New Longevity Drugs for Dogs Can Be Proof-of-Concept for Longevity Drugs for People

(p. A1) “When you adopt a dog, you’re adopting future heartbreak,” said Emilie Adams, a New Yorker who owns three Rhodesian Ridgebacks. “It’s worth it over time because you just have so much love between now and when they go. But their life spans are shorter than ours.”

In recent years, scientists have been chasing after drugs that might stave off this heartbreak by extending the lives of our canine companions. On Tuesday, the biotech company Loyal announced that it had moved one step closer to bringing one such drug to market. “The data you provided are sufficient to show that there is a reasonable expectation of effectiveness,” an official at the U.S. Food and Drug Administration informed the company in a recent letter. (Loyal provided a copy of the letter to The Times.)

That means that the drug, which Loyal declined to identify for proprietary reasons, has met one of the requirements for “expanded conditional approval,” a fast-tracked authorization for ani-(p. A19)mal drugs that fulfill unmet health needs and require difficult clinical trials. The drug is not available to pet owners yet, and the F.D.A. must still review the company’s safety and manufacturing data. But conditional approval, which Loyal hopes to receive in 2026, would allow the company to begin marketing the drug for canine life extension, even before a large clinical trial is complete.

. . .

. . . the letter, which came after years of discussion between Loyal and the F.D.A., suggests that the agency is open to canine longevity drugs, Ms. Halioua said.

. . .

Aging may be an inevitability, but it is not an unyielding one. Scientists have created longer-lived worms, flies and mice by tweaking key aging-related genes.

These findings have raised the tantalizing possibility that scientists might be able to find drugs that had the same life-extending effects in people. That remains an active area of research, but canine longevity has recently started to attract more attention, in part because dogs are good models for human aging and in part because many pet owners would love more time with their furry family members.

“There’s not a lot you wouldn’t do if you could stack the deck in your favor to preserve the life of your hairy, four-legged child,” said Ms. Adams, the Rhodesian Ridgeback owner.

For the full story, see:

Emily Anthes. “A Drug Aims to Extend Dogs’ Lives, Yes It Does.” The New York Times (Saturday, November 29, 2023): A1 & A19.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story was updated Nov. 29, 2023, and has the title “Could a Drug Give Your Pet More Dog Years?”)

“Context Switching Is the Mindkiller”

(p. B7) “My mind often feels…like a very wild storm,” Musk said Wednesday in the same interview. “I’m a fountain of ideas. I mean I have more ideas than I could possibly execute. So I have no shortage of ideas. Innovation is not a problem, execution is a problem.”

He was speaking at the New York Times DealBook Summit on Wednesday [Nov. 29, 2023] in New York City, a high-profile event run by one of the media juggernauts he has been openly needling.

He was only there, Musk said, because of his friendship with the host, Andrew Ross Sorkin. Or, as Musk called him on stage, “Jonathan.”

“I’m Andrew,” Sorkin said.

. . .

“Context switching is the mindkiller,” he tweeted the day after Thanksgiving, a favorite axiom of his that mixes a quote from the sci-fi book “Dune” with computer lingo for multitasking.

In “Dune,” fear is the mindkiller—the idea that the primal reaction to fear is to recoil rather than go forward. In essence, fear is an obstacle to be overcome to reach success. For Musk, the challenge to overcome is being able to handle switching between rockets and tweets and cars and brain computers and drilling machines and superhuman artificial intelligence.

. . .

In the moment that ricocheted around the world, Musk told advertisers unhappy with him to go f— themselves, saying he was unwilling to pander to their “blackmail” and warned they threatened to bankrupt the social-media platform he acquired slightly more than a year ago. And if they were successful, he warned, “See how Earth responds to that.”

. . .

To Musk, the likes of Disney are trying to squelch his freedom of speech. To others, they are simply exercising their rights to walk away.

“Go. F—. Yourself,” Musk said on stage to a stunned audience. “Is that clear? I hope it is. Hey, Bob, if you’re in the audience.”

