Category: Entrepreneurship

Knowledge from Self-Experimentation Should Be Publishable

(p. D4) When Bob Hariri developed a product he thought could be useful as a human-skin replacement for burn victims, he had no trouble finding a subject willing to test it–himself.
An entrepreneur and a neurosurgeon with both a medical degree and a doctorate, Dr. Hariri is one of a number of scientists who have experimented on themselves with new or yet-to-be approved medical products or technologies, and who say such practice can be indispensable in the development of innovative biomedical treatments.
Some scientists are pushing for self-experimentation data to be reported publicly and more systematically to aid scientific progress. Alex Zhavoronkov, chief executive of an aging-research company called InSilico Medicine Inc., and others hope to start a peer-reviewed journal on self-experimentation, where scientists and other qualified individuals would publish high-quality case studies of tests performed on themselves. He plans to launch a crowdfunding operation in the next few months to fund it.
The idea is “to unlock the knowledge [of self-experimentation] that resides there anyway,” says Dr. Zhavrononkov, who takes an old diabetes drug called metformin that is supposed to have antiaging properties, even though it hasn’t been approved for that purpose.
. . .
Advocates say self-experimentation can yield information that is hard to get from a clinical trial. The experimenter feels what it’s like to be the patient and gets insight into how to improve testing procedures. Also, a number of individual reports, when cobbled together, can start to yield a picture of whether a new treatment is likely to work or not, though one wouldn’t rely on those reports alone to conclude safety or effectiveness.

For the full story, see:
Wang, Shirley S. “Why Medical Researchers Experiment on Themselves.”The Wall Street Journal (Tues., January 26, 2016): D4.
(Note: ellipsis added.)
(Note: the online version of the story has the date Jan. 25, 2016, and has the title “IN THE LAB; More Medical Researchers Engage In Self-Experimentation.”)

Musk “Could Be Completely Delusional”

(p. B2) Tesla Inc. on Tuesday [January 23, 2018] unleashed a bold pay package for Chief Executive Elon Musk that again ties his compensation entirely to key performance benchmarks. This time, the goals take the electric-car maker to cosmic heights, including an ultimate aim of hitting $650 billion in market value.
. . .
Mr. Musk could net billions of dollars by hitting only a few of the milestones. Tesla said in a proxy filing the 20.26 million stock options today would have a preliminary value of about $2.62 billion. But if Tesla were to reach the audacious market value of $650 billion–as much as Amazon.com Inc. is worth today–the company said Mr. Musk’s stock award would reap him as much as $55.8 billion fully vested.
That total, however, assumes the company’s shares outstanding won’t be diluted. Tesla has added tens of millions of shares over the past several years, so that total dollar figure is unlikely.
. . .
Mr. Musk is saying, “I want to set an audacious goal, and then if I achieve it, then pay me audaciously,” said John Challenger, a longtime expert in corporate compensation as chief executive of Challenger, Gray & Christmas. “He is in some ways capturing the spirit of Silicon Valley.”
. . .
Mr. Musk had previously committed the company to reaching a market cap of $700 billion, something he reiterated last year. “I could be completely delusional, but I think I see a clear path to that outcome,” he told analysts in May.

For the full story, see:
Higgins, Tim. “Tesla Primes Musk’s Pay for Blastoff.” The Wall Street Journal (Weds., January 24, 2018): B2.
(Note: ellipses, and bracketed date, added.)
(Note: the online version of the story has the date JAN. 23, 2018, and has the title “Elon Musk Could Net Billions by Hitting Tesla’s New Milestones.” Where the wording of the two versions differs, the passages quoted above follow the wording of the online version.)

