Author: Art Diamond

Citron Research Alleged That DNA Vaccine Firm Inovio Is “the COVID-19 Version of Theranos”

(p. A10) Not long after researchers completed their work with mice, guinea pigs, ferrets and monkeys, Human Subject 8, an art director for a software company in Missouri, received an injection. Four days later, her sister, a schoolteacher, became Subject 14.

Together, the sisters make up about 5 percent of the first ever clinical trial of a DNA vaccine for the novel coronavirus. How they respond to it will help determine the future of the vaccine. If it proves safe in this trial and effective in future trials, it could become not only one of the first coronavirus vaccines, but also the first DNA vaccine ever approved for commercial use against a human disease.

. . .

In many of these studies, the vaccine recipe isn’t the only thing on trial. Gene-based vaccines — and at least 20 coronavirus vaccines in development fall into this category — have yet to make it to market. Should one end up in doctors’ offices amid the rush to shield billions from Covid-19, it would represent a new chapter for vaccine development.

And though vaccine research has never moved this quickly — potentially meaning enhanced risks for volunteers — it has never been easier to recruit subjects, according to Dr. John E. Ervin, who is overseeing the DNA vaccine trial at the Center for Pharmaceutical Research in Kansas City, Mo., in which the sisters are involved. For the Phase 1 trial of the vaccine, which was developed by Inovio Pharmaceuticals, 90 people applied for the 20 slots in Kansas City.

“We probably could charge people to let them in and still fill it up,” he said. (In fact, the participants were paid per visit.)

. . .

Inovio researchers engineered the vaccine in just three hours, according to Kate Broderick, the company’s senior vice president for research and development. Or, rather, their computer algorithm did: On Jan. 10 [2020], when Chinese researchers released the genetic code of the novel coronavirus, the team ran the sequence through its software, which popped out a formula.

This timeline struck some in the financial sector as too good to be true. Citron Research, which advises investors on companies to bet on, called Inovio “the Covid-19 version of Theranos,” referring to the blood-testing device company that imploded as its supposedly revolutionary product was revealed to be a hoax.

“Much like Theranos, Inovio claims to have a ‘secret sauce’ that, miraculously, no pharma giant has been able to figure out,” Citron Research wrote. “This is the same ‘secret sauce’ that supposedly developed a vaccine for Covid-19 in just three hours.”

For the full story, see:

Heather Murphy. “Fight Against Coronavirus Could Produce a First: A DNA Vaccine.” The New York Times (Friday, June 19, 2020): A10.

(Note: ellipses, and bracketed year, added.)

(Note: the online version of the story was updated June 22 [sic], 2020, and has the title “Guaranteed Ingredient in Any Coronavirus Vaccine? Thousands of Volunteers.”)

Covid-19 More Severe If You Inherited a Neanderthal Gene on Chromosome 3

(p. A6) A stretch of DNA linked to Covid-19 was passed down from Neanderthals 60,000 years ago, according to a new study.

Scientists don’t yet know why this particular segment increases the risk of severe illness from the coronavirus. But the new findings, which were posted online on Friday [July 3, 2020] and have not yet been published in a scientific journal, show how some clues to modern health stem from ancient history.

. . .

Last month, researchers compared people in Italy and Spain who became very sick with Covid-19 to those who had only mild infections. They found two places in the genome associated with a greater risk. One is on Chromosome 9 and includes ABO, a gene that determines blood type. The other is the Neanderthal segment on Chromosome 3.

But these genetic findings are being rapidly updated as more people infected with the coronavirus are studied. Just last week, an international group of scientists called the Covid-19 Host Genetics Initiative released a new set of data downplaying the risk of blood type. “The jury is still out on ABO,” said Mark Daly, a geneticist at Harvard Medical School who is a member of the initiative.

The new data showed an even stronger link between the disease and the Chromosome 3 segment. People who carry two copies of the variant are three times more likely to suffer from severe illness than people who do not.

. . .

(p. A7) Tony Capra, a geneticist at Vanderbilt University who was not involved in the study, thought it was plausible that the Neanderthal chunk of DNA originally provided a benefit — perhaps even against other viruses. “But that was 40,000 years ago, and here we are now,” he said.

It’s possible that an immune response that worked against ancient viruses has ended up overreacting against the new coronavirus. People who develop severe cases of Covid-19 typically do so because their immune systems launch uncontrolled attacks that end up scarring their lungs and causing inflammation.

Dr. Paabo said the DNA segment may account in part for why people of Bangladeshi descent are dying at a high rate of Covid-19 in the United Kingdom.

For the full story, see:

Carl Zimmer. “String of Neanderthal Genes May Increase Risk of Severe Illness.” The New York Times (Monday, July 6, 2020): A6-A7.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the story was updated July 8, 2020, and has the title “DNA Inherited From Neanderthals May Increase Risk of Covid-19.”)

The unpublished paper, mentioned above, is:

Zeberg, Hugo, and Svante Pääbo. “The Major Genetic Risk Factor for Severe Covid-19 Is Inherited from Neandertals.” bioRxiv (posted July 3, 2020).

