Health – Page 74 – artdiamondblog.com

Neural Implants “Restored Their Human Functionality”

Ray Kurzweil. Source of photo: online version of the WSJ article quoted and cited below.

(p. C12) Inventor and entrepreneur Ray Kurzweil is a pioneer in artificial intelligence–the principal developer of the first print-to-speech reading machine for the blind, and the first text-to-speech synthesizer, among other breakthroughs. He is also a writer who explores the future of information technology and how it is changing our world.

In a wide-ranging interview, Mr. Kurzweil and The Wall Street Journal’s Alan Murray discussed advances in artificial intelligence, nanotechnology, and what it means to be human. Here are edited excerpts of their conversation:
. . .
MR. MURRAY: What about life expectancy? Is there a limit?
MR. KURZWEIL: No. We’re constantly pushing back life expectancy. Now it’s going to go into high gear because of the inherent exponential progression of information technology. According to my models, within 15 years we’ll be adding more than a year to your remaining life expectancy each year.
MR. MURRAY: So if you play the odds right, you never hit the endpoint.
MR. KURZWEIL: Right. If you can hang in there for another 15 years, we could get to that point.

What Is Human?
MR. MURRAY: What does it mean to be human in a post-2029 world?
MR. KURZWEIL: It’s a slippery slope. But we’ve already gone down that slope. I’ve talked to people who have neural implants in their brain, for Parkinson’s, and I’ve asked them, “Are you still human? Are you less human?”
Generally speaking, they say, “It’s part of me.” And they’re very proud of it, because it restored their human functionality.

For the full interview, see:
Alan Murray, interviewer. “Man or Machine? Ray Kurzweil on how long it will be before computers can do everything the brain can do.” The Wall Street Journal (Fri., June 29, 2012): C12.
(Note: ellipsis added; bold in original.)

Bicyclists Create Negative Externalities for Pedestrians

“Bicyclists weave through pedestrians and motor traffic on Friday in San Francisco, where a fatal bike-pedestrian collision has sparked debate.” Source of caption and photo: online version of the WSJ article quoted and cited below.

(p. A3) SAN FRANCISCO–City prosecutors said they would file felony vehicular-manslaughter charges against a bicyclist who allegedly hit and killed a pedestrian, in a case that has become a flash point for debate over bicyclists’ rights in the city.

The manslaughter charges–unusually stiff for a bicycle accident–stem from a March 29 incident, when 36-year-old bicyclist Chris Bucchere allegedly ran a red traffic light and plowed into 71-year-old Sutchi Hui in a crosswalk. Mr. Hui died April 2 of injuries related to the collision.
. . .
The bicycle backlash has come to a head after a series of pedestrian deaths in the San Francisco Bay area. A 67-year-old woman died last August after a bicyclist allegedly hit her in a crosswalk after running a red light; the cyclist was convicted of a misdemeanor. Earlier this month, a cyclist allegedly struck and killed a 92-year-old woman in the suburb of El Cerrito while crossing a street; that case is under investigation.

For the full story, see:
JIM CARLTON. “U.S. NEWS; Reckless Riders Spur Backlash; Fatal Collision in San Francisco Leads to Manslaughter Charges Against Cyclist.” The Wall Street Journal (Sat., June 16, 2012): A3.
(Note: ellipsis added.)

93% of Donated Eyeglasses Are Not Usable

(p. D6) Giving used eyeglasses to poor countries may please the donors, but it is not worth the high delivery costs, a new study has concluded, and a $10 donation would do more good.
The study, led by Australian scientists and published in March in Optometry and Vision Science, found that only 7 percent of a test sample of 275 donated spectacles were usable. That raised the delivery cost to over $20 per usable pair. A simple eye exam and a set of ready-made glasses from China can be provided for just $10, the authors said.

For the full story, see:
DONALD G. McNEIL Jr. “GLOBAL UPDATE; Donations for Eyeglasses in Poor Nations Are Better Than Recycling Used Pairs.” The New York Times (Tues., April 24, 2012): D6.
(Note: the online version of the article has the date April 23, 2012.)

(Note: a more extended analysis of this example appears in an online article by Virginia Postrel. I am grateful for Dale Eesley for sending me a link to Postrel’s article.)

