Category: Science

Innovative Entrepreneurs Finance Basic Research in Mariana Trench

OceanDepthGraphic2011-08-10.jpgSource of graphic: online version of the NYT article quoted and cited below.

(p. D1) A new generation of daredevils is seeking to plunge through nearly seven miles of seawater to the bottom of a rocky chasm in the western Pacific that is veiled in perpetual darkness. It is the ocean’s deepest spot. The forbidding place, known as the Challenger Deep, is so far removed from the warming rays of the sun that its temperature hovers near freezing.

“When I was a kid, I loved not only amazing ocean exploration but space, too,” James Cameron, the director of “Avatar,” “Titanic” and “The Abyss,” said in an interview. “I can think of no greater fantasy than to be an explorer and see what no human eye has seen before.”
The would-be explorers can afford to live their dreams because of their extraordinarily deep pockets. Significantly, their ambitions far exceed those of the world’s seafaring nations, which have no plans to send people so deep.
The billionaires and millionaires include Mr. Cameron, the airline mogul Richard Branson and the Internet guru Eric E. Schmidt. Each is building, planning to build or financing the construction of minisubmarines meant to transport them, their friends and scientists into the depths. Entrepreneurs talk of taking tourists down as well.
The vehicles, meant to hold one to three people, are estimated to cost anywhere from $7 million to $40 million.

For the full story, see:
WILLIAM J. BROAD. “Ambitions as Deep as Their Pockets.” The New York Times (Tues., August 2, 2011): D1 & D4.
(Note: the online version of the article is dated August 1, 2011.)

“A Landmark Achievement for Regenerative Medicine”

TracheaMadeInLab2011-08-09.jpg “A lab-made windpipe was implanted June 9 into a 36-year-old patient whose own windpipe was obstructed by a tumor.” Source of caption and photo: online version of the WSJ article quoted and cited below.

(p. A3) Doctors have replaced the cancer-stricken windpipe of a patient with an organ made in a lab, a landmark achievement for regenerative medicine. The patient no longer has cancer and is expected to have a normal life expectancy, doctors said.

“He was condemned to die,” said Paolo Macchiarini, a professor of regenerative surgery who carried out the procedure at Sweden’s Karolinska University Hospital. “We now plan to discharge him [Friday].”
The transplantation of an entirely synthetic and permanent windpipe had never been successfully done before the June 9 procedure. The researchers haven’t yet published the details in a scientific journal.

For the full story, see:
GAUTAM NAIK. “Lab-Made Trachea Saves Man; Tumor-Blocked Windpipe Replaced Using Synthetic Materials, Patient’s Own Cells.” The Wall Street Journal (Fri., July 8, 2011): C8.

The Huge Value of Exposing Ourselves to Unexpected Evidence

Bill Bryson tells how much we learned from the remains of a man from the neolithic age, who has been called Ötzi:

(p. 377) His equipment employed eighteen different types of wood – a remarkable variety. The most surprising of all his tools was the axe. It was copper-bladed and of a type known as a Remedello axe, after a site in Italy where they were first found. But Ötzi’s axe was hundreds of years older than the oldest Remedello axe. ‘It was,’ in the words of one observer, ‘as if the tomb of a medieval warrior had yielded a modern rifle.’ The axe changed the timeframe for the copper age in Europe by no less than a thousand years.

But the real revelation and excitement were the clothes. Before Ötzi we had no idea – or, to be more precise, nothing but ideas – of how stone age people dressed. Such materials as survived existed only as fragments. Here was a complete outfit and it was full of surprises. His clothes were made from the skins and furs of an impressive range of animals – red deer, bear, chamois, goat and cattle. He also had with him a woven grass rectangle that was three feet long. This might have been a kind of rain cape, but it might equally have been a sleeping mat. Again, nothing like it had ever been seen or imagined.
Ötzi wore fur leggings held up with leather strips attached to a waist strap that made them look uncannily – almost comically – like the kind of nylon stockings and garter sets that Hollywood pin-ups wore in the Second World War. Nobody had remotely foreseen such a get-up. He wore a loincloth of goatskin and a hat made from the fur of a brown bear – probably a kind of hunting trophy. It would have been very warm and covetably stylish. The rest of his outfit was mostly made from the skin and fur of red deer. Hardly any came from domesticated animals, the opposite of what was expected.

Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.

The Lancet Accused Snow of Being “in the Pocket of Business Interests”

(p. 365) It is hard now to appreciate just how radical and unwelcome Snow’s views were. Many authorities actively detested him for them. The Lancet concluded that he was in the pocket of business interests which wished to continue to fill the air with ‘pestilent vapours, miasms and loathsome abominations of every kind’ and make themselves rich by poisoning their neighbours. ‘After careful enquiry,’ the parliamentary inquiry concluded, ‘we see no reason to adopt this belief.’

Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.
(Note: italics in original.)

We Tend to Ignore Information that Contradicts Our Beliefs

BelievingBrainBK2011-08-09.jpg

Source of book image: online version of the WSJ review quoted and cited below.

We learn the most when our priors are contradicted. But the dissonance between evidence and beliefs is painful. So we often do not see, or soon forget, evidence that does not fit with our beliefs.
The innovative entrepreneur is often a person who sees and forces herself to remember, the dissonant fact, storing it away to make sense of, or make use of, later. At the start, she may be alone in what she sees and what she remembers. So if we are to benefit from her ability and willingness to bear the pain of dissonance, she must have the freedom to differ, and she must have the financial wherewith-all to support herself until her vision is more widely shared, better understood, and more fruitfully applied.

(p. A13) Beliefs come first; reasons second. That’s the insightful message of “The Believing Brain,” by Michael Shermer, the founder of Skeptic magazine. In the book, he brilliantly lays out what modern cognitive research has to tell us about his subject–namely, that our brains are “belief engines” that naturally “look for and find patterns” and then infuse them with meaning. These meaningful patterns form beliefs that shape our understanding of reality. Our brains tend to seek out information that confirms our beliefs, ignoring information that contradicts them. Mr. Shermer calls this “belief-dependent reality.” The well-worn phrase “seeing is believing” has it backward: Our believing dictates what we’re seeing.
. . .
One of the book’s most enjoyable discussions concerns the politics of belief. Mr. Shermer takes an entertaining look at academic research claiming to prove that conservative beliefs largely result from psychopathologies. He drolly cites survey results showing that 80% of professors in the humanities and social sciences describe themselves as liberals. Could these findings about psychopathological conservative political beliefs possibly be the result of the researchers’ confirmation bias?
As for his own political bias, Mr. Shermer says that he’s “a fiscally conservative civil libertarian.” He is a fan of old-style liberalism, as in liberality of outlook, and cites “The Science of Liberty” author Timothy Ferris’s splendid formulation: “Liberalism and science are methods, not ideologies.” The “scientific solution to the political problem of oppressive governments,” Mr. Shermer says, “is the tried-and-true method of spreading liberal democracy and market capitalism through the open exchange of information, products, and services across porous economic borders.”
But it is science itself that Mr. Shermer most heartily embraces. “The Believing Brain” ends with an engaging history of astronomy that illustrates how the scientific method developed as the only reliable way for us to discover true patterns and true agents at work. Seeing through a telescope, it seems, is believing of the best kind.

For the full review, see:
RONALD BAILEY. “A Trick Of the Mind; Looking for patterns in life and then infusing them with meaning, from alien intervention to federal conspiracy.” The Wall Street Journal (Weds., July 27, 2011): A13.
(Note: ellipsis added.)

Book reviewed:
Shermer, Michael. The Believing Brain: From Ghosts and Gods to Politics and Conspiracies—How We Construct Beliefs and Reinforce Them as Truths. New York: Times Books, 2011.

