We Need to “Tolerate Heterodox Smart People” if We Want to Achieve Big Things

Peter Thiel is often quoted as having said many years ago that “We wanted flying cars, instead we got 140 characters” (as quoted in Lewis-Kraus 2024), a reference to the original limit to the length of a tweet on Twitter. The quotations below are all from the more recent Peter Thiel, who was having a conversation with NYT columnist Ross Douthat. He still believes that we are not boldly pursuing big goals, the only exception being A.I. Is the constraint that big goals are impossible to achieve, or do we lack people smart enough or motivated enough to pursue them, or do we regulate motivated smart people into discouraged despair?

(p. 9) One question we can frame is: Just how big a thing do I think A.I. is? And my stupid answer is: It’s more than a nothing burger, and it’s less than the total transformation of our society. My place holder is that it’s roughly on the scale of the internet in the late ’90s. I’m not sure it’s enough to really end the stagnation. It might be enough to create some great companies. And the internet added maybe a few percentage points to the G.D.P., maybe 1 percent to G.D.P. growth every year for 10, 15 years. It added some to productivity. So that’s roughly my place holder for A.I.

It’s the only thing we have. It’s a little bit unhealthy that it’s so unbalanced. This is the only thing we have. I’d like to have more multidimensional progress. I’d like us to be going to Mars. I’d like us to be having cures for dementia. If all we have is A.I., I will take it.

. . .

And so maybe the problems are unsolvable, which is the pessimistic view. Maybe there is no cure for dementia at all, and it’s a deeply unsolvable problem. There’s no cure for mortality. Maybe it’s an unsolvable problem.

Or maybe it’s these cultural things. So it’s not the individually smart person, but it’s how this fits into our society. Do we tolerate heterodox smart people? Maybe you need heterodox smart people to do crazy experiments.

. . .

I had a conversation with Elon a few weeks ago about this. He said we’re going to have a billion humanoid robots in the U.S. in 10 years. And I said: Well, if that’s true, you don’t need to worry about the budget deficits because we’re going to have so much growth, the growth will take care of this. And then — well, he’s still worried about the budget deficits. This doesn’t prove that he doesn’t believe in the billion robots, but it suggests that maybe he hasn’t thought it through or that he doesn’t think it’s going to be as transformative economically, or that there are big error bars around it. But yeah, there’s some way in which these things are not quite thought through.

For the full interview, see:

Douthat, Ross. “Are We Dreaming Big Enough?” The New York Times, SundayOpinion Section (Sunday, June 29, 2025): 9.

(Note: ellipses added.)

(Note: the online version of the interview has the date June 26, 2025, and has the title “Peter Thiel and the Antichrist.”)

Peter Thiel’s yearning many years ago for flying cars was quoted more recently in:

Lewis-Kraus, Gideon. “Flight of Fancy.” The New Yorker, April 22, 2024, 28-39.

Nimble Wine Entrepreneurs Adapt Grapes, and Wine-Making Method, to Warmer Temperatures and Changing Tastes

I have argued briefly in my Openness book, and at greater length in my “Innovative Dynamism Improves the Environment” article, that we tend to overestimate the harm from global warming in part because we tend to underestimate the nimble adaptability of entrepreneurs. The essay quoted below describes how wine entrepreneurs in Spain are returning to old grape varieties and old technologies for aging the wine, varieties and technologies that both are better adapted to warmer temperatures and are better at making the lighter and less alcoholic wines that are currently in higher demand.

(p. C3) In the rolling hills of Valencia in Spain, winemaker Pablo Calatayud has joined forces with scientists and archaeologists to mount a small viticultural revolution—one that reaches back to pre-Roman times to recreate what have become known as ancestral wines.

At his Celler del Roure, Calatayud is using large, egg-shaped clay amphorae to make wine pressed from grapes native to the region. The process is reconstructed from old texts and drawings carved into archaeological finds across the Mediterranean, including an ancient Iberian settlement that overlooks his own vineyard.

