If Corn Syrup Hurts Health Then Government Should Stop Subsidizing Corn Farming and Stop Quotas on Sugar Imports

Every semester for many years I would conclude my micro principles class discussing the ill effects of the U.S. government imposing quotas on the importation of sugar. I would point out that the quotas increase the price of sugar for American consumers. Since corn syrup is a substitute for sugar, the increase in the price of sugar will increase the demand for corn syrup.

To support the ill effects of corn syrup, I used to cite a commentary by Michael Waldholz:

In a speech to the International Congress on Obesity last summer, George Bray, a recognized expert on weight gain, said high fructose corn syrup is a “ticking bomb” in our diet because it is more readily converted into fat than other sugars. Unlike other sugars, fructose doesn’t trigger the release of insulin, which controls sugar consumption by telling the brain to send out a feeling of fullness. (Waldholz 2003, p. D3)

It would be interesting to check the current state of the evidence on whether Bray’s claim is true. But if so, then it provides support for Robert F. Kennedy, Jr.’s current initiative against corn syrup, which was discussed in a full-page article in the NYT in December 2024.

Paradoxically, the U.S. government increases the consumption of corn syrup in multiple ways. In my principles classes I pointed out the indirect effect of sugar quotas. The NYT article also points out the subsidies for corn production.

Kennedy wants to ban the use of corn syrup products in federally subsidized school lunches and ban their purchase using federal food stamps. He should also lobby his boss to end federal subsidies for corn production and end the federal quota program on sugar.

The WSJ commentary on corn syrup is:

Waldholz, Michael “Let’s Subtract ‘Added Sugar’ from Our Diets.” The Wall Street Journal (Thurs., Feb. 20, 2003): D3.

(Note: the online version of the Waldholz commentary has the same date as the print version and has the title “Let’s Ditch ‘Added Sugar’ From Our Regular Diets.”)

The NYT article on corn syrup is:

Jonathan Weisman. “Kennedy’s Crusade Comes to Trump Country.” The New York Times (Weds., December 11, 2024): A11.

(Note: the online version of the NYT article has the date Dec. 10, 2024, and has the title “Kennedy’s War on Corn Syrup Brings a Health Crusade to Trump Country.”)

Feds Waste at Least $4.3 Billion in Duplicate Payments to States Where Medicaid Recipients No Longer Reside

Do taxpayers know how much government fraud and inefficiency they are paying for? Hopefully DOGE can clean up these duplicate (and sometimes triplicate and more) payments. If the Wall Street Journal is capable of finding multiple payments, then surely the government itself can find and stop them.

(p. A1) Health insurers got double-paid by the Medicaid system for the coverage of hundreds of thousands of patients across the country, costing taxpayers billions of dollars in extra payments.

The insurers, which are paid by state and federal governments to cover low-income Medicaid recipients, collected at least $4.3 billion over three years for patients who were enrolled—and paid for—in other states, a Wall Street Journal analysis of Medicaid data found.

The patients were signed up for Medicaid in two states at once, in many cases following a move from one to the other. Most were getting all their healthcare services through one insurer in one state, even though Medicaid was paying insurers in both states to cover them.

Private insurers oversee Medicaid benefits for more than 70% of the about 72 million low-income and disabled people in the program. The companies get paid each month for each person they cover. They aren’t supposed to get paid if a patient leaves for another state.

. . .

(p. A9) The Journal’s analysis turned up some cases in which individuals were signed up in five or more states.

. . .

The Journal’s analysis used detailed Medicaid data, obtained under a research agreement with the federal government, to identify duplicate payments to managed-care companies. The analysis examined where double-enrollees got their medical care each month, using that as an indication of their state of residence.

. . .

“There is very little incentive for the managed-care organization to check eligibility,” said industry consultant Kevin Bagley, the former director of Nebraska’s Medicaid program. Bagley and other Medicaid experts said it is difficult for states to claw back payments from managed-care companies for covering relocated enrollees, largely because it can be unclear exactly when they left.

Sometimes a single insurance company covered the same person in more than one state. During the period covered by the Journal’s analysis, Centene insured about 25,000 people a year, on average, in two different states at the same time. For those people, the company was paid at least $151 million extra. Elevance received $48 million extra for covering the same person twice, and UnitedHealth got $53 million.

One Centene supervisor urged some of the company’s case managers in February to keep Medicaid recipients enrolled after they moved. “Please DO NOT close cases when you learn a member has moved out of state,” the supervisor said in a Microsoft Teams message. “If the member shows eligible and are out of state, they can still can [sic] utilize some of the benefits.”

