Mice on Taurine Lived 10% Longer and Looked Healthier

(p. A3) Scientists are exploring a new biological link to longer life.

Boosting levels of an amino acid called taurine made mice and worms live longer, according to research published Thursday [June 7, 2023] in the journal Science. Middle-aged monkeys given taurine supplements became healthier, researchers said. In humans, lower levels of taurine were associated with age-related problems.

“This is a very promising molecule,” said Vijay Yadav, an assistant professor of genetics and development at Columbia University, who co-wrote the paper.

People have been searching for life-extending substances for millennia. Other recent studies have explored antiaging properties of compounds including resveratrol, found in red wine, and the immunosuppressive drug rapamycin. Yadav said he first suspected taurine’s connection with aging over a decade ago when his lab compared the contents of blood drawn from people of different ages.

. . .

Researchers gave daily doses of taurine to hundreds of 14-month-old mice, considered middle-aged, and compared their average lifespans to mice that didn’t get extra taurine. The female mice given taurine lived 12% longer on average and male mice that got taurine lived 10% longer, researchers said.

Mice that received taurine also appeared to be healthier.

For the full story, see:

Dominique Mosbergen. “Amino Acid Found To Slow Down Aging.” The Wall Street Journal (Friday, June 9, 2023): A3.

(Note: ellipsis, and bracketed date, added. The online version is longer, but the passages quoted above appear in both versions.)

(Note: the online version of the story was updated June 9, 2023, and has the title “Is Taurine the Key to Longer Life? It Made Monkeys Healthier.”)

The Science paper on taurine mentioned above is:

Singh, Parminder, Kishore Gollapalli, Stefano Mangiola, Daniela Schranner, Mohd Aslam Yusuf, Manish Chamoli, Sting L. Shi, Bruno Lopes Bastos, Tripti Nair, Annett Riermeier, Elena M. Vayndorf, Judy Z. Wu, Aishwarya Nilakhe, Christina Q. Nguyen, Michael Muir, Michael G. Kiflezghi, Anna Foulger, Alex Junker, Jack Devine, Kunal Sharan, Shankar J. Chinta, Swati Rajput, Anand Rane, Philipp Baumert, Martin Schönfelder, Francescopaolo Iavarone, Giorgia di Lorenzo, Swati Kumari, Alka Gupta, Rajesh Sarkar, Costerwell Khyriem, Amanpreet S. Chawla, Ankur Sharma, Nazan Sarper, Naibedya Chattopadhyay, Bichitra K. Biswal, Carmine Settembre, Perumal Nagarajan, Kimara L. Targoff, Martin Picard, Sarika Gupta, Vidya Velagapudi, Anthony T. Papenfuss, Alaattin Kaya, Miguel Godinho Ferreira, Brian K. Kennedy, Julie K. Andersen, Gordon J. Lithgow, Abdullah Mahmood Ali, Arnab Mukhopadhyay, Aarno Palotie, Gabi Kastenmüller, Matt Kaeberlein, Henning Wackerhage, Bhupinder Pal, and Vijay K. Yadav. “Taurine Deficiency as a Driver of Aging.” Science 380, no. 6649 (June 9, 2023): eabn9257.

“By Far the Biggest Risk to Global Climate Comes From Volcanoes”

(p. C9) What’s the connection between sugar and Xi Jinping? Why does the political turbulence in today’s Middle East trace back to the Cretaceous period? How did the humble potato revolutionize the world? Why did the great Mayan cities of the ninth century run out of potable water? What does the contemporary West African practice of polygyny—one man, many wives—have to do with the trans-Atlantic slave trade?

Peter Frankopan raises these beguiling questions—and many others, bless him—in “The Earth Transformed,” a book that examines the entire sweep of the relationship between humans and nature.

. . .

Whereas Mr. Frankopan never disguises the fact that he is on the greenish side of the climate-change conversation, he steers clear of enviro-preaching and finger-wagging.  . . .  In words that will startle many of us, he says that “by far the biggest risk to global climate comes from volcanoes.” He contrasts the “considerable thought and attention” that have gone into planning for a warming world with the almost complete absence of planning or funding on the likely implications of major volcanic eruptions. Estimates put the chances of a mega-eruption—one that could cost “hundreds of millions of lives”—at one in six before the year 2100.