This sort of winemaking is not just a stunt, and Calatayud is hardly alone. Rising temperatures in most European wine regions are changing the taste and potency of red wine. Warmer weather means that grapes ripen more quickly and more intensely, with more sugar and thus more alcohol. In Spain, the alcohol level in notable wines aged in oak barrels now routinely exceeds 15%. But many consumers are turning away from such dark, heavy, tannin-rich wines, demanding instead reds that are lighter, more refreshing and lower in alcohol.

The grape varieties used to make ancestral wines are better suited to warmer climes than such stars of modern winemaking as Cabernet Sauvignon, Merlot and Tempranillo. The ancient varieties tend to ripen later, some even in late October, with lower sugar levels, and some have thinner skins, which makes them less tannic.

And in contrast to the oak barrels favored for aging modern red wines, which can add heavy, smoky flavors, amphorae don’t affect a wine’s taste. The clay allows for gentle micro-oxygenation—exposure to outside air—helping to preserve acidity and aromatic freshness.

As a result, the new amphora wines are breezy, light-colored and fruity on the nose—but never sweet nor exceeding 13% alcohol.

The results have pleased both critics and consumers. Wines by Celler del Roure now receive ratings as high as 96 points from top reviewers like Robert Parker Wine Advocate and are exported globally, including to the U.S.

For the full essay, see:

Bojan Pancevski. “The Growing Buzz Around Ancestral Wines.” The Wall Street Journal (Sat., July 19, 2025): C3.

(Note: the online version of the essay has the date July 17, 2025, and has the same title as the print version.)

Trump’s Budget Director Is Competently Dedicated to Dismantling the Deep State

Before the 2024 Presidential election I quoted an op-ed piece by Walter Block and another by Thomas Sowell in which Block argued, and Sowell implied, that given the choice between Donald Trump and Kamala Harris, the better choice was Trump. I still agree with their op-eds.

A related, but different issue is whether on balance, Trump’s policies will hurt or help the economy. His tariffs, industrial policy, and crony deals will hurt. His deregulation and downsizing of government will help. I hope, but do not know, that the helps will help more than the hurts hurt.

The New York Times ran a long front-page article on Trump’s Budget Director Russell T. Vought that bolsters my hope. I quote from that article below. Vought is serious and competent and dedicated to “a much smaller bureaucracy.” When he nominated him, Trump wrote “Russ knows exactly how to dismantle the Deep State and end weaponized government.”

But a Vought failure would not prove Block and Sowell wrong. Even if Trump does more to harm the economy than to help it, he still will not match the harm that would have been done by Harris.

(p. A1) Russell T. Vought, the White House budget director, was preparing the Trump administration’s 2026 budget proposal this spring when his staff got some surprising news: Elon Musk’s cost-cutting team was unilaterally axing items that Mr. Vought had intended to keep.

Mr. Vought, a numbers wonk who rarely raises his voice, could barely contain his frustration, telling colleagues that he felt sidelined and undermined by the haphazard chaos of the Musk-led Department of Government Efficiency, according to six people with knowledge of his comments who, like others interviewed for this article, spoke on the condition of anonymity for fear of retribution.

. . .

Mr. Vought, who also directed the White House Office of Management and Budget in President Trump’s first term, had spent four years in exile from power. He worked through Joseph R. Biden Jr.’s presidency from an old rowhouse near the Capitol, where he complained of pigeons infesting his ceiling and coordinated with other Trump loyalists to draw up sweeping, detailed plans for a comeback.

He had carefully analyzed mistakes from the first term. And he had laid out steps to achieve the long-sought conservative goal of a president with dramatically expanded authority over the executive branch, including the power (p. A14) to cut off spending, fire employees, control independent agencies and deregulate the economy.

. . .

He works long hours and weekends in his suite in the Eisenhower Executive Office Building next to the White House, where he oversees a staff of more than 500.