For the full commentary, see:

Tim Higgins. “Storm in Musk’s Mind Casts Shadow on Vehicle Launch.” The Wall Street Journal (Monday, Dec. 4, 2023): B7.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the commentary has the date December 2, 2023, and has the title “The Storm Brewing Inside Elon Musk’s Mind Gets Out.” The 7th, 8th, and 9th sentences quoted above, appear in the online, but not in the print, version of the commentary. Also, the online version of the sentence on being able to handle switching, contains seven added words of detail.)

The science-fiction Dune book mentioned above is:

Herbert, Frank. Dune. Deluxe ed. New York: Ace, 2019 [1st ed. 1965].

“If Something Similar Happens Here, I Want to Know That I Have a Firearm”

(p. A1) Two weeks ago, Zvika Arran reluctantly drew a gun at an Israeli state-run shooting class for those seeking firearms licenses, part of a massive spike in applications since the Hamas-led attacks on Oct. 7 [2023].

Mr. Arran said he was repelled by the idea of owning the pistol that now sits in a safe in his house. But his sense of security, like that of so many Israelis, was shattered when Hamas fighters overran communities near the Gaza Strip, killing an estimated 1,200 people and abducting more than 240 hostages, according to Israeli officials.

“God forbid, if something similar happens here, I want to know that I have a firearm,” said Mr. Arran, 48, who lives in Eliav, a small town that borders the Israeli-occupied West Bank.

. . .

(p. A6) Another resident of Eliav, Maayan Rosenberg-Schatz, said that like so many other Israelis, she no longer believed the Israeli military — which took hours to arrive at some embattled communities on Oct. 7 — would reach them in time in a crisis.

Two days after the attacks, she sat down with two of her young children to plan how to escape should Palestinian attackers invade their home.

“We talked about trying to flee to the roof, maybe escaping from there,” said Ms. Rosenberg-Schatz, 42, who applied for a gun license along with her husband. “But in the end, there’s no replacement for having a weapon.”

Ms. Rosenberg-Schatz, who described herself as politically center-left, said she was concerned that proliferating guns might fall into the wrong hands.

“Everyone tells you they’re worried about that — but they still feel unsafe” without a gun, she added. “Suddenly, we feel this fear deep down in our guts, and it’s really difficult to argue with that.”

For the full story, see:

Aaron Boxerman and Talya Minsberg. “Galvanized by Fear, Israelis Arm Themselves.” The New York Times (Saturday, December 16, 2023): A1 & A6.

(Note: ellipsis, and bracketed year, added.)

(Note: the online version of the story has the date Dec. 15, 2023, and has the title “Private Gun Ownership in Israel Spikes After Hamas Attacks.”)

James Watt Saw that “Environmental Extremists” Want “Centralized Planning and Control of the Society”

(p. A20) James G. Watt, who as President Ronald Reagan’s first Interior secretary tilted environmental policies sharply toward commercial exploitation, touching off a national debate over the development or preservation of America’s public lands and resources, died on May 27 [2023] in Arizona.

. . .

In one of his first official pronouncements, Mr. Watt declared that Interior Department policies over the years had swung too far toward conservation under the influence of “environmental extremists,” and away from the development of public resources that he said was needed for economic growth and national security.

He soon transferred control of many of the resources to private industry, restoring what he regarded as a proper balance to the nation’s patrimony. He opened most of the Outer Continental Shelf — nearly all of America’s coastal waters — to drilling leases by oil and gas companies. He widened access to coal on federal lands, and eased restrictions on strip-mining, which scarred landscapes and was cheaper than cutting deep mine shafts.

He increased industry access to wilderness areas for drilling, mineral mining and lumbering; gave private owners of hotels, restaurants and shops wider rights in national parks; curtailed the program to protect endangered species; cut funds to acquire land for national and state parks; and added money to build roads, bridges, hotels and other man-made structures in the parks.

. . .