. . .

The history of the Earth is a history of large-scale transformations that have wreaked havoc in some cases and blessed us with benign climatic eras in others (such as the Roman Warm Period from 300 B.C. to A.D. 500). The most famous instance of the former was the asteroid strike in the Yucatán Peninsula 66 million years ago in which our beloved dinosaurs were wiped out. The rise of humankind, Mr. Frankopan writes, was the result of an “extraordinary series of flukes, coincidences, long shots and serendipities” that made the planet hospitable to our existence. It was “geological chance” that gave the Middle East its oil reserves, the result of warming in Cretaceous times.

. . .

Mr. Frankopan’s thesis is that civilizations thrive best when they are resilient to shocks. Yet “hyperfragility,” he believes, is the name of the game in the 21st century—whether in response to warming, a rudderless U.S., Mr. Xi and Taiwan, Vladimir Putin’s war in Ukraine, or a nuclear Saudi Arabia and Iran. The march of history has left such places as Uruk, Nineveh, Harappa, Angkor and Tikal in ruins, not because of climate change but because of a lack of resilience to shocks, made worse by obtuse planning and even worse decision-making. That’s the lesson Mr. Frankopan is trying to teach us.

For the full review, see:

Tunku Varadarajan. “Doom May Have to Be Delayed.” The Wall Street Journal (Saturday, April 22, 2023): C9.

(Note: ellipses added.)

(Note: the online version of the review has the date April 20, 2023, and has the title “‘The Earth Transformed’ Review: Doom May Be Delayed.”)

The book under review is:

Frankopan, Peter. The Earth Transformed: An Untold History. New York: Alfred A. Knopf, 2023.

So-Called “Inflation Reduction Act” Mandates Pharma Firms Dishonestly Say They Voluntarily Negotiated Prices

(p. A15) The pharmaceutical company Merck claims in a lawsuit filed this week that the “Drug Price Negotiation Program for Medicare,” part of last summer’s Inflation Reduction Act, is an unconstitutional taking of company’s property and a violation of the company’s freedom of speech. If successful, this lawsuit will prevent the unconstitutional practice of forcing drug companies to sell drugs to the U.S. government at a government-determined price.

To make the provision of the 2022 law constitutional, Congress could have imposed price controls, or it could have bargained with pharmaceutical companies using the massive marketing power of Medicare, which accounts for some half of all American drug spending. Instead, Congress tried to prevent pharmaceutical companies from walking away from any potential deal. Under the act, secret negotiations force pharmaceutical companies to agree to government-determined prices amounting to massive discounts off market-based prices, under the threat of crippling taxes and penalties.

Americans tend to support pharmaceutical “price negotiations,” but oppose “price controls.” Knowing this, Congress set up a ruse.

. . .

. . ., the law essentially requires a company to communicate that it agreed to the set price—compelled speech that is prohibited by the First Amendment. Time and again, the Supreme Court has declared forced speech beyond the power of the government. The government’s only seeming interest is to pretend that a system of unilateral price controls and mandated sales is actually a system of voluntary negotiations.

For the full commentary, see:

Daniel E. Troy. “An Unconstitutional Offer Drug Companies Can’t Refuse.” The Wall Street Journal (Friday, June 9, 2023): A15.

(Note: ellipses added.)

(Note: the online version of the commentary has the date June 8, 2023, and has the same title as the print version.)

An Hawaiian Wants Land She Can Own and Control, Even if Not in Hawaii

(p. 1) When Pauline Kauinani Souza was a child in Hawaii, she spent early mornings watering her grandfather’s watermelons and papaya trees.

Her family lived frugally, eating homemade bread and heating water over a fire for bathing. But the no-frills life came with the ultimate perk: living near the beach and drifting off to sleep at night to the sound of waves gently crashing on the shore.

Now, at 80, Ms. Souza lives in Las Vegas, a desert city of neon reinvention far from the ocean and her ancestral home. It is not paradise, but it is full of Native Hawaiians like her who have flocked there in recent years for the endless entertainment, reasonable cost of living and something few people can find in Hawaii: a house they can afford.