With Cuts in Red Tape, Firms Invest More

(p. A1) WASHINGTON — A wave of optimism has swept over American business leaders, and it is beginning to translate into the sort of investment in new plants, equipment and factory upgrades that bolsters economic growth, spurs job creation — and may finally raise wages significantly.
While business leaders are eager for the tax cuts that take effect this year, the newfound confidence was initially inspired by the Trump administration’s regulatory pullback, not so much because deregulation is saving companies money but because the administration has instilled a faith in business executives that new regulations are not coming.
“It’s an overall sense that you’re not going to face any new regulatory fights,” said Granger MacDonald, a home builder in Kerrville, Tex. “We’re not spending more, which is the main thing. We’re not seeing any savings, but we’re not seeing any increases.”
. . .
(p. A10) Only a handful of the federal government’s reams of rules have actually been killed or slated for elimination since Mr. Trump took office. But the president has declared that rolling back regulations will be a defining theme of his presidency. On his 11th day in office, Mr. Trump signed an executive order “on reducing regulation and controlling regulatory costs,” including the stipulation that any new regulation must be offset by two regulations rolled back.
That intention and its rhetorical and regulatory follow-ons have executives at large and small companies celebrating. And with tax cuts coming and a generally improving economic outlook, both domestically and internationally, economists are revising growth forecasts upward for last year and this year.
. . .
. . . economists see a plausible connection between Mr. Trump’s determination to prune the federal rule book and the willingness of businesses to crank open their vaults. Measures of business confidence have climbed to record heights during Mr. Trump’s first year.
. . .
“We have spent the past dozen years or longer operating in environments that have had an increasing regulatory burden,” said Michael S. Burke, the chairman and chief executive of Aecom, a Los Angeles-based multinational consulting firm that specializes in infrastructure projects. “That burden has slowed down economic growth, it’s slowed down investment in infrastructure. And what we’ve seen over the last year is a big deregulatory environment.”
. . .
The White House sees its efforts as having their intended effect. Mr. Trump boasted about his deregulatory efforts last month at an event where he stood in front of a small mountain of printouts representing the nation’s regulatory burden and ceremonially cut a large piece of “red tape.”
The chairman of the White House Council of Economic Advisers, Kevin Hassett, said in an interview that the administration’s freeze on new regulations, in particular, appeared to have buoyed confidence. Though he cautioned that it could take years of research to pin down the magnitude of the effects, he said deregulation was “the most plausible story” to explain why economic growth in 2017 had outstripped most forecasts.
“Our view is, the ‘no new regulations’ piece has to be more powerful than we thought,” he said.

For the full story, see:
BINYAMIN APPELBAUM and JIM TANKERSLEY. “With Red Tape Losing Its Grip, Firms Ante Up.” The New York Times (Tues., January 2, 2018): A1 & A10.
(Note: ellipses added.)
(Note: the online version of the story has the date JAN. 1, 2018, and has the title “The Trump Effect: Business, Anticipating Less Regulation, Loosens Purse Strings.”)

Cuts in Red Tape Build Business Confidence

TrumpCutsRedTape2018-01-31.jpg“President Trump described his administration’s deregulation efforts in remarks at the White House on Thursday. He then stood between two piles of paper representing government regulations in 1960, (20,000 pages, he said), and today — a pile that was about six feet tall (said to be 185,000 pages).” Source of caption and photo: online version of the NYT article quoted and cited below.

(p. A22) WASHINGTON — President Trump said on Thursday that his administration was answering “a call to action” by rolling back regulations on environmental protections, health care, financial services and other industries as he made a push to showcase his accomplishments near the end of his first year in office.
The remarks highlighted an area where Mr. Trump has perhaps done more to change the policies of his predecessor than any other, with regulatory shifts that have affected wide sections of the economy.
. . .
Echoing his days as a real estate developer with the flair of a groundbreaking, Mr. Trump used an oversize pair of scissors to cut a ribbon his staff had set up in front of two piles of paper, representing government regulations in 1960 (20,000 pages, he said), and today — a pile that was about six feet tall (said to be 185,000 pages).
. . .
. . . , several economic indicators — and comments from companies large and small — suggest that a shift in federal regulatory policy is building business confidence and accelerating economic growth, developments Mr. Trump certainly took credit for on Thursday [December 14, 2017].
A survey of chief executives released this month by the Business Roundtable found that, for the first time in six years, executives did not cite regulation as the top cost pressure facing their companies.
“C.E.O.s appear to be responding to the administration’s energetic focus on regulation,” Joshua Bolten, the roundtable’s president, said this month.

For the full story, see:

ERIC LIPTON and DANIELLE IVORY. “Most Far-Reaching’ Rollback of Rule.” The New York Times (Sat., DEC. 15, 2017): A22.
(Note: ellipses, and bracketed date, added.)
(Note: the online version of the story has the date DEC. 14, 2017, and has the title “Trump Says His Regulatory Rollback Already Is the ‘Most Far-Reaching’.” The online page for this article says that it appeared on p. A16 of the New York edition. My page number above is from my paper, which was probably the midwest edition.)

