Health – Page 70 – artdiamondblog.com

Working Rat Kidney Is Created in Lab

(p. A10) Researchers at Massachusetts General Hospital in Boston have made functioning rat kidneys in the laboratory, a bioengineering achievement that may one day lead to the ability to create replacement organs for people with kidney disease.
The scientists said the rat kidneys produced urine in the laboratory as well as when transplanted into rats. The kidneys were made by stripping donor kidneys of their cells and putting new cells that regenerate tissue into them. Stripping an organ leaves a natural scaffold of collagen and other compounds, called the extracellular matrix, which provides a framework for new cells and preserves the intricate internal architecture of the kidney as well as its basic shape.
Dr. Harald C. Ott, senior author of a paper describing the research that was published online Sunday by the journal Nature Medicine, said that the work was still in its early stages and that there were many hurdles to creating fully functional kidneys for people. But he noted that replacement organs made in this way would have advantages over those made with artificial scaffolds or other techniques.

For the full story, see:
HENRY FOUNTAIN. “Rat Kidneys Made in Lab Point to Aid for Humans.” The New York Times (Mon., April 15, 2013): A10.
(Note: the online version of the story has the date April 14, 2013.)

Hunter-Gatherers Complained of Hunger and Food Monotony

(p. 30) Based on numerous historical encounters with aboriginal tribes, we know [hunter-gatherers] often, if not regularly, complained about being hungry. Famed anthropologist Colin Turnbull noted that although the Mbuti frequently sang to the goodness of the forest, they often complained of hunger. Often the com-(p. 31)plaints of hunter-gathers were about the monotony of a carbohydrate staple, such as mongongo nuts, for every meal; when they spoke of shortages, or even hunger, they meant a shortage of meat, and a hunger for fat, and a distaste for periods of hunger. Their small amount of technology gave them sufficiency for most of the time, but not abundance.

Source:
Kelly, Kevin. What Technology Wants. New York: Viking Adult, 2010.
(Note: “hunter-gathers” substituted for “they” by AMD.)

Liver Transplant Pioneer Roy Calne Has a “Rebellious Nature”

“Roy Y. Calne” Source of caption and photo: online version of the NYT interview quoted and cited below.

(p. D2) Sir Roy Calne is a pioneer of organ transplants — the surgeon who in the 1950s found ways to stop the human immune system from rejecting implanted hearts, livers and kidneys. In 1968 he performed Europe’s first liver transplant, and in 1987 the world’s first transplant of a liver, heart and lung.
. . .
When you were studying medicine in early-1950s Britain, what was the prevailing attitude toward organ transplantation?
It didn’t exist! While a medical student, I recall being presented with a young patient with kidney failure. I was told to make him as comfortable as possible because he would die in two weeks.
This troubled me. Some of our patients were very young, very deserving. Aside from their kidney disease, there was nothing else wrong with them. I wondered then if it might be possible to do organ transplants, because kidneys are fairly simple in terms of their plumbing. I thought in gardening terms. Might it not be possible to do an organ graft, replacing a malfunctioning organ with a healthy one? I was told, “No, that’s impossible.”
Well, I’ve always tended to dislike being told that something can’t be done. I’ve always had a somewhat rebellious nature. Just ask my wife.

For the full interview, see:
CLAUDIA DREIFUS, interviewer. “A CONVERSATION WITH ROY Y. CALNE; “I’ve always tended to dislike being told that something can’t be done. I’ve always had a somewhat rebellious nature.”” The New York Times (Weds., November 27, 2012): D2.
(Note: ellipsis added; bold in original to indicate interviewer (Dreifus) question.)
(Note: the online version of the interview has the date November 26, 2012 and has the title “A CONVERSATION WITH ROY Y. CALNE; Organ Transplant Pioneer Talks About Risks and Rewards.”)

Energy-Efficient Buildings Increase Indoor CO2 Pollution and Impair Decision-Making

(p. C4) Carbon dioxide at levels normally found indoors is usually considered benign, especially compared with carbon monoxide. But a study finds that even modestly elevated CO2 can impair decision-making.
. . .
Given the emphasis on energy-efficient buildings, which are often more airtight, the study suggests that carbon dioxide might be an indoor pollutant to worry about–especially in conference rooms, where important decisions are hashed out.