“I own it outright,” she said proudly of her two-bedroom, ranch-style home in Las Vegas. “In Hawaii, there aren’t many people who can say that.”

Increasingly, Las Vegas is drawing Hawaiians who came to visit and decided to stay, convinced that an affordable faux version of the islands is better than an endless struggle to make ends meet in the real thing.

Between 2011 and 2021, the population of Native Hawaiians and (p. 19) other Pacific Islanders in Clark County, Nev., which includes Las Vegas, grew by about 40 percent, for a total of nearly 22,000 people. That was the greatest number of newcomers in that demographic in any county outside Hawaii, according to population estimates from the U.S. Census Bureau. In that same period, the total population of Clark County grew by about 17 percent.

For many, the draw is real estate: Houses in the Las Vegas area have a median listing price of about $460,000, compared with about $800,000 in Honolulu, according to Federal Reserve Economic Data.

Americans migrating for cheaper housing is not unusual, as seen most dramatically in the decades-long shift from the Northeast to the Sunbelt. But this migration from the impossibly lush natural landscape of the islands to the brash desert of Las Vegas is a particularly vivid glimpse of how the search for housing remakes the country in sometimes surprising ways.

. . .

In 2022, Hawaii had the highest cost of living out of all 50 states and the District of Columbia, according to data from the Council for Community and Economic Research. The state imports the vast majority of its food, making everyday groceries especially expensive. And strict regulations on building have contributed to housing shortages and prices out of reach for many.

For the full story, see:

Eliza Fawcett and Hana Asano. “Priced Out of Paradise’ But Hawaiians Thrive in Desert.” The New York Times, First Section (Sunday, May 21, 2023): 1 & 19.

(Note: ellipsis added.)

(Note: the online version of the story has the date May 20, 2023, and has the title “There’s No Ocean in Sight. But Many Hawaiians Make Las Vegas Their Home.” The online version says that the print version has the title “Desert Provides A New Paradise For Hawaiians” but my national print version has the title “They’re ‘Priced Out of Paradise’ But Hawaiians Thrive in Desert.”)

As Millennials Age They Shift to Republicans

(p. B4) Fifteen years ago, a new generation of young voters propelled Barack Obama to a decisive victory that augured a new era of Democratic dominance.

Fifteen years later, those once young voters aren’t so young — and aren’t quite so Democratic.

. . .

This shift toward the right among the young voters who propelled Mr. Obama to victory 15 years ago is part of a larger pattern: Over the last decade, almost every cohort of voters under 50 has shifted toward the right, based on an analysis of thousands of survey interviews archived at the Roper Center.

It’s not necessarily a stunning finding. Political folklore has long held that voters become more conservative as they get older. But it is nonetheless at odds with a wave of recent reports or studies suggesting otherwise. The Financial Times, for instance, wrote that “millennials are shattering the oldest rule in politics” by not moving to the right as they age.

For the full commentary, see:

Nate Cohn. “Millennials Aren’t an Exception. They Have Moved to the Right.” The New York Times, First Section (Sunday, June 4, 2023): A16.

(Note: ellipsis added.)

(Note: the online version of the commentary was updated June 2, 2023, and has the title “Millennials Are Not an Exception. They’ve Moved to the Right.”)

Man Died When Pharmacist Refused to Give Him EpiPen Without the Mandated Prescription

(p. A15) Rates of hospital admissions for asthma, nut allergies in children, and prescriptions for EpiPens (used to treat extreme reactions) have all tripled in recent decades. Not only are food allergies now more common in children, but they are less likely to be outgrown with age than in years past.

The causes and consequences of this epidemic are the subject of “Allergic,” an important and deeply researched book by Theresa MacPhail, a medical anthropologist who memorably portrays the human face of disease.   . . .   Ms. MacPhail . . . has a personal connection to this subject: Her father died after being stung by a bee on the main street of the New Hampshire town where she grew up. (His girlfriend drove him to a drugstore instead of a hospital; even though he was in extremis, the pharmacist refused to dispense an EpiPen without a prescription.)

For the full review, see:

John J. Ross. “BOOKSHELF; Runny Noses, Itchy Eyes.” The Wall Street Journal (Wednesday, May 24, 2023): A15.