Innovation Skeptics Fail to See Its Broad Benefits

(p. B11) Professor Juma died on Dec. 15 [2017] at his home in Cambridge, Mass. He was 64. His wife said the cause was cancer. At his death he was widely credited as having been an important force in ensuring that biotechnology would play a critical role in improving economic life in many developing countries, especially in sub-Saharan Africa.
“Calestous understood that people often resist the changes that come with innovation, and that overcoming this resistance can be very important in enabling societies to move ahead,” said Douglas W. Elmendorf, dean of the Kennedy School. “So he tried to understand why people resist innovation, and what can be done to make them feel comfortable with change.”
Professor Juma’s latest book, “Innovation and Its Enemies” (2016), described how technological change is often greeted with public skepticism. Beneath such opposition, he argued, is the belief that only a small segment of society will benefit from potential progress, while the much broader society bears the greatest risk.
. . .
Professor Juma could be lighthearted in the classroom or in public in order to make his points. With more than 100,000 followers on Twitter, he shared with them cartoons that teased skeptics of science and innovation. One of his last posts featured a game show called “Facts Don’t Matter.” In it, a contestant is told: “I’m sorry, Jeannie, your answer was correct, but Kevin shouted his incorrect answer over yours, so he gets the points.”

For the full obituary, see:
ADEEL HASSAN. “Calestous Juma, 64, Advocate of African Progress, Dies.” The New York Times (Tues., January 2, 2018): B11.
(Note: ellipsis, and bracketed year, added.)
(Note: the online version of the obituary has the date JAN. 1, 2018, and has the title “Calestous Juma, 64, Dies; Sought Innovation in African Agriculture.”)

The most recent book by Juma, mentioned above, is:
Juma, Calestous. Innovation and Its Enemies: Why People Resist New Technologies. New York: Oxford University Press, 2016.

Incentive Packages to Big Incumbent Firms Hurt Local Start-Ups

(p. A1) When New Jersey announced a $7 billion package of tax incentives to try to lure Amazon’s second headquarters to Newark, local officials saw a chance to jump-start a city that has long struggled with poverty and joblessness.
Many economists, however, saw something else: a failed development strategy that they had hoped was falling out of favor.
. . .
(p. A15) Gina Schaefer, who owns a dozen hardware stores in the Washington area, said she did not mind paying taxes, and had learned to deal with the bureaucratic hurdles that come with running a small business in the area. But she said it was frustrating to watch local governments — three of the 20 finalists for the Amazon project are in the Washington area — roll out the red carpet for a multibillion-dollar corporation. Suddenly, she said, her tax dollars could be flowing to one of her most daunting competitors.
“There are no incentives for those of us who are already here,” Ms. Schaefer said. Alluding to Amazon’s chief executive, Jeff Bezos, she added, “Why should the richest man in the history of the world get money to open his business?”
Indeed, tax incentives tend to flow overwhelmingly to big, established companies, rather than to the local start-ups that research has shown are a more significant source of job growth. And some who have studied the issue say incentives rarely work: Companies will play cities and states off one another to save money, but ultimately base site-selection decisions mostly on other factors.

For the full story, see:
BEN CASSELMAN. “Risks for Cities In Sweetening Amazon’s Pot.” The New York Times (Sat., JAN. 27, 2018): A1 & A15.
(Note: ellipsis added.)
(Note: the online version of the story has the date JAN. 26, 2018, and has the title “Promising Billions to Amazon: Is It a Good Deal for Cities?”)

45 Start-Ups Working on New Processor Chips

(p. B1) SAN FRANCISCO — For years, tech industry financiers showed little interest in start-up companies that made computer chips.
How on earth could a start-up compete with a goliath like Intel, which made the chips that ran more than 80 percent of the world’s personal computers? Even in the areas where Intel didn’t dominate, like smartphones and gaming devices, there were companies like Qualcomm and Nvidia that could squash an upstart.
But then came the tech industry’s latest big thing — artificial intelligence. A.I., it turned out, works better with new kinds of computer chips. Suddenly, venture capitalists forgot all those forbidding roadblocks to success for a young chip company.
Today, at least 45 start-ups are working on chips that can power tasks like speech and self-driving cars, and at least five of them have raised more than $100 million from investors. Venture capitalists invested more than $1.5 billion in chip start-ups last year, nearly doubling the investments made two years ago, according to the research firm CB Insights.
The explosion is akin to the sudden proliferation of PC and hard-drive makers in the 1980s. While these are small companies, and not all will survive, they have the power to fuel a period of rapid technological change.

