“Two Self-Made Mill Owners” in Golden Age of Capitalism Collected and Preserved “Literary Treasures”

(p. C6) A consortium of British libraries and museums has announced that it successfully raised more than $20 million to buy a “lost” library containing rare manuscripts by Robert Burns, Walter Scott and the Brontës, heading off an auction and preserving the collection intact.

. . .

“A collection of literary treasures of this importance comes around only once in a generation,” Richard Ovenden, the head of the Bodleian Libraries at Oxford, said in a news release earlier this month announcing the deal.

. . .

Alfred and William Law, two self-made mill owners who grew up less than 20 miles from the Brontë home in Haworth (which is now the Brontë Parsonage Museum), began collecting what became the Honresfield Library in the 1890s.

. . .

In the announcement, Gabriel Heaton, the Sotheby’s specialist who organized the planned sale, called it “a collection like no other that has come to market in recent decades.”

For the full story, see:

Jennifer Schuessler. “$20 Million Raised to Preserve a ‘Lost Library’.” The New York Times (Saturday, December 25, 2021): C6.

(Note: ellipses added.)

(Note: the online version of the story has the date Dec. 24, 2021, and has the title “Group Raises $20 Million to Preserve ‘Lost’ Brontë Library.”)

“Endless” Trial-and-Error Experiments Led to Creation of Islet Cells to Cure Type 1 Diabetes

(p. 1) Brian Shelton’s life was ruled by Type 1 diabetes.

. . .

His ex-wife, Cindy Shelton, took him into her home in Elyria, Ohio. “I was afraid to leave him alone all day,” she said.

Early this year, she spotted a call for people with Type 1 diabetes to participate in a clinical trial by Vertex Pharmaceuticals. The company was testing a treatment developed over decades by a scientist who vowed to find a cure after his baby son and then his teenage daughter got the devastating disease.

Mr. Shelton was the first patient. On June 29, [2021] he got an infusion of cells, grown from stem cells but just like the insulin-producing pancreas cells his body lacked.

Now his body automatically controls its insulin and blood sugar levels.

Mr. Shelton, now 64, may be the first person cured of the disease with a new treatment that has experts daring to hope that help may (p. 18) be coming for many of the 1.5 million Americans suffering from Type 1 diabetes.

“It’s a whole new life,” Mr. Shelton said. “It’s like a miracle.”

. . .

One problem was the source of the cells — they came from unused fertilized eggs from a fertility clinic. But in August 2001, President George W. Bush barred using federal money for research with human embryos. Dr. Melton had to sever his stem cell lab from everything else at Harvard. He got private funding from the Howard Hughes Medical Institute, Harvard and philanthropists to set up a completely separate lab with an accountant who kept all its expenses separate, down to the light bulbs.

Over the 20 years it took the lab of 15 or so people to successfully convert stem cells into islet cells, Dr. Melton estimates the project cost about $50 million.

The challenge was to figure out what sequence of chemical messages would turn stem cells into insulin-secreting islet cells. The work involved unraveling normal pancreatic development, figuring out how islets are made in the pancreas and conducting endless experiments to steer embryonic stem cells to becoming islets. It was slow going.

. . .

The next step for Dr. Melton, knowing he’d need more resources to make a drug that could get to market, was starting a company.

. . .

His company Semma was founded in 2014, a mix of Sam and Emma’s names.

One challenge was to figure out how to grow islet cells in large quantities with a method others could repeat. That took five years.

The company, led by Bastiano Sanna, a cell and gene therapy expert, tested its cells in mice and rats, showing they functioned well and cured diabetes in rodents.

At that point, the next step — a clinical trial in patients — needed a large, well financed and experienced company with hundreds of employees. Everything had to be done to the exacting standards of the Food and Drug Administration — thousands of pages of documents prepared, and clinical trials planned.