For the full story, see:
Daniel Akst. “WEEK IN IDEAS; Week in Ideas: Daniel Akst; POLLUTANTS; Blame It on the Air.” The Wall Street Journal (Sat., October 27, 2012): C4.
(Note: ellipsis added.)
(Note: the online version of the story has the date October 26, 2012.)

The study summarized is:
Satish, Usha, Mark J. Mendell, Krishnamurthy Shekhar, Toshifumi Hotchi, Douglas Sullivan, Siegfried Streufert, and William J. Fisk. “Is Co2 an Indoor Pollutant? Direct Effects of Low-to-Moderate Co2 Concentrations on Human Decision-Making Performance.” Environmental Health Perspectives (Sept. 20, 2012): 1-35.
(Note: it is not clear to me if Environmental Health Perspectives is an online journal or an online working paper series. Whatever it is, it is affiliated with the National Institute of Environmental Health Sciences.)

Greater Efforts to Save Premature Babies Inflates U.S. Infant-Mortality

(p. A13) The federally chartered Institute of Medicine issued a comprehensive report last month on the state of American health. Saying that “Other high-income countries outrank the United States on most measures of health,” the report concluded that the U.S. “is among the wealthiest nations in the world, but it is far from the healthiest.”
. . .
As the report’s authors point out, the U.S. has the highest infant-mortality rate among high-income countries.
. . .
Doctors in the U.S. are much more aggressive than foreign counterparts about trying to save premature babies. Thousands of babies that would have been declared stillborn in other countries and never given a chance at life are saved in the U.S. As a result, the percentage of preterm births in America is exceptionally high–65% higher than in Britain, and about double the rates in Finland and Greece.
Unfortunately, some of the premature babies that American hospitals try to save don’t make it. Their deaths inflate the overall infant mortality rate.

For the full commentary, see:
SALLY C. PIPES. “OPINION; Those Misleading World Health Rankings; The numbers are distorted because, for instance, U.S. doctors try so hard to save premature babies.” The Wall Street Journal (Tues., February 5, 2013): A13.
(Note: ellipses added.)
(Note: the online version of the commentary has the date February 4, 2013.)

Jobs’ Protest Against Mortality: Omit the On-Off Switches on Apple Devices

(p. 571) . . . [Jobs] admitted that, as he faced death, he might be overestimating the odds out of a desire to believe in an afterlife. “I like to think that something survives after you die,” he said. “It’s strange to think that you accumulate all this experience, and maybe a little wisdom, and it just goes away. So I really want to believe that something survives, that maybe your consciousness endures.”
He fell silent for a very long time. “But on the other hand, perhaps it’s like an on-off switch,” he said. “Click! And you’re gone.”
Then he paused again and smiled slightly. “Maybe that’s why I never liked to put on-off switches on Apple devices.”

Source:
Isaacson, Walter. Steve Jobs. New York: Simon & Schuster, 2011.
(Note: ellipsis and bracketed “Jobs” added; italics in original.)

Unemployment Increases Risk of Heart Attack

As a defender of the process of innovation through creative destruction, I try to be alert to evidence on creative destruction’s benefits and costs. The highest cost is usually viewed as technological unemployment. The evidence below will have to be examined and, if sound, added to the costs.

(p. D6) Unemployment increases the risk of heart attack, a new study reports, and repeated job loss raises the odds still more.
. . .
After adjusting for well-established heart attack risks — age, sex, smoking, income, hypertension, cholesterol screening, exercise, depression, diabetes and others — the researchers found that being unemployed also increased the risk of a heart attack, by an average of 35 percent.

For the full story, see:
NICHOLAS BAKALAR. “Job Loss Raises Threat of Heart Attack.” The New York Times (Tues., November 27, 2012): D6.
(Note: ellipsis added.)
(Note: the online version of the story has the date November 26, 2012.)