Centene’s spokesman said the company is required to maintain coverage for members until the state decides whether to disenroll a beneficiary.

The inspector general for the federal Department of Health and Human Services examined the issue of double payments several years ago in a study looking only at people enrolled in multiple state-paid managed care plans in August in 2019 and 2020.

The results led the team of investigators to conclude that taxpayers were wasting about $1 billion a year, said John Hagg, assistant inspector general for audit services at the oversight agency.

“It should be low hanging fruit,” said Hagg. “The data is there showing it is a problem. This is ripe for correction.”

For the full story see:

Christopher Weaver, Anna Wilde Mathews, and Tom McGinty. “Medicaid Spent Billions Covering Same Patients Twice.” The Wall Street Journal (Fri., March 28, 2025): A1 & A9.

(Note: ellipsis, and bracketed date, added.)

(Note: the online version of the WSJ article has the date March 26, 2025, and has the title “Taxpayers Spent Billions Covering the Same Medicaid Patients Twice.” The passages quoted above omit the subheadings that appear in the print, but not the online, version of the article.)

Boris Johnson Proud He Got Covid-19 Vaccines to Brits Fast

The article quoted below is based on Mark Landler’s interview with Boris Johnson that Johnson gave to promote his Unleashed book. Johnson’s “proudest achievement” is the speed with which British citizens received Covid-19 vaccines. Similarly, I believe one of Donald Trump’s proudest achievements during his first administration was the speed with which his Operation Warp Speed brought American citizens the Covid-19 vaccines.

(p. C5) In March 2021, during the depths of the pandemic, Johnson wrote that he weighed a military raid on a warehouse in the Netherlands to seize five million doses of Covid vaccine that he said were being held illegally by the Dutch government. Having run through the options, one of his military advisers warned him that this would constitute an invasion of a NATO ally.

“I knew he was right,” Johnson wrote. “I secretly agreed with what they all thought but did not want to say aloud: that the whole thing was nuts.”

However harebrained, the scheme was in the service of what Johnson casts as his proudest achievement in government: Britain’s vaccine rollout, one of the fastest of any advanced economy. He credits not just the brilliance of the scientists at Oxford who formulated the AstraZeneca vaccine or the National Health Service, which rapidly distributed it, but also Brexit, which he said enabled Britain to approve the vaccine faster than its European Union neighbors.

Critics insist that Britain could have acted unilaterally, even if it were still a member of the European Medicines Agency, which approves drugs for the E.U. Johnson dismissed that as magical thinking. “Did the Pasteur Institute?” he asked. “Did the Max Planck Institute? Did anybody else?”

For the full story, see:

Mark Landler. “A Case for Trump, And Perhaps Himself.” The New York Times. (Weds., October 16, 2024): C5.

(Note: ellipses added.)

(Note: the online version has the date Oct. 12, 2024, and has the title “Boris Johnson Makes a Case for Trump’s Return, and Perhaps, His Own.”)

Boris Johnson’s book mentioned in my initial comments is:

Johnson, Boris. Unleashed. New York: Harper, 2024.

“Make America’s Showers Great Again”

Today’s entry is the latest in my series on the Trump administration’s efforts to massively deregulate the American economy.

(p. A2) WASHINGTON—President Trump took aim at a low-pressure target: wimpy showers.

Trump signed an executive order on Wednesday [April 9, 2025] rolling back a federal regulation he has blamed for poor water pressure.

. . .

“No longer will shower heads be weak and worthless,” said a draft of Trump’s order, adding that it intended to “make America’s showers great again.”

For the full story see:

Alex Leary. “President Steamed Over Low-Pressure Showers.” The Wall Street Journal (Thurs., April 10, 2025): A2.

(Note: ellipsis, and bracketed date, added.)

(Note: the online version of the WSJ article was updated April 9, 2025, and has the title “Trump Takes Aim at Low-Pressure Showers With Executive Order.”)

Rampant Fraud in ‘Skin’ Bandages Paid by Medicare

A “quirk” in the Medicare law allows ‘skin’ bandage firms to charge, and have Medicare pay them, exorbitant prices. Are such quirks accidents or intentional? Medicare rules are so voluminous and obscure that few have an incentive to look carefully at the details. But the firms selling ‘skin’ bandages had an incentive. Entrepreneurs within these firms saw an opportunity and seized it. But they are what William Baumol called “destructive entrepreneurs.” Their energy and talent works against the general good.

