful script, almost magical in its regularity and fineness.

Source:
Greenblatt, Stephen. The Swerve: How the World Became Modern. New York: W. W. Norton & Company, 2011.

“The Metric System Can Be Our Operating System Without Being Our Interface”

(p. C6) The outcome was perhaps foreshadowed, as Mr. Marciano points out, when President Ford, using a customary unit, noted that American industries were “miles ahead” when it came to adopting the metric system.
Mr. Marciano tells his story more or less without editorializing, until the end. Surveying the centuries of fights over measurement, he finishes on a rather intriguing point: Standardization no longer matters that much.
. . .
. . . , with the computerization of life, we don’t have to worry about converting from one measurement to another; our software does this for us. We can still speak in pounds or feet, even if everything in the world of manufacturing and technology is really, at bottom, done in the metric system. In the evocative terminology of Mr. Marciano, “the metric system can be our operating system without being our interface.”

For the full review, see:
SAMUEL ARBESMAN. “Liters and Followers; Gerald Ford once proudly declared the country was ‘miles ahead’ in converting to the metric system.” The Wall Street Journal (Sat., Aug. 2, 2014): C6.
(Note: ellipses added.)
(Note: the online version of the review has the date Aug. 1, 2014, and has the title “Book Review: ‘Whatever Happened to the Metric System?’ by John Bemelmans Marciano; Gerald Ford once proudly declared the country was ‘miles ahead’ in converting to the metric system.” )

The book being reviewed is:
Marciano, John Bemelmans. Whatever Happened to the Metric System?: How America Kept Its Feet. New York: Bloomsbury USA, 2014.

Notaries Were Useful in a Contractual Society

(p. 111) Notaries were not figures of great dignity, but in a contractual and intensely litigious culture, they were legion. The Florentine notary Lapo Mazzei describes six or seven hundred of them crowded into (p. 112) the town hall, carrying under their arms bundles of documents, ” each folder thick as half a bible.” Their knowledge of the law enabled them to draw up local regulations, arrange village elections, compose letters of complaint. Town officials who were meant to administer justice often had no clue how to proceed; the notaries would whisper in their ears what they were meant to say and would write the necessary documents. They were useful people to have around.

Source:
Greenblatt, Stephen. The Swerve: How the World Became Modern. New York: W. W. Norton & Company, 2011.