(Note: ellipses added.)

(Note: the online version of the review has the date May 23, 2023, and has the title “BOOKSHELF; ‘Allergic’ Review: Runny Noses, Itchy Eyes.”)

The book under review is:

MacPhail, Theresa. Allergic: Our Irritated Bodies in a Changing World. New York: Random House, 2023.

Even Environmentalists Face Trade-Offs: Plans to Refill the Salton Sea May Hasten an Overdue Large Earthquake

(p. A1) It has been about three centuries since the last great earthquake on the southern San Andreas Fault, the most treacherous seismic hazard in California. For decades researchers have puzzled over why it has been so long. The average interval of large earthquakes along that portion of the fault has been 180 years over the past 1,000 years.

While seismologists agree that Southern California is due for the Big One, a group of researchers published a paper on Wednesday [June 7, 2023] in the journal Nature that offers a reason for the period of seismic silence along the southern San Andreas, the tension-wracked meeting point of the North American and Pacific tectonic plates.

. . .

Mr. Hill and his co-authors found that major earthquakes along the southern San Andreas fault tended to happen when a large body of water, Lake Cahuilla, was filling or was full with water from the Colorado River in what are now the Coachella and Imperial valleys.

The lake has drained over the last three centuries and all that remains is the vestigial Salton Sea.

. . .

The research published in Nature, which builds on a paper on which Dr. Philibosian was a writer in 2011, raises questions about plans to rehabilitate parts of the Salton Sea, . . . .  . . .  As the sea dries out, toxic dust is left behind and blown into the air, posing a hazard for nearby residents.

. . .

Impounding more water in the Salton Sea could tamp down the dust.Impounding more water in the Salton Sea could tamp down the dust.  . . .  But a major change in the water level could also trigger seismic activity, according to Dr. Philibosian.

For the full story, see:

Thomas Fuller. “Scientists Offer Reason for a Sleepy San Andreas Fault.” The New York Times, First Section (Sunday, June 11, 2023): A20.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the story has the date June 7, 2023, and has the title “The San Andreas Fault Is Sleepy Near Los Angeles. Researchers Have an Idea Why.”)

The Nature article published online on June 7 and mentioned above is:

Hill, Ryley G., Matthew Weingarten, Thomas K. Rockwell, and Yuri Fialko. “Major Southern San Andreas Earthquakes Modulated by Lake-Filling Events.” Nature (2023) DOI: 10.1038/s41586-023-06058-9.

“They Just Invest in How to Navigate This Bureaucracy”

(p. A1) Capella Space, a San Francisco-based start-up, is building a fleet of small, inexpensive satellites that can track enemy troops as they move at night, or under cloud cover that traditional optical satellites cannot see through.

Fortem Technologies, a small aerospace company in Utah, wants to supply the Pentagon with a new type of unmanned aircraft that can disable enemy drones.

HawkEye 360, a Virginia-based firm, has used private equity funds to launch its own satellites that use radio waves emitted by communications equipment and other electronic devices to detect the presence of enemy troop concentrations.

Each of these systems is getting real-world testing in the war in Ukraine, earning praise from top government officials there and validating investors who have been pouring money into the field.

But they are facing a stiff challenge on another field of battle: the Pentagon’s slow-moving, risk-averse military procurement bureaucracy.

When it comes to drones, satellites, artificial intelligence and other fields, start-up companies frequently offer the Pentagon cheaper, faster and more flexible options than the weapons systems produced by the handful of giant contractors the Pentagon normally relies on.

But while the military has provided small grants and short-term contracts to many start-ups, those agreements often expire too quickly and are not large enough for young companies to meet their payrolls — or grow as rapidly as their venture capital investors expect. Several have been forced to lay people off, delaying progress on new technologies and war-fighting tools.

. . .

(p. A8) From the early months of the war, SpaceX’s Starlink, the Elon Musk-founded satellite internet service, had played a critical role for frontline Ukrainian troops. But small drones and a denser collection of satellites are also helping to provide the capacity for pervasive surveillance, allowing Ukraine to identify and track threats and targets constantly.