Same Government that Allows Violence, Prioritizes Taxing Soda

“One vocal opponent of the tax is Courtland Boozé, a City Council member who calls it a hardship on poor people.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. 14) Even here at a sweaty Zumba class sponsored by a nonprofit group called Weigh of Life, the city’s proposal for a one-cent-per-ounce tax on sugar-sweetened beverages, which is to appear on the November ballot, meets up against the hard realities of residents’ lives.

“What don’t I have?” asked Rita Cerda, a longtime soda devotee, ticking off her ailments, including diabetes, high blood pressure and asthma. She is also overweight.
“I have problems drinking water,” she said. “I don’t like water.”
The proposed tax, a license fee on businesses selling sweetened drinks, would require owners of bodegas, theaters, convenience stores and other outlets to tally ounces sold and, presumably, pass the cost on to customers.
. . .
Courtland Boozé is a City Council member and a vocal opponent of the soda tax. “We are primarily an economically suppressed community,” he said. “It will be a huge hardship.
“I eat sweet potato pie and candied yams,” continued Mr. Boozé, who is from Louisiana. “And what about cupcakes? Are they going to tax those?”
The city’s Chamber of Commerce is also opposed to the tax. A group fighting the tax that includes the beverage industry has begun dropping off “Community Coalition Against Beverage Taxes” placards at La Flore de Jalisco Market, a small, cheerful grocery store where soda bottles in dozens of hues match the colorful piñatas hanging from the ceiling.
. . .
Charles Finnie, known as Chuck, a vice president of BMWL, a San Francisco lobbying firm, called the tax “an administrative nightmare for local businesses” that would also put them at a competitive disadvantage, with customers opting for cheaper soda in nearby cities.
. . .
At the RYSE Youth Center, founded 12 years ago after the killing of four high school students, the soda issue seemed both close to the heart and far away.
Kayla Miller, an 18-year-old college freshman, said that if complexion problems from too much sugar would not deter her friends from drinking sodas, neither would a tax.
Shivneel Sen, 14, does not favor the tax but knows how the money should be spent if it passes.
“The police came heck of late,” he said, recalling the recent death of a best friend. “We need more of them.”
Kimberly Aceves, the center’s executive director, says that too often, the burden for making healthy choices falls unfairly on young people. Society may say “go exercise,” she said, “but if the community isn’t safe, how many kids are going to go out running?”
“Soda is bad for you,” Ms. Aceves said. “So is violence.”

For the full story, see:
PATRICIA LEIGH BROWN. “RICHMOND JOURNAL; Plan to Tax Soda Gets a Mixed Reception.” The New York Times, First Section (Sun., June 3, 2012): 14.
(Note: ellipses added.)
(Note: the online version of the article has the date June 2, 2012.)

For Federal Regulators “It’s Easier Not to Approve than to Approve”

“Xavier Lauth, a scientist, working with zebra fish in a lab at the Center for Aquaculture Technologies.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. B1) SAN DIEGO — If Americans ever eat genetically engineered fast-growing salmon, it might be because of a Soviet biologist turned oligarch turned government minister turned fish farming entrepreneur.

That man, Kakha Bendukidze, holds the key to either extinction or survival for AquaBounty Technologies, the American company that is hoping for federal approval of a type of salmon that would be the first genetically engineered animal in the human food supply.
But 20 months since the Food and Drug Administration tentatively concluded that the fish would be safe to eat and for the environment, there has been no approval. And AquaBounty is running out of money.
Mr. Bendukidze, the former economics minister of Georgia and AquaBounty’s largest shareholder, says the company can stay afloat a while longer. But he is skeptical that genetically altered salmon will be approved in the United States in an election year, given the resistance from environmental and consumer groups.
“I understand politically that it’s easier not to approve than to approve,” Mr. Bendukidze said during a recent visit to a newly acquired laboratory in San Diego, where jars of tiny zebra fish for use in genetic engineering experiments are stacked on shelves. While many people would be annoyed by the approval, he said, “There will be no one except some scientists who will be annoyed if it is not approved.”
. . .
(p. B6) Mr. Bendukidze, 56, began his career as a molecular biologist in a research institute outside Moscow, working on genetically engineering viruses for vaccine use. He later started a company selling biology supplies. When parts of the Soviet economy were privatized, he earned a reputation as a corporate raider, building through acquisitions and leading United Heavy Machinery, a large maker of equipment for mining, oil drilling and power generation.
In 2004, Mr. Bendukidze returned to his native Georgia as economics minister under Mikheil Saakashvili, the newly elected president. With a free-market philosophy and a penchant for insulting those who disagreed with him, Mr. Bendukidze earned his share of enemies as he moved to deregulate and privatize the economy.
He still lives in Georgia and now spends his time as chairman of the Free University of Tbilisi, which he founded. He also set up Linnaeus Capital Partners to manage his money. It has increasingly focused on aquaculture, with stakes in companies in Greece, Israel and Britain, in addition to AquaBounty.