On the wall is a photo of his favorite president, Calvin Coolidge, the farm boy and small-town mayor historians say most purely embodied the conservative principles of small government and fiscal austerity.

. . .

“Russ knows exactly how to dismantle the Deep State and end weaponized government,” Mr. Trump wrote in a statement when nominating Mr. Vought.

. . .

Rob Fairweather, who spent 42 years at the Office of Management and Budget and wrote a book about how it operates, said there is reason for Mr. Vought to have confidence in a legal victory.

“What he’s doing is radical, but it’s well thought out,” Mr. Fairweather said. “He’s had all these years to plan. He’s looked clearly at the authorities and boundaries that are there, and is pushing past them on the assumption that at least some of it will hold up in the courts.”

Mr. Vought is already looking forward to that outcome, declaring on Glenn Beck’s show this spring: “We will have a much smaller bureaucracy as a result of it.”

For the full story see:

Coral Davenport. “Ticking Boxes on His Checklist To Make Trump All-Powerful.” The New York Times (Tues., September 30, 2025): A1 & A14.

(Note: ellipses added.)

(Note: the online version of the story was updated Oct. 3, 2025, and has the title “The Man Behind Trump’s Push for an All-Powerful Presidency.”)

The Review of Austrian Economics Publishes Diamond’s Review of Creative Destruction

The Review of Austrian Economics published my review of Dalton and Logan’s Creative Destruction book on Sept. 17. It can be viewed, but not printed or saved, at: https://rdcu.be/eIMJN

Adjuvants Did Not Arise from Theory, but from Open-Eyed Trial-And-Error Experimentation

Sometimes you see journalists, commentators, or politicians saying that ordinary people should not use trial-and-error experiments with health treatments, but instead listen to the advice of certified scientists. Listen to the “science” we hear. But many of the most common practices in medicine originated with ordinary trial-and-error experiments of the sort that can be conducted with little if any certified expertise.

Consider adjuvants. An adjuvant “helps” the primary therapy; aluminum can be an adjuvant to a vaccine or, with cancer, radiation can be an adjuvant to a surgery. As the passages quoted below show, the first vaccine adjuvants were not discovered through the theorizing of a certified genius. A motivated alert and practical veterinarian wanted to protect horses from disease. He noticed that a horse vaccine worked better when, by chance, the horse also had an infection at the vaccination site. He speculated that the inflammation from the infection aroused the immune system. So why not try deliberately causing inflammation? He tried different substances, landing on tapioca as the best of what he tried. Others later found aluminum to be more reliable.

Maybe what often matters most for medical progress is a sense of open-eyed urgency and a persistent willingness to engage in trial-and-error experimentation. The uncertified can have those traits. When they do, we should not ridicule, ban, or cancel them.

(p. A14) The origins of added aluminum in vaccines can be traced back nearly a century. In a stable on the outskirts of Paris, a young veterinarian had made a peculiar discovery: mixing tapioca into his horses’ diphtheria vaccines made them more effective.

The doctor, Gaston Ramon, had noticed that the horses who developed a minor infection at the injection site had much more robust immunity against diphtheria. He theorized that adding something to his shots that caused inflammation — ingredients he later named adjuvants, derived from the Latin root “to help” — helped induce a stronger immune response.

After testing several candidates — including bread crumbs, petroleum jelly and rubber latex — he found success with a tapioca-laced injection, which produced slight swelling and far more antibodies.

Tapioca never caught on as an adjuvant. But in 1932, a few years after Dr. Ramon’s studies were published, the United States began including aluminum salts in diphtheria immunizations, as they were found to invoke a similar but more reliable effect.

Today, aluminum adjuvants are found in 27 routine vaccines, and nearly half of those recommended for children under 5.

This extra boost of immunity is not needed in all types of vaccines. Shots that contain a weakened form of a virus, like the measles mumps and rubella shot, or created with mRNA technology, like the Pfizer and Moderna Covid-19 vaccines, generate strong enough immune responses on their own.