Chance intervened. In April 2019, at a meeting at Massachusetts General Hospital, Dr. Melton ran into a former colleague, Dr. David Altshuler, who had been a professor of genetics and medicine at Harvard and the deputy director of the Broad Institute. Over lunch, Dr. Altshuler, who had become the chief scientific officer at Vertex Pharmaceuticals, asked Dr. Melton what was new.

Dr. Melton took out a small glass vial with a bright purple pellet at the bottom.

“These are islet cells that we made at Semma,” he told Dr. Altshuler.

Vertex focuses on human diseases whose biology is understood. “I think there might be an opportunity,” Dr. Altshuler told him.

Meetings followed and eight weeks later, Vertex acquired Semma for $950 million. With the acquisition, Dr. Sanna became an executive vice president at Vertex.

. . .

Less than two years after Semma was acquired, the F.D.A. allowed Vertex to begin a clinical trial with Mr. Shelton as its initial patient.

For the full story, see:

Gina Kolata. “A Cure for Severe Diabetes? For an Ohio Patient, It Worked.” The New York Times, First Section (Sunday, November 28, 2021): 1 & 18.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story has the date Nov. 27, 2021, and has the title “A Cure for Type 1 Diabetes? For One Man, It Seems to Have Worked.”)

Taking “Capital Allocation Away From People Who Have Demonstrated Great Skill in Capital Allocation”

(p. 1) The richest people on earth typically devote a share of their vast resources to charity. That is the bargain and the expectation, anyway.

Jeff Bezos, until very recently the world’s richest human, has been applying himself dutifully if a bit cautiously to the task, giving money to food banks and homeless families while pledging $10 billion of the fortune he earned through the online retailer Amazon to fight climate change.

The latest richest human, Elon Musk, has taken a rather different tack. There was the public spat with the director of the World Food Programme on Twitter, for instance, announcing, “If WFP can describe on this Twitter thread exactly how $6B will solve world hunger, I will sell Tesla stock right now and do it.”

. . .

And, of course, there is the ongoing insistence that his moneymaking efforts, running both the electric carmaker Tesla and the rocket company SpaceX, are already better-(p. 8)ing humankind, thank you very much.

Mr. Musk is practicing “troll philanthropy.”

That’s what Benjamin Soskis, senior research associate in the Center on Nonprofits and Philanthropy at the Urban Institute, has called it, noting that Mr. Musk seems to be having fun with this novel approach.

“He doesn’t seem to care much about using his philanthropy to curry public favor,” Mr. Soskis said. “In fact, he seems to enjoy using his identity as a philanthropist in part to antagonize the public.”

. . .

“The particular barrier for donors from a tech background is they don’t just think their genius has made them good at what they do, they also think what they do commercially also makes society better,” said Rhodri Davies, a philanthropy commentator who wrote a piece on Mr. Musk called “The Edgelord Giveth.”

Mr. Musk, for instance, has said that getting humankind to Mars through SpaceX is an important contribution and has written and spoken acerbically about what he calls “anti-billionaire BS,” including attempts to target taxes at billionaires.

“It does not make sense to take the job of capital allocation away from people who have demonstrated great skill in capital allocation and give it to an entity that has demonstrated very poor skill in capital allocation, which is the government,” Mr. Musk said on Monday at an event hosted by The Wall Street Journal.

At the same time, Mr. Kharas said a more charitable reading of Mr. Musk’s exchange with the World Food Programme is possible. He could just genuinely want to know how the money will be spent and is putting in public, on Twitter, the due diligence work that institutional giving does behind closed doors.

“I think this idea that he was willing to engage was really good,” Mr. Kharas of the Brookings Institution said of Mr. Musk. “I think his response was extremely sensible. It was basically, ‘Show me what you can do. Demonstrate it. Provide me with some evidence. I’ll do it.’”

For the full story, see:

Nicholas Kulish. “Elon Musk, Trolling Away.” The New York Times SundayBusiness Section (Sunday, December 12, 2021): 1 & 8.

(Note: ellipses added.)