For the full story, see:
ANDREW POLLACK. “An Entrepreneur Bankrolls a Genetically Engineered Salmon.” The New York Times (Tues., May 22, 2012): B1 & B6.
(Note: ellipsis added.)
(Note: the online version of the article has the date May 21, 2012.)

“Kakha Bendukidze acquired the lab after agreeing to give AquaBounty more cash.” Source of caption and photo: online version of the NYT article quoted and cited above.

Rats, Motivated by Cheese, and Stimulated by Electricity and Chemicals, Grow Neurons and Walk Again

“After several weeks of neurorehabilitation, previously paralyzed rats initiated a walking gait and soon began sprinting, climbing stairs and avoiding obstacles.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A13) Rats with a spinal cord injury that left their hind legs completely paralyzed learned to walk again on their own after an intensive training course that included electrical stimulation of the brain and the spine, scientists reported on Thursday.
. . .
The report, published online on Thursday in the journal Science, provides a striking demonstration of what until recently few scientists thought possible: complete rehabilitation after a disabling blow to the spinal cord. After weeks of training, many of the rats could walk as well as before the injury, and some could run.
. . .
The rats then began a daily regimen. Outfitted with tiny vests, held upright on their back legs but left to bear their full weight, the rats tried to move toward a piece of cheese that beckoned nearby. They lurched forward like furry paratroopers, unsteady on their feet after a hard landing.
The scientists provided stimulation in three places: electrically, in the motor area of the brain and in the spinal cord below the injury, and chemically, infusing the wound area with drugs thought to promote growth.
And growth is what they got. After two to three weeks of 30-minute daily sessions, the rats began to take their first voluntary steps. After six weeks, all of the rats could walk on their own, and some could run and climb stairs.
. . .
In effect, . . . , the training forces the brain to recruit what is left of the neural system to get the job done. Neurons sprout like seedlings on a Chia Pet when they are seeking new connections, and the scientists found increases of 300 percent and more in projections in the brain stem and around the injury — evidence that the nervous system was remapping its connections.

For the full story, see:
BENEDICT CAREY. “In Rat Experiment, New Hope for Spine Injuries.” The New York Times (Fri., June 1, 2012): A13.
(Note: online version of the story is dated May 31, 2012.)

Global Warming Would Reduce Deaths from Flu

(p. 4) According to the National Oceanic and Atmospheric Administration, this January was the fourth warmest in the documented history of weather in the contiguous United States.
. . .
. . . , our warm winter may have one unforeseen and felicitous consequence: a drastic reduction in the incidence of influenza.
. . .
This year’s flu season, . . . , didn’t officially begin until late last month. And while a true number is difficult to reach — not every sick person is tested, for instance, and the cause of a death in the hospital can be clouded by co-morbidities — it is likely that no more than a few hundred people in America, and possibly far fewer, have died of the flu this winter. Indeed, by any measurement, the statistics are historic and heartening. For every individual who has been hospitalized this season, 22 people were hospitalized in the 2010-11 flu season. Even more strikingly, 122 children died of flu last season and 348 during the flu outbreak of 2009-10 — while this time around that number is 3.

For the full commentary, see:

CHARLES FINCH. “OPINION; The Best Part About Global Warming.” The New York Times (Tues., March 4, 2012): 4.
(Note: ellipses added.)
(Note: the online version of the review is dated March 2, 2012.)