A new generation of cheaper and more precise attack drones carrying bombs can loiter in the air autonomously until they find their targets. Artificial intelligence-backed computer systems can fuse this collected data and other feeds to make targeting decisions, faster than any human.

The Ukrainians have also innovated a great deal themselves, impressing Pentagon officials as they have converted commercial drones, for example, into mini bombers.

Taken together, said Thomas X. Hammes, who studies war-fighting history at the Pentagon-backed National Defense University, the developments represent a “genuine military revolution,” and one that is happening much more quickly than the shift from infantry that traveled by foot in World War I to the motorized and mechanized armies of World War II.

. . .

(p. A9) Perhaps the most revolutionary use of American technology in Ukraine has been the application of software that uses artificial intelligence, made by Palantir, to help with targeting efforts. The company’s chief executive, Alex Karp, traveled to Ukraine last year to meet with President Volodymyr Zelensky.

“If you go into battle with old school technology,” Mr. Karp said this year at an event to discuss artificial intelligence tools in warfare, “and you have an adversary that knows how to install and implement digitalized targeting in A.I., you obviously are at a massive disadvantage.”

Some experts say that artificial intelligence, which has been used in Ukraine to help sift through the massive loads of data being accumulated from surveillance, will ultimately prove as disruptive to the nature of war-fighting as nuclear weapons.

. . .

For Primer, the small artificial-intelligence firm based in downtown San Francisco, it was a breakthrough moment.

Not long after the war in Ukraine started, its engineers, working with Western allies, tapped into a tidal wave of intercepted Russian radio communications. It used advanced software to clean up the crackly sound, automatically translated the conversations, and most importantly, isolated moments when Russian soldiers in Ukraine were discussing weapons systems, locations and other tactically important information.

This same work would have taken hundreds of intelligence analysts to identify the few relevant clues in the mass of radio traffic. Now it was happening in a matter of minutes.

The findings were quickly matched up with other so-called open source intelligence streams, like geolocation data pulled from social media accounts, giving updates on the location of troops or equipment, that could be matched with surveillance video from drones or images from satellites.

“It’s getting situational awareness,” said Sean Gourley, the founder of Primer.

Yet at the same time, the Pentagon was still deciding when to move ahead with major purchases of its technology. The company was burning through its cash reserves too quickly, so Mr. Gourley laid off engineers and other staff members.

“These engineers are great at creating solutions to solve these problems, which is what matters,” Mr. Gourley said. “But there is the uncertainty: When is this contract going to close? It’s very, very hard to justify that spend.”

Mr. Gourley said he decided instead to invest more money in a government relations push, hiring a former top aide to the Senate Armed Services Committee to help the company promote its business in Washington.

“The big defense companies, they don’t really kind of invest in the tech,” he said. “They just invest in how to navigate this bureaucracy. That kind of sucks, but that’s how you’ve got to play this game.”

In interviews, nearly a dozen top executives of technology-oriented companies shared stories of stalled efforts or frustration.

For the full story, see:

Eric Lipton. “Pentagon Is Slow At Signing Deals With Innovators.” The New York Times (Monday, May 22, 2023): A1 & A8-A9.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the story has the date May 21, 2023, and has the title “Start-Ups Bring Silicon Valley Ethos to a Lumbering Military-Industrial Complex.”)

Data Set Too Small to Support Claim of 250,000 Annual ER Deaths Due to Misdiagnosis

(p. A17) A shocking headline recently claimed that every year 250,000 people in the U.S. die after misdiagnosis in the emergency room. Even more shocking, the statistic was extrapolated from the death of one man—in a Canadian emergency room more than a decade ago.

. . .

The statistical methods used to arrive at the report’s estimate of 250,000 deaths are very bad, resulting in inaccurate findings that exaggerate potential harm in ERs. The estimate was derived from a single study that included only 503 patients discharged from two Canadian emergency rooms from August to December 2004. Researchers found that among the 503 patients, one person unexpectedly died related to a delay in diagnosis by an ER physician. The patient had signs of an aortic dissection—a tear in the major vessel that carries blood from the heart. For reasons we don’t know, the diagnosis was delayed for seven hours.