(Note: the online version of the story has the date Dec. 10, 2021, and has the title “Elon Musk’s Latest Innovation: Troll Philanthropy.”)

Bloomberg Will Donate $750 Million to Support Charter Schools

(p. A19) American public education is broken. Since the pandemic began, students have experienced severe learning loss because schools remained closed in 2020—and even in 2021 when vaccinations were available to teachers and it was clear schools could reopen safely. Many schools also failed to administer remote learning adequately.

Before the pandemic, about two-thirds of U.S. students weren’t reading at grade level, and the trend has been getting worse. Results from the National Assessment of Educational Progress, commonly known as the nation’s report card, show that in 2019, eighth-grade math scores had already fallen significantly.

Teachers understand the severity of the problem, and many are doing heroic work, yet some of their union representatives are denying reality. “There is no such thing as learning loss,” said Cecily Myart-Cruz, head of the Los Angeles teachers union, in an interview with Los Angeles Magazine this past summer. “Our kids didn’t lose anything. It’s OK that our babies may not have learned all their times tables. They learned resilience.”

What nonsense. How about reading, writing and arithmetic, the critical skills we are funding schools to teach?

Instead of giving students the skills they need to succeed in college or in a trade, the public education system is handing them diplomas that say more about their attendance record than their academic achievement. This harms students, especially those from low-income families. When and if they graduate, they will try to find work in an economy that values knowledge and skills above all else, and their old schools will say to them: “Good luck!”

. . .

We know what works, because we can see it in real time. Success Academy’s network of 47 public charter schools is serving New York children whose families predominantly live below the poverty line. Their students are outperforming public-school students in Scarsdale, N.Y.—the wealthiest town on the East Coast and the second-wealthiest town in America—by significant margins. Yet a statewide cap on charter schools is blocking Success Academy from expanding.

. . .

Today there are long waiting lists for charter schools across the country, but mayors and governors aren’t getting the support they need from Congress and the White House to open new charter schools. To begin meeting the demand for charters, Bloomberg Philanthropies is launching a five-year, $750 million effort to create seats for 150,000 more children in 20 metro areas across the country.

For the full commentary, see:

Bloomberg, Michael R. “Why I’m Backing Charter Schools.” The Wall Street Journal (Thursday, Dec. 2, 2021): A19.

(Note: ellipses added.)

(Note: the online version of the commentary has the date December 1, 2021, and has the same title as the print version.)

University of Chicago’s Milton Friedman Center Now Run by “Former Obama Staffers Who Cheer” . . . “Moves Toward Socialism”

(p. A15) Colleges’ ideological turn leftward has become sharper. At my own institution, a center dedicated to Milton Friedman is now run by former Obama staffers who cheer on the Biden administration’s moves toward socialism.

These policies reward professors and administrators who can then raise the price of their services. It’s basic economics that subsidizing demand increases the price of the product. Tuition rising as loan subsidies expand is no different. It isn’t a coincidence that education and health care, the industries in which government subsidies are most pervasive, took the highest price increases over the past 15 years—3.7% and 3.1% a year, compared with the 1.8% average across industries.

For the full commentary, see:

Tomas J. Philipson. “College Subsidies Are a Feedback Loop for Bigger Government.” The Wall Street Journal (Friday, June 11, 2021): A15.

(Note: the online version of the commentary has the date June 10, 2021, and has the title “College Subsidies Are a Feedback Loop for Bigger Government.”)

Choppin at Hughes Medical Institute Hired Good Scientists and Let Them Pursue Hunches and Serendipitous Insights

(p. A27) Purnell Choppin, whose research on how viruses multiply helped lay the foundation for today’s fight against the Covid-19 pandemic, died on July 3 [2021] at his home in Washington, one day shy of his 92nd birthday.

. . .

Dr. Choppin (pronounced show-PAN) focused on measles and influenza, but his research, and the methods he developed to conduct it, proved critical for later work on other viruses, including severe acute respiratory syndrome coronavirus 2, the virus behind the Covid-19 pandemic, said David Baltimore, an emeritus professor of biology at the California Institute of Technology and a winner of the 1975 Nobel Prize in Physiology or Medicine.