He accused his critics of using sham environmental concerns to achieve “centralized planning and control of the society.” He told Business Week: “Look what happened to Germany in the 1930s. The dignity of man was subordinated to the powers of Nazism. The dignity of man was subordinated in Russia. Those are the forces that this thing can evolve into.”

For the full obituary, see:

Robert D. McFadden. “James G. Watt, 85, Dies; Secretary Who Favored Developing Wilderness.” The New York Times (Saturday, June 10, 2023): A20.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the obituary has the date June 8, 2023, and has the title “James G. Watt, Polarizing Interior Secretary Under Reagan, Dies at 85.”)

Rich Chinese “Moved Hundreds of Billions of Dollars Out of” China in 2023

(p. B1) Affluent Chinese have moved hundreds of billions of dollars out of the country this year [2023], seizing on the end of Covid precautions that had almost completely sealed China’s borders for nearly three years.

They are using their savings to buy overseas apartments, stocks and insurance policies. Able to fly again to Tokyo, London and New York, Chinese travelers have bought apartments in Japan and poured money into accounts in the United States or Europe that pay higher interest than in China, where rates are low and falling.

The outbound shift of money in part indicates unease inside China about the sputtering recovery after the pandemic as well as deeper problems, like an alarming slowdown in real estate, the main storehouse of wealth for families. For some people, it is also a reaction to fears about the direction of the economy under China’s leader, Xi Jinping, who has cracked down on business and strengthened the government’s hand in many aspects of society.

In some cases, Chinese are improvising to get around China’s strict government controls on transferring money overseas. They have bought gold bars small enough to be scattered unobtrusively through carry-on luggage, as well as large stacks of foreign currency.

Real estate is an option, too. Chinese have emerged as the main buyers of Tokyo apartments costing $3 million or more, and they often pay with suitcases of cash, said Zhao Jie, the chief executive of Shenjumiaosuan, an online real estate listing service in Tokyo. “It’s really hard work to count this kind of cash.”

Before the pandemic, he said, (p. B5) Chinese buyers typically bought Tokyo studio apartments for $330,000 or less to rent out. Now they are buying much larger units and obtaining investment visas to relocate their families.

All told, an estimated $50 billion a month has been taken out of China this year, mainly by Chinese households and private-sector companies.

For the full story, see:

Keith Bradsher and Joy Dong. “Suitcases of Cash: How China’s Money Flows Out.” The New York Times (Tuesday, Nov. 28, 2023): B1 & B5.

(Note: bracketed year added.)

(Note: the online version of the story has the same date as the print version, and has the title “Gold Bars and Tokyo Apartments: How Money Is Flowing Out of China.”)

Almost 50% of Modern Drugs Have Their Source in Folk Medicine

(p. 17) At the heart of “Most Delicious Poison” is an evolutionary oxymoron that sustains life as we know it: Poisons — in deserts or rainforests, at the corner bar or in your fridge — threaten life while offering possibilities for persistence, and the pleasures that we take from substances that would otherwise be deadly hint at the ways life on earth manages to thrive in a landscape of toxins.  . . .

“Scratch beneath the surface of a coffee bean, a red pepper flake, a poppy capsule, a Penicillium mold, a foxglove leaf, a magic mushroom, a marijuana bud, a nutmeg seed or a brewer’s yeast cell, and we find a bevy of poisons,” Whiteman writes.

Caffeine is another natural wonder best approached with caution. “Caffeine and the human mind,” says Whiteman, can seem like a match made in heaven. “Taken in the appropriate doses, caffeine not only feels life-giving but is: Drink a few cups a day and you won’t live forever but a little longer.” Whiteman sorts through data suggesting as much, though, anecdotally, on a fall morning in the dark, it sure feels true.

But caffeine can be deadly. In October of this year [2023], the parents of a University of Pennsylvania student with a congenital heart condition sued Panera Bread over their “Charged Lemonade,” on the grounds that a substance containing three Red Bulls’ worth of caffeine should have been marketed as an energy drink, potentially saving their daughter’s life.