Since patients are not paying, they have little incentive to reveal the fraud. So the taxpayers are robbed. In a system where the patients are the payers they would have an incentive to reveal fraud, and to seek alternatives to over-priced medical therapies.

But what of the poor, you ask? Susan Feigenbaum proposed an insurance system where patients would receive lump sum payments for different ailments. Then poor patients could be payers, and have the incentives of payer.

(p. 1) Seniors across the country are wearing very expensive bandages.

Made of dried bits of placenta, the paper-thin patches cover stubborn wounds and can cost thousands of dollars per square inch.

Some research has found that such “skin substitutes” help certain wounds heal. But in the past few years, dozens of unstudied and costly products have flooded the market.

Bandage companies set ever-rising prices for new brands of the products, taking advantage of a loophole in Medicare rules, The New York Times found. Some doctors then buy the coverings at large discounts but charge Medicare the full sticker price, pocketing the difference.

Partly because of these financial incentives, many patients receive the bandages who do not need them. The result, experts said, is one of the largest examples of Medicare waste in history.

Private insurers rarely pay for skin substitutes, arguing that they are unproven and unnecessary. But Medicare, the government insurance program for seniors, routinely covers them. Spending on skin substitutes exceeded $10 billion in 2024, more than double the figure in 2023, according to an analysis of Medicare data done for The Times by Early Read, a firm that evaluates costs for large health companies.

Medicare now spends more on the bandages than on ambulance rides, anesthesia or CT scans, the analysis found.

. . .

(p. 19) . . . experts in health care costs said the spike had been driven . . . by sellers and doctors taking advantage of Medicare’s pricing rules. The government will reimburse any price that a company sets for brand-new skin substitutes, even if it is far above the market average. The higher the price, the larger the doctors’ cut.

And the bigger the bandage, the more they can charge. For one patient in Nevada, Medicare spent $14 million on skin substitutes over the course of a year, according to billing records reviewed by The Times. The wound of a patient in Washington State persisted after Medicare paid $6 million for the coverings. A man in Texas got $1.3 million of bandages despite having no wound at all. Health executives trying to ferret out suspicious spending identified these patients and shared their stories with The Times.

As the Trump administration — and particularly the new Department of Government Efficiency run by Elon Musk — aims to shrink the federal purse, profligate Medicare spending is a ripe target, experts said.

Companies have billed Medicare for hundreds of thousands of urinary catheters that doctors never ordered. Other schemes have peddled urine tests and knee braces. In 2023, a federal watchdog agency flagged skin substitute spending as wasteful for both taxpayers and Medicare enrollees, who ultimately pay the costs with higher premiums.

“It’s the patients, it’s the taxpayers — unfortunately everyone is footing a part of the bill for this outsized spend,” said Dana Rye, an executive with Duly Health and Care, a Chicago-based medical group where payments for skin substitutes have risen 1,400 percent since 2022.

. . .

Five years ago, the most expensive skin substitute cost $1,042 per square inch, while some were as cheap as $45. Today, the three most expensive products on the market each cost more than $21,000. (Samaritan Biologics, a company in Memphis that sells the three products, did not answer questions about why they cost so much.)

Companies can set such high prices because of a quirk in Medicare pricing rules, industry experts said. For the first six months of a new bandage product’s life, Medicare will set the reimbursement rate at whatever price a company chooses. After that, the agency adjusts the reimbursement to reflect the actual price paid by doctors after any discounts.

To circumvent the reimbursement drop, some companies simply roll out new products.

In April 2023, Medicare began reimbursing $6,497 for every square inch of a bandage called Zenith, sold by Legacy Medical Consultants, a company in Fort Worth, Texas. Six months later, Zenith’s reimbursement fell to $2,746.

That month, October 2023, Medicare began reimbursing $6,490 for a new Legacy product, a “dual layer” bandage called Impax.

Marketing materials for the two products use identical photographs and similar language. The company describes both products as providing “optimal wound covering and protection during the treatment of wounds.”

Since 2022, spending on Zenith and Impax has exceeded $2.6 billion, according to Early Read’s analysis.

. . .

A cottage industry of doctors and nurses make house calls to treat wounds. Some skin substitute companies pitch themselves to wound care doctors by offering a cut of the rising bandage prices.