But in vaccines that contain only small fragments of the pathogen, which would garner little attention from the immune system, adjuvants help stimulate a stronger response, allowing vaccines to be given in fewer doses.

Scientists believe that aluminum salts work in two ways. First, aluminum binds to the core component of the vaccine and causes it to diffuse into the bloodstream more slowly, giving immune cells more time to build a response.

It’s also thought that aluminum operates more directly, enhancing the activity of certain immune cells, though this mechanism is not fully understood.

For the full story see:

Teddy Rosenbluth. “Aluminum in Vaccines Is a Good Thing, Scientists Say.” The New York Times (Sat., January 25, 2025): A14.

(Note: ellipsis, and bracketed date, added.)

(Note: the online version of the story has the date Jan. 24, 2025, and has the title “Yes, Some Vaccines Contain Aluminum. That’s a Good Thing.”)

Norma Swenson Defended Health Freedom for Women

A recurring question raised by my libertarian and classical liberal friends is: how can we persuade others of the value of freedom? One answer is to especially seek conversation with those who strongly object to losing their freedom in some part of their life that they value. As I read the obituary of Norma Swenson, co-author of the book Our Bodies, Ourselves, I thought I recognized her as a libertarian fellow-traveler. She passionately sought for herself and other women to have greater freedom in making their own medical decisions.

Today, born out of outrage over the government’s over-reaching Covid controls, a “health freedom” movement has grown and organized, seeking more broadly (though not always consistently) for all adults to be able to make their own medical decisions.

Libertarians and classical liberals should let those seeking health freedom know that we are with them, in principle and in practice. Many of my own blog entries defend health freedom, for instance here and here.

(p. B11) Norma Swenson was working to educate women about childbirth, championing their right to have a say about how they delivered their babies, when she met the members of the collective that had put out the first rough version of what would become the feminist health classic “Our Bodies, Ourselves.”

. . .

She . . . [knew] quite a bit about the medical establishment, the paternalistic and condescending behavior of male doctors (only 6 percent of incoming medical students were women in 1960) and the harmful effect such behavior had on women’s health. She had lived it, during the birth of her daughter in 1958.

. . .

She would go on to help make “Our Bodies, Ourselves” a global best seller.

. . .

The author Barbara Ehrenreich called it a manifesto of medical populism.

. . .

It was her daughter’s birth that had made Ms. Swenson an activist. She wanted to deliver the baby naturally, without medication. Her decision was such an anomaly that residents at the Boston Lying-In Hospital gathered to watch her labor. It went swimmingly.

But Ms. Swenson, who was in a 12-bed ward, was surrounded by women who were suffering. They were giving birth according to the practices of the era: with a dose of scopolamine, a drug that induced so-called twilight sleep and hallucinations, followed by a shot of Demerol, an opioid.

She remembered the women screaming, trying to climb out of their beds, calling for their mothers and cursing their husbands before being knocked out by the Demerol, their babies delivered by forceps.

It was barbaric, she thought. “These women weren’t being helped,” she said in 2018, “they were being controlled.”

For the full obituary, see:

Penelope Green. “Norma Swenson, 93, an Author Of ‘Our Bodies, Ourselves.” The New York Times (Friday, June 20, 2025): B11.

(Note: ellipses, and bracketed word, added.)

(Note: the online version of the obituary was updated June 16, 2025, and has the title “Norma Swenson, an Author of ‘Our Bodies, Ourselves,’ Dies at 93.”)

The most recent edition of the book co-authored by Norma Swenson is:

Boston Women’s Health Book Collective. Our Bodies, Ourselves. New York: Atria Books, 2011.

F.D.A. Approves Vertex’s Nonaddictive Drug to Block Pain

Ann Case and Angus Deaton’s Deaths of Despair is a depressing but important book. I have read parts of it but plan to read it from cover to cover soon. They document and analyze a substantial group of Americans, mostly whites without college degrees, who die from alcohol, narcotics, or suicide. Starting in the 1990s their numbers grew. Part of the problem for some of the despairing is having jobs that give them hope for a better future, jobs that at least allow them to securely start and raise a family.