And yet used in moderation, the poison that we drink in pumpkin spice lattes blocks adenosine receptors — adenosine being a brain-produced neurotransmitter that would otherwise encourage you to rest.

. . .

Big Pharma’s relationship to Indigenous knowledge is a recurring motif. “Indigenous healers have yielded nearly 50 percent of all modern drugs we use today,” writes Whiteman.

For the full review, see:

Robert Sullivan. “Toxic Relationships.” The New York Times Book Review (Sunday, December 24, 2023): 17.

(Note: ellipses added.)

(Note: the online version of the review was updated Dec. 4, 2023, and has the title “All Things in Moderation, Especially When They’re Toxic.”)

The book under review is:

Whiteman, Noah. Most Delicious Poison: The Story of Nature’s Toxins―from Spices to Vices. New York: Little, Brown Spark, 2023.

Slow Regulatory Approval Is “A Pretty Big Barrier to Entry” for Smaller and Safer Innovative Nuclear Reactors

(p. B1) . . ., the great hope for the future of nuclear power is to go small.

Nearly a dozen companies are developing reactors that are a fraction of the size of those at Vogtle, betting that they will be quicker and cheaper to build. As the United States looks to transition away from fossil fuels that have underpinned its economy for 150 years, nuclear power is getting renewed interest, billions of dollars from the Biden administration and support from Republicans.

One reason is that nuclear plants can run at all hours, in any season. To those looking to replace coal and gas with wind and solar energy, nuclear power can provide a vital backstop when the air is calm or the sky is cloudy.

“The United States is now committed to trying to accelerate the deployment of nuclear energy,” John Kerry, President Biden’s climate envoy, said in September. “It’s what we believe we absolutely need in order to win this battle.”

. . .

(p. B4) One recent Pew survey found that 57 percent of Americans favor more nuclear plants, up from 43 percent in 2016. Republicans have traditionally backed atomic energy, but the survey found rising support among Democrats.

While many environmental groups still oppose nuclear power, some skeptics are softening.

. . .

For nearly five decades, the Nuclear Regulatory Commission has regulated large light-water reactors. Now it has to consider a dizzying array of new technologies and their safety characteristics.

The approval process can be slow. To date, the N.R.C. has certified only one small reactor design, developed by NuScale Power. NuScale’s light-water technology is similar to existing plants, but the company argued that smaller reactors required different safety rules, such as smaller evacuation zones in case of accidents. Securing approval took a decade and cost $500 million.

“It’s a pretty big barrier to entry,” said Jose Reyes, NuScale’s chief executive. “And this was for a technology that regulators are already familiar with.”

At a recent House hearing, Republicans and Democrats alike complained that a draft rule meant to help license advanced reactors was 1,173 pages long and largely unworkable.

“Everyone agrees that reactors need to be safe,” said Adam Stein, director of nuclear innovation at the Breakthrough Institute, a pronuclear research organization. “But it’s also possible for a regulator to be too conservative and too risk-averse.”

For the full story, see:

Brad Plumer and Ivan Penn. “Going Small to Confront a Big Problem.” The New York Times (Tuesday, Nov. 28, 2023): B1 & B4.

(Note: ellipses added.)

(Note: the online version of the story has the date Nov. 12 [sic], 2023, and has the title “U.S. Bets on Small Nuclear Reactors to Help Fix a Huge Climate Problem.”)

Coral Reefs 100 Miles Off Texas Coast Are “Stunning,” “Massive,” and “Healthy”

(p. A5) OFF THE COAST OF GALVESTON, Texas — Divers descending into azure waters far off the Texas coast dip below a horizon dotted with oil and gas platforms into an otherworldly landscape of undersea mountains crusted with yellow, orange and pink coral as far as the eye can see.

Some of the world’s healthiest coral reefs can be found in the Gulf of Mexico, about 100 miles off the Texas coast. Sheltered in a deep, cool habitat far from shore, the reefs in the Flower Garden Banks National Marine Sanctuary boast a stunning amount of coral coverage. . . .