Dr. Caroline Fife, a wound care doctor from Texas who often writes about industry excesses, shared on her blog last year an email she received from an undisclosed skin substitute company. The company boasted that other doctors had developed “a healthy revenue stream” from its bandages and that a patch smaller than a credit card “would generate a little over $20,000 for your practice.”

Some companies offer doctors a “bulk discount” of up to 45 percent, according to doctor interviews and contracts reviewed by The Times. But doctors then collect a Medicare reimbursement for the full price of the product.

For the full story, see:

Sarah Kliff and Katie Thomas. “‘Skin’ Bandages Cost Medicare, And Doctors Get a Cut of Billions.” The New York Times, First Section. (Sun., April 13, 2025): 1 & 19.

(Note: ellipses added.)

(Note: the online version was updated April 14, 2025, and has the title “Medicare Bleeds Billions on Pricey Bandages, and Doctors Get a Cut.”)

The article by William Baumol praised in my initial comments is:

Baumol, William J. “Entrepreneurship: Productive, Unproductive, and Destructive.” The Journal of Political Economy 98, no. 5, Part 1 (Oct. 1990): 893-921.

The article by Susan Feigenbaum praised in my initial comments is:

Feigenbaum, Susan. “Body Shop’ Economics: What’s Good for Our Cars May Be Good for Our Health.” Regulation 15, no. 4 (Fall 1992): 25-31.

“A.I.s Are Overly Complicated, Patched-Together Rube Goldberg Machines Full of Ad-Hoc Solutions”

A.I. can be a useful tool for searching and summarizing the current state of consensus knowledge. But I am highly dubious that it will ever be able to make the breakthrough leaps that some humans are sometimes able to make. And I am somewhat dubious that it will ever be able to make the resilient pivots that all of us must sometimes make in the face of new and unexpected challenges.

(p. B2) In a series of recent essays, [Melanie] Mitchell argued that a growing body of work shows that it seems possible models develop gigantic “bags of heuristics,” rather than create more efficient mental models of situations and then reasoning through the tasks at hand. (“Heuristic” is a fancy word for a problem-solving shortcut.)

When Keyon Vafa, an AI researcher at Harvard University, first heard the “bag of heuristics” theory, “I feel like it unlocked something for me,” he says. “This is exactly the thing that we’re trying to describe.”

Vafa’s own research was an effort to see what kind of mental map an AI builds when it’s trained on millions of turn-by-turn directions like what you would see on Google Maps. Vafa and his colleagues used as source material Manhattan’s dense network of streets and avenues.

The result did not look anything like a street map of Manhattan. Close inspection revealed the AI had inferred all kinds of impossible maneuvers—routes that leapt over Central Park, or traveled diagonally for many blocks. Yet the resulting model managed to give usable turn-by-turn directions between any two points in the borough with 99% accuracy.

Even though its topsy-turvy map would drive any motorist mad, the model had essentially learned separate rules for navigating in a multitude of situations, from every possible starting point, Vafa says.

The vast “brains” of AIs, paired with unprecedented processing power, allow them to learn how to solve problems in a messy way which would be impossible for a person.

. . .

. . ., today’s AIs are overly complicated, patched-together Rube Goldberg machines full of ad-hoc solutions for answering our prompts. Understanding that these systems are long lists of cobbled-together rules of thumb could go a long way to explaining why they struggle when they’re asked to do things even a little bit outside their training, says Vafa. When his team blocked just 1% of the virtual Manhattan’s roads, forcing the AI to navigate around detours, its performance plummeted.

This illustrates a big difference between today’s AIs and people, he adds. A person might not be able to recite turn-by-turn directions around New York City with 99% accuracy, but they’d be mentally flexible enough to avoid a bit of roadwork.

For the full commentary see:

Christopher Mims. “We Now Know How AI ‘Thinks.’ It Isn’t Thinking at All.” The Wall Street Journal (Saturday, April 26, 2025): B2.

(Note: ellipses added.)

(Note: the online version of the commentary has the date April 25, 2025, and has the title “We Now Know How AI ‘Thinks’—and It’s Barely Thinking at All.”)

A conference draft of the paper that Vafa co-authored on A.I.’s mental map of Manhattan is:

Vafa, Keyon, Justin Y. Chen, Ashesh Rambachan, Jon Kleinberg, and Sendhil Mullainathan. “Evaluating the World Model Implicit in a Generative Model.” In 38th Conference on Neural Information Processing Systems (NeurIPS). Vancouver, BC, Canada, Dec. 2024.