More Blacks Die of Covid-19 Partly Due to Greater Use of Public Transit

(p. A7) African-Americans may be dying at higher rates than white people from Covid-19, the disease caused by the novel coronavirus, in part because of black people’s heavier reliance on public transportation for commuting, two new studies by economists suggest.

One of the studies, by University of Virginia economist John McLaren, found that the racial discrepancy remained even after controlling for income or insurance rates. Instead, Mr. McLaren found the gap was due in part to the fact that black workers are more likely to get to work via public transit, including subways and buses.

About 10.4% of black commuters take public transit, versus 3.4% of white commuters, according to the Census. After controlling for the use of public transit, Mr. McLaren finds the racial disparity in Covid-19 deaths is less pronounced.

. . .

The other study, by Christopher Knittel and Bora Ozaltun, both of the Massachusetts Institute of Technology, found that a 10% increase in the share of a county’s residents who use public transit versus those who telecommute raised Covid-19 death rates by 1.21 per 1,000 people when looking at counties around the U.S.—or by 0.48 per 1,000 people when focusing only on counties within individual states. In their analysis, the researchers controlled for race, income, age, climate and other characteristics.

For the full story, see:

David Harrison. “Virus Deaths Linked to Transit.” The Wall Street Journal (Monday, June 29, 2020): A7.

(Note: ellipsis added.)

(Note: the online version of the story has the date June 28, 2020, and has the title “Public Transit Use Is Associated With Higher Coronavirus Death Rates, Researchers Find.”)

The first academic study mentioned above, is:

McLaren, John. “Racial Disparity in Covid-19 Deaths: Seeking Economic Roots with Census Data.” National Bureau of Economic Research, NBER Working Paper #27407, June 2020.

The second academic study mentioned above, is:

Knittel, Christopher R., and Bora Ozaltun. “What Does and Does Not Correlate with Covid-19 Death Rates.” National Bureau of Economic Research, NBER Working Paper #27391, June 2020.

Art Diamond Interviewed on Using Masks and Speeding Vaccines to Stop Covid-19

I was interviewed early on Mon., July 20, 2020 on Jim Blasingame’s Small Business Advocate radio program on using masks and speeding vaccines to stop Covid-19.

Wearing Even Homemade Masks Could Bring Covid-19 “Under Control”

(p. A6) Face masks are emerging as one of the most powerful weapons to fight the novel coronavirus, with growing evidence that facial coverings help prevent transmission—even if an infected wearer is in close contact with others.

Robert Redfield, director of the Centers for Disease Control and Prevention, said he believes the pandemic could be brought under control over the next four to eight weeks if “we could get everybody to wear a mask right now.” His comments, made Tuesday [July 14, 2020] with the Journal of the American Medical Association, followed an editorial he and others wrote there emphasizing “ample evidence” of asymptomatic spread and highlighting new studies showing how masks help reduce transmission.

. . .

Researchers from around the world have found wearing even a basic cloth face covering is more effective in reducing the spread of Covid-19 than wearing nothing at all. And many are now examining the possibility that masks might offer some personal protection from the virus, despite initial thinking that they mostly protect others.

. . .

“It was surprising in a good way to see that a homemade mask could do so well . . . that we don’t have to get a very fancy mask,” Dr. Verma said.

. . .

Wearing a mask is “one of the most urgent things we can do to get our country under control,” said Melanie Ott, director of the Gladstone Institute of Virology. “We’re all waiting for the vaccine, we’re waiting for therapeutics, and we’re not there.”

For the full story, see:

Caitlin McCabe. “Evidence Mounts That Masks Help Curb Infections.” The Wall Street Journal (Monday, July 19, 2020): A6.

(Note: ellipses between passages, and bracketed date, added. Ellipsis internal to passage, in original.)

(Note: the online version of the story has the date July 18, 2020, and has the title “Face Masks Really Do Matter. The Scientific Evidence Is Growing.”)

The editorial in the Journal of the American Medical Association (JAMA), mentioned above, is:

Brooks, John T., Jay C. Butler, and Robert R. Redfield. “Universal Masking to Prevent Sars-CoV-2 Transmission—the Time Is Now.” JAMA (published online, in advance of print, on July 14, 2020).

Some of the new evidence supporting the use of masks can be found in the following two academic articles:

Verma, Siddhartha, Manhar Dhanak, and John Frankenfield. “Visualizing the Effectiveness of Face Masks in Obstructing Respiratory Jets.” Physics of Fluids 32, no. 6 (published online on June 30, 2020).

Wang, Xiaowen, Enrico G. Ferro, Guohai Zhou, Dean Hashimoto, and Deepak L. Bhatt. “Association between Universal Masking in a Health Care System and Sars-Cov-2 Positivity among Health Care Workers.” JAMA (published online, in advance of print, on July 14, 2020).

When Khrushchev Voted With His Feet for Freedom

(p. A23) Sergei N. Khrushchev, a former Soviet rocket scientist and the son of Nikita S. Khrushchev, the Soviet leader during the Cold War of the 1950s and ’60s, died on June 18 [2020] at his home in Cranston, R.I.