The Dupre article mentioned above, is:
Dupre, Matthew E., Linda K. George, Guangya Liu, and Eric D. Peterson. “The Cumulative Effect of Unemployment on Risks for Acute Myocardial Infarction.” Archives of Internal Medicine 172, no. 22 (Dec. 10, 2012): 1731-37.
(Note: the Archives of Internal Medicine has been re-named JAMA Internal Medicine.)

Resveratrol Activates Sirtuins to Switch on Energy Producing Mitochondria

A new study, just published in the prestigious journal Science, appears to substantially vindicate the recently beleaguered resveratrol longevity research of David Sinclair:

. . . a new study led by David Sinclair of the Harvard Medical School, who in 2003 was a discoverer resveratrol’s role in activating sirtuins, found that resveratrol did indeed influence sirtuin directly, though in a more complicated way than previously thought. . . . . . . activated, the sirtuins do several things, one of which is to switch on a second protein that spurs production of the mitochondria, which provide the cell’s energy. This would explain why mice treated with resveratrol ran twice as far on a treadmill before collapsing from exhaustion as untreated mice.

For the full story, see:
NICHOLAS WADE. “New Optimism on Resveratrol.” New York Times “Well” Blog Posted on MARCH 11, 2013. URL: http://well.blogs.nytimes.com/2013/03/11/new-optimism-on-resveratrol/
(Note: ellipses added.)

The Sinclair article (see last-listed co-author) is:
Hubbard, Basil P., Ana P. Gomes, Han Dai, Jun Li, April W. Case, Thomas Considine, Thomas V. Riera, Jessica E. Lee, Sook Yen E (sic), Dudley W. Lamming, Bradley L. Pentelute, Eli R. Schuman, Linda A. Stevens, Alvin J. Y. Ling, Sean M. Armour, Shaday Michan, Huizhen Zhao, Yong Jiang, Sharon M. Sweitzer, Charles A. Blum, Jeremy S. Disch, Pui Yee Ng, Konrad T. Howitz, Anabela P. Rolo, Yoshitomo Hamuro, Joel Moss, Robert B. Perni, James L. Ellis, George P. Vlasuk, and David A. Sinclair. “Evidence for a Common Mechanism of Sirt1 Regulation by Allosteric Activators.” Science 339, no. 6124 (March 8, 2013): 1216-19.

Most in NYC Oppose Bloomberg’s Nanny State Soda Ban

“Theodore Ogunbiyi-Roche, 10, who is visiting from London, drank a large soda in Times Square . . . ” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A18) . . . , New Yorkers are cool to Mayor Michael R. Bloomberg’s plan to prohibit sales of large sugary drinks in city restaurants, stadiums and movie theaters, according to a . . . poll by The New York Times.

Six in 10 residents said the mayor’s soda plan was a bad idea, compared with 36 percent who called it a good idea. A majority in every borough was opposed; Bronx and Queens residents were more likely than Manhattanites to say the plan was a bad idea.
. . .
. . . those opposed overwhelmingly cited a sense that Mr. Bloomberg was overreaching with the plan and that consumers should have the freedom to make a personal choice . . .
“The ban is at the point where it is an infringement of civil liberties,” Liz Hare, 43, a scientific researcher in Queens, said in a follow-up interview. “There are many other things that people do that aren’t healthy, so I think it’s a big overreach.”
Bob Barocas, 64, of Queens, put it more bluntly: “This is like the nanny state going off the wall.”

For the full story, see:
MICHAEL M. GRYNBAUM and MARJORIE CONNELLY. “60% in City Oppose Soda Ban, Calling It an Overreach by Bloomberg, Poll Finds.” The New York Times (Thurs., August 23, 2012): A18.
(Note: ellipses in caption and article added.)
(Note: the online version of the story has the date August 22, 2012, and the title “60% in City Oppose Bloomberg’s Soda Ban, Poll Finds.”)

Stanford Meta-Study Finds Organic Food Is No More Nutritious than Much Cheaper Non-organic Food

“Conventional strawberries in Watsonville, California. Researchers say organic foods are no more nutritious and no less likely to be contaminated.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A20) Does an organic strawberry contain more vitamin C than a conventional one?