Health Freedom Is a Right AND Can Yield More and Faster Therapies

The headline of the article on the front page of the NYT says “No Evidence for Healing Powers,” and goes on to slam unsophisticated right-wingers as irresponsibly pushing ivermectin as a therapy for cancer. In the article the NYT publishes a ludicrous picture from a right-winger’s Facebook page where he has spread veterinary ivermectin cream on his tongue and says “tastes like dead cancer.”

But this is unfair and tendentious caricature. A friend recently sent me an Instagram post by a chiropractor suffering from glioblastoma who has taken ivermectin and mebendazole. He briefly sketches the hypothesized mechanisms for activity of the two drugs, consistent with research published in scientific papers.

Glioblastoma is a serious, often fatal, brain cancer. He had surgery, but knows that surgery often does not cure, so he threw a Hail Mary and took ivermectin and mebendazole. These drugs have long track-records for safety, having been tested and approved for other uses. Doctors can, and have, prescribed drugs for off-label uses for decades.

Decades ago minoxidil was approved as an blood pressure medicine. I asked my then-doctor to prescribe it for me for its rumored effects as a hair loss cure. He did, so I crushed the tablets and somehow applied them to my scalp, which proceeded to itch, but not grow hair. It was a low-risk, modest-chance-of-success experiment. I think I had a right to try it, and that no government or expert had a right to forbid it. (Eventually minoxidil was approved for hair loss and branded Rogaine–which still didn’t work for me.)

In a free country adults should have wide latitude to make decisions about what risks they take; to scuba dive, to drive NASCAR, to go into space, and yes to take ivermectin and mebendazole. And the ludicrous right-winger? Hey, maybe even he has rights.

The NYT headline says there is “no evidence” for ivermectin. Below I cite a survey article that identifies 24 articles published in scientific journals identifying mechanisms by which ivermectin may be effective against cancer. There’s plenty of evidence, just not from randomized double-blind clinical trials (RCTs). But as long-time readers of this blog may remember, I have posted many entries giving useful actionable evidence that takes forms other than RCTs.

“No evidence”? Maybe the NYT was seeking plausible deniability by running its article on April 1st.

Oh, and by the way, allowing health freedom might sometimes result in better and faster therapies. I am currently reading Rethinking Diabetes by Gary Taubes. He tells the story (pp. 346-356) of Richard K. Bernstein, an engineer with Type 1 diabetes who was suffering from various serious ailments from his diabetes, in spite of the doctors saying it was being well-controlled by insulin. In his 40s, he was only expected to live another 10 years. Well he bought a new device that was not supposed to be bought by patients. The medical profession thought patients could not handle the information. (His wife was an MD, so he ‘bought’ it by asking her to buy it for him.) The device allowed him to get frequent readings of his blood sugar, and thereby to better control it, ultimately through changes in diet. When he tried to share what he had learned, he had trouble finding anyone who would take him seriously, so in his 40s he enrolled in medical school, and started publishing papers and books describing his results.

Richard K. Bernstein died on April 15, 2025 at age 90.

[Below are some relevant quotations from a NYT companion piece to the front-page article. The companion piece provides only slightly less tendentious background information on ivermectin.]

(p. A21) . . . there is not evidence to support people taking ivermectin to treat cancer.

. . .

Scientists do not dispute that ivermectin is powerfully effective — against parasites. The drug was such a breakthrough in the fight against tropical parasitic diseases that two scientists who studied it won the Nobel Prize in 2015.

The Food and Drug Administration has approved ivermectin tablets to treat certain parasitic infections, and the agency has authorized ivermectin lotions to kill lice and creams to help with rosacea. Veterinarians also use the drug to prevent and treat parasitic diseases in animals.

. . .

Studies in human cells suggest that the drug may kill certain types of cancer cells in a way that triggers the immune system, said Dr. Peter P. Lee, chair of the department of immuno-oncology at Beckman Research Institute of City of Hope in Duarte, Calif. In mouse studies, Dr. Lee has seen that the drug, on its own, does not shrink breast tumors. But it’s possible that the drug may have benefits for breast cancer when used alongside existing cancer immunotherapy, he said. Researchers are studying a combination of ivermectin and an investigational cancer drug in people with breast cancer.

While some inaccurate social media posts claim that ivermectin can treat cancer because tumors themselves are parasitic, the promise of ivermectin for cancer has nothing to do with its anti-parasitic effect, Dr. Lee said. Rather, it seems that the drug may be able to modulate a signal involved with cancer growth.