“To see that much coral in one place is really magnificent — an experience that most people don’t get on reefs in this day and age,” said Michelle Johnston, the acting superintendent and research coordinator for the federally protected area.

. . .

Sanctuary officials say even in the occasional years when Flower Garden Banks has experienced more serious bleaching than this year, it has bounced back quickly thanks to its overall health and depth, and it’s already recovering this year.

. . .

The Flower Garden Banks stands out for its amount of coral cover — an average of over 50 percent across some areas of the sanctuary — compared with around 10 percent cover in the Caribbean and Northwest Atlantic region, Manzello said. Its corals are also about 60 feet below the surface and surrounded by even deeper waters, compared with many reefs where corals are in shallower water just offshore.

. . .

The corals in the Flower Garden Banks were able to flourish so far from shore because of mountain-like formations called salt domes, which lifted the corals high enough to catch the light, Johnston said.

Divers travel from around the world to see the reefs at Flower Garden Banks, where colorful fish, manta rays, sharks and sea turtles waft through and worms that look like Christmas trees pop in and out of corals.

. . .

Lauren Tinnes, a nurse from Colorado, described rounding a bluff on her dive this fall and being surrounded by massive reefs as schools of fish darted through. She found the description from so long ago apt: “It’s like a field of flowers,” she said.

For the full story, see:

JAMIE STENGLE, LM OTERO and KENDRIA LaFLEUR, Associated Press. “Coral Reefs Off Texas Coast Thrive, Defying Trend.” Omaha World-Herald (Saturday, Nov. 25, 2023): A5.

(Note: ellipses added.)

(Note: the online version of the story was updated Jan. 1, 2024, and has the title “Climate change is hurting coral worldwide. But these reefs off the Texas coast are thriving.”)

An Observant Muslim Bears Witness to the Genocidal Slaughter of Israeli Jews on October 7, 2023

(p. A17) A fetal heartbeat flutters and then stills, a bullet lodged in the embryonic heart. The mother survives the shooting and her child’s stillbirth. A body that has been decomposing for almost three weeks lies on the autopsy table, riddled with knife and bullet wounds. Another is nearby, the man’s bluetooth receiver still clipped onto his shirt. Death came as a surprise.

This is Israel. I arrived on Oct. 19 [2023] to spend 10 days as a human-rights observer with the permission of the nation’s Foreign Affairs Ministry and help from Israel Defense Forces officer Kobi Valer. As an observant Muslim, I felt a duty to come and bear witness. What I saw will remain with me forever.

. . .

One word continually came to mind: genocide.

. . .

The Oct. 7 genocide was different, more barbaric than anything before it. The attacks were cloaked in the language and metaphors of Islam, yet corrupted with cosmic enmity for the Jewish people, Judaism, global Jewry and the Jewish state. They revealed again that Islamism is a virulent impostor of Islam with intentions anathema to the faith. And there was no doubt of Islamism’s guilt: I saw real-time footage generated by the Hamas commandos’ own GoPro cameras. I heard phone calls exclaiming the Shahadah—the Islamic declaration of faith—as they murdered, executed, burned, pillaged and then broadcast their crimes.

. . .

The Oct. 7 attack was premeditated, organized and targeted, seeking to destroy as many Israelis as possible. Hamas tortured and immolated its victims, including children, pregnant women and the unborn.

For the full commentary, see:

Qanta A. Ahmed. “The Scenes of Genocide I Saw in Israeli Morgues.” The Wall Street Journal (Saturday, Nov. 11, 2023): A17.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the commentary has the date November 10, 2023, and has the same title as the print version.)

Refusenik Sharansky Argues That Palestinians Have Human Rights but Not the Right to Murder Jews

(p. A15) An Israeli politician and human-rights advocate, Mr. Sharansky was once the best-known refusenik—a name for Soviet Jews who were denied permission to emigrate to Israel. In February 1986, he became “the first political prisoner released by Mikhail Gorbachev.” He served as a cabinet minister in every Israeli government from 1996 to 2005, including a stint as Ariel Sharon’s deputy prime minister from 2001 to 2003.