Lunar Entrepreneurs

(p. A1) Now that the last space shuttle has landed back on Earth, a new generation of space entrepreneurs would like to whip up excitement about the prospect of returning to the Moon.
. . .
(p. A3) “It’s probably the biggest wealth creation opportunity in modern history,” said Barney Pell, a former NASA computer scientist turned entrepreneur and now a co-founder of Moon Express. While Moon Express might initially make money by sending small payloads, the big fortune would come from bringing back platinum and other rare metals, Dr. Pell said.
“Long term, the market is massive, no doubt,” he said. “This is not a question of if. It’s a question of who and when. We hope it’s us and soon.”
Like the aviation prizes that jump-started airplane technology a century ago, the Google Lunar X Prize is meant to rally technologists and entrepreneurs. It is administered by the X Prize Foundation, which handed out $10 million in 2004 to the first private team to build a spacecraft that could carry people 60 miles above the Earth’s surface. (The winner, SpaceShipOne, was built by the aerospace designer Burt Rutan with backing from Paul Allen, the software magnate.)

For the full story, see:
KENNETH CHANG. “In a Private Race to the Moon, Flights of Fancy Are in the Air.” The New York Times (Fri., July 22, 2011): A1 & A3.
(Note: the online version of the story is dated July 21, 2011 and has the title “Race to the Moon Heats Up for Private Firms.”)

John Crandon Proved Scurvy Caused by Lack of Vitamin C

(p. 167) . . . , in 1939 a Harvard Medical School surgeon named John Crandon decided to settle matters once and for all by the age-old method of withholding Vitamin C from his diet for as long as it took to make himself really ill. It took a surprisingly long time. For the first eighteen weeks, his only symptom was extreme fatigue. (Remarkably, he continued to operate on patients throughout this period.) But in the nineteenth week he took an abrupt turn for the worse – so much so that he would almost certainly have died had he not been under close medical supervision. He was injected with 1,000 milligrams of Vitamin C and was restored to life (p. 168) almost at once. Interestingly, he had never acquired the one set of symptoms that everyone associates with scurvy: the falling out of teeth and bleeding of gums.

Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.
(Note: ellipsis added.)

Obstacles to Curing Scurvy: A Deadly Experiment and Putting Theory Before Evidence

(p. 165) What was needed was some kind of distilled essence – an antiscorbutic, as the medical men termed it – that would be effective against scurvy but portable too. In the 1760s, a Scottish doctor named William Stark, evidently encouraged by Benjamin Franklin, conducted a series of patently foolhardy experiments in which he tried (p. 166) to identify the active agent by, somewhat bizarrely, depriving himself of it. For weeks he lived on only the most basic of foods – bread and water chiefly – to see what would happen. What happened was that in just over six months he killed himself, from scurvy, without coming to any helpful conclusions at all.
In roughly the same period, James Lind, a naval surgeon, conducted a more scientifically rigorous (and personally less risky) experiment by finding twelve sailors who had scurvy already, dividing them into pairs, and giving each pair a different putative elixir – vinegar to one, garlic and mustard to another, oranges and lemons to a third, and so on. Five of the groups showed no improvement, but the pair given oranges and lemons made a swift and total recovery. Amazingly, Lind decided to ignore the significance of the result and doggedly stuck with his personal belief that scurvy was caused by incompletely digested food building up toxins within the body.

Source:
Bryson, Bill. At Home: A Short History of Private Life. New York: Doubleday, 2010.

Drug from David Sinclair’s Sirtris Start-Up Lengthens Life of Obese Mice

MiceLiveLonger2011-08-19.jpg“An obese mouse given the drug SRT-1720, center, and one not given the drug, right.” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A1) Sustaining the flickering hope that human aging might somehow be decelerated, researchers have found they can substantially extend the average life span of obese mice with a specially designed drug.