But doctors still need larger, randomized clinical trials to better understand whether ivermectin could treat cancer. Just because a drug seems to work in animals doesn’t mean those results will translate into real-world outcomes, Dr. Johnson noted. There are “hundreds of medications that look to be promising in a preclinical setting” every year, he said, adding, “The vast majority of those will never be shown to be effective in humans.”

. . .

Doctors generally view ivermectin as safe at the doses prescribed to treat parasitic infections.

For the full story, see:

Dani Blum. “What Ivermectin Can and Can’t Do, and What the Dangers Are.” The New York Times (Tues., April 1, 2025): A21.

(Note: ellipses added.)

(Note: the online version has the date March 31, 2025, and has the title “What Ivermectin Can (and Can’t) Do.” In the first quoted sentence, the print version says “no evidence” and the online version says “not evidence.”)

The Blum article that I just quoted and cited, is a secondary companion article to a longer front-page article, also on ivermectin:

Richard Fausset. “No Evidence for Healing Powers, but ‘Tastes Like Dead Cancer’.” The New York Times (Tues., April 1, 2025): A1 & A21.

(Note: the online version has the date March 31, 2025, and has the title “Why the Right Still Embraces Ivermectin.”)

The paper cited below reviewed the published scientific literature as of 2020 on the mechanisms through which ivermectin could have anti-cancer effects, finding 24 articles documenting one or more mechanisms.

Tang, Mingyang, Xiaodong Hu, Yi Wang, Xin Yao, Wei Zhang, Chenying Yu, Fuying Cheng, Jiangyan Li, and Qiang Fang. “Ivermectin, a Potential Anticancer Drug Derived from an Antiparasitic Drug.” Pharmacological Research 163 (Jan. 2021): 105207.

Tang and co-authors are optimistic in their summary section quoted below. [In this quote IVM is “ivermectin” and MDR is “multidrug resistance”.]

. . ., the broad-spectrum antiparasitic drug IVM, which is widely used in the field of parasitic control, has many advantages that suggest that it is worth developing as a potential new anticancer drug. IVM selectively inhibits the proliferation of tumors at a dose that is not toxic to normal cells and can reverse the MDR of tumors. Importantly, IVM is an established drug used for the treatment of parasitic diseases such as river blindness and elephantiasis. It has been widely used in humans for many years, and its various pharmacological properties, including long- and short-term toxicological effects and drug metabolism characteristics are very clear. (Tang et al. Jan. 2021, pp. 7-8)

The paper cited below reviewed the published scientific literature as of 2019 on the effect of mebendazole on cancer, and found 26 in vitro studies showing anti-cancer biological effects, 14 in vivo studies showing anti-tumor effects, and six Phase 1 or Phase 2 clinical trials listed in ClinicalTrials.gov.

Guerini, Andrea Emanuele, Luca Triggiani, Marta Maddalo, Marco Lorenzo Bonù, Francesco Frassine, Anna Baiguini, Alessandro Alghisi, Davide Tomasini, Paolo Borghetti, Nadia Pasinetti, Roberto Bresciani, Stefano Maria Magrini, and Michela Buglione. “Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature.” Cancers 11, no. 9 (Aug. 2019): article #1284.

Gary Taubes’s book, praised by Marty Makary and Siddhartha Mukherjee, and mentioned by me near the end of my commentary, is:

Taubes, Gary. Rethinking Diabetes: What Science Reveals About Diet, Insulin, and Successful Treatments. New York: Knopf, 2024.

[I thank Ivette Locay for sending me a link useful for my commentary.]

Director of the N.I.H. Was “Subject to Censorship by the Actions of the Biden Administration”

During the Covid-19 pandemic, I had an invited essay cancelled by the OECD in which I argued for freedom of speech in science, and especially for toleration of a diversity of views during the pandemic. So I have sympathy for the attacks Dr. Bhattacharya suffered during the pandemic and wish him well as the Director of the National Institutes of Health.

(p. B1) Dr. [Jay] Bhattacharya, who has a medical degree and is a professor of medicine but never practiced, burst into the spotlight in October 2020, when he co-wrote an anti-lockdown treatise, the Great Barrington Declaration. It argued for “focused protection” — a strategy to protect the elderly and vulnerable while letting the virus spread among younger, healthier people.

Many scientists countered that walling off at-risk populations from the rest of society was a pipe dream.