The goal of the Canadian study was to measure all kinds of medical errors, not to estimate the death rate from erroneous or late diagnoses. The sample size wasn’t big enough for that. Had nobody in the study sample died, would that mean that ERs never make fatal errors? Obviously not.

The AHRQ report misused this single death to estimate a death rate across the entire U.S. Dividing one death by 503 patients, the researchers estimate a death rate of 0.2%. They then multiply 0.2% by total annual ER visits in the U.S.—130 million—and come up with 250,000 deaths.

For the full commentary, see:

Kristen Panthagani. “A Study Sounds a False Alarm About America’s Emergency Rooms.” The Wall Street Journal (Friday, Dec. 30, 2022): A17.

(Note: ellipsis added.)

(Note: the online version of the commentary has the date December 29, 2022, and has the same title as the print version.)

Milton Friedman Was a “Formative Intellectual Influence” to George Shultz

(p. A13) [George] Shultz, an unflamboyant personality once described by a college classmate as a “steady, plodding intellect,” reached the commanding heights of American government, holding four cabinet posts over his career from secretary of the Treasury to state. Shultz died in 2021 at the age of 100.

. . .

For a time Shultz was on track for a career in academia, working in the economics department at MIT and later the University of Chicago. “Chicago is what started me,” Shultz said. Milton Friedman, a formative intellectual influence and enduring friend, methodically deepened Shultz’s faith in free markets and his skepticism of government intervention in the economy. “Milton didn’t hit the tennis ball hard but it always came back,” Shultz once remarked, “which was reflective of the way he argued, too.”

. . .

. . . Shultz was hardly immune from being wrong. For example: Along with the rest of the State Department, he tried to talk Reagan out of using the line “Mr. Gorbachev, tear down this wall.” Shultz worried it was too provocative.

The cautionary tale is that many know Shultz from perhaps the biggest error in judgment he ever made, some 90 years into his life. That’s his association with Elizabeth Holmes, the Silicon Valley founder convicted of fraud in federal court. Shultz was one of Ms. Holmes’s first marks, and he helped her assemble a board for her blood-testing company from his Rolodex. Among the wreckage was Shultz’s relationship with his own grandson, Tyler, who early on discovered the company’s misrepresentations.

For the full review, see:

Kate Bachelder Odell. “BOOKSHELF; Subsume the Ego And Stay Loyal.” The Wall Street Journal (Tuesday, March 7, 2023): A13.

(Note: ellipses, and bracketed name, added.)

(Note: the online version of the review has the date March 6, 2023, and has the title “BOOKSHELF; ‘In the Nation’s Service’ Review: George Shultz’s Quiet Strength.”)

The book under review is:

Taubman, Philip. In the Nation’s Service: The Life and Times of George P. Shultz. Stanford, Cal.: Stanford University Press, 2023.

In 2021 Summers and Blanchard Worried That Biden’s Covid Stimulus Would Fuel Inflation

(p. A2) When Congress passed President Biden’s $1.9 trillion American Rescue Plan in early 2021, which included checks to households, enhanced jobless benefits and aid to state and local governments, inflation was around 2% and unemployment, though coming down, still above 6%.

At the time many forecasters thought the stimulus could push demand above the economy’s potential to supply goods and services and unemployment below its long-run natural rate of around 4%. Yet few thought this would meaningfully raise inflation. In previous decades unemployment had remained similarly low without raising price pressures.

A few disagreed, notably former Treasury Secretary Lawrence Summers and Blanchard. Both warned the stimulus was so large it would push the economy dangerously into overheating territory.

For the full commentary, see:

Greg Ip. “CAPITAL ACCOUNT; Why Did Inflation Take Off? Two Top Economists Answer.” The Wall Street Journal (Wednesday, May 24, 2023): A2.

(Note: the online version of the commentary has the date May 23, 2023, and has the title “CAPITAL ACCOUNT; Why Inflation Erupted: Two Top Economists Have the Answer.”)

A 2021 article that documented Summers’s and Blanchard’s worry that Biden’s huge stimulus might fuel inflation is:

Ip, Greg. “Inflation Risk: Little Now, but Some See Danger Ahead.” The Wall Street Journal (Tues., March 2, 2021).