The drug, SRT-1720, protects the mice from the usual diseases of obesity by reducing the amount of fat in the liver and increasing sensitivity to insulin. These and other positive health effects enable the obese mice to live 44 percent longer, on average, than obese mice that did not receive the drug, according to a team of researchers led by Rafael de Cabo, a gerontologist at the National Institute on Aging.
Drugs closely related to SRT-1720 are now undergoing clinical trials in humans.
The findings “demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals,” Dr. de Cabo and colleagues write in Thursday’s issue of the new journal Scientific Reports. Their conclusion supports claims that had been thrown in doubt by an earlier study that was critical of SRT-1720.
A drug that makes it cost-free to be obese may seem more a moral hazard than an incentive to good health. But the rationale behind the research is somewhat different: the researchers are trying to capture the benefits that allow mice on very low-calorie diets to live longer. It just so happens that such benefits are much easier to demonstrate in mice under physiological stress like obesity than in normal mice.
. . .
. . . , a small pharmaceutical concern in Cambridge, Mass., designed SRT-1720 and a set of similar drugs to mimic resveratrol — the trace ingredient of red wine that is thought to activate protective proteins called sirtuins.
The sirtuins help bring about the 30 percent extension of life span enjoyed by mice and rats that are kept on very low-calorie diets.

For the full story, see:
NICHOLAS WADE. “Longer Lives for Obese Mice, With Hope for Humans of All Sizes.” The New York Times (Fri., August 19, 2011): A1 & A3.
(Note: ellipses added.)
(Note: the online version of the story was dated August 18, 2011.)

“A Brilliant and Exhilarating and Profoundly Eccentric Book”

DeutschDavid2011-08-14.jpg

“David Deutsch.” Source of caption and photo: online version of the NYT review quoted and cited below.

(p. 16) David Deutsch’s “Beginning of Infinity” is a brilliant and exhilarating and profoundly eccentric book. It’s about everything: art, science, philosophy, history, politics, evil, death, the future, infinity, bugs, thumbs, what have you. And the business of giving it anything like the attention it deserves, in the small space allotted here, is out of the question. But I will do what I can.
. . .
The thought to which Deutsch’s conversation most often returns is that the European Enlightenment of the 17th and 18th centuries, or something like it, may turn out to have been the pivotal event not merely of the history of the West, or of human beings, or of the earth, but (literally, physically) of the universe as a whole.
. . .
(p. 17) Deutsch’s enthusiasm for the scientific and technological transformation of the totality of existence naturally brings with it a radical impatience with the pieties of environmentalism, and cultural relativism, and even procedural democracy — and this is sometimes exhilarating and sometimes creepy. He attacks these pieties, with spectacular clarity and intelligence, as small-­minded and cowardly and boring. The metaphor of the earth as a spaceship or life-­support system, he writes, “is quite perverse. . . . To the extent that we are on a ‘spaceship,’ we have never merely been its passengers, nor (as is often said) its stewards, nor even its maintenance crew: we are its designers and builders. Before the designs created by humans, it was not a vehicle, but only a heap of dangerous raw materials.” But it’s hard to get to the end of this book without feeling that Deutsch is too little moved by actual contemporary human suffering. What moves him is the grand Darwinian competition among ideas. What he adores, what he is convinced contains the salvation of the world, is, in every sense of the word, The Market.

For the full review, see:
DAVID ALBERT. “Explaining it All: David Deutsch Offers Views on Everything from Subatomic Particles to the Shaping of the Universe Itself.” The New York Times Book Review (Sun., August 14, 2011): 16-17.
(Note: ellipses between paragraphs added; ellipsis in Deutsch quote in original.)
(Note: the online version of the review is dated August 12, 2011 and has the title “Explaining it All: How We Became the Center of the Universe.”)

Book under review:
Deutsch, David. The Beginning of Infinity: Explanations That Transform the World. New York: Viking Adult, 2011.