“The issue of how viruses infect cells was very much on his mind, and the mechanisms he worked out studying influenza were central to thinking about coronaviruses,” Dr. Baltimore said. “Thanks to his work and that of so many others, when the pandemic hit, we were able to formulate questions about the virus in quite precise terms.”

Dr. Choppin was equally well known as an administrator, first at Rockefeller and then at the Howard Hughes Medical Institute, which hired him in 1985 as its chief medical officer. He later ran the institute for 12 years, turning it from a modest-size research organization into a global research powerhouse.

. . .

With a calm, easygoing demeanor that disguised a fierce, visionary ambition, Dr. Choppin took an innovative approach to funding. Unlike other institutions, which provide grants for specific projects, he focused on identifying top researchers and then showering them with money and resources. Even better, he did not ask them to move to the institute, in Chevy Chase, Md. — they could stay where they were and let the Hughes largesse come to them.

. . .

While Dr. Choppin was sometimes criticized for making safe bets on established scientists who probably didn’t need his help, he made no apologies, and had the track record to prove the soundness of his approach: Dozens of Hughes researchers had gone on to become members of the National Academy of Sciences, and six won the Nobel Prize.

“We bet on people who look like they are going to be winners,” he told The Washington Post in 1988. “You look for originality. How they pick a problem and stick to it. Their instinct for the scientific jugular.”

For the full obituary, see:

Clay Risen. “Purnell Choppin, 91, Researcher Who Focused on Viruses.” The New York Times, First Section (Sunday, July 25, 2021): 27.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary has the date July 23, 2021, and has the title “Purnell Choppin, 91, Dies; Researcher Laid Groundwork for Pandemic Fight.”)

Dolly Parton Sings and Donates with “Effective Sympathy”

The above is an “embed” from a YouTube video posted by singer (and English Professor) Ryan Cordell. The lyrics were written by Gretchen McCulloch and the tune is from Dolly Parton’s “Jolene.” The YouTube URL is: https://www.youtube.com/watch?v=cCwNQtnI64I

In my book Openness to Creative Destruction: Sustaining Innovative Dynamism, I write about “effective sympathy” which I describe as “actions taken by sympathetic observers that actually save or improve the lives of those who are suffering” (p. 110). I admire Dolly Parton for donating copies of The Little Engine That Could to poor children. I also admire Dolly Parton for donating a million dollars to help start research on the Moderna vaccine for Covid-19. Dolly Parton knows how to practice effective sympathy.

(p. 12) She wrote “I Will Always Love You” and “Jolene” on the same day and built a theme park around herself. She has given memorable onscreen performances as a wisecracking hairstylist and harassed secretary. She even helped bring about the creation of “Buffy the Vampire Slayer.”

Now, Dolly Parton’s fans are crediting her with saving the world from the coronavirus. It’s an exaggerated, tongue-in-cheek claim, to be sure. But for legions of admirers, Ms. Parton’s donation this spring to Vanderbilt University Medical Center, which worked with the drugmaker Moderna to develop a coronavirus vaccine, was another example of how her generosity and philanthropy have made her one of the world’s most beloved artists.

. . .

“Her money helped us develop the test that we used to first show that the Moderna vaccine was giving people a good immune response that might protect them,” Dr. Denison said on Tuesday.

Ms. Parton told the BBC on Tuesday [November 17, 2020] that she was excited to hear her contribution provided a “little seed money that will hopefully grow into something great and help to heal this world.”

. . .

On Monday [November 16, 2020], after Moderna announced that early trials of the vaccine showed a 94.5 percent effectiveness rate, fans reacted rapturously.

. . .

Ryan Cordell, an associate professor of English at Northeastern University in Boston, filmed himself singing a song about the vaccine to the tune of “Jolene.”