For the full story, see:
CADE METZ. “Bets on A.I. Open a New Chip Frontier.” The New York Times (Mon., January 15, 2018): B1 & B3.
(Note: the online version of the story has the date JAN. 14, 2018, and has the title “Big Bets on A.I. Open a New Frontier for Chip Start-Ups, Too.”)

Weather Channel Entrepreneur Was a Global Warming Skeptic

(p. B1) John S. Coleman, a co-founder of the Weather Channel, the original meteorologist on ABC’s “Good Morning America” and, later in his career, a vocal climate change skeptic, died on Saturday [January 20, 2018] at Summerlin Hospital Medical Center in Las Vegas. He was 83.
. . .
His career took him through broadcast positions in Omaha, Milwaukee and Peoria, Ill. He joined the fledgling “Good Morning America” in 1975 and stayed for seven years.
“He was sort of a weather rock star at the time,” said Joseph D’Aleo, whom Mr. Coleman recruited out of academia to lend a hand at “Good Morning America” and to help him develop his idea for a 24-7 weather channel.
“He was dedicated to everything he did; he’d sometimes take off after the morning shows, get on an airplane, go halfway across the country and meet with venture capitalists to present his idea,” Mr. D’Aleo said in an interview.
But after a year of false starts, Mr. D’Aleo said, Mr. Coleman “felt a little bit like Sancho Panza behind Don Quixote and his impossible dream.”
. . .
The American Meteorological Society named Mr. Coleman broadcast meteorologist of the year in 1983, citing his “many years of service in presenting weather reports of high informational, educational and professional quality.”
. . .
By the time he retired in 2014, he had become a lightning rod for controversy over his views on climate change.
At the top of his personal blog, he wrote: “There is no significant man-made global warming at this time, there has not been any in the past and there is no reason to fear any in the future.”

For the full obituary, see:
TIFFANY Hsu. “John Coleman, 83, TV Weather Pioneer.” The New York Times (Weds., January 24, 2018): B14.
(Note: ellipses, and bracketed date, added.)
(Note: the online version of the obituary has the date JAN. 21, 2018, and has the title “John S. Coleman, Weather Channel Co-Founder, Dies at 83.”)

Tinkerers Create Cheap Prosthetic Hands with 3-D Printers

(p. D1) The proliferation of 3-D printers has had an unexpected benefit: The devices, it turns out, are perfect for creating cheap prosthetics. Surprising numbers of children need them: One in 1,000 infants is born with missing fingers, and others lose fingers and hands to injury. Each year, about 450 children receive amputations as a result of lawn mower accidents, according to a study in Pedatrics..
State-of-the-art prosthetic replacements are complicated medical devices, powered by batteries and electronic motors, and they can cost thousands of dollars. Even if children are able to manage the equipment, they grow too quickly to make the investment practical. So most do without, fighting to do with one hand what most of us do with two.
E-nable, an online volunteer organization, aims to change that. Founded in 2013 by Jon Schull, the group matches children like Dawson in need of prosthetic hands and fingers with volunteers able to make them on 3-D printers. Designs may be downloaded into the machines at no charge, and members who create new models share their software plans freely with others.
The materials for a 3-D-printed prosthetic hand can cost as little as $20 to $50, and some experts say they work just as well, if not better, than much costlier devices. Best of all, boys and girls usually love their D.I.Y. prosthetics.

For the full story, see:
Mroz, Jacqueline. “Hand of a Superhero.” The New York Times (Tues., Feb. 17, 2015): D1 & D6..
(Note: the online version of the story has the date FEB. 16, 2015. I do not have the print version, so I cannot confirm if there are differences between the online and print versions, and am not sure if the whole passage quoted above appears on p. D1, or if some or all of it is from p. D6.)