The growth in narcotics use is thoughtfully described in an earlier book, Dreamland by Sam Quinones. In some of the book Quinones writes about the same non-degree despairing whites as Case and Deaton, but he also in other parts of the book, discusses rising narcotics use among the better-off. His is a thoughtful complex narrative, involving diverse victims and diverse causes.

One component is that, from desire for euphoria, or to end pain, people start using narcotics that are addictive. Then they must fight, or succumb to, the addiction for the rest of their lives. For those drawn in by a desire to end pain, the news in the passages quoted below is important–the approval of suzetrigine, a drug that blocks some kinds of pain without being addictive. Quinones in his 2015 book reports his conversation with an expert who was pessimistic that such a drug would ever be possible (pp. 311-312).

A second reason suzetrigine is of interest is that it is being brought to market by Vertex, a firm that I have discussed in earlier blog entries, most recently here. Vertex was a once-small innovative mission-oriented start-up that got big. The continuing question is whether the big Vertex can sustain its earlier innovative culture.

(p. A11) The Food and Drug Administration approved a new medication Thursday [Jan. 30, 2025] to treat pain from an injury or surgery. It is expensive, with a list price of $15.50 per pill. But unlike opioid pain medicines, it cannot become addictive.

That is because the drug, suzetrigine, made by Vertex Pharmaceuticals and to be sold as Journavx, works only on nerves outside the brain, blocking pain signals. It cannot get into the brain.

Researchers say they expect it to be the first of a new generation of more powerful nonaddictive drugs to relieve pain.

To test the drug, Vertex, which is based in Boston, conducted two large clinical trials, each with approximately 1,000 patients who had pain from surgery. They were randomly assigned to get a placebo; to get the opioid sold as Vicodin, a widely used combination pain medicine of acetaminophen (Tylenol) and hydrocodone; or to get suzetrigine.

. . .

Suzetrigine eased pain as much as the combination opioid. Both were better than the placebo at relieving pain.

For the full story see:

Gina Kolata. “F.D.A. Approves a Non-Addictive Opioid.” The New York Times (Sat., February 1, 2025): A11.

(Note: ellipsis, and bracketed date, added.)

(Note: the online version of the story has the date Jan. 30, 2025, and has the title “F.D.A. Approves Drug to Treat Pain Without Opioid Effects.”)

The Case and Deaton book, cited in my introductory comments, is:

Case, Anne, and Angus Deaton. Deaths of Despair and the Future of Capitalism. Princeton, N.J.: Princeton University Press, 2020. Reprint, pb 2021 (with new preface).

The Quinones book, cited in my introductory comments, is:

Quinones, Sam. Dreamland: The True Tale of America’s Opiate Epidemic. New York: Bloomsbury Press, 2015.

National Academy of Sciences Paper Warns Scientific “Fraud Is Growing Exponentially”

In previous blog entries I have cited evidence that top medical scientists have committed fraud in the areas of Alzheimer’s and cancer research. The research discussed in the passages quoted below reports a related but broader problem. In these accounts the fraud consisted mainly of doctored data and images, but did not mainly consist also of wholly fabricated text, which apparently is what new evidence reveals is being increasingly cranked out by paper mills.

The journals accepting these papers are presumably mainly the lower level, and less-cited, journals, and so this fraud arguably may be less damaging to the ongoing progress of science than the more sophisticated fraud carried out by top scientists and published in top journals. This argument assumes that scientists build on work published in the top journals. A problem with this argument is that many times, truly pathbreaking innovations are at first rejected by “top” journals and are only accepted by “lower” level journals. (For instance Hans Krebs’s paper on what is now known as the “Krebs cycle,” that must be memorized by all aspiring doctors, was rejected by the prestigious Nature and published by the much less prestigious Enzymologia (Lane 2022, p. 55).)