For the full story, see:

Maria Cramer. “Dolly: A Star of Country, a Songwriter, a Virus Hero.” The New York Times, First Section (Sunday, November 22, 2020): 12.

(Note: ellipses, and bracketed dates, added.)

(Note: the online version of the story has the date Nov. 17, 2020, and has the title “Dolly Parton: Singer, Songwriter, Pandemic Savior?” The online version says that the title of the New York print version was “Dolly: Country Music Legend, Songwriter, Pandemic Hero” and its page number was 8. The title of my National print version was “Dolly: A Star of Country, a Songwriter, a Virus Hero” and its page number was 12.)

My book mentioned above is:

Diamond, Arthur M., Jr. Openness to Creative Destruction: Sustaining Innovative Dynamism. New York: Oxford University Press, 2019.

The use of The Little Engine That Could to encourage entrepreneurial perseverance is analyzed in:

Yandle, Bruce. “I Think I Can! Does the Little Engine That Could Matter?” Journal of Private Enterprise 26, no. 2 (Spring 2011): 127-42.

Neighborhood Center Delivered the Air-Conditioning that NYC Had Promised

(p. A7) It seemed like a noble idea to offer quick help during the pandemic: New York City would give away free air-conditioners this summer to low-income older people who are stuck indoors.

It turned out to be a far more complicated mission for the city.

. . .

The difficulty in getting a free air-conditioner left many seniors frustrated and confused by what they described as a bureaucratic, inefficient process.

Concepcion Reyes, who is 67 and has asthma, said she made numerous phone calls to a handful of city agencies from her stuffy apartment last week, after seeing her neighbor snag a free air-conditioner from the city.

“I’ve been in the shower two times already today,” Ms. Reyes, who lives at Holmes Towers, a public housing building on the Upper East Side of Manhattan, said last week. “I’m sweating bullets.”

. . .

Frustrated by delays, officials at the Stanley M. Isaacs Neighborhood Center in Manhattan spent nearly $30,000 on 56 air-conditioners for older people.

Rosalina Acevedo, who is 73 and diabetic, had one of the units installed in her bedroom at Holmes Towers in July [2020]. When she turned it on for the first time, she instantly felt relief.

“It was delicious,” she said.

Gregory J. Morris, the center’s executive director, said the city should have worked with community groups that could easily have provided a list of older residents with serious health conditions who urgently needed the units. The city had its own lists, and names were missing.

“They were desperate,” he said of the older people his center works with. “There was no timeline from the city. If you’re in the middle of a heat wave, do I wait longer for the city? Or do I step in and solve the problem?”

For the full story, see:

Emma G. Fitzsimmons. “The Wait for Promised Air-Conditioners Leaves Some Older Residents Sweating.” The New York Times (Saturday, August 22, 2020): A7.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story has the date Aug. 21, 2020, and has the title “Older New Yorkers Sweat It Out, Waiting for Promised Air-Conditioners.”)

If Jeff Bezos Really Wanted to Reverse Global Warming

(p. A15) Jeff Bezos’ $10 billion commitment to fight climate change, which he announced last week, brings to mind an episode of “South Park” that aired during the financial crisis. A succession of characters put their money into the market only to see it go instantly to zero before their eyes.

. . .

There’s one way Mr. Bezos might make a real splash and possibly even a difference. With his Blue Origin venture he adopted a “just do it” attitude toward spaceflight. Mr. Bezos could adopt the same “just do it” approach to testing the hypothesis that warming could be halted by using aircraft to distribute inert aerosols in the upper atmosphere to block a small amount of sunlight reaching the earth. A highly reputable climate warrior, New York University’s Gernot Wagner, estimates that around $2 billion a year would be enough to offset the warming seen so far. Other researchers have produced similar estimates.

For the full commentary, see:

Holman W. Jenkins, Jr. “BUSINESS WORLD; How Bezos Can Influence Climate.” The Wall Street Journal (Wednesday, February 26, 2020): A15.