Libertarian Law Professor Defends Free Choice in Health Care

“Randy E. Barnett has argued against the health care law.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A1) WASHINGTON — When Congress passed legislation requiring nearly all Americans to obtain health insurance, Randy E. Barnett, a passionate libertarian who teaches law at Georgetown, argued that the bill was unconstitutional.
. . .
. . . over the past two years, through his prolific writings, speaking engagements and television appearances, Professor Barnett has helped drive the question of the health care law’s constitutionality from the fringes of academia into the mainstream of American legal debate and right onto the agenda of the United States Supreme Court.
. . .
. . . the challenge championed by Professor Barnett: that Congress’s power to set rules for commerce does not extend to regulating “inactivity,” like choosing not to be insured.
. . .
(p. A14) He is a fierce advocate of economic freedom who is accustomed to being a legal underdog. In 2004, in his first (and, he says, probably his last) appearance before the Supreme Court, he argued that Congress could not criminalize the production of home-grown marijuana for personal medical use. There again, critics said he would lose 8 to 1. He did lose, but took satisfaction in the actual vote, 6 to 3.
. . .
Professor Barnett’s work on the health care law fits into a much broader intellectual project, his defense of economic freedom. He has long argued that the Supreme Court went too far in upholding New Deal economic laws — a position that concerns his liberal critics.
Even a close friend and fellow Georgetown law professor, Lawrence B. Solum, says that Professor Barnett is aware of the “big divide between his views and the views of lots of other people,” and that his political philosophy is “much more radical” than his legal argument in the health care case. Professor Barnett, for his part, insists that if the health law is struck down, it will not “threaten the foundation of the New Deal.” But, he allowed, it would be “a huge symbolic victory for limited government.”

For the full story, see:
SHERYL GAY STOLBERG and CHARLIE SAVAGE. “Libertarian’s Pet Cause Reaches Supreme Court.” The New York Times (Tues., March 27, 2012): A1 & A14.
(Note: ellipses added.)
(Note: the online version of the story is dated March 26, 2012 and has the title “Vindication for Challenger of Health Care Law.”)

Quantum Computers May Revolutionize Nanotechnology and Drug Design

“Scott Aaronson.” Source of caption and photo: online version of the NYT commentary quoted and cited below.

(p. D5) When people hear that I work on quantum computing — one of the most radical proposals for the future of computation — their first question is usually, “So when can I expect a working quantum computer on my desk?” Often they bring up breathless news reports about commercial quantum computers right around the corner. After I explain the strained relationship between those reports and reality, they ask: “Then when? In 10 years? Twenty?”

Unfortunately, this is sort of like asking Charles Babbage, who drew up the first blueprints for a general-purpose computer in the 1830s, whether his contraption would be hitting store shelves by the 1840s or the 1850s. Could Babbage have foreseen the specific technologies — the vacuum tube and transistor — that would make his vision a reality more than a century later? Today’s quantum computing researchers are in a similar bind. They have a compelling blueprint for a new type of computer, one that could, in seconds, solve certain problems that would probably take eons for today’s fastest supercomputers. But some of the required construction materials don’t yet exist.
. . .
While code-breaking understandably grabs the headlines, it’s the more humdrum application of quantum computers — simulating quantum physics and chemistry — that has the potential to revolutionize fields from nanotechnology to drug design.
. . .
Like fusion power, practical quantum computers are a tantalizing possibility that the 21st century may or may not bring — depending on the jagged course not only of science and technology, but of politics and economics.

For the full commentary, see:
SCOTT AARONSON. “ESSAY; Quantum Computing Promises New Insights, Not Just Supermachines.” The New York Times (Tues., December 6, 2011): D5.
(Note: ellipses added.)
(Note: the online version of the commentary is dated December 5, 2011.)

Purging Senescent Cells Makes Mice More Youthful and Vigorous

“CELL SUICIDE. A subdermal fat layer, middle, in a mouse purged of senescent cells. These mice can run much longer and have larger fat deposits.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. D3) Until recently, few people gave much thought to senescent cells. They are cells that linger in the body even after they have lost the ability to divide.