Maybe — or maybe not.
Stanford University scientists have weighed in on the “maybe not” side of the debate after an extensive examination of four decades of research comparing organic and conventional foods.
They concluded that fruits and vegetables labeled organic were, on average, no more nutritious than their conventional counterparts, which tend to be far less expensive. Nor were they any less likely to be contaminated by dangerous bacteria like E. coli.
The researchers also found no obvious health advantages to organic meats.
. . .
The conclusions will almost certainly fuel the debate over whether organic foods are a smart choice for healthier living or a marketing tool that gulls people into overpaying. The production of organic food is governed by a raft of regulations that generally prohibit the use of synthetic pesticides, hormones and additives.
The organic produce market in the United States has grown quickly, up 12 percent last year, to $12.4 billion, compared with 2010, according to the Organic Trade Association. Organic meat has a smaller share of the American market, at $538 million last year, the trade group said.
. . .
In the study — known as a meta-analysis, in which previous findings are aggregated but no new laboratory work is conducted — researchers combined data from 237 studies, examining a wide variety of fruits, vegetables and meats. For four years, they performed statistical analyses looking for signs of health benefits from adding organic foods to the diet.
The researchers did not use any outside financing for their research. “I really wanted us to have no perception of bias,” Dr. Bravata said.

For the full story, see:
KENNETH CHANG. “Stanford Scientists Cast Doubt on Advantages of Organic Meat and Produce.” The New York Times (Tues., September 4, 2012): A20.
(Note: ellipses added.)
(Note: the online version of the story has the date September 3, 2012.)

Organic Food May Be Less Healthy than Non-Organic Food

Source of book image: http://www.leckeragency.com/sites/default/files/books/Schwarcz,%20Joe%20-%20The%20Right%20Chemistry%20Cover.jpeg

(p. D7) . . . , when did “chemical” become a dirty word? That’s a question raised by one of Canada’s brightest scientific minds: Joe Schwarcz, director of the Office for Science and Society at McGill University in Montreal. Dr. Schwarcz, who has received high honors from Canadian and American scientific societies, is the author of several best-selling books that attempt to set the record straight on a host of issues that commonly concern health-conscious people.

I’ve read two of his books, “Science, Sense and Nonsense” (published in 2009) and “The Right Chemistry” (2012), and recently attended a symposium on the science of food that Dr. Schwarcz organized at McGill.
What follows are tips from his books and the symposium that can help you make wiser choices about what does, and does not, pass your lips in 2013.
. . .
ORGANIC OR NOT? Wherever I shop for food these days, I find an ever-widening array of food products labeled “organic” and “natural.” But are consumers getting the health benefits they pay a premium for?
Until the 20th century, Dr. Schwarcz wrote, all farming was “organic,” with manure and compost used as fertilizer and “natural” compounds of arsenic, mercury and lead used as pesticides.
Might manure used today on organic farms contain disease-causing micro-organisms? Might organic produce unprotected by insecticides harbor cancer-causing molds? It’s a possibility, Dr. Schwarcz said. But consumers aren’t looking beyond the organic sales pitch.
Also questionable is whether organic foods, which are certainly kinder to the environment, are more nutritious. Though some may contain slightly higher levels of essential micronutrients, like vitamin C, the difference between them and conventionally grown crops may depend more on where they are produced than how.
A further concern: Organic producers disavow genetic modification, which can be used to improve a crop’s nutritional content, enhance resistance to pests and diminish its need for water. A genetically modified tomato developed at the University of Exeter, for example, contains nearly 80 times the antioxidants of conventional tomatoes. Healthier, yes — but it can’t be called organic.

For the full story, see:
JANE E. BRODY. “PERSONAL HEALTH; What You Think You Know (but Don’t) About Wise Eating.” The New York Times (Tues., January 1, 2013): D7.
(Note: ellipses added; bold in original.)
(Note: the online version of the article has the date DECEMBER 31, 2012.)

The Schwarcz books mentioned above, are:
Schwarcz, Joe. The Right Chemistry: 108 Enlightening, Nutritious, Health-Conscious and Occasionally Bizarre Inquiries into the Science of Daily Life. Toronto, Ontario: Doubleday Canada, 2012.
Schwarcz, Joe. Science, Sense & Nonsense. Toronto, Ontario: Doubleday Canada, 2009.