(Note: ellipsis added.)

(Note: the online version of the commentary has the date Feb. 25, 2020, and has the same title as the print version.)

Gernot Wagner’s aerosol injection research has been published in:

Smith, Wake, and Gernot Wagner. “Stratospheric Aerosol Injection Tactics and Costs in the First 15 Years of Deployment.” Environmental Research Letters 13, no. 12 (Nov. 23, 2018): 1-23.

American Food Aid May Have Prevented “the Collapse of the Soviet State”

(p. A15) Between 1921 and 1923, the United States, acting through Herbert Hoover’s American Relief Administration, supplied food and other aid to more than 10 million people caught up in the famine—created by war, revolution and the Bolshevik assault on the peasantry—then raging in the former Russian empire. The ARA operated, Mr. Smith tells us, “across a million square miles of territory in what was the largest humanitarian operation in history.”

Suspicious of, and embarrassed by, assistance from such a politically inconvenient source, the Kremlin accepted the ARA’s help only grudgingly and, once the crisis was over, “began to erase the memory of American charity,” Mr. Smith writes.

. . .

Mr. Smith argues that the ARA may “quite possibly” have prevented “the collapse of the Soviet state.” Did the decades of communist atrocity that followed cast a shadow over what was a very grand American gesture?

. . .

The ARA departed after the worst was past, but famine returned to the U.S.S.R. less than a decade later, a consequence of collectivization transformed, in Ukraine, to genocide. Millions died, but there were no calls for assistance from the Kremlin—only denials.

For the full story, see:

Andrew Stuttaford. “Feeding The Enemy.” The Wall Street Journal (Tuesday, December 17, 2019): A15.

(Note: ellipses added.)

(Note: the online version of the story has the date Dec. 16, 2019, and has the title “BOOKSHELF; ‘The Russian Job’ Review: Feeding the Enemy.”)

The book under review, is:

Smith, Douglas. The Russian Job: The Forgotten Story of How America Saved the Soviet Union from Ruin. New York: Farrar, Straus and Giroux, 2019.

“Tech Entrepreneurs Are Just as Mission Driven as People in Nonprofits”

(p. 2) The first rule of Silicon Valley venture capital is never insult a start-up. Founders are always killing it, disrupting the world.

If a start-up is fizzling, shuttering or caught scamming? The socially acceptable response is total silence.

Everyone knows that. Except Jason Palmer.

The start-up in question was AltSchool, a Mark Zuckerberg-backed project to turn school into a start-up experience. It had just announced it was pivoting out of existence after raising $174 million.

Mr. Palmer is in this field: He is a venture capitalist in Washington, D.C., focused on education technology. On June 29, he tweeted that AltSchool was always a bad idea, and he was glad that his firm hadn’t invested in it.

That single jab at a failed company sent the investor elite into conniptions.

. . .

So, two months after the tweet, how is Mr. Palmer feeling? The outrage that came both in public and private did not, in the end, oust him from the industry. He continues to invest.

For him, it was “a reminder,” he said, that tech entrepreneurs truly believe they are saving the world. He wanted to be clear now that he truly believes this, too. They were right. His tweet was very bad. He has been chastened.

“Tech entrepreneurs are just as mission driven as people in nonprofits,” Mr. Palmer said. “They believe they are helping the world just as much as nonprofit founders.”

But of course most start-ups fail, he added, a little quieter, and the tech world ought to learn how to talk about failure.

“In fact, most high-risk start-ups are nonprofits,” he said. “Effectively nonprofits.”

For the full story, see:

Nellie Bowles. “In Silicon Valley, Skin Is Thin.” The New York Times, SundayStyles Section (Sunday, Sept. 22, 2019): 2.

(Note: ellipsis added.)

(Note: the online version of the story has the date Sept. 20, 2019, and has the title “Want to Do Business in Silicon Valley? Better Act Nice.” (Where there is a slight difference in wording between the online and print versions, the passages quoted above follow the print version.)