The newly revealed fraud reduces even further the credibility of those on the left who order ordinary citizens to “follow the science” rather than follow their own eyes and their own judgement.

(BTW, Dr. Elisabeth Bik who is quoted in a couple of passages quoted below, is also a prominent source in Charles Piller’s Doctored, that documented widespread high-level fraud in the Alzheimer’s research community.)

(p. D1) For years, whistle-blowers have warned that fake results are sneaking into the scientific literature at an increasing pace. A new statistical analysis backs up the concern.

A team of researchers found evidence of shady organizations churning out fake or low-quality studies on an industrial scale. And their output is rising fast, threatening the integrity of many fields.

“If these trends are not stopped, science is going to be destroyed,” said Luís A. Nunes Amaral, a data scientist at Northwestern University and an author of the study, which was published in the Proceedings of the National Academy of Sciences on Monday [Aug. 4, 2025].

. . .

“Science relies on trusting what others did, so you do not have to repeat everything,” Dr. Amaral said.

By the 2010s, journal editors and watchdog organizations were warning that this trust was under threat. They flagged a growing number of papers with fabricated data and doctored images. In the years that followed, the factors driving this increase grew more intense.

As more graduate students were trained in labs, the competition for a limited number of research jobs sharpened. High-profile papers became essential for success, not just for landing a job, but also for getting promotions and grants.

Academic publishers have responded to the demand by opening thousands of new scientific journals every year. “All of the incentives are for publishers to publish more and more,” said Dr. Ivan Oransky, the executive director of the Center for Scientific Integrity.

. . .

(p. D3) Elisabeth Bik, a California-based expert on scientific fraud who was not involved in the study, said that it confirmed her early suspicions. “It’s fantastic to see all the work we’ve done now solidified into a much higher-level analysis,” she said.

Dr. Amaral and his colleagues warn that fraud is growing exponentially. In their new study, they calculated that the number of suspicious new papers appearing each year was doubling every 1.5 years. That’s far faster than the increase of scientific papers overall, which is doubling every 15 years.

. . .

In an executive order in May on “gold-standard science,” President Trump drew attention to the problem of scientific fraud. “The falsification of data by leading researchers has led to high-profile retractions of federally funded research,” the order stated.

. . .

Dr. Bik proposed that scientific publishers dedicate more of their profits to monitoring manuscripts for fraud, similar to how credit card companies check for suspicious purchases.

. . .

Dr. Oransky said that the way scientists are rewarded for their work would have to change as well. “To paraphrase James Carville, it’s the incentives, stupid,” he said. “We need to stop making it profitable to game the system.”

For the full story see:

Carl Zimmer. “Fake Papers Found to Be Churned Out At Fast Pace.” The New York Times (Tues., August 5, 2025): D1 & D3.

(Note: ellipses, and bracketed date and year, added.)

(Note: the online version of the story has the date Aug. 4, 2025, and has the title “Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds.” Where there was a minor difference in the wording between the online and print versions, the passages quoted above follow the online version.)

The academic paper documenting the substantial increase in scientific fraud is:

Richardson, Reese A. K., Spencer S. Hong, Jennifer A. Byrne, Thomas Stoeger, and Luís A. Nunes Amaral. “The Entities Enabling Scientific Fraud at Scale Are Large, Resilient, and Growing Rapidly.” Proceedings of the National Academy of Sciences 122, no. 32 (2025): e2420092122.

Nick Lane’s book, cited in my introductory comments, is:

Lane, Nick. Transformer: The Deep Chemistry of Life and Death. New York: W. W. Norton & Company, 2022.

“One Man’s Poison Is Another Man’s Cure”*

*The title “One Man’s Poison Is Another Man’s Cure” is a proverb that is widely attributed to the poet Lucretius. (I have not found a documented source.)

My commentary was posted on the Foundation for Economic Education (FEE) web site on Mon., Aug. 18, 2025.