Kodak Using Blockchain to Manage Digital Photo Property Rights

(p. B1) Shares of Eastman Kodak more than doubled after the company waded into the digital-currency world with plans to launch an initial coin offering.
Kodak on Tuesday [January 9, 2018] said the coin, KodakCoin, would be the backbone of a new platform that will help photographers license their work and track the unlicensed use of their images. The coin uses the technology behind bitcoin, called blockchain, to keep a digital ledger of the photographs.
. . .
“For many in the tech industry, ‘blockchain’ and ‘cryptocurrency’ are hot buzzwords, but for photographers who’ve long struggled to assert control over their work and how it’s used, these buzzwords are the keys to solving what felt like an unsolvable problem,” said Kodak CEO Jeff Clarke in a statement.
For the past several years, people have been experimenting with ways to use blockchain. At its essence, blockchain is an open record of transactions, maintained in an online ledger that is distributed across a network of computers, that cannot be tampered with. That makes it like an indelible time stamp, which could be useful in a case of copyright and digital-rights management.

For the full story, see:

Erik Holm and Paul Vigna. “Kodak Snaps Is Crypto-Moment.”The Wall Street Journal (Weds., Jan 10, 2018): B1-B2.
(Note: ellipsis, and bracketed date, added.)
(Note: the online version of the story has the date Jan 9, 2018, and has the title “Kodak Catches Crypto Fever.” The online version has two additional paragraphs between the last two paragraphs quoted above.)

“Without Amazon, We Wouldn’t Be Here”

(p. B1) KANATA, Ontario — Truth be told, the headquarters of Instant Pot don’t look much like a church.
But inside this sterile, gray office building on the outskirts of Ottawa, behind a door marked only by a small metal sign, a new religion has been born.
Its deity is the Instant Pot, a line of electric multicookers that has become an internet phenomenon and inspired a legion of passionate foodies and home cooks. These devotees — they call themselves “Potheads” — use their Instant Pots for virtually every kitchen task imaginable: sautéing, pressure-cooking, steaming, even making yogurt and cheesecakes. Then, they evangelize on the internet, using social media to sing the gadget’s praises to the unconverted.
. . .
(p. B5) I went to Kanata to get a peek behind the scenes of the Instant Pot phenomenon and meet its creator: Robert Wang, who invented the device and serves as chief executive of Double Insight, its parent company. What I found was a remarkable example of a new breed of 21st-century start-up — a homegrown hardware business with only around 50 employees that raised no venture capital funding, spent almost nothing on advertising, and achieved enormous size primarily through online word-of-mouth. It is also a testament to the enormous power of Amazon, and its ability to turn small businesses into major empires nearly overnight.
. . .
In 2010, after several months of sluggish sales in and around Ontario, Mr. Wang listed the Instant Pot on Amazon, where a community of food writers eventually took notice. Vegetarians and paleo dieters, in particular, were drawn to the device’s pressure-cooking function, which shaved hours off the time needed to cook pots of beans or large cuts of meat.
Sensing viral potential, Instant Pot sent test units to about 200 influential chefs, cooking instructors and food bloggers. Reviews and recipes appeared online, and sales began to climb.
. . .
Mr. Wang credits the device’s technological advances — most notably, a group of sensors that keep the cooker from overheating or exploding under pressure.
Instant Pot’s internet fandom also gives it a leg up. The food bloggers behind popular recipe sites like Nom Nom Paleo were early converts to electric pressure-cooking, and cookbook authors took note of the device’s cult appeal. Mr. Wang says that more than 1,500 Instant Pot cookbooks have been written, including several of Amazon’s current best-sellers.
Amazon has played a particularly large role in Instant Pot’s rise. Early on, Instant Pot joined the “Fulfillment by Amazon” program, in which Amazon handles the packing and shipping of a seller’s products in exchange for a cut of each item sold. Eventually, Instant Pot sent Amazon wholesale shipments directly from factories in China, and Amazon began promoting the machines in its major annual sales. At one point, more than 90 percent of Instant Pot’s sales came through Amazon.
“Without Amazon, we wouldn’t be here,” Mr. Wang said.

For the full story, see:
KEVIN ROOSE. “The Shift; Instant Pot’s Inner Sanctum.” The New York Times (Mon., December 18, 2017): B1 & B5.
(Note: ellipses added.)
(Note: the online version of the story has the date DEC. 17, 2017, and has the title “The Shift; Inside the Home of Instant Pot, the Kitchen Gadget That Spawned a Religion.”)