Before emigrating to Israel, he spent nine years in Soviet prisons accused of treason. He’s 75 but jokes that he’s 66: “My nine years in prison don’t count.”

. . .

Mr. Sharansky abhors Oslo. Still regarded in some circles as the touchstone of Israeli-Palestinian compromise, the agreement handed control of Palestinian land to Yasser Arafat’s Palestinian Authority in the belief that he would be able to subdue Hamas. “I’m not against compromises with the Palestinians,” Mr. Sharansky says. “I’ve said I’m for a two-state solution from the moment I came to Israel. I want Palestinians to have the same rights as I, but they should never have an opportunity to destroy me.”

At Oslo, he says, Israel foisted “a ruthless dictator on the Palestinians. We told them, “Like it or not, he will be your leader.’ With [Bill] Clinton and all the free world, we gave Arafat the power to destroy all the beginnings of freedom of the Palestinian people and helped build a generation of haters.” Mr. Sharansky says it’s “absolutely ridiculous” that a “fifth generation” of Palestinians lives in refugee camps, but he says “their leaders are to blame. And the free world, that gives money to these leaders—a lot of money.”

Mr. Sharansky is certain that Israel’s security can be assured only by a free Palestinian society, in which people “enjoy a normal life, normal freedom, the opportunity to vote and have their own human rights.” In “The Case for Democracy” (2004), he wrote: “I remain convinced that a neighbor who tramples on the rights of its own people will eventually threaten the security of my people.” The book was published a year before Israel “disengaged” from the Gaza Strip, withdrawing the army and forcibly uprooting Jews who had settled there.

That decision led Mr. Sharansky to resign from Sharon’s cabinet. Arafat had failed to tame Hamas, and Mr. Sharansky believed Gaza would be taken over by the terrorist group, whose ideology is “suicide for the sake of destroying the state of Israel.” He resigned before disengagement took effect, because he didn’t want to “take responsibility for the fact that we, by our own hands, were creating the biggest terrorist base in the Middle East, and that missiles will come one day to Ashkelon,” a coastal city less than 10 miles from the Gaza border.

For the full interview, see:

Tunku Varadarajan, interviewer. “THE WEEKEND INTERVIEW; A Refusenik in a Country at War.” The Wall Street Journal (Saturday, Oct. 28, 2023): A15.

(Note: ellipsis added.)

(Note: the online version of the interview has the date October 27, 2023, and has the title “THE WEEKEND INTERVIEW; Opinion: A Refusenik in a Country at War.” In the original the word “refusenik” was italicized in the body of the interview.)

Natan Sharansky’s book mentioned above is:

Sharansky, Natan. The Case for Democracy: The Power of Freedom to Overcome Tyranny and Terror. New York: PublicAffairs, 2004.

Americans Buy SUVs, Rejecting Limited Space in Their Vehicles

(p. A6) Not all consumers think of the energy consumption and environmental benefits the same way, especially in the U.S. While EV sales accounted for 15% of the global car market last year, that was only 7.3% in the U.S.

Meanwhile, smaller vehicles, or sedans, lost a lot of ground in the U.S. market over the past decade. In 2012, sedans accounted for 50% of the U.S. auto retail space, with SUVs at just over 30%, and trucks at 13.5%, according to car-buying resource Edmunds. By 2022, U.S. sedan share dropped to 21%, while SUVs hit 54.5% and trucks grew to 20%.

“People don’t want to be limited by their space in their car,” said Eric Frehsée, president of the Tamaroff Group of dealerships in southeast Michigan. “Everyone wants a 7-passenger.”

For the full story, see:

ALEXA ST. JOHN, Associated Press. “Big Cars Erase Gains from Cleaner Tech.” Omaha World-Herald (Wednesday, Nov. 29, 2023): A6.

(Note: the online version of the story has the date Nov. 28, 2023, and has the title “Buyers go for bigger cars, erasing gains from cleaner tech. EVs would help.”)