Below are notes on sources supporting claims I make in the commentary.

https://www.1daysooner.org/ [website of group defending human challenge trials]

Attia, Peter. Outlive: The Science and Art of Longevity. New York: Harmony, 2023, pp. 78 & 84-86. [source of Attia’s views of rapamycin]

Bailey, Clifford J., and Caroline Day. “Metformin: Its Botanical Background.” Practical Diabetes International 21, no. 3 (April 2004): 115-17. [source on metformin]

Freeberg, Ernest. The Age of Edison: Electric Light and the Invention of Modern America, Penguin History American Life. New York: The Penguin Press, 2013, pp. 87 & 200-201. [source on electrification of New York faster than London]

Glanville, Jacob, Mark Bellin, Sergei Pletnev, Baoshan Zhang, Joel Christian Andrade, Sangil Kim, David Tsao, Raffaello Verardi, Rishi Bedi, Sindy Liao, Raymond Newland, Nicholas L. Bayless, Sawsan Youssef, Ena S. Tully, Tatsiana Bylund, Sujeong Kim, Hannah Hirou, Tracy Liu, and Peter D. Kwong. “Snake Venom Protection by a Cocktail of Varespladib and Broadly Neutralizing Human Antibodies.” Cell 188 (2025): 1-18. https://www.cell.com/cell/abstract/S0092-8674(25)00402-7

Harrison, David E., Randy Strong, Zelton Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, J. Erby Wilkinson, Krystyna Frenkel, Christy S. Carter, Marco Pahor, Martin A. Javors, Elizabeth Fernandez, and Richard A. Miller. “Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice.” Nature 460, no. 7253 (July 16, 2009): 392-95. https://www.nature.com/articles/nature08221

Ineichen, Benjamin V., Eva Furrer, Servan L. Grüninger, Wolfgang E. Zürrer, and Malcolm R. Macleod. “Analysis of Animal-to-Human Translation Shows That Only 5% of Animal-Tested Therapeutic Interventions Obtain Regulatory Approval for Human Applications.” PLOS Biology 22, no. 6 (2024): e3002667. [The title is misleading because the main message of the article is that “Notably, our meta-analysis showed an 86% concordance between positive results in animal and clinical studies.” The authors further explain: “We conclude that, contrary to widespread assertions, the rate of successful animal-to-human translation may be higher than previously reported. Nonetheless, the low rate of final approval indicates potential deficiencies in the design of both animal studies and early clinical trials.” (The quotations are both from the Abstract on p. 1) (See also: “How can we make sense of the fact that animal studies and early clinical trials seem to show promise, yet there is very limited official approval for these therapies? There are 2 possible explanations: One scenario is that the strict requirements of RCTs and regulatory approval are causing many potentially valuable treatments to be left behind. The other scenario is that both animal studies and early clinical trials may have limitations in their design, such as a lack of proper randomization and blinding, which affects their internal validity [45].” p. 12 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002667)]

Jewett, Christina. “Charlatans’ No Reason to Curb Untested Drugs, Kennedy Says.” The New York Times (Fri., June 6, 2025): A1 & A11. https://www.nytimes.com/2025/06/05/health/kennedy-stem-cells-experimental-treatments.html?searchResultPosition=1

Kinch, Michael. Between Hope and Fear: A History of Vaccines and Human Immunity. New York: Pegasus Books, 2018, pp. 33-34. [one source on Jesty]

Mandavilli, Apoorva. “Man of 200 Snake Bites May Be the Antivenom.” The New York Times (Sat., May 3, 2025): A1 & A19. https://www.nytimes.com/2025/05/02/health/snakes-universal-antivenom-tim-friede.html?searchResultPosition=1