The nation’s medical leadership, including Dr. Francis S. Collins, who retired last week, and Dr. Anthony S. Fauci, then director of the National Institute of Allergy and Infectious Diseases, denounced the plan. Referring to Dr. Bhattacharya and his co-authors as “fringe epidemiologists,” Dr. Collins wrote in an email that “there needs to be a quick and devastating takedown of its premises.”

Dr. Bhattacharya told senators on Wednesday [March 5, 2025] that he had been “subject to censorship by the actions of the Biden administration.” Past N.I.H. officials, he said, “oversaw a culture of cover-up, obfuscation and a lack of tolerance for ideas that differ from theirs.”

For the full story see:

Benjamin Mueller and Sheryl Gay Stolberg. “Guarded Nominee for N.I.H. Faces Sharp Questions on Vaccines and Research Cuts.” The New York Times (Thursday, March 6, 2025): A18.

(Note: bracketed date added.)

(Note: the online version of the story has the date March 5, 2025, and has the title “Guarded N.I.H. Nominee Faces Sharp Questions on Vaccines and Research Cuts.”)

George Church Is Optimistic About A.I., but in 2019 Also Was Optimistic He Would Reverse Aging in Dogs by 2022

Steve Lohr had an article in the NYT promoting the possibility that generative intelligence from A.I. will bring us scientific breakthroughs quicker. A new startup called “Lila” is trying to achieve this. George Church of Harvard is onboard.

Back on Sun., Dec. 8, 2019, 60 Minutes on ran a very optimistic segment in which Church says that through his lab’s work on gene editing, age reversal for dogs “might be a couple years away and then that takes another ten years to get through the human clinical trials” (Church as quoted in Pelley 2019).

In Lohr’s recent article, Church is quoted as saying ““I think science is a really good topic for A.I.” (Church as quoted in Lohr, p. B5). The article describes science as basically a mechanical process of trial and error. Some science is like that, like when Gerhard Domagk had his lab crank through hundreds of chemicals to find one (Prontosil) that was a broad spectrum antibiotic. Maybe A.I. could more efficiently crank through a large set of possibilities. The only example of medical advance through A.I. in the article is that “Lila’s A.I. has generated novel antibodies to fight disease” (Lohr, p. B5).

A.I. can combine what is known in novel ways and produce text that is new, but is not necessarily sensible, correct, or useful, let alone a profound leap.

So it is not clear to me how well A.I. could help define and prioritize the possibilities. Lila scientists are feeding their A.I. program scientific literature, presumably weighting differing views by some bibliometric measures, like citations or journal rankings. But often a leap or breakthrough is at first rejected by the top journals, and not heavily cited by the establishment.

I do not see how A.I. could identify those early breakthroughs, much less be the source of them. And making and identifying such breakthroughs are key steps in scientific progress.

I was was pumped when I heard Church’s optimism in 2019 for longevity breakthroughs. But now it is more than five years later, and I have not seen claims of age reversal for dogs, let alone for humans. Maybe Covid delayed progress. Or maybe Church is not a good judge of what is required for scientific breakthroughs. This latter possibility seems more likely given Church’s hyper-enthusiasm for generative A.I.

Steve Lohr’s article is:

Lohr, Steve. “A.I. May Hasten Leaps in Science.” The New York Times (Thurs., March 13, 2025): B1 & B5.

(Note: the online version of the Steve Lohr article has the date March 10, 2025, and has the title “The Quest for A.I. ‘Scientific Superintelligence’.”)

A transcript of the 60 Minutes segment on Church is:

Pelley, Scott. “A Harvard Geneticist’s Goal: To Protect Humans from Viruses, Genetic Diseases, and Aging.” In 60 Minutes. CBS News, (Sun., Dec. 8, 2019).

Croatian Government Does Not Learn from Distant Past (or Recent Past) That Price Controls Do Not Work

In Croatia, as in the United States, inflation resulted when each government “flooded the country with cash” to buy votes during the Covid pandemic.

(p. 4) In 301 A.D., the Emperor Diocletian made a bold but ultimately unsuccessful bid to address the inflation that was rampaging across the eastern half of the divided Roman Empire.

Prices of everything from purple thread and feathers to slaves and cattle were dictated by his Edict on Maximum Prices. Violators faced the death penalty. Diocletian gave up power about four years after issuing his edict, watching his measure fail from his sprawling retirement palace in the heart of what became the city of Split in Croatia.