But on Nov. 2, in what could be a landmark experiment in the study of aging, researchers at the Mayo Clinic reported that if you purge the body of its senescent cells, the tissues remain youthful and vigorous.
. . .
. . . the startling result is plausible because it ties together an emerging body of knowledge about senescent cells. And it raises the possibility that attacks on the cells might postpone the diseases of aging and let people live out more of their life span in good health.
. . .
The finding was made in a strain of mice that age fast and usually die of heart arrhythmia. So despite their healthier tissues, the mice purged of senescent cells died at the usual age of heart problems. Dr. van Deursen’s team is now testing to see whether normal mice will live longer when purged of senescent cells.
The treatment was started when the normal mice were a year old, and they have now been treated for five months. Next month they will run treadmill tests to see if they are in better shape than a comparison group of untreated mice, Dr. van Deursen said.
The genetic method used to purge mice of senescent cells cannot be used in people. Instead of trying to remove senescent cells from elderly people, Dr. Peeper believes, it may be more effective to identify which of the factors that the senescent cells secrete are the source of their ill effects and to develop drugs that block these factors.
But Dr. van Deursen thinks it would be better to go after the senescent cells themselves. In his view it should be easy enough by trial and error to find chemicals that selectively destroy senescent cells, just like the targeted chemicals now used to treat certain kinds of cancer. And unlike the cancer cells, which proliferate so fast that they soon develop resistance, the senescent cells cannot replicate, so they should be easy targets.
Several companies and individuals have already approached the Mayo Clinic to explore developing such drugs. “They think it’s possible, and they are very enthusiastic,” Dr. van Deursen said. “So I can guarantee that there will be initiatives to find drugs that kill senescent cells and mimic the system that we have developed in the mouse.”
. . .
“If you remove the senescent cells you improve things considerably, but you can’t reverse the process or completely stop the aging because it has other causes,” Dr. van Deursen said. “Personally I think we can slow aging down, and over time we will become more and more successful.

For the full story, see:

NICHOLAS WADE. “In Body’s Shield Against Cancer, a Culprit in Aging May Lurk.” The New York Times (Tues., November 22, 2011): D3.
(Note: ellipses added.)
(Note: the online version of the story is dated November 21, 2011.)

Simple Heuristics Can Work Better than Complex Formulas

(p. C4) Most business people and physicians privately admit that many of their decisions are based on intuition rather than on detailed cost-benefit analysis. In public, of course, it’s different. To stand up in court and say you made a decision based on what your thumb or gut told you is to invite damages. So both business people and doctors go to some lengths to suppress or disguise the role that intuition plays in their work.
Prof. Gerd Gigerenzer, the director of the Max Planck Institute for Human Development in Berlin, thinks that instead they should boast about using heuristics. In articles and books over the past five years, Dr. Gigerenzer has developed the startling claim that intuition makes our decisions not just quicker but better.
. . .
The economist Harry Markowitz won the Nobel prize for designing a complex mathematical formula for picking fund managers. Yet when he retired, he himself, like most people, used a simpler heuristic that generally works better: He divided his retirement funds equally among a number of fund managers.
A few years ago, a Michigan hospital saw that doctors, concerned with liability, were sending too many patients with chest pains straight to the coronary-care unit, where they both cost the hospital more and ran higher risks of infection if they were not suffering a heart attack. The hospital introduced a complex logistical model to sift patients more efficiently, but the doctors hated it and went back to defensive decision-making.
As an alternative, Dr. Gigerenzer and his colleagues came up with a “fast-and-frugal” tree that asked the doctors just three sequential yes-no questions about each patient’s electrocardiographs and other data. Compared with both the complex logistical model and the defensive status quo, this heuristic helped the doctors to send more patients to the coronary-care unit who belonged there and fewer who did not.

For the full commentary, see:
By MATT RIDLEY. “MIND & MATTER; All Hail the Hunch–and Damn the Details.” The Wall Street Journal (Sat., December 24, 2011): C4.
(Note: ellipsis added.)

A couple of Gigerenzer’s relevant books are:
Gigerenzer, Gerd. Gut Feelings: The Intelligence of the Unconscious. New York: Penguin Books, 2007.
Gigerenzer, Gerd. Rationality for Mortals: How People Cope with Uncertainty. New York: Oxford University Press, USA, 2008.