. . .

“I’m not a defector,” Sergei Khrushchev told The Providence Journal in 2001. “I’m not a traitor. I did not commit any treason. I work here and I like this country.”

Still, he said, he felt that becoming an American citizen had given him a new lease on life. “I’m feeling like a newborn,” he told The A.P. “It’s the beginning of a new life.”

. . .

Americans had a close-up look at the Soviet leader and his family in 1959, when he visited the United States at the invitation of President Dwight D. Eisenhower.

. . .

Sergei Khrushchev said years later, in the interview with The Providence Journal, that during that trip his family felt as if they had landed on Mars, seeing things they had never imagined. “It was palms, cars, highways, everything,” he said. He took home movies of it all, including Times Square.

They were especially baffled by the concept of Disneyland, then four years old but already a top attraction in Southern California. When told that his family would not be allowed to visit the park out of concerns for their safety, the premier exploded in anger: “What is it? Is there an epidemic of cholera there or something? Or have gangsters taken hold of the place?”

For the full obituary, see:

Katharine Q. Seelye. “Sergei N. Khrushchev, 84, Rocket Scientist and the Son of a Former Soviet Premier.” The New York Times (Thursday, June 25, 2020): A23.

(Note: ellipses, and bracketed date, added.)

(Note: the online version of the obituary has the date June 24, 2020, and the title “Sergei Khrushchev, Son of Former Soviet Premier, Dies at 84.”)

Covid-19 Caused Mass Transit Use to “Plummet by 80%” or More

(p. D1) Fears of being exposed to germs in cramped underground spaces have reportedly caused mass transit ridership to plummet by 80% in urban centers such as Milan and San Francisco—and by up to 96% in hot spots including New York, Washington, D.C., and Paris. When they head back to their corner offices, car-shunning members of the C-suite set might be more likely to commute in prudent solitude on electric bikes than to trudge up subway steps.

“No one wants to be in a dirty cab. We don’t want to be on a bus or subway. People want their own mode of transportation that they control,” said Michael Burtov, author of “The Evergreen Startup.” Mr. Burtov, who works with entrepreneurs as part of MIT’s Enterprise Forum, also noted a severe dip in usage of shared bikes and scooters; who yearns to spend an afternoon wiping down handlebars or riding in gloves? “For individualized modes of transportation, which are affordable and really efficient, it’s a renaissance.”

To wit, Seattle’s Rad Power Bikes recently announced that sales had leapt nearly 300% this April compared with the same period in 2019. Its Dutch competitor VanMoof claimed a similar growth of 264% for the first half of 2020 compared with the same six months last year.

For the full story, see:

Matthew Kitchen. “Wanted: A Safer Commute.” The Wall Street Journal (Saturday, June 27, 2020): D1.

(Note: the online version of the story has the same date as the print version, and has the title “Wary of Subways? 6 Electric Options for a Solo Work Commute.”)

The book by Burtov, mentioned above, is:

Burtov, Michael. The Evergreen Startup: The Entrepreneur’s Playbook for Everything from Venture Capital to Equity Crowdfunding. Hypercritical Publishing, 2020.

With Covid-19, War on Plastic Takes “a Back Seat to the Larger Quest for the Health and Security of Travelers”

(p. B9) Will planetary health be as urgent to travelers focused on preserving personal health? In a germophobic world, will single-use plastics make a comeback?

“The work on reduction of plastic is going to take a back seat to the larger quest for the health and security of travelers,” said Megan Epler Wood, the managing director of the Sustainable Tourism Asset Management Program at Cornell University.

For the full commentary, see:

Elaine Glusac. “Is the Green Wave Over?” The New York Times (Saturday, May 16, 2020): B9.

(Note: the online version of the commentary was updated May 6 [sic], 2020, and has the same title as the print version.)

Fauci Tries to Explain Shifting Position on Face Masks

(p. A9) . . . Dr. Fauci grew testy when Representative David B. McKinley, Republican of West Virginia, asked him if he thought the news media had treated Mr. Trump unfairly — Dr. Fauci declined to answer — and whether he regretted not advising people more forcefully to wear masks earlier in the pandemic.

“OK, we’re going to play that game,” Dr. Fauci said, seemingly irked. Mr. McKinley said it was a yes-or-no question.

“There is more than a yes or no, by the tone of your question,” Dr. Fauci shot back. “I do not regret that. Let me explain to you what happened. At that time, there was a paucity of equipment that our health care providers needed who put themselves daily in harm’s way of taking care of people who are ill.”

For the full story, see:

Sheryl Gay Stolberg and Noah Weiland. “Experts Sketch Gloomy Picture Of Virus Spread.” The New York Times (Wednesday, June 24, 2020): A1 & A9.

(Note: ellipsis added.)

(Note: the online version of the story has the date June 23, 2020, and has the title “Fauci, Citing ‘Disturbing Surge,’ Tells Congress the Virus Is Not Under Control.”)