Mannick, Joan B., Giuseppe Del Giudice, Maria Lattanzi, Nicholas M. Valiante, Jens Praestgaard, Baisong Huang, Michael A. Lonetto, Holden T. Maecker, John Kovarik, Simon Carson, David J. Glass, and Lloyd B. Klickstein. “mTOR Inhibition Improves Immune Function in the Elderly.” Science Translational Medicine 6, no. 268 (2014): doi:10.1126/scitranslmed.3009892. https://www.science.org/doi/abs/10.1126/scitranslmed.3009892?__hsfp=1773666937&__hstc=12316075.81f04695664b9dc054b5f524eb53b5a4.1525132803174.1525132803175.1525132803176.1&__hssc=12316075.1.1525132803177

Morgan, Kate. “Vaccine Protesters Find Winning Slogan: ‘Health Freedom.” The New York Times (Weds., Jan. 1, 2025): A11. https://www.nytimes.com/2024/12/28/well/health-freedom-medical-freedom-covid.html?searchResultPosition=1

Smith, Dana G. “Is the Secret to a Longer Life Hidden in a Transplant Drug?” The New York Times (Weds., Sept. 25, 2024): A1 & ?. https://www.nytimes.com/2024/09/24/well/live/rapamycin-aging-longevity-benefits-risks.html

Subbaraman, Nidhi. “A Universal Antivenom, from a Man Bitten by Snakes 200 Times.” The Wall Street Journal (Sat., June 14, 2025): C5. https://www.wsj.com/science/biology/snake-bite-blood-universal-antivenom-6de30fda?mod=Searchresults_pos1&page=1

Whiteman, Noah. Online notes to accompany Most Delicious Poison: The Story of Nature’s Toxins―from Spices to Vices. New York: Little, Brown Spark, 2023. [source of claim that 40% of drugs come from traditional medicine]

Zuckerman, Gregory. A Shot to Save the World: The inside Story of the Life-or-Death Race for a Covid-19 Vaccine. New York: Portfolio/Penguin, 2021, pp. 5-6. [one source on Jesty]

Brigham and Epstein Have the Guts to Nudge the Overton Window

The Overton Window is the range of “officially acceptable” or “politically correct” policy views. The left has been successful at shifting the window in their direction, for instance, in cancelling those who question any aspect of the global warming ideology for being outside polite discourse. In the face of cancel culture it takes courage to challenge the current Overton Window. Brigham and Epstein (see below) have that courage. Their views should be considered.

(p. B12) Exxon Mobil, Occidental Petroleum and other oil giants are expected to receive billions of dollars of incentives to collect and bury carbon emissions. Texas oil billionaire Ben “Bud” Brigham and pro-fossil-fuels activist Alex Epstein want to turn off the tap.

Brigham, a serial entrepreneur and libertarian from Austin, is urging President Trump and the Republicans who are considering slashing a host of energy incentives to go further and nix tax credits for carbon capture.

. . .

Brigham says he doubts carbon capture can be profitable without public funding and that it is a distraction from firms’ core mission of finding oil and gas. He says that the subsidies distort markets and encourage cronyism.

A geophysicist by training, Brigham made his fortune building and selling two oil companies for a total of about $7 billion. He is an Ayn Rand fan who has produced two movies based on the philosopher’s work. He was also a major backer of what is now the Civitas Institute, a conservative center that launched in 2022 at the University of Texas at Austin.

Brigham first met Epstein, another Rand fan, about a decade ago. The two men bonded over a common belief in the importance of free markets and fossil fuels. Epstein is the author of “The Moral Case for Fossil Fuels,” a book saying that the imperative to fuel societies flourishing with oil and gas outweighs climate-change risks. It has given Republicans ammunition to counter the left’s climate push, oil lobbyists say.

For the full story, see:

Benoît Morenne. “Oil Tycoon, Philosopher Fight Carbon-Capture Goals.” The Wall Street Journal (Tues., July 1, 2025): B12.

(Note: ellipsis added.)

(Note: the online version of the story has the date June 28, 2025, and has the title “The Oil Tycoon and the Philosopher Threatening Big Oil’s Bet on Carbon Capture.”)

Epstein’s book, mentioned above, is:

Epstein, Alex. The Moral Case for Fossil Fuels. New York: Portfolio, 2014.