Now Croatia’s government is trying a similar tactic to rein in prices that have soared in recent years and sparked protests and retail boycotts by the country’s beleaguered consumers.

. . .

The rules that came into effect this month are the Croatian government’s third attempt at controlling prices by fiat since September 2022. The first two efforts were largely ineffective, with retailers simply refusing to stock most price-controlled goods.

. . .

Economists blame the increases on a three-headed hydra of pandemic-era economic rescue packages that flooded the country with cash, increases in public sector wages and retailers rounding up prices after Croatia adopted the euro in 2023.

. . .

John H. Cochrane, an economist and fellow at the Hoover Institution, a research center, pointed to the role Diocletian’s edict played in causing shortages and fueling a black market.

“It’s like trying to stem the symptoms rather than treating the underlying disease,” Mr. Cochrane said of price controls. “It offers people the appearance of help for a while, and then it takes a few weeks or, a month or two, for all the problems to break out.”

For the full story, see:

Joe Orovic. “A Croatian Plan to Rein In Prices Echoes the Tack of an Emperor.” The New York Times, First Section. (Sun., March 9, 2025): 4.

(Note: ellipses added.)

(Note: the online version was updated March 10, 2025, and has the title “Echoing a Roman Emperor, Croatia Tries to Cap Soaring Prices.” Where there is a slight difference in wording, the passages quoted above follow the online version.)

Mark Twain “Dared to State Things That Others Only Thought”

I have read three of Ron Chernow’s massive biographies, the ones on Rockefeller, Washington, and Hamilton. Because they are massive, reading them takes a long time, at least for a slow reader like me. But I learned a lot that is important or useful from them, especially the ones on Rockefeller and Hamilton. Because I am an admirer of both Chernow and Twain, I look forward to also reading Chernow’s biography of Twain.

(p. C7) More than a century after his death, Mark Twain remains one of the most recognizable voices in American literature—the author of “The Adventures of Tom Sawyer” (1876), “Life on the Mississippi” (1883) and “Adventures of Huckleberry Finn” (1884), the latter among the most consequential novels ever written in English and possibly (if you believe Ernest Hemingway) the source of American literature itself.

. . .

In his biography of the famed satirist, Ron Chernow tracks, with patience and care, Twain’s journey over nearly eight tumultuous decades. Mr. Chernow’s tale is enlivened by blazing quotes from Twain’s prodigious interviews, diaries and letters.  . . .  The quotes tend to burn a hole in the page, and it’s difficult for a biographer to recover. Mr. Chernow, whose lives of George Washington, Alexander Hamilton and Ulysses S. Grant are revered for their sound scholarship, clear writing and strong narrative drive, weaves Twain’s sizzling remarks almost seamlessly into his own narrative.

We watch as Twain lunges from coast to coast, rolling up and down the Mississippi (as a riverboat pilot in his early days), moving from country to country, writing books and articles, investing large sums in various hair-brained schemes.

. . .

This was, in Twain’s own phrase, the Gilded Age. He admired, even idealized, those who made huge sums of money through their entrepreneurial energy and acumen. He had the same energy, but he didn’t have the right vehicles for speculation nor the business sense to make his investments pay off. As Mr. Chernow observes, Twain could well have enjoyed an easy life of writing and giving lectures, having married a wealthy woman and published several bestsellers. “Instead, he had started a publishing house and financed a typesetter”—the Paige Compositor, which was supposed to replace manual typesetting but failed spectacularly because of engineering flaws—“before he had the expertise or requisite fortune to bring them to completion.” His expenses soon dwarfed his income and he was forced to abandon his Hartford mansion, never to return.

. . .

Twain was “a man who professed to be chronically lazy,” says Mr. Chernow, yet he left behind him a vast portfolio of writings that included 30 books, several thousand magazine articles and some 12,000 letters. “Mark Twain had not only moved people to laughter and tears with his books,” Mr. Chernow writes, “but had challenged them with unorthodox views as he ventured out from his safe cubbyhole as the avuncular humorist. He had dared to state things that others only thought.” It’s because of this bravery, and his peerless gift for expression, that we still value him and will never stop reading his books, which never grow old.

For the full review see:

Jay Parini. “A Most American Writer.” The Wall Street Journal (Saturday, May 10, 2025): C7.

(Note: ellipses added.)

(Note: the online version of the review has the date May 9, 2025, and has the title “‘Mark Twain’: The Most American Writer.”)

The book under review is:

Chernow, Ron. Mark Twain. New York: The Penguin Press, 2025.